天津NAIII期临床试验-一项在复发/难治性慢性淋巴细胞白血病或小淋巴细胞淋巴瘤患者中比较 BGB-16673 与匹妥布替尼的安全性和有效性的研究

登记号	CTR20261365	试验状态	进行中
申请人联系人	李越	首次公示信息日期	2026-04-13
申请人名称	百济神州（苏州）生物科技有限公司

登记号	CTR20261365
相关登记号	暂无
药物名称	NA
药物类型	化学药物
临床申请受理号	企业选择不公示
适应症	复发/难治性慢性淋巴细胞白血病或小淋巴细胞淋巴瘤
试验专业题目	一项在复发/难治性慢性淋巴细胞白血病或小淋巴细胞淋巴瘤患者中比较BGB-16673 与匹妥布替尼的安全性和有效性的 3 期、开放性、随机研究
试验通俗题目	一项在复发/难治性慢性淋巴细胞白血病或小淋巴细胞淋巴瘤患者中比较 BGB-16673 与匹妥布替尼的安全性和有效性的研究
试验方案编号	BGB-16673-304	方案最新版本号	2.0 版
版本日期:	2026-01-16	方案是否为联合用药	否

申请人名称	[["百济神州（苏州）生物科技有限公司"]]
联系人姓名	李越	联系人座机	4008203-159	联系人手机号
联系人Email	Clinicaltrials@beonemed.com	联系人邮政地址	北京市-北京市-昌平区中关村生命科学园，科学院路30号	联系人邮编	102206

本研究旨在比较 BGB-16673 与匹妥布替尼用于既往接受过共价 Bruton 酪氨酸激酶抑制剂（cBTKi）治疗的复发或难治性（R/R）慢性淋巴细胞白血病（CLL）或小淋巴细胞淋巴瘤（SLL）患者的有效性和安全性。

试验分类	安全性和有效性	试验分期	III期	设计类型	平行分组
随机化	随机化	盲法	开放	试验范围	国际多中心试验

年龄	18岁(最小年龄)至 无上限 (最大年龄)
性别	男+女
健康受试者	无
入选标准	[["患者在签署知情同意书时必须≥ 18 岁或达到研究所在地区的法定同意年龄（以较大者为准）。"],["根据 2018 年 iwCLL 标准确诊为CLL 或 SLL 且需要治疗。"],["既往接受过 cBTKi 治疗 CLL/SLL。患者需在既往接受过至少 1 线含 cBTKi 的治疗后出现复发或难治性疾病。"],["对于 SLL 患者，经计算机断层扫描/磁共振成像评估有可测量病灶，定义为至少 1个淋巴结的最长直径> 1.5 cm，且 2 个垂直径可测量。"],["ECOG 体能状态评分为 0 ~ 2。"],["筛选期患者必须器官功能良好。"],["其他方案定义的入选标准。"]]
排除标准	[["已知有幼淋巴细胞白血病、有 Richter 转化病史或目前怀疑发生 Richter 转化。"],["已知有出血性疾病史，如血友病 A、血友病 B、血管性血友病，或需要输血或其他医疗干预的自发性出血史。"],["研究药物首次给药前 6 个月内有缺血性卒中或颅内出血史。"],["既往接受过任何 BTK 蛋白降解剂或ncBTKi。"],["现存或既往出现 CLL/SLL 中枢神经系统受累，包括脑、脊髓、软脑膜和脑脊液 （影像学、细胞学或活检证实）。"],["需要肠外全身治疗的活动性真菌、细菌和/或病毒感染。"],["HIV 血清学（HIV 抗体）状态阳性。"],["在研究药物首次给药前≤ 28 天接受过任何重大手术的患者。研究药物首次给药前患者必须已从手术和/或手术并发症中充分恢复。"],["其他方案定义的排除标准。"]]

试验药	[["中文通用名:NA 英文通用名:BGB-16673 商品名称:NA","剂型:NA 规格:NA 用法用量:NA 用药时程:NA"]] 序号 名称 用法
对照药	[["中文通用名:匹妥布替尼 英文通用名:Pirtobrutinib 商品名称:NA","剂型:NA 规格:NA 用法用量:NA 用药时程:NA"]] 序号 名称 用法

主要终点指标及评价时间	[["以独立审查委员会（IRC）确定的无进展生存期（PFS）","最长大约3年","有效性指标"]] 序号 指标 评价时间 终点指标选择
次要终点指标及评价时间	[["总生存期（OS）","最长大约3年","有效性指标"],["由研究者评估确定的无进展生存期（PFS）","最长大约3年","有效性指标"],["由IRC 和研究者评估确定的总缓解率(ORR)、PR 伴淋巴细胞增多症或更佳缓解的发生率、缓解持续时间(DOR)","最长大约3年","有效性指标"],["至下一线CLL/SLL 治疗时间（TTNT）","最长大约3年","有效性指标"],["治疗中出现的不良事件和严重不良事件的患者数量","最长大约3年","安全性指标"],["欧洲癌症研究与治疗组织生活质量问卷（EORTC）IL409的基线变化","最长大约3年","有效性指标"]] 序号 指标 评价时间 终点指标选择

1	姓名	邱录贵	学位	硕士	职称	主任医师
	电话	13821266636	Email	qiulg@ihcams.ac.cn	邮政地址	天津市-天津市-静海区团泊大道28号
	邮编	301636	单位名称	中国医学科学院血液病医院（中国医学科学院血液学研究所）

[["中国医学科学院血液病医院（中国医学科学院血液学研究所）","邱录贵/易树华","中国","天津市","天津市"],["河南省肿瘤医院","周可树","中国","河南省","郑州市"],["苏州大学附属第一医院","李彩霞","中国","江苏省","苏州市"],["达州市中心医院","吴福道","中国","四川省","达州市"],["北京协和医院","张薇","中国","北京市","北京市"],["广西医科大学第一附属医院","李静","中国","广西壮族自治区","南宁市"],["浙江大学医学院附属第一医院","俞文娟","中国","浙江省","杭州市"],["徐州医科大学附属医院","桑威","中国","江苏省","徐州市"],["南昌大学第二附属医院","汪清铭","中国","江西省","南昌市"],["湖南省肿瘤医院","周辉","中国","湖南省","长沙市"],["四川省医学科学院·四川省人民医院","黄晓兵","中国","四川省","成都市"],["福建医科大学附属协和医院","郑正津","中国","福建省","福州市"],["大连医科大学附属第二医院","王晓波","中国","辽宁省","大连市"],["西安交通大学第二附属医院（西北医院）","王芳侠","中国","陕西省","西安市"],["宁波大学附属第一医院","欧阳贵芳","中国","浙江省","宁波市"],["贵州省人民医院","肖仕珊","中国","贵州省","贵阳市"],["南通大学附属医院","施文瑜","中国","江苏省","南通市"],["无锡市人民医院","杨蕾","中国","江苏省","无锡市"],["兰州大学第一医院","李子坚","中国","甘肃省","兰州市"],["西南医科大学附属医院","李晓明","中国","四川省","泸州市"],["昆明医科大学第一附属医院","史明霞","中国","云南省","昆明市"],["江门市中心医院","梁惠如","中国","广东省","江门市"],["温州医科大学附属第一医院","沈志坚","中国","浙江省","温州市"],["山西白求恩医院","田卫伟","中国","山西省","太原市"],["中山大学附属肿瘤医院（中山大学肿瘤防治中心，中山大学肿瘤研究所）","梁洋","中国","广东省","广州市"],["中国医科大学附属盛京医院","廖爱军","中国","辽宁省","沈阳市"],["吉林大学第一医院","白鸥","中国","吉林省","长春市"],["上海交通大学医学院附属仁济医院","杜鹃","中国","上海市","上海市"],["滨州医学院附属医院","高娜","中国","山东省","滨州市"],["青海大学附属医院","耿惠","中国","青海省","西宁市"],["许昌市中心医院","梅书豪","中国","河南省","许昌市"],["哈尔滨医科大学附属第一医院","王树叶","中国","黑龙江省","哈尔滨市"],["泰安市中心医院","王玲","中国","山东省","泰安市"],["河北医科大学第四医院","刘丽宏","中国","河北省","石家庄市"],["华中科技大学同济医学院附属协和医院","崔国惠","中国","湖北省","武汉市"],["Fundaleu","Miguel Pavlovsky","Argentina","Caba","Caba"],["Centro Oncologico De Integracion Regional (Coir)","Maria Laura Viudez","Argentina","Mendoza","Mendoza"],["Hospital Privado De Rosario","Jose Luis Fedele","Argentina","Rosario","Rosario"],["Sanatorio Allende","Evelin Colombo","Argentina","Cordoba","Cordoba"],["Austin Health","Denise Lee","Australia","Victoria","Heidelberg"],["Cabrini Hospital Malvern","Adrian Minson","Australia","Victoria","MALVERN EAST"],["Concord Repatriation General Hospital","Emma Verner","Australia","New South Wales","Concord"],["Flinders Medical Centre","Hui Peng Lee","Australia","South Australia","Bedford PK"],["Linear Clinical Research","Katharine Lewis","Australia","Western Australia","Nedlands"],["Peter Maccallum Cancer Centre","John Seymour","Australia","Victoria","Melbourne"],["St Vincent'S Hospital Melbourne","Masa Lasica","Australia","Victoria","Fitzroy"],["The Alfred Hospital","Constantine Tam","Australia","Victoria","Melbourne"],["Calvary Mater Newcastle","Alex Holmes","Australia","New South Wales","WARATAH"],["Peninsula Private Hospital","Patricia Walker","Australia","Victoria","Frankston"],["St George Private Hospital","Adrian Selim","Australia","New South Wales","Kogarah"],["John Flynn Private Hospital","Julian Verran","Australia","Queensland","Tugun"],["Sunshine Coast Hospital And Health Service","Greg Orchard","Australia","Queensland","Birtinya"],["Pindara Private Hospital","Hanlon Sia","Australia","Queensland","Benowa"],["Ramsay Health Care - Westmead Private Hospital","Abir Bhattacharyya","Australia","New South Wales","Westmead"],["Medizinische Universitatsklinik Innsbruck","Jan-Paul Bohn","Austria","Innsbruck","Innsbruck"],["Universitatsklinik Fur Innere Medizin Iii Universitatsklinikum Der Pmu Landeskrankenhaus Salzburg","Alexander Egle","Austria","Salzburg","Salzburg"],["Ordensklinikum Linz Gmbh Elisabethinen","Thomas Bauer","Austria","Linz","Linz"],["Uk St. Poelten","Petra Pichler","Austria","St. Polten","St. Polten"],["Medical University Graz","Annkristin Heine","Austria","Graz","Graz"],["Uz Gent","Willem Daneels","Belgium","Gand","Gand"],["Chu Ucl Namur","Helene Vellemans","Belgium","Yvoir","Yvoir"],["Chu De Liege","Aurelie Jaspers","Belgium","Liege","Liege"],["Az Groeninge - Campus Loofstraat","Koen Van Eygen","Belgium","Kortrijk","Kortrijk"],["Institut Jules Bordet","Virginie De Wilde","Belgium","Anderlecht","Anderlecht"],["Chc Montlegia","Renaud Roufosse","Belgium","Liege","Liege"],["Az Sint-Maarten","Toine Mercier","Belgium","Mechelen","Mechelen"],["Inca - Instituto Nacional De Cancer","Ricardo Bigni","Brazil","Rio De Janeiro","Rio De Janeiro"],["Hospital Nove De Julho/ Dasa","Celso Arrais Rodrigues Da Silva","Brazil","Sao Paulo","Sao Paulo"],["Hcfmusp- Hospital Das Clinicas Da Faculdade De Medicina Da Universidade De Sao Paulo","Raphael Costa Bandeira De Melo","Brazil","Sao Paulo","Sao Paulo"],["Ensino E Terapia De Inovacao Clinica Amo-Etica","Marianna Lima","Brazil","Salvador","Salvador"],["Hospital Felicio Rocho","Lysla Cardoso","Brazil","Belo Horizonte","Belo Horizonte"],["Centro De Pesquisa Clinica Dom Bosco Ltda","Wolney Barreto","Brazil","Aracatuba","Aracatuba"],["Hospital De Clinicas De Goiania - Ufg","Renato Sampaio Tavares","Brazil","Goiania","Goiania"],["Ictr - Instituto Do Cancer E Transplante De Curitiba","Samir Kanaan Nabha","Brazil","Curitiba","Curitiba"],["Instituto D'Or De Pesquisa E Ensino - Oncocentro","Livia Ponte","Brazil","Fortaleza","Fortaleza"],["Centre De Lutte Contre Le Cancer - Institut Bergonie","Fontanet Bijou","France","BORDEAUX","BORDEAUX"],["Chu Nancy - Hopital Brabois","Pierre Feugier","France","Vandoeuvre-les-Nancy","Vandoeuvre-les-Nancy"],["Centre Henri-Becquerel","Stephane Lepretre","France","Rouen Cedex 1","Rouen Cedex 1"],["Chu Tours - Hopital Bretonneau","Caroline Dartigeas","France","TOURS","TOURS"],["Hopital Saint-Louis","Catherine Thieblemont","France","Paris","Paris"],["Iuc Toulouse Oncopole","Loic Ysebaert","France","Toulouse","Toulouse"],["Centre Hospitalier Universitaire Nantes-Hotel Dieu","Anne Lok","France","NANTES","NANTES"],["Hospital Estaing","Romain Guieze","France","CLERMONT-FERRAND","CLERMONT-FERRAND"],["Uniklinik Koeln (Aoer)","Petra Langerbeins","Germany","Koln","Koln"],["Universitatsklinikum Bonn","Ruth Miriam Koerber","Germany","Bonn","Bonn"],["Universitaetsklinikum Ulm","Eugen Tausch","Germany","Ulm","Ulm"],["Abteilung Hamatologie, Onkologie Und Palliativmedizin Robert-Bosch-Krankenhaus","Nicola Giesen","Germany","Stuttgart","Stuttgart"],["Stadtisches Klinikum Karlsruhe","Henriette Huber","Germany","Karlsruhe","Karlsruhe"],["Luebecker Onkologische Schwerpunktpraxis - Dres. Med. Kisro/Weber","Jens Kisro","Germany","Lubeck","Lubeck"],["Gemeinschaftspraxis Fur Hamatologie Und Onkologie Dortmund","Sandra Ketzler-Henkel","Germany","Dortmund","Dortmund"],["Gemeinschaftspraxis Fuer Haematologie Und Onkologie Westerstede","Jan Janssen","Germany","Westerstede","Westerstede"],["St. Josef-Hospital Klinikum Der Ruhr-Universitat Bochum","Julia Von Tresckow","Germany","Bochum","Bochum"],["Shaare Zedek Medical Center","Yishai Ofran","Israel","Jerusalem","Jerusalem"],["Rabin Medical Center","Liron Hofstetter","Israel","Petah Tikva","Petah Tikva"],["Hadassah University Hospital - Ein Kerem","Neta Goldschmidt","Israel","Jerusalem","Jerusalem"],["Sourasky Tel-Aviv Medical Center","Yair Herishanu","Israel","Tel Aviv - Jaffa","Tel Aviv - Jaffa"],["Sheba Medical Center","Ohad Benjamini","Israel","Ramat Gan","Ramat Gan"],["Meir Medical Center","Gilad Itchaki","Israel","Kfar-Sava","Kfar-Sava"],["Bnai Zion Medical Center","Tamar Tadmor","Israel","Haifa","Haifa"],["Aou Di Bologna Policlinico S.Orsola Malpighi","Pier Luigi Zinzani","Italy","Bologna","Bologna"],["Ospedale San Raffaele","Paolo Ghia","Italy","Milano","Milano"],["Azienda Socio Sanitaria Territoriale Grande Ospedale Metropolitano Niguarda","Marina Deodato","Italy","Milano","Milano"],["Azienda Ospedaliera Di Padova","Andrea Visentin","Italy","Padova","Padova"],["Kumamoto University Hospital","Hiro Tatetsu","Japan","Kumamoto","Kumamoto"],["Osaka Metropolitan University Hospital","Yosuke Nakaya","Japan","Osaka","Osaka"],["Aichi Cancer Center Hospital - Clinical Oncology","Shigeru Kusumoto","Japan","Aichi","Nagoya"],["Cancer Institute Hospital Of Jfcr","Dai Maruyama","Japan","Tokyo","Koto-ku"],["Tokyo Metropolitan Komagome Hospital","Tomomi Tobai","Japan","Tokyo","Bunkyo-ku"],["Matsuyama Red Cross Hospital","Tomoaki Fujisaki","Japan","Ehime","Matsuyama-shi"],["Aiiku Hospital","Minoru Kanaya","Japan","Hokkaido","Sapporo-Shi"],["Okayama University Hospital","Takumi Kondo","Japan","Okayama","Okayama-shi"],["Hiroshima Red Cross Hospital & Atomic-Bomb Survivors Hospital","Tsuyoshi Muta","Japan","Hiroshima","Hiroshima-shi"],["Kindai University Hospital","Takahiro Kumode","Japan","Osaka","Sakai"],["Yamagata University Hospital","Takuma Suzuki","Japan","Yamagata","Yamagata-shi"],["Dokkyo Medical University Saitama Medical Center","Toru Kiguchi","Japan","Saitama","Koshigaya"],["Kyushu University Hospital","Yoshikane Kikushige","Japan","Fukuoka","Fukuoka-Shi"],["Fukushima Medical University Hospital","Takayuki Ikezoe","Japan","Fukushima","Fukushima City"],["Oita Prefectural Hospital","Eiichi Ohtsuka","Japan","Oita","Oita"],["Kochi Medical School Hospital","Kensuke Kojima","Japan","Kochi","Nankoku"],["Japanese Red Cross Kyoto Daini Hospital","Eri Kawata","Japan","Kyoto","Kyoto-shi"],["Japanese Red Cross Aichi Medical Center Nagoya Daiichi Hospital","Tatsunori Goto","Japan","Aichi","Nakamura-ku"],["National Hospital Organization (Nho)-Disaster Medical Center","Naohiro Sekiguchi","Japan","Tokyo","Tachikawa-shi"],["Severance Hospital Yonsei University Health System","Jin Seok Kim","Korea","Seoul Teugbyeolsi","Seodaemun-Gu"],["Seoul National University Hospital","Ja Min Byun","Korea","Seoul Teugbyeolsi","Seoul"],["Seoul St. Mary'S Hospital The Catholic University Of Korea","Ki Seong Eom","Korea","Seoul Teugbyeolsi","Seocho-Gu"],["Pusan National University Hospital","Ho-Jin Shin","Korea","Busan Gwang'yeogsi","Seo-Gu"],["Seoul National University Bundang Hospital","Jeong-Ok Lee","Korea","Gyeonggi-do","Seongnam-si"],["Gyeongsang National University Hospital","Gyeong-Won Lee","Korea","Gyeongsangnamdo","Jinju-Si"],["Christus Latam Hub Center Of Excellence And Innovation Sc","Willy Gutierrez","Mexico","Monterrey","Monterrey"],["Centro De Investigacion Clinica Gramel","Itzel Martinez","Mexico","Mexico","Mexico"],["Centro De Investigacion Clinica De Oaxaca","Gabriel Ibanez","Mexico","Oaxaca De Juarez","Oaxaca De Juarez"],["Centro Hemato Oncologico Privado De Toluca","Angel Villanueva","Mexico","Toluca De Lerdo","Toluca De Lerdo"],["Universitair Medisch Centrum Utrecht","Sanne De Haart","Netherlands","Utrecht","Utrecht"],["University Of Medical Center Groningen (Umcg)","Mar Bellido","Netherlands","Groningen","Groningen"],["Albert Schweitzer Ziekenhuis","Mark-David Levin","Netherlands","DORDRECHT","DORDRECHT"],["Canisius Wilhelmina Ziekenhuis","Susan De Jonge","Netherlands","Nijmegen","Nijmegen"],["Groene Hart Hospital","Henriette Levenga","Netherlands","Gouda","Gouda"],["Catharina Hospital","Marten Nijziel","Netherlands","EJ Eindhoven","EJ Eindhoven"],["Tauranga Hospital","Marie Hughes","New Zealand","Tauranga","Tauranga"],["North Shore Hospital","Rory Bennett","New Zealand","Auckland","Auckland"],["Wellington Regional Hospital (Ccdhb)","Robert Weinkove","New Zealand","Wellington","Wellington"],["Wielospecjalistyczne Centrum Onkologii I Traumatologii Im. M. Kopernika W Lodzi","Tadeusz Robak","Poland","Lodz","Lodz"],["Copernicus Podmiot Leczniczy Sp. Z O.O. Wojewodzkie Centrum Onkologii","Hanna Ciepluch","Poland","Gdansk","Gdansk"],["Swietokrzyskie Centrum Onkologii Samodzielny Publiczny Zaklad Opieki Zdrowotnej W Kielcach","Pawel Steckiewicz","Poland","Kielce","Kielce"],["Uniwersytecki Szpital Kliniczny Nr 1 W Lublinie Uniwersytet Medyczny W Lublinie","Waldemar Tomczak","Poland","Lublin","Lublin"],["Narodowy Instytut Onkologii Im. Marii Sklodowskiej-Curie Hematology Unit","Ewa Paszkiewicz-Kozik","Poland","WARSZAWA","WARSZAWA"],["Wojewodzki Szpital Zespolony Im. L. Rydygiera W Toruniu","Weronika Piszczek","Poland","Torun","Torun"],["Uniwersytecki Szpital Kliniczny Im. Jana Mikulicza-Radeckiego We Wroclawiu","Tomasz Wrobel","Poland","Wroclaw","Wroclaw"],["Szpital Kliniczny Mswia Z Warminsko-Mazurskim Centrum Onkologii","Janusz Halka","Poland","Olsztyn","Olsztyn"],["Institutul Oncologic","Ciprian Tomuleasa","Romania","Cluj-Napoca","Cluj-Napoca"],["Coltea Clinical Hospital","Andrei Colita","Romania","Bucharest","Bucharest"],["Institutul Regional De Oncologie Iasi","Catalin Danaila","Romania","Iasi","Iasi"],["Tan Tock Seng Hospital- Haematology","Ming Sheng Lim","Singapore","Singapore","Singapore"],["Singapore General Hospital","Chandramouli Nagarajan","Singapore","Singapore","Singapore"],["Hospital Universitario Puerta De Hierro Majadahonda","Jose Antonio Garcia Vela","Spain","MAJADAHONDA","MAJADAHONDA"],["Hospital Universitario Virgen Del Rocio","Guillermo Rodriguez","Spain","Sevilla","Sevilla"],["Hospital Universitario Fundacion Jimenez Diaz","Sergio Ramos Cillan","Spain","Madrid","Madrid"],["Hospital Universitari Son Espases","Antonio Gutierrez","Spain","Palma de Mallorca","Palma de Mallorca"],["Ico Badalona","Marta Julia Arenas","Spain","Badalona","Badalona"],["Hospital Universitario De Burgos","Francisco Javier Diaz","Spain","Burgos","Burgos"],["Hospital Universitario De Gran Canaria Dr. Negrin","Alexia Suarez Cabrera","Spain","Las Palmas de Gran Canaria","Las Palmas de Gran Canaria"],["Sahlgrenska Universitetssjukhuset","Per-Ola Andersson","Sweden","Goteborg","Goteborg"],["Karolinska Universitetssjukhuset - Solna","Anders Osterborg","Sweden","Stockholm","Stockholm"],["Universitatsspital Bern","Martin Andres","Switzerland","Bern","Bern"],["Universitatsspital Zurich","Thorsten Zenz","Switzerland","Zurich","Zurich"],["Oxford University Hospitals Nhs Foundation Trust","Danmei Xu","United Kingdom","Oxford","Oxford"],["Kent And Canterbury Hospital","Moya Young","United Kingdom","Canterbury","Canterbury"],["Norfolk And Norwich University Hospitals Nhs Foundation Trust","Nimish Shah","United Kingdom","Norwich","Norwich"],["Hull Royal Infirmary","David Allsup","United Kingdom","Hull","Hull"],["Sheffield Teaching Hospitals","Peter Toth","United Kingdom","Sheffield","Sheffield"],["University Hospitals Sussex Nhs Foundation Trust","Timothy Chevassut","United Kingdom","Brighton","Brighton"],["Salisbury Foundation Trust","James Milnthorpe","United Kingdom","Salisbury","Salisbury"],["Spire Leeds Healthcare Spire Leeds Hospital","Talha Munir","United Kingdom","Roundhay","Roundhay"],["Dana-Farber Cancer Institute","Inhye Ahn","United States","Massachusetts","Boston"],["Medical University Of South Carolina","Ash Gurumurthi","United States","South Carolina","Charleston"],["Memorial Sloan Kettering Cancer Center Mskcc","Meghan Thompson","United States","New York","New York"],["Mayo Clinic Rochester","Lindsey Roeker","United States","Minnesota","Rochester"],["University Of California San Diego (Ucsd) - Moores Cancer Center","Michael Choi","United States","California","La Jolla"],["Fred Hutchinson Cancer Research Center","Jennifer Huang","United States","Washington","Seattle"],["University Of Rochester","Paul Barr","United States","New York","Rochester"],["Washington University School Of Medicine","Brad Kahl","United States","Missouri","Saint Louis"],["University Of Texas Southwestern Medical Center","Heather Wolfe","United States","Texas","Dallas"],["Medstar Georgetown University Hospital","Kieron Dunleavy","United States","District of Columbia","Washington"],["Northwestern University","Shuo Ma","United States","Illinois","Chicago"],["Md Anderson Cancer Center","Nitin Jain","United States","Texas","Houston"],["Fox Chase Cancer Center","Shazia Nakhoda","United States","Pennsylvania","Philadelphia"],["Ochsner Clinic Foundation","Carter Davis","United States","Louisiana","New Orleans"],["University Of Chicago Medical Center","Michael Thirman","United States","Illinois","Chicago"],["Karmanos Cancer Institute","Jay Yang","United States","Michigan","Detroit"],["Columbia University Medical Center","Nicole Lamanna","United States","New York","New York"],["Duke University Medical Center","Andrea Sitlinger","United States","North Carolina","Durham"],["Cancer & Blood Specialty Clinic","Michael Chung","United States","California","Los Alamitos"],["Blue Ridge Cancer Care (Oncology And Hematology Associates Of Southwest Virginia)","Amanda Gillespie-Twardy","United States","Virginia","Roanake"],["Mount Sinai Comprehensive Cancer Center","Jacqueline Barrientos","United States","Florida","Miami"],["University Of North Carolina At Chapel Hill","Deborah Stephens","United States","North Carolina","Chapel Hill"],["John Theurer Cancer Center-Hackensack University Medical Center","Lori Leslie","United States","New Jersey","Hackensack"],["The University Of Kansas Cancer Center","Marc Hoffmann","United States","Kansas","Westwood"],["Ucla Department Of Medicine - Hematology/Oncology","Herbert Eradat","United States","California","Los Angeles"],["Dayton Physician Network","Charles Bane","United States","Ohio","Dayton"],["Mayo Clinic Jacksonville","Ricardo Parrondo","United States","Florida","Jacksonville"],["Mayo Clinic Phoenix","Talal Hilal","United States","Arizona","Phoenix"],["Weill Cornell Medical College Newyork-Presbyterian Hospital","Erin Mulvey","United States","New York","New York"],["University Of Alabama At Birmingham Hospital","Lauren Shea","United States","Alabama","Birmingham"],["Atrium Health - Levine Cancer Institute (Lci)","Ryan Jacobs","United States","North Carolina","Charlotte"],["Christiana Care","Jamal Misleh","United States","Delaware","Newark"],["Summit Cancer Centers","Arvind Chaudhry","United States","Washington","Spokane"],["Mission Cancer And Blood","Tara Graff","United States","Iowa","Waukee"],["Kaiser Permanente Northern California","Jennifer Suga","United States","California","Vallejo"],["Northwest Medical Specialties","Manas Agastya","United States","Washington","Tacoma"],["Mary Bird Perkins Cancer Center","Andrew Dalovisio","United States","Louisiana","Baton Rouge"],["Kaiser Permanente Southern California","Ashraf Aziz","United States","California","Irvine"],["Stanford Cancer Institute","Bita Fakhri","United States","California","Palo Alto"],["Titan Health Partners Llc D/B/A Astera Cancer Care","Siu-Long Yao","United States","New Jersey","East Brunswick"],["Auxilio Mutuo Cancer Center","Adelba Torres","United States","Puerto Rico","San Juan"],["Gunderson Health System","Lori Rosenstein","United States","Wisconsin","La Crosse"],["Pllc - Nashville Tennessee Oncology","Michael Byrne","United States","Tennessee","Tennessee"],["Cancer Specialists Of North Florida","Zelia Bowman","United States","Florida","Jacksonville"],["Our Lady Of The Lake Hospital","Nakhle Saba","United States","Louisiana","Baton Rouge"],["Atrium Health Wake Forest Baptist","Ryan Jacobs","United States","North Carolina","Winston-Salem"],["Kaiser Permanente - Oakland Medical Center","Jennifer Suga","United States","California","Oakland"],["Kaiser Permanente - Roseville Medical Center","Jennifer Suga","United States","California","Roseville"],["Kaiser Permanente - San Francisco Medical Center - Oncology","Jennifer Suga","United States","California","San Francisco"],["Kaiser Permanente - Santa Clara Medical Center - Oncology/Hematology","Jennifer Suga","United States","California","Santa Clara"],["Kaiser Permanente - Walnut Creek Medical Center","Jennifer Suga","United States","California","Walnut Creek"],["Texas Oncology- Palestine Cancer Center","Shail Dalal","United States","Texas","Palestine"]]

序号	机构名称	主要研究者	国家	省（州）	城市

[["中国医学科学院血液病医院（中国医学科学院血液学研究所）伦理审查委员会","同意","2026-03-30"]]

序号	名称	审查结论	批准日期/备案日期

进行中（尚未招募）

目标入组人数	国内: 50 ； 国际: 500 ；
已入组人数	国内: 登记人暂未填写该信息； 国际: 84 ；
实际入组总人数	国内: 登记人暂未填写该信息； 国际: 登记人暂未填写该信息；

第一例受试者签署知情同意书日期	国内：登记人暂未填写该信息；     国际：2025-09-04；
第一例受试者入组日期	国内：登记人暂未填写该信息；     国际：2025-10-06；
试验完成日期	国内：登记人暂未填写该信息；     国际：登记人暂未填写该信息；