北京注射用EfimosferminalfaIII期临床试验-一项在确诊或疑似F2或F3期MASH参与者中评价Efimosfermin alfa注射液的安全性和耐受性的临床研究（BOS-580-302）

登记号	CTR20263158	试验状态	进行中
申请人联系人	明扬	首次公示信息日期	2026-08-14
申请人名称	葛兰素史克（中国）投资有限公司

登记号	CTR20263158
相关登记号	CTR20263057
药物名称	注射用Efimosfermin alfa
药物类型	生物制品
临床申请受理号	企业选择不公示
适应症	适用于代谢相关脂肪性肝炎（MASH）合并中度至进展期肝纤维化（符合2期（F2）至3期（F3）肝纤维化）成人患者的治疗
试验专业题目	一项在确诊或疑似F2或F3期代谢相关脂肪性肝炎（MASH）参与者中评价Efimosfermin alfa的安全性和耐受性的III期、随机、双盲、安慰剂对照、三臂研究（ZENITH-2）
试验通俗题目	一项在确诊或疑似F2或F3期MASH参与者中评价Efimosfermin alfa注射液的安全性和耐受性的临床研究（BOS-580-302）
试验方案编号	306246	方案最新版本号	修正案1（终版）
版本日期:	2026-01-21	方案是否为联合用药	否

申请人名称	[["葛兰素史克（中国）投资有限公司"]]
联系人姓名	明扬	联系人座机	021-24228876	联系人手机号	15951009705
联系人Email	yang.ming@iqvia.com	联系人邮政地址	上海市-上海市-浦东新区耀龙路1359号，晶耀商务广场1幢6楼	联系人邮编	200124

主要目的：评估efimosfermin的安全性和耐受性。次要目的：评估efimosfermin对ELF评分的影响；评估efimosfermin对VCTE-LSM评分的影响；评估efimosfermin对MRE评分的影响；评估efimosfermin对HFF和ALT正常化的影响；评估efimosfermin对血糖和代谢生物标志物的影响；评估efimosfermin对脂质的影响；评估efimosfermin的免疫原性；评估efimosfermin的稳态PK特征。

试验分类	安全性和有效性	试验分期	III期	设计类型	平行分组
随机化	随机化	盲法	双盲	试验范围	国际多中心试验

年龄	18岁(最小年龄)至 75岁(最大年龄)
性别	男+女
健康受试者	无
入选标准	[["能够且愿意理解并签署书面ICF（该ICF须在研究程序开始前获得）"],["入组时年龄≥18岁且≤75岁"],["根据美国心脏协会的定义，既往或目前存在代谢综合征诊断标准的5项指标中的至少2项（Grundy et al, 2005）：a. 肥胖/超重（BMI≥25 kg/m^2；亚洲地区BMI≥23 kg/m^2），或男性腰围≥40英寸（102 cm），女性腰围≥35英寸（89 cm），b. 甘油三酯升高：≥150 mg/dL（1.7 mmol/L）或正在服用降甘油三酯药物，c. HDL胆固醇降低：男性，≤1.03 mmol/L（40 mg/dL）；女性，≤1.29 mmol/L（50 mg/dL），d. 空腹血糖升高（≥100 mg/dL；≥5.6 mmol/L），或接受降糖药物治疗，e. 高血压"],["既往或目前存在确诊或疑似MASH诊断标准的3项指标中的至少1项：a. 随机分组前≤3个月内增强肝纤维化（ELF）评分≥7.7且≤11.3，b. 随机分组前≤3个月，VCTE-LSM≥8.0 kPa且<20 kPa，c. 肝活检结果符合疑似MASH，每个NAS分项评分至少1分且有肝纤维化证据。注：VCTE和ELF应在筛选期间进行，除非在另一项efimosfermin研究的合格性评估中已进行过评估。"],["过去6个月内体重稳定（变化≤5%）"],["未妊娠、未哺乳且符合以下条件之一的女性有资格参加研究：i. 不符合方案第10.5节中有生育能力的参与者（POCBP）的定义，或ii. 若为POCBP，则必须在治疗期间和研究药物末次给药后至少持续16周遵守避孕指南所列要求。注：有关避孕要求的详细信息参见方案第10.5节（附录5：避孕指南）。"]]
排除标准	[["维生素D水平≤12 ng/mL。维生素D水平>12 ng/mL但<20 ng/mL的参与者应同意按照标准治疗或当地指南补充维生素D，以确保快速恢复至正常水平。"],["ALT或AST≥5×正常值上限（ULN）"],["总胆红素≥1.3 mg/dL。确诊Gilbert综合征的参与者若出现孤立性总胆红素升高≥1.3 mg/dL且直接胆红素≤总胆红素的20%，则可入组研究；否则需排除。"],["血清白蛋白≤3.5 g/dL"],["国际标准化比值（INR）≥1.3，且非治疗性抗凝所致。接受长期抗凝治疗且INR值较高的参与者可由研究者和研究医学监查员酌情纳入研究。"],["碱性磷酸酶（ALP）≥2×ULN"],["血红蛋白（Hb）≤11.0 g/dL（男性）和≤10.0 g/dL（女性）"],["中性粒细胞≤1500/mm^3（黑人参与者：≤1200/mm^3）；确诊良性种族中性粒细胞减少症的参与者可由研究医学监查员酌情纳入研究。"],["血小板（PLT）计数<140,000/mm^3；PLT计数在110,000/mm^3至140,000/mm^3之间的参与者，经研究者与研究医学监查员讨论后可被纳入研究。"],["血清肌酐≥1.5 mg/dL或根据慢性肾脏病流行病学协作组公式（2021年）计算的肌酐清除率≤60 mL/min/1.73 m^2。"],["甲胎蛋白≥20 ng/mL"],["促甲状腺激素超出正常参考范围，除非游离甲状腺素值在正常范围内"],["甘油三酯≥500 mg/dL"],["HbA1c≥9.0%"],["MELD 3.0评分≥12，除非该评分升高并非由肝功能障碍引起（例如Gilbert综合征）"],["筛选时磷脂酰乙醇（PEth）≥80 ng/mL"],["有合并感染以下任一病毒的证据：a. 人类免疫缺陷病毒，b. 乙型肝炎病毒（筛选时检出HBsAg），c. 丙型肝炎病毒（HCV）。注：应使用聚合酶链反应（PCR）检测HCV抗体阳性参与者的HCV核糖核酸（RNA）水平；排除HCV RNA阳性（可检测出）的参与者。HCV抗体检测阳性且筛选PCR检测结果呈阴性的参与者还必须有记录显示在筛选前≥6个月检测结果呈阴性。"],["任何其他原因导致的慢性肝病，包括但不限于酒精性肝病；存在门静脉高压证据；病毒性肝炎，或任何肝硬化病史提示肝硬化证据；或筛选或第1天前出现失代偿性肝病表现，如临床腹水、出血性胃食道静脉曲张、肝肾综合征或肝性脑病。"],["现患或有慢性胆道疾病史（包括症状性或复杂性胆石症），或既往6个月内有急性胆囊炎病史、接受过胆道手术或介入操作。"],["有胰腺疾病（包括胰腺炎）病史或证据。注：对于筛选前>6个月有急性胆石性胰腺炎病史的参与者，如果事件已痊愈且无并发症、已接受胆囊切除术且胆总管通畅，则有资格参加研究。"],["有1型糖尿病史或谷氨酸脱羧酶自身抗体阳性（成人隐匿性自身免疫性糖尿病），或严重T2DM并发症，包括但不限于重度胃轻瘫和自主神经病变"],["筛选前12周内有显著骨病史，如符合骨密度低于年轻成人平均值≥2.5个标准差（SD）的骨质疏松症，骨软化症，或有骨折史或骨手术史（即，内置物植入、关节置换、骨移植或截肢术）"],["有肾上腺疾病史（如库欣综合征、艾迪生病），或使用影响下丘脑-垂体-肾上腺轴的治疗（如长期口服糖皮质激素）"],["当前或既往存在有临床意义的心脏异常或功能障碍，如充血性心力衰竭；肺动脉高压；复杂性先天性心脏病；严重心律失常；活动性心肌缺血；或筛选前6个月内发生有临床意义的心血管事件，如急性冠脉综合征、短暂性脑缺血发作、控制不佳的高血压或脑血管意外"],["既往或当前存在表明参与研究存在显著安全性风险的心电图（ECG）异常诊断，包括但不限于家族性长QT综合征病史；尖端扭转性室性心动过速家族史；或筛选时使用Fridericia公式基于心率校正的静息QT间期（QTcF）≥450 ms（男性）或≥470 ms（女性）"],["既往3年内有任何器官系统的恶性肿瘤史（局限性皮肤基底细胞癌或原位宫颈癌除外），无论是否接受过治疗，即使无局部复发或转移证据亦需排除"],["筛选前12周内接受过任何重大手术，或存在可能危及参与者安全的手术或医学状况；研究期间计划进行手术，经研究者评估认为会妨碍参与者参与研究"],["存在研究者认为可能危及参与者安全或方案依从性的任何疾病"],["对研究药物或其辅料，或对相似生物类别药物、FGF21蛋白类似物、Fc融合蛋白或其他蛋白质治疗药物有超敏反应史（如速发严重过敏反应或肝毒性）"],["根据当地影像机构的指南，存在VCTE、MRI或MRE的禁忌症"],["给药前12个月内有药物滥用史，或筛选时进行的实验室检查提示药物滥用证据。若参与者当前正在使用处方药物（例如，阿片类药物、苯二氮卓类药物）且检测结果呈阳性，研究者可酌情考虑纳入研究。允许使用娱乐用或医用大麻以及含大麻素制品。"],["筛选前12个月内曾有持续≥3个月的过量饮酒史；或当前存在持续≥3个月的过量饮酒行为，定义为：a. 男性每周摄入≥196 g/14 U酒精，女性每周摄入≥112 g/7 U酒精，其中1"单位"酒精相当于12盎司（355 mL）啤酒、5盎司（150 mL）葡萄酒或1.5盎司（44 mL）烈酒。鼓励研究者运用最佳临床判断和病史评估，排除大量饮酒者（https://www.niaaa.nih.gov/alcohols-effects-health/what-standard-drink; https://www.niaaa.nih.gov/health-professionals-communities/core-resource-on-alcohol/basics-defining-how-much-alcohol-too-much）。"],["因精神疾病或身体疾病（如传染病）而接受监管或强制隔离治疗"],["随机分组前2周内接种过任何疫苗。注：入组后，允许在研究期间接种疫苗。"],["排除使用维生素E或吡格列酮的参与者，除非满足以下任一条件：（1）入组前已停用维生素E或吡格列酮；或（2）入组前剂量已稳定≥6个月，且研究期间保持该剂量不变。"],["排除使用GLP-1受体激动剂的参与者，除非同时满足以下条件（1）筛选前剂量已稳定≥6个月；（2）过去≥6个月内体重变化<5%。注：允许在第52周后启动GLP-1治疗。"],["筛选前≤6个月内或研究期间使用过resmetirom或saroglitazar。注：研究期间亦禁止使用resmetirom。"],["筛选前≤6个月和研究期间启动长期减重干预措施（包括药物、结构化体重管理计划和手术）"],["筛选前使用过以下任何药物，但经研究医学监查员批准的短期治疗（≤4周）除外：orlistat、氯卡色林、芬特明-托吡酯和纳曲酮-安非他酮。"],["使用与诱导脂肪变性相关的药物（如甲氨蝶呤、胺碘酮、他莫昔芬、硝苯地平和丙戊酸盐）以及药效学作用可能持续超过6个月的药物"],["筛选前禁止使用以下合并用药：a. 治疗MASH的试验药物。注：所有用于治疗MASH的试验药物应在随机分组前≥6个月停用。若参与者既往或同时使用具有持久药效学作用的药物（例如，小干扰[si] RNA），必须与研究医学监查员讨论。b. 口服或注射用皮质类固醇；筛选前可能允许短期使用口服或全身性皮质类固醇（≤14天）。注：允许使用已注册剂量规格的吸入性、鼻用或外用类固醇。c. 已知具有肝毒性风险的草药和膳食补充剂，除非在随机分组前至少8周已停药。"],["随机分组前合并用药发生以下变化：a. 在随机分组前≤90天调整过抗糖尿病药物的剂量，如二肽基肽酶4抑制剂、钠-葡萄糖协同转运蛋白2抑制剂和胰岛素促泌剂（例如，磺酰脲类药物和meglitinides）。注：随机分组前≤90天胰岛素剂量调整≥25%也作为排除标准。b. 在随机分组前≤90天调整过降脂药物（例如，他汀类药物、胆汁酸树脂/螯合剂、前蛋白转化酶枯草杆菌蛋白酶kexin-9抑制剂、烟酸、贝特类药物）的剂量，c. 在随机分组前≤8周调整过草药和膳食补充剂的剂量"]]

试验药	[["中文通用名:注射用Efimosferminalfa 英文通用名:EfimosferminalfaPowderforSolutionforInjection 商品名称:NA","剂型:注射剂 规格:150mg/瓶 用法用量:皮下注射（SC），每4周一次（Q4W）；225mg（注射体积1.5mL） 用药时程:52周"],["中文通用名:注射用Efimosferminalfa 英文通用名:EfimosferminalfaPowderforSolutionforInjection 商品名称:NA","剂型:注射剂 规格:150mg/瓶 用法用量:皮下注射（SC），每4周一次（Q4W）；300mg（注射体积2.0mL） 用药时程:52周"]] 序号 名称 用法
对照药	[["中文通用名:安慰剂 英文通用名:Placebo 商品名称:NA","剂型:注射剂 规格:NA 用法用量:皮下注射（SC），每4周一次（Q4W） 用药时程:52周"]] 序号 名称 用法

主要终点指标及评价时间

[["TEAE的发生率和严重程度。","第52周","安全性指标"],["导致停药的TEAE的发生率和严重程度。","第52周","安全性指标"],["3级和4级实验室检查结果异常的发生率。","第52周","安全性指标"]] 序号 指标 评价时间 终点指标选择

次要终点指标及评价时间

[["所有参与者ELF评分从基线至第52周的绝对和相对变化。达到ELF评分改善≥0.5。","第52周","有效性指标"],["第52周时所有参与者的VCTE-LSM评分较基线的绝对变化和相对变化。第52周时达到VCTE-LSM较基线的变化≥30%。","第52周","有效性指标"],["在具有MRE评分的参与者子集中第52周时MRE评分较基线的绝对变化和相对变化。","第52周","有效性指标"],["第52周时所有参与者的MRI-PDFF HFF较基线的绝对变化和相对变化。第52周时所有参与者的ALT、AST和ALT/AST比值较基线的绝对变化和相对变化。第52周时达到ALT和HFF恢复正常。第52周时达到HFF≤5%。","第52周","有效性指标"],["第52周时合并T2DM参与者的HbA1c较基线的变化。第52周时所有参与者的体重较基线的变化。","第52周","有效性指标"],["第52周时所有参与者中空腹总胆固醇、LDL-C、HDL-C和空腹甘油三酯较基线的变化。","第52周","有效性指标"],["第52周时ADA的发生率。","第52周","有效性指标"],["具有多次给药后PK数据的参与者的efimosfermin血清浓度。","多次给药后","有效性指标+安全性指标"]] 序号 指标 评价时间 终点指标选择

1	姓名	尤红	学位	医学博士	职称	主任医师
	电话	13521130181	Email	youhongliver@ccmu.edu.cn	邮政地址	北京市-北京市-西城区永安路95号北京友谊医院体检中心二单元602
	邮编	100052	单位名称	首都医科大学附属北京友谊医院

[["首都医科大学附属北京友谊医院","尤红","中国","北京市","北京市"],["温州医科大学附属第一医院","郑明华","中国","浙江省","温州市"],["南京市第二医院","杨永峰","中国","江苏省","南京市"],["镇江市第三人民医院","谭友文","中国","江苏省","镇江市"],["首都医科大学附属北京佑安医院","张晶","中国","北京市","北京市"],["中国医科大学附属第一医院","李异玲","中国","辽宁省","沈阳市"],["广州医科大学附属市八医院","关玉娟","中国","广东省","广州市"],["四川大学华西医院","唐红","中国","四川省","成都市"],["萍乡市人民医院","李兴","中国","江西省","萍乡市"],["徐州医科大学附属医院","颜学兵","中国","江苏省","徐州市"],["北京清华长庚医院","杨明","中国","北京市","北京市"],["四川省人民医院","林建梅","中国","四川省","成都市"],["重庆大学附属三峡医院","安选","中国","重庆市","重庆市"],["南昌大学第二附属医院","孙水林","中国","江西省","南昌市"],["首都医科大学附属北京地坛医院","谢雯","中国","北京市","北京市"],["天津市第三中心医院","叶青","中国","天津市","天津市"],["宁波市第二医院","付丽云","中国","浙江省","宁波市"],["南昌大学第一附属医院","程娜","中国","江西省","南昌市"],["聊城市人民医院","王思奎","中国","山东省","聊城市"],["青岛市市立医院","辛永宁","中国","山东省","青岛市"],["郑州大学第一附属医院","余祖江","中国","河南省","郑州市"],["郑州市第六人民医院","李广明","中国","河南省","郑州市"],["福建医科大学附属第一医院","朱月永","中国","福建省","福州市"],["杭州师范大学附属医院","施军平","中国","浙江省","杭州市"],["沈阳市第六人民医院","吴威","中国","辽宁省","沈阳市"],["瑞安市人民医院","洪亮","中国","浙江省","温州市"],["苏州市第五人民医院","朱传武","中国","江苏省","苏州市"],["深圳市龙华区人民医院","姜春梅","中国","广东省","深圳市"],["上海市公共卫生临床中心","陈良","中国","上海市","上海市"],["上海市同仁医院","张琴","中国","上海市","上海市"],["上海市第一人民医院","陆伦根","中国","上海市","上海市"],["河南省人民医院","尚佳","中国","河南省","郑州市"],["洛阳市中心医院","张国强","中国","河南省","洛阳市"],["財團法人私立高雄醫學大學附設中和紀念醫院","余明隆","中国台湾","高雄","高雄"],["國立成功大學醫學院附設醫院","鄭斌男","中国台湾","台南","台南"],["台灣大學醫學院附設醫院","劉俊人","中国台湾","台北","台北"],["長庚醫療財團法人高雄長庚紀念醫院","胡琮輝","中国台湾","高雄鸟松区","高雄鸟松区"],["台北醫學大學附設醫院","高偉育","中国台湾","台北市","台北市"],["戴德森醫療財團法人嘉義基督教醫院","陳啟益","中国台湾","嘉义市","嘉义市"],["香港中文大學","黃煒燊","中国香港","沙田","沙田"],["瑪麗醫院","麥龍兒","中国香港","香港","香港"],["Sheba Medical Center","Ehud Zigmond","以色列","Ramat-Gan","Ramat-Gan"],["Assuta Medical Center","Ziv Ben Ari","以色列","Tel Aviv","Tel Aviv"],["Shaare Zedek Medical Center","Gadi Lalazar","以色列","Jerusalem","Jerusalem"],["Rambam Health Care Campus","Tarek Saadi","以色列","Haifa","Haifa"],["Rabin Mc Belinson Campus","Michal Cohen","以色列","Petach Tikva","Petach Tikva"],["Wolfson Medical Center","Vera Dreizin","以色列","Holon","Holon"],["Hadassah University Hospital - Ein Kerem","Rifaat Safadi","以色列","Jerusalem","Jerusalem"],["Kaplan Medical Center","Mariya Likhter","以色列","Rehovot","Rehovot"],["Soroka University Medical Center","Ali Abu Juma","以色列","Beer-Sheva","Beer-Sheva"],["The Lady Davis Carmel Medical Center","Eli Zuckerman","以色列","Haifa","Haifa"],["Barzilai Medical Center","Nave Firestein","以色列","Ashkelon","Ashkelon"],["Health Corporation of Galilee Medical Center","Michal Carmiel Haggai","以色列","Naharyia","Naharyia"],["Tel Aviv Sourasky Medical Center-Derma","Elena Izkhakov","以色列","Tel Aviv","Tel Aviv"],["UMHATEM 'N.I. Pirogov', EAD","Kamen Danov","保加利亚","Sofia","Sofia"],["DCC ‘Alexandrovska’, EOOD","Diana Stefanova-Petrova","保加利亚","Sofia","Sofia"],["MHAT ‘Hadzhi Dimitar’, OOD","Dimitar Pavlov","保加利亚","Sliven","Sliven"],["Medical Center Hera EOOD","Ivan Popadiyn","保加利亚","Sofia","Sofia"],["UMHAT ‘Sv. Georgi’, EAD","Dragomir Gerov","保加利亚","Plovdiv","Plovdiv"],["ACIBADEM CITY CLINIC TOKUDA UNIVERSITY HOSPITAL EAD","Rozalina Balabanska","保加利亚","Sofia","Sofia"],["MHAT Trakia - Park","Ivan Sirakov","保加利亚","Stara Zagora","Stara Zagora"],["Military Medical Academy - MHAT - Sofia","Marina Konaktchieva","保加利亚","Sofia","Sofia"],["MHAT Uni Hospital","Tsvetolyub Mitev Marinov","保加利亚","Panagyurishte","Panagyurishte"],["MHAT ‘Lozenets’","Nonka Yurukova","保加利亚","Sofia","Sofia"],["MHAT 'Sv. Sofia', OOD","Gergana Taneva","保加利亚","Sofia","Sofia"],["DCC ‘Ascendent’ EAD","Gerasim Temelkov","保加利亚","Sofia","Sofia"],["Medical Center Futuremeds EOOD","Vesela Georgieva","保加利亚","Plovdiv","Plovdiv"],["Medical center Arcus Medical AD","Ilko Kosturkov","保加利亚","Veliko Tarnovo","Veliko Tarnovo"],["DIEX Recherche Quebec Inc.","Pascale Chouinard","加拿大","Quebec","Quebec"],["London Health Sciences Centre (LHSC) - University Hospital","Mohammad Khan","加拿大","Ontario","London"],["University of Alberta","Mang Ma","加拿大","Alberta","Edmonton"],["Okanagan Clinical Trials","Mallory Myers","加拿大","British Columbia","Kelowna"],["Toronto General Hospital","Keyur Patel","加拿大","Ontario","Toronto"],["Charlton Digestive Disease Centre","Marco Amedeo Puglia","加拿大","Ontario","Hamilton"],["University of Calgary, Heritage Medical Research Clinic, CWPH Building","Henry Nguyen","加拿大","Alberta","Calgary"],["University of Manitoba","Nabiha Faisal","加拿大","Manitoba","Winnipeg"],["(G.I.R.I.) GI Research Institute","Alnoor Ramji","加拿大","British Columbia","Vancouver"],["McGill University Health Centre/Glen Site / Royal Victoria Hospital","Giada Sebastiani","加拿大","Quebec","Montreal"],["Unity Hospital ICU and Trauma","Pintukumar Bhakhar","印度","Gujarat","Surat"],["Gujarat Gastro and Vascular Hospital","Saumin Shah","印度","Gujarat","Surat"],["Midas institute of Gastroenterology","Shrikant Mukewar","印度","Maharashtra","Nagpur"],["Centre for Clinical Research, John C. Martin Centre for Liver Research and Innovations","Abhijit Chowdhury","印度","West Bengal","Kolkata"],["Pandit Bhagwat Dayal Sharma Post Graduate Institute of Medical Sciences","Tarana Gupta","印度","Haryana","Rohtak"],["Yashoda Hospital","Dharmesh Kapoor","印度","Andhra Pradesh","Secunderabad"],["SUM Ultimate Medicare","Ayaskanta Singh","印度","Orissa","Bhubaneswar"],["Dayanand Medical College and Hospital","Vandana Midha","印度","Punjab","Ludhiana"],["NRS Medical College","Pinaki Roy","印度","West Bengal","Kolkata"],["All India Institute of Medical Science","Manas Panigrahi","印度","Orissa","Bhubaneswar"],["BAPS Pramukhswami Hospital","Prashant Dobariya","印度","Gujarat","Surat"],["Amrita Institute Of Medical Sciences and Research Centre","Arun Valsan","印度","Kerala","Kochi"],["Sahyadri Super Speciality Hospital-Hadapsar","Kiran Shinde","印度","Maharashtra","Pune"],["Government Medical College","Krishnadas Devadas","印度","Kerala","Trivandrum"],["IPGMER and SSKM Hospital","Prasenjit Halder","印度","West Bengal","Kolkata"],["Bezmialem Vakif Universitesi Tip Fakultesi Hastanesi","Metin Basaranoglu","土耳其","Istanbul","Istanbul"],["Koc University Hospital","Suleyman Cihan Yurdaydin","土耳其","Istanbul","Istanbul"],["Ege University Medical Faculty","Fulya Gunsar","土耳其","Izmir","Izmir"],["Kocaeli Universitesi Tip Fakultesi","Hasan Yilmaz","土耳其","Kocaeli","Kocaeli"],["Rize Recep Tayyip Erdogan University Education and Research Hospital","Yusuf Yilmaz","土耳其","Rize","Rize"],["Karadeniz Tecnical Uni. Med. Fac.","Arif Cosar","土耳其","Trabzon","Trabzon"],["LKH - Universitaetsklinikum Graz","Vanessa Stadlbauer Koellner","奥地利","Graz","Graz"],["AKH - Medizinische Universitat Wien","Michael Trauner","奥地利","Vienna","Vienna"],["Klinikum Klagenfurt am Worthersee","Markus Peck Radosavljevic","奥地利","Klagenfurt","Klagenfurt"],["Medizinische Universitat Innsbruck","Heinz Zoller","奥地利","Innsbruck","Innsbruck"],["Klinik Hietzing","Thomas Stulnig","奥地利","Wien","Wien"],["HC-UFG - Hospital das Clinicas da Universidade Federal de Goias","Daniela Espindola Antunes","巴西","Goiás","Goiania"],["Universidade Municipal de Sao Caetano do Sul (USCS)","Fábio Luiz Maximiano","巴西","Sao Paulo","Sao Caetano do Sul"],["Newdata Clinical Trials","Alex Vianey Callado Franca","巴西","Sergipe","Aracaju"],["Hospital Moinhos de Vento","Fernando Herz Wolff","巴西","Rio Grande do Sul","Porto Alegre"],["Hospital Alianca Salvador","Raymundo Parana Ferreira Filho","巴西","Bahia","Salvador"],["Hospital de Clinicas de Porto Alegre","Mario Reis Alvares da Silva","巴西","Rio Grande do Sul","Porto Alegre"],["Hospital Ernesto Dornelles","Felipe Mazzoleni","巴西","Rio Grande do Sul","Porto Alegre"],["HUWC - UFC - Hospital Universitario Walter Cantidio - Universidade Federal do Ceara","Renan Montenegro Junior","巴西","Ceará","Fortaleza"],["Instituto Brasil de Pesquisa Clinica-IBPCLIN S/A","Luis Augusto Tavares Russo","巴西","Rio do Janeiro","Rio de Janeiro"],["HUJBB-UFPA - Hospital Universitario Joao de Barros Barreto - Universidade Federal do Para","Joao Felicio","巴西","Pará","Belém"],["L2IP Instituto de Pesquisas Clinicas Ltda","Eduardo Vasconcellos","巴西","Distrito Federal","Brasilia"],["Clinica de Endocrinologia e Metabologia Ltda.","Joao Borges","巴西","Distrito Federal","Brasilia"],["UNESP - Faculdade de Medicina da Universidade Estadual Paulista - Campus Botucatu","Giovanni Faria Silva","巴西","Sao Paulo","Botucatu"],["General Hospital of Athens Laiko","George Papatheodoridis","希腊","Athens","Athens"],["General Hospital of Athens ‘Evangelismos’","Nikolaos Viazis","希腊","Athens","Athens"],["General Hospital of Thessaloniki ‘Hippokration’","Ioannis Goulis","希腊","Thessaloniki","Thessaloniki"],["AHEPA General Hospital of Thessaloniki","Christos Savopoulos","希腊","Thessaloniki","Thessaloniki"],["General Hospital of Athens ‘Hippokration’","Spilios Manolakopoulos","希腊","Athens","Athens"],["University General Hospital of Heraklion","Konstantinos Karmiris","希腊","Heraklion","Heraklion"],["Charite - Campus Virchow-Klinikum","Muenevver Demir","德国","Berlin","Berlin"],["Universitaetsmedizin der Johannes Gutenberg-Universitaet Mainz","Christian Labenz","德国","Rheinland Pfalz","Mainz"],["Universitaetsklinikum Heidelberg","Uta Merle","德国","Baden Wuerttemberg","Heidelberg"],["EPIMED- Gesellschaft fuer epidemiologische und klinische Forschung in der Medizin mbH","Hartmut Stocker","德国","Berlin","Berlin"],["Universitaetsklinikum Hamburg-Eppendorf","Malte Wehmeyer","德国","Hamburg","Hamburg"],["Universitaetsklinikum des Saarlandes","Joern Schattenberg","德国","Saarland","Homburg / Saar"],["EUGASTRO GmbH","Ingolf Schiefke","德国","Sachsen","Leipzig"],["Universitaetsklinikum Leipzig AoeR","Sabine Lieb","德国","Sachsen","Leipzig"],["Universitaetsklinikum Muenster","Jonel Trebicka","德国","Nordrhein Westfalen","Muenster"],["Gruppo Humanitas - Humanitas Research Hospital (Istituto Clinico Humanitas)","Alessio Aghemo","意大利","Milano","Rozzano"],["Fondazione Policlinico Universitario Agostino Gemelli IRCCS","Antonio Gasbarrini","意大利","Roma","Roma"],["Azienda Ospedaliera Universitaria Policlinico Sant'Orsola Malpighi IRCCS","Paolo Caraceni","意大利","Bologna","Bologna"],["Azienda Ospedaliero Universitaria Ospedali Riuniti di Foggia","Gaetano Serviddio","意大利","Foggia","Foggia"],["Azienda Ospedale-Universita di Padova","Francesco Paolo Russo","意大利","Padova","Padova"],["Azienda Ospedaliera Universitaria Careggi","Fabio Marra","意大利","Firenze","Firenze"],["Universita Campus Bio-Medico di Roma","Umberto Vespasiani Gentilucci","意大利","Roma","Roma"],["Fondazione IRCCS CA' Granda Ospedale Maggiore Policlinico","Luca Valenti","意大利","Milano","Milano"],["Fondazione IRCCS CA' Granda Ospedale Maggiore Policlinico","Pietro Lampertico","意大利","Milano","Milano"],["Azienda Ospedaliero-Universitaria Citta della Salute e della Scienza di Torino","Elisabetta Bugianesi","意大利","Torino","Torino"],["Azienda Socio Sanitaria Territoriale Papa Giovanni XXIII","Stefano Fagiuoli","意大利","Bergamo","Bergamo"],["Ospedale San Raffaele","Patrizia Rovere Querini","意大利","Milano","Milano"],["Azienda Ospedaliero Universitaria delle Marche","Giuseppe Tarantino","意大利","Ancona","Ancona"],["Singapore General Hospital- Parent","Boon Bee George Goh","新加坡","Singapore","Singapore"],["National University Hospital","Mark Dhinesh Muthiah","新加坡","Singapore","Singapore"],["Changi General Hospital","Rahul Kumar","新加坡","Singapore","Singapore"],["Ehime University Hospital","Yoichi Hiasa","日本","Ehime-Ken","Toon-shi"],["Institute of Science Tokyo Hospital","Yasuhiro Asahina","日本","Tokyo-To","Bunkyo-ku"],["NHO Takasaki General Medical Center","Atsushi Naganuma","日本","Gunma-Ken","Takasaki-shi"],["Osakafu Saiseikai Suita Hospital","Toshihide Shima","日本","Osaka-Fu","Suita-shi"],["Aichi Medical University Hospital","Jun Arai","日本","Aichi-Ken","Nagakute-shi"],["Gifu Municipal Hospital","Hideki Hayashi","日本","Gifu-Ken","Gifu-shi"],["Kagoshima University Hospital","Seiichi Mawatari","日本","Kagoshima-Ken","Kagoshima-shi"],["Nara Medical University Hospital","Norihisa Nishimura","日本","Nara-Ken","Kashihara-shi"],["Ogaki Municipal Hospital","Hidenori Toyoda","日本","Gifu-Ken","Ogaki-shi"],["Oita Cardiovascular Hospital","Masataka Seike","日本","Oita-Ken","Oita-shi"],["Saga University Hospital","Hirokazu Takahashi","日本","Saga-Ken","Saga-shi"],["St. Marianna University Hospital","Tsunamasa Watanabe","日本","Kanagawa-Ken","Kawasaki-shi"],["University Hospital, Kyoto Prefectural University of Medicine","Yuya Seko","日本","Kyoto-Fu","Kyoto-shi"],["Yokohama City University Hospital","Michihiro Iwaki","日本","Kanagawa-Ken","Yokohama-shi"],["Fukuoka University Hospital","Keiji Yokoyama","日本","Fukuoka-Ken","Fukuoka-shi"],["Kumamoto University Hospital","Yasuhito Tanaka","日本","Kumamoto-Ken","Kumamoto-shi"],["Kurume University Hospital","Toru Nakamura","日本","Fukuoka-Ken","Kurume-shi"],["Nagaoka Chuo General Hospital","Masaaki Takamura","日本","Niigata-Ken","Nagaoka-shi"],["Saitama Medical University Hospital","Satoshi Mochida","日本","Saitama-Ken","Iruma-gun"],["Shin-yurigaoka General Hospital","Kento Imajo","日本","Kanagawa-Ken","Kawasaki-shi"],["Hiroshima University Hospital","Masataka Tsuge","日本","Hiroshima-Ken","Hiroshima-shi"],["Osaka General Medical Center (Kyuseiki Sogo Iryo C)","Takayuki Yakushijin","日本","Osaka-Fu","Osaka-shi"],["Japanese Red Cross Musashino Hospital","Nobuharu Tamaki","日本","Tokyo-To","Musashino-shi"],["JCHO Shimonoseki Medical Center","Akira Kato","日本","Yamaguchi-Ken","Shimonoseki-shi"],["Iwate Medical University Hospital","Hidekatsu Kuroda","日本","Iwate-Ken","Shiwa-gun"],["Kagawa University Hospital","Asahiro Morishita","日本","Kagawa-Ken","Kita-gun"],["Tokai University Hospital","Tatehiro Kagawa","日本","Kanagawa-Ken","Isehara-shi"],["Asahikawa Medical University Hospital","Koji Sawada","日本","Hokkaido","Asahikawa-shi"],["Nihon University Itabashi Hospital","Hirofumi Kogure","日本","Tokyo-To","Itabashi-ku"],["Hyogo Medical University Hospital","Hirayuki Enomoto","日本","Hyogo-Ken","Nishinomiya-shi"],["Mie University Hospital","Hayato Nakagawa","日本","Mie-Ken","Tsu-shi"],["Aotearoa Clinical Trials","Tien Lim","新西兰","Auckland","Auckland"],["Christchurch Hospital NZ","Jing Hieng Jeffery Ngu","新西兰","Christchurch","Christchurch"],["Capital, Coast and Hutt Valley District – Wellington Regional Hospital","Stephen Inns","新西兰","Lower Hutt","Lower Hutt"],["Bay of Plenty Clinical School","Alex Lampen-Smith","新西兰","Tauranga","Tauranga"],["CeCim","Elizabeth Arriagada Hernandez","智利","Santiago","Santiago"],["Enroll Spa","Jorge Orlando Contreras Basulto","智利","Santiago","Santiago"],["Hospital Clinico Universidad de Chile","Jaime Poniachik","智利","Santiago","Santiago"],["Hospital Las Higueras","Carlos Roberto Valenzuela Valenzuela","智利","Talcahuano","Talcahuano"],["AZ Maria Middelares","Christophe Van Steenkiste","比利时","Gent","Gent"],["UZA","Sven Francque","比利时","Edegem","Edegem"],["HUB Erasme","Christophe Moreno","比利时","Brussels","Brussels"],["UZ Gent","Anja Geerts","比利时","Gent","Gent"],["CENTRE HOSPITALIER UNIVERSITAIRE DE LIEGE","Jean Delwaide","比利时","Liege","Liege"],["Cliniques Universitaires Saint-Luc","Nicolas Lanthier","比利时","Woluwe-Saint-Lambert","Woluwe-Saint-Lambert"],["King Faisal Specialist Hospital & Research Center","Faisal Abaalkhail","沙特阿拉伯","Riyadh","Riyadh"],["National Guard Health Affairs: King Abdulaziz Medical City","Faisal Sanai","沙特阿拉伯","Jeddah","Jeddah"],["King Saud University","Khalid Alswat","沙特阿拉伯","Riyadh","Riyadh"],["Imam Abdulrahman Bin Faisal University","Mona Ismail","沙特阿拉伯","Dammam","Dammam"],["King Fahad Specialist Hospital","Hadi Kuriry","沙特阿拉伯","Dammam","Dammam"],["Centre Hospitalier Lyon Sud","Cyrielle Caussy","法国","Rhone","Pierre Benite cedex"],["CHU Bordeaux - Hopital Haut-Leveque","Paul Hermabessiere","法国","Gironde","Pessac Cedex"],["CHU Angers - Hopital Hotel Dieu","Jerome Boursier","法国","Maine et Loire","Angers Cedex 9"],["Hopital Avicenne","Veronique Grando Lemaire","法国","Seine St Denis","Bobigny cedex"],["Hospital de brabois","Jean-Pierre Bronowicki","法国","Meurthe et Moselle","Vandoeuvre-lès-Nancy"],["CHU Rennes - Hopital Pontchaillou","Edouard Bardou Jacquet","法国","Ille et Vilaine","Rennes cedex 09"],["Hopital Saint-Antoine","Violaine Ozenne","法国","Paris","Paris"],["Hopital Henri Mondor","Anne Varaut","法国","Val de Marne","Créteil"],["Hopital Cochin","Lucia Parlati","法国","Paris","Paris"],["CHU Nice - Hopital de l'Archet 2","Rodolphe Anty","法国","Alpes Maritimes","Nice Cedex 3"],["CHU Strasbourg - Nouvel Hopital Civil","Francois Habersetzer","法国","Bas Rhin","Strasbourg"],["Hopital Paul Brousse","Rodolphe Sobesky","法国","Val de Marne","Villejuif"],["Centre Hospitalier de la Croix Rousse","Massimo Levrero","法国","Gironde","Lyon"],["Groupe Hospitalier Pitie-Salpetriere","Vlad Ratziu","法国","Paris","Paris Cedex 13"],["CHU Clermont Ferrand - Hopital d'Estaing","Armando Abergel","法国","Puy de Dome","Clermont Ferrand cedex 1"],["Hopital Beaujon","Laurent Castera","法国","Hauts de Seine","Clichy cedex"],["CHU Amiens - Hopital Sud","Eric Nguyen Khac","法国","Somme","Amiens Cedex"],["CHU Lille - Hopital Claude Huriez","Philippe Mathurin","法国","Nord","Lille cedex"],["Sante Atlantique Elsan","Annie Lim","法国","Loire Atlantique","Saint-Herblain"],["ID Clinic Arkadiusz Pisula","Ewa Janczewska","波兰","Myslowice","Myslowice"],["Santa Familia PTG Lodz","Maciej Jablkowski","波兰","Lodz","Lodz"],["SPZOZ Szpital Uniwersytecki w Krakowie","Michal Kukla","波兰","Krakow","Krakow"],["Centrum Medyczne Pratia Katowice","Elzbieta Blach","波兰","Katowice","Katowice"],["Gyncentrum Sp. z o.o.","Marek Olakowski","波兰","Katowice","Katowice"],["SOLUMED Centrum Medyczne","Magdalena Andrzejewska","波兰","Poznan","Poznan"],["GASTROMED Sp. z o.o.","Wit Cezary Danilkiewicz","波兰","Lublin","Lublin"],["Medical Network Spolka z o. o., WIP Warsaw IBD Point Profesor Kierkus","Jaroslaw Kierkus","波兰","Warszawa","Warszawa"],["MELITA MEDICAL SP. Z O. O.","Jaroslaw Leszczyszyn","波兰","Wroclaw","Wroclaw"],["AMICARE spolka z ograniczona odpowiedzialnoscia spolka komandytowa","Hubert Zatorski","波兰","Lodz","Lodz"],["Campbelltown Hospital","Vincent Ho","澳大利亚","New South Wales","Campbelltown"],["Princess Alexandra Hospital","James Thomas","澳大利亚","Queensland","Woolloongabba"],["Genesis Research Services","Lay Gan","澳大利亚","New South Wales","Broadmeadow"],["Austin Hospital","Marie Sinclair","澳大利亚","Victoria","Heidelberg"],["Flinders Medical Centre","Kate Muller","澳大利亚","South Australia","Bedford Park"],["Wollongong Hospital","Neha Tiwari","澳大利亚","New South Wales","Wollongong"],["Fiona Stanley Hospital","Raj Uchila","澳大利亚","Western Australia","Murdoch"],["Westmead Hospital","Jacob George","澳大利亚","New South Wales","Westmead"],["Coastal Digestive Health","Hans Seltenreich","澳大利亚","Queensland","Maroochydore"],["The Alfred Hospital","Stuart Roberts","澳大利亚","Victoria","Melbourne"],["Footscray Hospital","Zina Valaydon","澳大利亚","Victoria","Footscray"],["Royal Prince Alfred Hospital","Simone Strasser","澳大利亚","New South Wales","Camperdown"],["Royal Melbourne Hospital","Ashok Raj","澳大利亚","Victoria","Parkville"],["Nepean Hospital","Martin Weltman","澳大利亚","New South Wales","Kingswood"],["Royal North Shore Hospital","Cameron Gofton","澳大利亚","New South Wales","St Leonards"],["St Vincent's Hospital Melbourne","Alexander Thompson","澳大利亚","Victoria","Fitzroy"],["Accel Research Sites - Lakeland","James Andersen","美国","Florida","Lakeland"],["Accel Research Sites - Maitland CRU","Eva Maria Heurich","美国","Florida","Maitland"],["Advanced Clinical Research","Lazaro Garcia","美国","Florida","Miami"],["American Research Corporation (ARC)","Eric Lawitz","美国","Texas","San Antonio"],["IMA Clinical Research Austin","Nomita Kim","美国","Texas","Austin"],["Velocity Clinical Research Waco","Gregg Lucksinger","美国","Texas","Waco"],["Velocity Clinical Research - Los Angeles","Joseph Lamb","美国","California","Los Angeles"],["Velocity Clinical Research, Van Nuys","Robert Jenders","美国","California","Van Nuys"],["Velocity Clinical Research Seattle","Kris Kowdley","美国","Washington","Seattle"],["A+ Research Inc.","Carlos Ramos","美国","Florida","Miami"],["Velocity Clinical Research, Salt Lake City","Barbara Rizzardi","美国","Utah","West Jordan"],["Velocity Clinical Research, Austin","Michael Patrick Zimmerman","美国","Texas","Austin"],["Epic Medical Research-DeSoto","Haresh Boghara","美国","Texas","DeSoto"],["Peak Gastroenterology Associates","Bhaktasharan Patel","美国","Colorado","Colorado Springs"],["EmVenio Research at Riverdale","Deon Miller","美国","Georgia","Riverdale"],["ABMED Clinical Research Corp","Paige Kreegel","美国","Florida","Cape Coral"],["Accurate Clinical Research, Inc.","Brian Chou","美国","Texas","Humble"],["DM Clinical Research- Tomball","Muhammad Irfan","美国","Texas","Tomball"],["Digestive Research of Central Texas, LLC","Hanumantha Ancha","美国","Texas","Waco"],["Ocala GI Research","Robert Barish","美国","Florida","Ocala"],["DSI Research LLC","Anjali Morey","美国","Ohio","Springboro"],["Headlands Research Brownsville","Christopher Romero","美国","Texas","Brownsville"],["Olympus Clinical Research - Sugar Land","Harish Thakkar","美国","Texas","Sugar Land"],["Gateway GI Research, LLC","Brian McMorrow","美国","Missouri","St. Louis"],["Covenant Metabolic Specialists LLC","Guy Neff","美国","Florida","University Park"],["Santa Maria Gastroenterology Medical Group","Keval Shah","美国","California","Santa Maria"],["Covenant Metabolic Specialists LLC","Charles Smith","美国","Florida","Ft Myers"],["Fomat Medical Research, Inc.","Elias Tarakji","美国","California","Arcadia"],["AdMed Research, LLC","Barbara Moscoso","美国","Florida","Miami"],["IMA Clinical Research Manhattan","Eli Shalenberg","美国","New York","New York"],["Icahn School of Medicine at Mount Sinai PRIME","Jawad Ahmad","美国","New York","New York"],["3SYNC Research - Miami Lakes","Miguel Aponte","美国","Florida","Miami Lakes"],["Mercy Medical Center","Paul Thuluvath","美国","Maryland","Baltimore"],["Elixia at Catalina Research Institute","Rizwana Mohseni","美国","California","Montclair"],["IMA Clinical Research Warren","Samar Hameed","美国","New Jersey","Warren"],["Elixia at Lonestar Clinical Research","Valentine Ebuh","美国","Texas","Dallas"],["Kansas Medical Clinic","Shekhar Challa","美国","Kansas","Topeka"],["West Michigan Clinical Research Center","Allan Coates","美国","Michigan","Wyoming"],["Imagine Research of Palm Beach County","Aaron Cohen","美国","Florida","Boynton Beach"],["Velocity Clinical Research, Syracuse","Rachel Dubroff","美国","New York","East Syracuse"],["Intermountain Health Transplant Research","Christopher Danford","美国","Utah","Salt Lake"],["Endeavor Clinical Trials, P.A.","Emanuel DeNoia","美国","Texas","San Antonio"],["Doral Medical Research, LLC","Jorge Diaz","美国","Florida","Hialeah"],["Novum Clinical Research, LLC","Edriss Estime","美国","Florida","Clermont"],["Innovation Medical Research Center - Palmetto Bay","Karen Figueredo Reyes","美国","Florida","Palmetto Bay"],["Texas Clinical Research Institute, LLC","Reem Ghalib","美国","Texas","Arlington"],["Ilumina Medical Research","Luis Alvarado Lopez","美国","Florida","Kissimmee"],["D&H National Research Centers, Inc.","Jorge Amaya","美国","Florida","Miami"],["Manassas Clinical Research Center","Nabil Andrawis","美国","Virginia","Manassas"],["Valley Clinical Trials - Covina dba Flourish Research","Masoud Azizad","美国","California","Northridge"],["Preferred Research Partners, Inc.","John Baber","美国","Arkansas","Little Rock"],["Neoclinical Research","Isaac Bassan","美国","Florida","Hialeah"],["Felicidad Medical Research, LLC","Francisco Bautista","美国","Florida","Miami"],["Acclaim Clinical Research","Julie Vu","美国","California","San Diego"],["Optimus U Corp","Yaneicy Gonzalez Rojas","美国","Florida","Miami"],["University of Alabama at Birmingham","Meagan Gray","美国","Alabama","Birmingham"],["Nature Coast Clinical Research - Inverness","Paul Hellstern","美国","Florida","Inverness"],["Jacksonville Center for Clinical Research","Jeffry Jacqmein","美国","Florida","Jacksonville"],["Novel Research LLC","Everald Manning","美国","Texas","Bellaire"],["Adobe Clinical Research LLC","Sam Moussa","美国","Arizona","Tucson"],["DM Clinical Research Dallas","Danielle Coulter","美国","Texas","Irving"],["Woodholme Gastroenterology","Kenolisa Onwueme","美国","Maryland","Glen Burnie"],["Galen Hepatology","Chirag Patel","美国","Tennessee","Chattanooga"],["Elevate Clinical Research","Joe Pouzar","美国","Texas","Houston"],["GMC Clinical Research, LLC","Nazir Rahim","美国","California","Folsom"],["University of Pennsylvania-Perelman Center for Advanced Medicine","Rajender Reddy","美国","Pennsylvania","Philadelphia"],["Tandem Clinical Research Marrero LA","Gary Reiss","美国","Louisiana","Marrero"],["IMIC, Inc.","Miguel Rodriguez","美国","Florida","Miami"],["UCSF Fresno","Marina Roytman","美国","California","Fresno"],["Homestead Associates in Research Inc","Gilberto Seco","美国","Florida","Homestead"],["Springfield Clinic","Dmitry Shuster","美国","Illinois","Springfield"],["Piedmont Hospital Transplant Institute","Lance Stein","美国","Georgia","Atlanta"],["Akron Gastro Research, LLC","Ganesh Veerappan","美国","Ohio","Akron"],["Lucas Research, Inc.","Kathryn Lucas","美国","North Carolina","Morehead City"],["University of Michigan","Vincent Chen","美国","Michigan","Ann Arbor"],["Mayo Clinic","Manal Abdelmalek","美国","Minnesota","Rochester"],["FDI Clinical Research - San Juan","Grisell Ortiz-Lasanta","美国","Puerto Rico","San Juan"],["Duke University Medical Center","Amreen Dinani","美国","North Carolina","Durham"],["UNC Chapel Hill","Sidney Barritt","美国","North Carolina","Chapel Hill"],["Indiana University Health","Raj Vuppalanchi","美国","Indiana","Indianapolis"],["UCSD Clinical and Translational Research Institute","Rohit Loomba","美国","California","La Jolla"],["Medical University of South Carolina (MUSC) Research Nexus Laboratory","Don Rockey","美国","South Carolina","Charleston"],["Arizona Clinical Trials","Aimee Bachelier","美国","Arizona","Tucson"],["Arizona Clinical Trials","Anita Kohli","美国","Arizona","Chandler"],["Clinical Research Institute of Ohio, LLC (CRIOH)","Naim Alkhouri","美国","Ohio","Westlake"],["Houston Research Institute","Rukan Daccak","美国","Texas","Pasadena"],["Coastal Research Institute LLC","John Poulos","美国","North Carolina","Fayetteville"],["Quality Research Incorporated","Robert Morin","美国","Texas","San Antonio"],["Kansas City Research Institute, LLC","Paresh Patel","美国","Missouri","Kansas City"],["Houston Research Institute","Joseph Galati","美国","Texas","Houston"],["Gastrointestinal Specialists of Georgia, PC","Aasim Sheikh","美国","Georgia","Marietta"],["Jubilee Clinical Research, Inc","Elliot Shin","美国","Nevada","Las Vegas"],["Eximia Research - VA, LLC dba DLDS","John Smith","美国","Virginia","Norfolk"],["Richmond VA Medical Center","Michael Fuchs","美国","Virginia","RICHMOND"],["Pinnacle Clinical Research-Austin","Rohit Puskoor","美国","Texas","Austin"],["Saint Louis University","Brent Tetri","美国","Missouri","St. Louis"],["University of California Davis Health System","Albert Do","美国","California","Sacramento"],["Delta Research Partner, LLC","Bal Raj Bhandari","美国","Louisiana","Bastrop"],["University of California San Francisco","Mandana Khalili","美国","California","San Francisco"],["Weill Cornell Medicine","Sonal Kumar","美国","New York","New York"],["KAD Clinical Research","Adrian Di Bisceglie","美国","Missouri","St. Louis"],["Ralph H. Johnson VA Medical Center","Don Rockey","美国","South Carolina","Charleston"],["Gastroenterology Center of the MidSouth PC","Ziad Younes","美国","Tennessee","Cordova"],["Digestive Health Specialists, PA","Robert Smith","美国","Mississippi","Tupelo"],["GI Alliance -Gurnee","Jonathan Rosenberg","美国","Illinois","Gurnee"],["GI Alliance","Timothy Ritter","美国","Texas","Southlake"],["UCLA Medical Center","Sammy Saab","美国","California","Los Angeles"],["King's College Hospital","Kosh Agarwal","英国","Greater London","London"],["Royal London Hospital","William Alazawi","英国","Greater London","London"],["Aintree University Hospital","Cyril Sieberhagen","英国","Merseyside","Liverpool"],["Chelsea and Westminster Hospital","Robin Abeles","英国","Greater London","London"],["Royal Free Hospital","Rajeshwar Mookerjee","英国","Greater London","London"],["Addenbrooke's Hospital","Michael Allison","英国","Cambridgeshire","Cambridge"],["Bristol Royal Infirmary","Kushala Abeysekera","英国","Bristol","Bristol"],["Amsterdam UMC, Locatie VUMC","Onno Holleboom","荷兰","Amsterdam","Amsterdam"],["Erasmus Medisch Centrum","Willem Pieter Brouwer","荷兰","Rotterdam","Rotterdam"],["Bernhoven","Moniek Gorter","荷兰","Uden","Uden"],["Hospital General Universitario Gregorio Maranon","Luis Ibanez Samaniego","西班牙","Madrid","Madrid"],["Hospital Universitari Vall d'Hebron - VHIR","Juan Manuel Pericas Pulido","西班牙","Barcelona","Barcelona"],["Hospital de la Santa Creu i Sant Pau","German Soriano Pastor","西班牙","Barcelona","Barcelona"],["Hospital General de Tomelloso","Alfredo Lucendo Villarin","西班牙","Ciudad Real","Tomelloso"],["Complejo Hospitalario Universitario A Coruna","Alfonso Soto Gonzalez","西班牙","La Coruna","A Coruna"],["Hospital Universitario Reina Sofia","Manuel Rodriguez Peralvarez","西班牙","Cordoba","Cordoba"],["Hospital Universitario Marques de Valdecilla","Paula Iruzubieta Coz","西班牙","Cantabria","Santander"],["Pratia ES Sirius Barcelona","Claudia Georgina Pardo Rivas","西班牙","Barcelona","Barcelona"],["Hospital Clinico Universitario de Valladolid","Rocio Aller de la Fuente","西班牙","Valladolid","Valladolid"],["Hospital Quironsalud Barcelona","Fernando Cereto Castro","西班牙","Barcelona","Barcelona"],["Hospital Universitario Virgen del Rocio","Manuel Romero Gomez","西班牙","Sevilla","Sevilla"],["Policlinica Gipuzkoa","Juan Ignacio Arenas Ruiz Tapiador","西班牙","Guipuzcoa","Donostia-San Sebastian"],["Hospital General Universitario de Valencia","Mercedes Latorre Sanchez","西班牙","Valencia","Valencia"],["Hospital Universitario Fundacion Alcorcon","Conrado Fernandez Rodriguez","西班牙","Madrid","Alcorcon"],["Hospital Universitario de La Princesa","Yolanda Real Martinez","西班牙","Madrid","Madrid"],["Complejo Asistencial Universitario de Leon","Francisco Jorquera Plaza","西班牙","Leon","Leon"],["Glenny Corp. S.A.","Gabriel Alejandro Aballay Soteras","阿根廷","Buenos Aires","CABA"],["Buenos Aires Macula S.A","Raul Adrover","阿根廷","Buenos Aires","Buenos Aires"],["CINME - Centro De Investigaciones Metabolicas","Maria Margarita Anders","阿根廷","Buenos Aires","CABA"],["Hospital Provincial del Centenario","Fernando Bessone","阿根廷","Santa Fe","Rosario"],["Fundacion Respirar","Matias Sebastian Bori","阿根廷","Buenos Aires","Ciudad Autonoma de Buenos Aires"],["Centro Medico Arsema","Marcelo Martin Casas","阿根廷","Buenos Aires","CABA"],["DIM Clinica Privada","Eduardo Fassio","阿根廷","Buenos Aires","Ramos Mejia"],["Clinica Mayo de Urgencias Medicas Cruz Blanca SRL","Ana Gracia Palazzo","阿根廷","Tucuman","San Miguel de Tucuman"],["HIGEA","Roberto Rafael Perez Ravier","阿根廷","Mendoza","Mendoza"],["Hospital General de Agudos Dr. J. M. Ramos Mejia","Marcela Paola Alicia De Sousa Coelho","阿根廷","Ciudad Autonoma Buenos Aires","Ciudad Autonoma de Bs As"],["Sanatorio Privado de la Canada - Cordoba","Eduardo Manuel Petenian","阿根廷","Cordoba","Cordoba"],["Instituto de Investigaciones Clinicas Cordoba S.A.","Maria Ranz y Alvarez","阿根廷","Cordoba","Cordoba"],["Hospital Universitario Austral","Marcelo Oscar Silva","阿根廷","Buenos Aires","Pilar"],["Clinica de Nefrologia Urologia y Enf. Cardiovasculares S.A.","Luis Alejandro Gaite","阿根廷","Santa Fe","Santa Fe"],["Keimyung University Dongsan Hospital","Byoung Kuk Jang","韩国","Daegu","Daegu"],["Seoul National University Bundang Hospital","Eun Sun Jang","韩国","Gyeonggi-do","Seongnam"],["Samsung Medical Center","Wonseok Kang","韩国","Seoul","Seoul"],["Yonsei University Wonju Severance Christian Hospital","Moon Young Kim","韩国","Gangwon-do","Wonju-si"],["Soon Chun Hyang University Hospital (SCHUH) Bucheon","SangGyune Kim","韩国","Gyeonggi-do","Bucheon-si"],["Severance Hospital, Yonsei University Health System","Seung Up Kim","韩国","Seoul","Seoul"],["Korea University Guro Hospital","Young-Sun Lee","韩国","Seoul","Seoul"],["Seoul National University Hospital","Su Jong Yu","韩国","Seoul","Seoul"],["Kyungpook National University Hospital","Won Young Tak","韩国","Daegu","Daegu"],["Asan Medical Center","Won-Mook Choi","韩国","Seoul","Seoul"],["CHA Bundang Medical Center, CHA University","Yeonjung Ha","韩国","Gyeonggi-do","Seongnam-si"],["The Catholic University of Korea, Seoul St. Mary’s Hospital","Jeong Won Jang","韩国","Seoul","Seoul"],["Ajou University Hospital","Soon Sun Kim","韩国","Gyeonggi-do","Suwon-si"],["Pusan National University Hospital","Jeong Heo","韩国","Busan","Busan"],["Hospital Universitario Dr. Jose Eleuterio Gonzalez","Carlos Alejandro Cortez Hernandez","墨西哥","Nuevo Leon","Monterrey"],["Centro de Investigacion y Gastroenterologia","Alma Laura Ladron de Guevara Cetina","墨西哥","Estado de Mexico","Ciudad de Mexico"],["Instituto de Diabetes, Obesidad y Nutricion S.C.","Leobardo Sauque Reyna","墨西哥","Morelos","Cuernavaca"],["Consultorio Medico","Armando Rafael Vargas Flores","墨西哥","Jalisco","Guadalajara"],["FAICIC S. de R.L. de C.V.","Aracely Cruz Palacios","墨西哥","Veracruz","Veracruz"],["Instituto Jalisciense de Metabolismo","Eduardo Marquez Rodriguez","墨西哥","Jalisco","Guadalajara"],["Centro de Investigacion Clinica de Oaxaca","Adan Eustorgio Manuel Martinez","墨西哥","Oaxaca","Oaxaca de juarez"],["CENTRO DE INVESTIGACION ONCOLOGICA GALERIAS","Ivan Omar Vazquez Campos","墨西哥","Aguascalientes","Aguascalientes"],["Instituto Nacional de Ciencias Medicas y Nutricion Dr. Salvador Zubiran","Ignacio Garcia Juarez","墨西哥","Distrito Federal","Mexico City"]]

序号	机构名称	主要研究者	国家	省（州）	城市

[["首都医科大学附属北京友谊医院生命伦理委员会","同意","2026-06-18"]]

序号	名称	审查结论	批准日期/备案日期

进行中（尚未招募）

目标入组人数	国内: 90 ； 国际: 1250 ；
已入组人数	国内: 登记人暂未填写该信息； 国际: 登记人暂未填写该信息；
实际入组总人数	国内: 登记人暂未填写该信息； 国际: 登记人暂未填写该信息；

第一例受试者签署知情同意书日期	国内：登记人暂未填写该信息；     国际：登记人暂未填写该信息；
第一例受试者入组日期	国内：登记人暂未填写该信息；     国际：登记人暂未填写该信息；
试验完成日期	国内：登记人暂未填写该信息；     国际：登记人暂未填写该信息；