上海Risankizumab(ABBV-066)1200mg静脉注射剂量组III期临床试验-Risankizumab维持治疗对诱导治疗应答的克罗恩病受试者

登记号	CTR20190774	试验状态	进行中
申请人联系人	汤村	首次公示信息日期	2020-02-10
申请人名称	AbbVie Inc./ Boehringer Ingelheim Pharma GmbH & Co. KG/ 艾伯维医药贸易（上海）有限公司

登记号	CTR20190774
相关登记号	CTR20190772;CTR20190773;
药物名称	Risankizumab (ABBV-066)1200mg 静脉注射剂量组
药物类型	生物制品
临床申请受理号	企业选择不公示
适应症	中重度克罗恩病
试验专业题目	对诱导治疗应答的克罗恩病受试者评价Risankizumab疗效和安全性多中心随机双盲安慰剂对照维持和扩展研究
试验通俗题目	Risankizumab维持治疗对诱导治疗应答的克罗恩病受试者
试验方案编号	M16-000，版本4.01	方案最新版本号	暂无
版本日期:	暂无	方案是否为联合用药	企业选择不公示

申请人名称	1 2 3
联系人姓名	汤村	联系人座机	021-62631346	联系人手机号	暂无
联系人Email	rachel.tang@abbvie.com	联系人邮政地址	上海市石门路288号兴业太古汇 2座30楼 艾伯维医药贸易（上海）有限公司	联系人邮编	200041

子研究1: 随机、双盲、安慰剂对照维持治疗。 为了评估在研究M16-006或研究M15-991中对IV risankizumab诱导治疗应答的中重度活动性CD受试者中risankizumab相对于安慰剂的疗效和安全性。 子研究3: 开放标签（OL）长期扩展研究。 为了评估完成子研究1、2或研究M15-989的受试者中risankizumab的长期安全性。另外的目的是进一步研究risankizumab的长期疗效和耐受性。

试验分类	安全性和有效性	试验分期	III期	设计类型	平行分组
随机化	随机化	盲法	双盲	试验范围	国际多中心试验

年龄	18岁(最小年龄)至 80岁(最大年龄)
性别	男+女
健康受试者	无
入选标准	1 参加并完成研究M16-006、研究M15-991或研究M15-989。包括完成研究M16-006、研究M15-991或研究M15-989最终的内镜检查。 2 在研究M16-006或研究M15-991末次访视时实现临床应答，定义为平均每日排便次数（SF）减少≥30%和/或平均每日腹痛（AP）评分减少≥30%，且均未较诱导治疗研究的基线时加重。这不适用于从研究M15-989入组的受试者。 3 如为女性，受试者必须符合本方案第5.2.4节避孕建议所述的标准。 4 受试者必须能够并愿意提供书面的知情同意并遵守本研究方案的要求，包括SC注射剂的自我给药或护理者给药（如果根据当地要求被允许的话）。在日本，如果受试者年龄小于20岁，受试者的父母或法定监护人必须愿意给出书面知情同意。
排除标准	1 由于任何原因，研究者认为受试者不是本研究合适的候选者。如果在研究M16-006、研究M15-991的末次访视或研究M15-989期间进行的内镜检查中发现了结肠高级别异型增生或结肠癌，则受试者不应参加研究M16-000。 2 已知对risankizumab或任何研究药物的赋形剂或CHO的成分过敏的受试者，或在研究M16-006、M15-991或M15-989期间发生AE，研究者判定受试者不适合本研究。 3 在研究M16-006、M15-991或M15-989的末次访视时确认尿妊娠试验阳性。 4 在整个研究M16-006、M15-991或M15-989中，受试者不符合既往和伴随用药的要求。 5 受试者出现任何活动性或慢性的复发感染，根据研究者的评估受试者不是本研究合适的候选者。 6 存在已知的淋巴组织增生性疾病史，包括淋巴瘤，或有可能出现淋巴组织增生性疾病的体征和症状，如淋巴结病变和/或脾肿大。

试验药	序号 名称 用法 1 中文通用名:Risankizumab(ABBV-066)1200mg静脉注射剂量组 用法用量:静脉注射液，注入5%葡萄糖液中，静脉给药-非研究试验分组，仅用于患者挽救治疗。 2 中文通用名:Risankizumab(ABBV-066)360mg皮下注射组 用法用量:皮下注射液（预充式注射装置）、药品规格90mg/ml，共4支，皮下给药，每8周给药。-高剂量组 3 中文通用名:Risankizumab(ABBV-066）180mg皮下注射剂量组 用法用量:皮下注射液（预充式注射装置）、药品规格90mg/ml，共2支，皮下给药，每8周给药。-低剂量组
对照药	序号 名称 用法 1 中文通用名:安慰剂皮下注射组 用法用量:安慰剂为0.9%的氯化钠皮下注射液，3.33ml每支（预充式注射装置），共2或4支，皮下给药，每8周给药。

主要终点指标及评价时间

序号 指标 评价时间 终点指标选择 1 子研究1n第52周实现临床缓解的受试者比例和第52周实现内镜下应答的受试者比例。 第52周 有效性指标 2 子研究3n主要终点：长期安全性评估。 220周，持续评估 安全性指标 3 安全性分析将在安全集中进行，它包括所有接受至少一剂研究药物的受试者。在整个研究过程中，将评估AEs的发生率、生命体征的变化、体检结果和临床实验室数据。 子研究1 52周 和子研究3 220周 有效性指标+安全性指标

次要终点指标及评价时间

序号 指标 评价时间 终点指标选择 1 子研究1n第52周出现临床缓解（CDAI 第52周 有效性指标 2 子研究1n在基线（诱导治疗）时正在接受皮质类固醇治疗的受试者中，第52周时停用皮质类固醇达90天并且达到临床缓解的受试者比例。 第52周 有效性指标 3 子研究1n在基线（诱导治疗）时正在接受皮质类固醇治疗的受试者中，第52周时停用皮质类固醇的受试者比例。 第52周 有效性指标 4 子研究1n第0周和第52周时持续临床缓解的患者比例。 第52周 有效性指标 5 子研究1n第52周时出现增强临床应答的受试者比例。 第52周 有效性指标 6 子研究1n第52周时出现临床缓解和内镜下应答的受试者比例。 第52周 有效性指标 7 子研究1n第52周时出现内镜下愈合的受试者比例。 第52周 有效性指标 8 子研究1n第52周时出现内镜下缓解的受试者比例。 第52周 有效性指标 9 子研究1n在基线（诱导治疗）时存在EIMs的受试者中，第52周时出现EIMs缓解的受试者比例。 第52周 有效性指标 10 子研究1n第52周时出现深度缓解的受试者比例。 第52周 有效性指标 11 子研究1n直到第52周接受住院治疗的受试者比例。 第52周 有效性指标 12 子研究1n在基线（诱导治疗）时存在引流瘘管的受试者中，第52周时有引流瘘管的受试者比例。 第52周 有效性指标 13 子研究1n第52周时，FACIT-疲劳量表相对于第0周的变化。 第52周 有效性指标 14 子研究1n第52周时，简表-36相对于第0周的变化。 第52周 有效性指标 15 子研究1n直到第52周接受CD相关手术治疗的受试者比例。 第52周 有效性指标 16 子研究1n第52周时，CSS相对于第0周的变化。 第52周 有效性指标 17 子研究1nIBDQ相对于第0周随时间的变化 52周,持续评价中 有效性指标 18 子研究1nWPAI-CD相对于第0周随时间的变化 52周,持续评价中 有效性指标 19 子研究1nEQ-5D-5L相对于第0周随时间的变化 52周,持续评价中 有效性指标 20 子研究1n第52周时，平均每天AP相对于第0周的变化 第52周 有效性指标 21 子研究1n平均每天SF相对于第0周随时间的变化 52周,持续评价中 有效性指标 22 子研究1nFCP相对于第0周随时间的变化 52周,持续评价中 有效性指标 23 子研究1nhs-CRP相对于第0周随时间的变化 52周,持续评价中 有效性指标 24 子研究1n随着时间的变化出现临床缓解受试者的比例 52周,持续评价中 有效性指标 25 子研究1n随着时间的变化出现增强临床应答受试者的比例 52周,持续评价中 有效性指标 26 子研究1n随着时间的变化出现临床应答受试者的比例 52周,持续评价中 有效性指标 27 子研究1n第52周时，SES-CD相对于第0周的变化 第52周 有效性指标 28 子研究1n第52周时，SES-CD相对于基线（诱导治疗）的变化 第52周 有效性指标 29 子研究1n在基线（诱导治疗）时SES-CD溃疡面子评分≥ 2的受试者中，第52周每个肠段出现SES-CD溃疡面子评分为≤ 1的受试者比例 第52周 有效性指标 30 子研究1n随着时间的变化出现内镜下缓解受试者的比例 52周,持续评价中 有效性指标 31 子研究1nPGIS相对于第0周随时间的变化 52周,持续评价中 有效性指标 32 子研究1n随时间变化的PGIC 52周,持续评价中 有效性指标 33 子研究1n在基线（诱导治疗）时正在接受皮质类固醇治疗的受试者中，随时间变化停用皮质类固醇的受试者比例 52周,持续评价中 有效性指标 34 子研究1n在基线（诱导治疗）时正在接受皮质类固醇治疗的受试者中，随时间变化停用皮质类固醇并达到临床缓解的受试者比例 52周,持续评价中 有效性指标 35 子研究1n在基线（诱导治疗）时正在接受皮质类固醇治疗的受试者中，第52周前停用皮质类固醇至少90天并且在第0周和第52周均达到临床缓解的受试者比例 第0周和第52周 有效性指标 36 子研究1n在基线（诱导治疗）时正在接受皮质类固醇治疗的受试者中，第52周前停用皮质类固醇至少90天并且在第40、48和52周均达到临床缓解的受试者比例 第40、48和52周 有效性指标 37 子研究3n每次访视时出现临床缓解受试者的比例 第56周及后续的每24周 有效性指标 38 子研究3n每次访视时出现增强临床应答受试者的比例 第56周及后续的每24周 有效性指标 39 子研究3n失去增强应答的时间 第56周及后续的每24周 有效性指标 40 子研究3n失去临床缓解的时间 第56周及后续的每24周 有效性指标 41 子研究3n在基线（诱导治疗）时使用皮质类固醇的受试者中，每次访视时停用皮质类固醇并达到临床缓解的受试者比例 第56周及后续的每24周 有效性指标 42 子研究3n在基线（诱导治疗）时使用皮质类固醇的受试者中，每次访视时停用皮质类固醇的受试者比例 第56周及后续的每24周 有效性指标 43 子研究3n在第0周为临床缓解的受试者在每次访视时仍临床缓解的比例 第56周及后续的每24周 有效性指标 44 子研究3n每次访视时出现内镜下应答受试者的比例 第56周及后续的每96周 有效性指标 45 子研究3n每次访视时出现内镜下愈合受试者的比例 第56周及后续的每96周 有效性指标 46 子研究3n在基线（诱导治疗）时存在EIMs的受试者中，出现EIMs缓解的受试者比例 第56周及后续的每24周 有效性指标 47 子研究3n每次访视时CSS相对于第0周的变化 第56周及后续的每24周 有效性指标 48 子研究3n每次访视时接受住院治疗的受试者比例 第56周及后续的每24周 有效性指标 49 子研究3n在基线（诱导治疗）时存在引流瘘管的受试者中，每次访视时有引流瘘管的受试者比例 第56周及后续的每24周 有效性指标 50 子研究3n每次访视时FACIT-疲劳量表相对于第0周的变化 第56周及后续的每24周 有效性指标 51 子研究3n每次访视时简表-36相对于第0周的变化 第56周及后续的每24周 有效性指标 52 子研究3n每次访视时接受CD相关手术治疗的受试者比例 第56周及后续的每24周 有效性指标 53 子研究3n每次访视时IBDQ的变化 第56周及后续的每24周 有效性指标 54 子研究3n每次访视时WPAI-CD的变化 第56周及后续的每24周 有效性指标 55 子研究3n每次访视时EQ-5D-5L的变化 第56周及后续的每24周 有效性指标 56 子研究3n每次访视时平均每天AP的变化 第56周及后续的每24周 有效性指标 57 子研究3n每次访视时平均每天SF的变化 第56周及后续的每24周 有效性指标 58 子研究3n每次访视时FCP的变化 第56周及后续的每24周 有效性指标 59 子研究3n每次访视时hs-CRP的变化 第56周及后续的每24周 有效性指标 60 子研究3n每次访视时出现内镜下缓解受试者的比例 第56周及后续的每24周 有效性指标 61 子研究3n每次访视时PGIS相对于第0周的变化 第56周及后续的每24周 有效性指标 62 子研究3n每次访视的PGIC 第56周及后续的每24周 有效性指标

1	姓名	冉志华，医学博士	学位	暂无	职称	主任医师
	电话	138 0186 8827	Email	zhihuaran@vip.163.com	邮政地址	上海市浦东新区浦建路160号
	邮编	200041	单位名称	上海交通大学医学院附属仁济医院

序号	机构名称	主要研究者	国家	省（州）	城市
1	上海交通大学医学院附属仁济医院	冉志华	中国	上海	上海
2	中山大学附属第六医院	高翔	中国	广东省	广州
3	浙江大学医学院附属邵逸夫医院	曹倩	中国	浙江省	杭州
4	上海交通大学医学院附属瑞金医院	钟捷	中国	上海	上海
5	浙江大学医学院附属第二医院	陈焰	中国	浙江省	杭州
6	南昌大学第一附属医院	陈幼祥	中国	江西省	南昌
7	江苏省人民医院	张国新	中国	江苏省	南京
8	华中科技大学同济医学院附属同济医院	田德安	中国	湖北省	武汉
9	华中科技大学同济医学院附属协和医院	侯晓华	中国	湖北省	武汉
10	四川大学华西医院	温忠慧	中国	四川省	成都
11	中南大学湘雅二医院	刘德良	中国	湖南省	长沙
12	天津总医院	王邦茂	中国	天津	天津
13	上海东方医院	郑萍	中国	上海	上海
14	香港大学深圳医院	司徒伟基	中国	广东省	深圳
15	中国人民解放军陆军军医大学第二附属医院	郭红	中国	重庆	重庆
16	河北医科大学附属第二医院	张晓岚	中国	河北省	石家庄
17	武汉大学人民医院	安萍	中国	湖北省	武汉
18	金华市中心医院	丁进	中国	浙江省	金华市
19	广东省人民医院	沙卫红	中国	广东省	广州
20	ASST Rhodense	Saibeni, Simone	Italy	Lombardia	Rho
21	The Hospital of Hyogo College of Medicine	Hida, Nobuyuki	Japan	Hyogo	Nishinomiya-shi
22	Yokohama Municipal Citizen's Hospital	Koganei, Kazutaka	Japan	Kanagawa	Yokohama
23	Physician's Research Group	Cho, Doo-Sang	United States of America	Arizona	Tempe
24	Tampere University Hospital	Jussila, Airi	Finland	Pirkanmaa	Tampere
25	Tampere	Kronborg, Ian	Australia	Victoria	FOOTSCRAY
26	Western States Clinical Res	Jain, Rajesh	United States of America	Colorado	Wheat Ridge
27	Winelands Medical Research Ctr	Tarr, Gareth	South Africa	Western Cape	STELLENBOSCH
28	Lyell McEwin Hospital	Tee, Derrick	Australia	South Australia	ELIZABETH VALE
29	Charité Universit？tsmedizin Campus Mitte	Schirbel, Anja	Germany	Berlin	Berlin
30	West Virginia University	Kupec, Justin	United States of America	West Virginia	MORGANTOWN
31	Clinactis	Van Nostrand, Bill	United States of America	Tennessee	MILLINGTON
32	Optimed Research, Ltd.	McNeil, Donald	United States of America	Ohio	COLUMBUS
33	Children's Hospital of Pittsburgh of UPMC	Kim, Sandra	United States of America	Pennsylvania	Pittsburgh
34	Centrum Medyczne Medyk	Filip, Rafal	Poland	Podkarpackie	Rzeszów
35	Misericordia Community Hospita	Walters, Brennan	Canada	Alberta	EDMONTON
36	Covenant Health	Siffledeen, Jesse	Canada	Alberta	Edmonton
37	Delta Waves, Inc.	Lewey, Scot Michael	United States of America	Colorado	COLORADO SPRINGS
38	Vilo Research Group Inc	Ojeas, Harry	United States of America	Texas	Houston
39	ASST Rhodense	Manes, Gianpiero	Italy	Lombardia	Rho
40	Azienda Ospedaliera San Camillo Forlanini	Kohn, Anna	Italy	Lazio	Rome
41	Caro Health Plaza	Mahfooz, Naveed	United States of America	Michigan	Caro
42	Facey Medical Foundation	Beshay, Magued	United States of America	California	Mission Hills
43	Universal Axon Clinical Resear	Martinez, Luis	United States of America	Florida	DORAL
44	Ospedale Policlinico San Martino/ Università Degli Studi Di Genova	Savarino, Vincenzo	Italy	Liguria	Genoa
45	Svendborg Sygehus, Sygehusenhe	Aalykke, Claus	Denmark	Syddanmark	Nyborg
46	Advanced Clinical Research (ACR) - Salt Lake City	Smith, Kent	United States of America	Utah	WEST JORDAN
47	Columbus Regional Research Ins	Steinbook, Michael	United States of America	Georgia	COLUMBUS
48	HonorHealth Research Institute - Shea	Shah, Akshay	United States of America	Arizona	SCOTTSDALE
49	Faculdade de Medicina do ABC	Catapani, Wilson	Brazil	Sao Paulo	Santo André
50	Kelsey Research Foundation	Galler, Greg	United States of America	Texas	HOUSTON
51	Medical University of South Carolina	Lodhia, Nilesh	United States of America	South Carolina	CHARLESTON
52	Shiga University of Medical Science Hospital	Bamba, Shigeki	Japan	Shiga	Otsu
53	Legacy Mount Hood Medical Center	Schoeppner, Harald	United States of America	Oregon	Gresham
54	AZ Sint-Maarten	Van Dongen, Jurgen	Belgium	Antwerpen	Mechelen
55	Hopital Hotel-Dieu de Levis	Bourdages, Raymond	Canada	Quebec	LEVIS
56	Centrum Zdrowia MDM	Ziolkowski, Bartlomiej	Poland	Mazowieckie	Warsaw
57	NHO Fukuyama Medical Center	Toyokawa, Tatsuya	Japan	Hiroshima	FUKUYAMA-SHI
58	Centralny Szpital Kliniczny MSWiA w Warszawie	Rydzewska, Grazyna	Poland	Mazowieckie	Warszawa
59	East Coast Institute for Research, LLC	Ahmadi, Anis	United States of America	Florida	JACKSONVILLE
60	Northwest Med Care	Naygandhi, Yamini	United States of America	Texas	CYPRESS
61	Gastroenterology Research of L	Rinesmith, Scott	United States of America	Ohio	LIMA
62	Med-Care Research, Inc.	Segui, Armando	United States of America	Florida	NORTH MIAMI BEACH
63	West Gastroenterology Medical	Simmons, Timothy	United States of America	California	LOS ANGELES
64	Ocean Blue Med Research Ctr	Terrelonge, Antonio	United States of America	Florida	MIAMI
65	South Lake Pain Institute, Inc	Paez, Julio	United States of America	Florida	CLERMONT
66	East Coast Institute for Research, LLC	Barlow, William	United States of America	Florida	JACKSONVILLE
67	Hepatobiliary Associates of Ne	Esposito, Stephen	United States of America	New York	FLUSHING
68	Great Lakes Medical Research	Kitchen, Timothy	United States of America	New York	WESTFIELD
69	Wenatchee Valley Hosp & Clinic	Lake, Jason	United States of America	Washington	WENATCHEE
70	Klaipeda University Hospital	Jakovlevaite, Violeta	Lithuania	Klaipeda	Klaipeda
71	Ctr for Advanced Gastroenterol	Mushahwar, Andria	United States of America	Florida	Maitland
72	NZOZ All-Medicus	Gonciarz, Maciej	Poland	Slaskie	Katowice
73	Mie University Hospital	Horiki, Noriyuki	Japan	Mie	Tsu-shi
74	Klinicki bolnicki centar Rijeka	Mijandrusic-Sincic, Brankica	Croatia	Primorsko-goranska zupanija	Rijeka
75	Delricht Research	Dennis, Patrick	United States of America	Louisiana	New Orleans
76	University of Vermont Medical Center	Frasca, Joseph	United States of America	Vermont	Burlington
77	Univ Texas HSC San Antonio	Wright, Randy	United States of America	Texas	SAN ANTONIO
78	DM Clinical Research/Southwest	Berkelhammer, Charles	United States of America	Illinois	OAK LAWN
79	Southwest Gastroenterology	Berkelhammer, Charles	United States of America	Illinois	OAK LAWN
80	Innovation Research	Alegret Salutation, Ramon	United States of America	Florida	Miami
81	Medical Center Altamedika	Shevnia, Bohdan	Ukraine	Vinnytska oblast	Vinnytsia
82	Medical Center Altamedika	Shevnia, Bohdan	Ukraine	Vinnytska oblast	Vinnytsia
83	Clinical Center University of Sarajevo	Saray, Aida	Bosnia and Herzegovina	Sarajevo	Sarajevo
84	Perm state medical university n.a. E.A. Vagner	Khlynova, Olga	Russian Federation	Permskiy kray	Perm
85	Centro de Investigaciones Clínicas Vi？a del Mar	Fuster, Francisco	Chile	Valparaíso	Vi？a del Mar
86	Clinical Research Solutions	Naem, Duplicte_Mohamed	United States of America	Ohio	MIDDLEBURG HEIGHTS
87	Gunma University Hospital	Uraoka, Toshio	Japan	Gunma	Maebashi-shi
88	Great Lakes Gastroenterology Research LLC	Friedenberg, Keith	United States of America	Ohio	Mentor
89	Nordsjallands Hospital	Rannem, Terje	Denmark	Hovedstaden	Frederikssund
90	Centro Hospitalar de Sao Joao, EPE	Lopes, Susana	Portugal	Porto	Porto
91	Centro Hospitalar Lisboa Norte, EPE	Fernandes, Samuel	Portugal	Lisboa	lisboa
92	Weill Cornell Medicine	Solomon, Aliza	United States of America	New York	New York
93	IPO Lisboa FG, EPE	Rosa, Isadora	Portugal	Lisboa	Lisboa
94	Centro Hosp de Lisboa Central	Ramos, Jaime	Portugal	Lisboa	LISBON
95	Hospital Senhora da Oliveira de Guimar？es, EPE	Dias de Castro, Francisca	Portugal	Braga	Guimar？es
96	Asheville Gastro Assoc	Harlan III, William	United States of America	North Carolina	ASHEVILLE
97	Suburban Clinical Research	Dongre, Vinayak	United States of America	Illinois	NAPERVILLE
98	Wake Forest Baptist Medical Center	Bloomfeld, Richard	United States of America	North Carolina	WINSTON SALEM
99	PrimeCare Research Associates	Knapp, William	United States of America	Missouri	FLORISSANT
100	Vidant Medical Group, d/b/a Vidant Multi-Specialty Clinic-Kinston	Marilley, Mark	United States of America	North Carolina	Kinston
101	Midamerica Centers of Clinical	Jabbari, Siavash	United States of America	Missouri	ARNOLD
102	Vidant Medical Group, d/b/a Vidant Multi-Specialty Clinic-Kinston	Johnson, Kenneth	United States of America	North Carolina	Kinston
103	Istanbul University Cerrahpasa Medical Faculty	Erzin, Yusuf	Turkey	Istanbul	Istanbul
104	Ankara Univ Medical Faculty	Toruner, Murat	Turkey	Ankara	ANKARA
105	Mersin University Medical	Sezgin, Orhan	Turkey	Mersin	Mersin
106	Hospital Garcia de Orta, E.P.E	Vieira, Ana	Portugal	Setubal	Almada
107	Unidade Local De Saude Do Alto Minho	Lopes, Luis	Portugal	Viana do Castelo	VIANA DO CASTELO
108	Erciyes University Medical Fac	Yurci, Alper	Turkey	Kayseri	Melikgazi
109	Digestive Dis Care/Excel Med	Mehta, Nilesh	United States of America	New York	NEW HYDE PARK
110	University Hospital Zurich	Biedermann, Luc	Switzerland	Zuerich	Zurich
111	Kantonsspital St. Gallen	Sulz, Michael	Switzerland	Sankt Gallen	St. Gallen
112	Lenox Hill Hospital, Northwell	Swaminath, Arun	United States of America	New York	New York
113	Alliance Clinical Research	Devereaux, Christopher	United States of America	Alabama	BIRMINGHAM
114	Dayton Gastroenterology, Inc.	Knoll, Aaron	United States of America	Ohio	ENGLEWOOD
115	Medical University of South Carolina	Quiros, J.	United States of America	South Carolina	CHARLESTON
116	Cascade Gastroenterology	Bochner, Richard	United States of America	Oregon	BEND
117	Kyiv Railway Clinical Hosp ?2	Kyrychenko, Olga	Ukraine	Kyiv	KYIV
118	Fukuoka University Hospital	Hirai, Fumihito	Japan	Fukuoka	Fukuoka-shi
119	San Francisco VA Med Ctr	Shergill, Amandeep	United States of America	California	SAN FRANCISCO
120	United Gastroenterologists	Hong, John	United States of America	California	Los Alamitos
121	Indianapolis Gastroenterology	Haynes, Paul	United States of America	Indiana	INDIANAPOLIS
122	International Research Partners	Falcon, Juan	United States of America	Florida	Doral
123	Duplicate_Floridian Clinical Research	Palmer, Dean	United States of America	Florida	Hialeah
124	Centex Studies, Inc. - Houston	Pouzar, Joe	United States of America	Texas	Houston
125	Percuro Clinical Research, Ltd	Loomes, Dustin	Canada	British Columbia	Victoria
126	CISSS de la Monteregie	Desilets, Etienne	Canada	Quebec	GREENFIELD PARK
127	Charité Universit？tsmedizin Campus Mitte	Fischer, Andreas	Germany	Berlin	Berlin
128	Washington University-School of Medicine	Gutierrez, Alexandra	United States of America	Missouri	ST. LOUIS
129	Clinical Research Center FL	Herman, Craig	United States of America	Florida	POMPANO BEACH
130	Sapporo Tokushukai Hospital	Ashida, Toshifumi	Japan	Hokkaido	Sapporo
131	Precision Research Institute - Houston	Shivshanker, Krishnamurthy	United States of America	Texas	Houston
132	Advanced Research Associates	Ceimo, Joanne	United States of America	Arizona	GLENDALE
133	Alabama Clinical Therapeutics, LLC	Flippo, Gregory	United States of America	Alabama	Birmingham
134	Atlanta Center for Clinical Research	Brkic-Vukotic, Ognjenka	United States of America	Georgia	ROSWELL
135	Burke Internal Medicine & Research	Gabra, Nashwa	United States of America	Virginia	Burke
136	James J. Peters VA Medical Center	Greenberg, Pietra	United States of America	New York	BRONX
137	Clinical Neuroscience	Dever, Michael	United States of America	Tennessee	Memphis
138	Mid Columbia Research	Megna, Lucien	United States of America	Washington	RICHLAND
139	GI Micro Surgery Institute	Noar, Mark	United States of America	Maryland	TOWSON
140	Johns Hopkins University School of Medicine	Lazarev, Mark	United States of America	Maryland	Baltimore
141	Yamagata University Hospital	Abe, Yasuhiko	Japan	Yamagata	Yamagata-shi
142	UKM Medical Centre	Raja Ali, Raja Affendi	Malaysia	Selangor	Kuala Lumpur
143	Southern Star Research Institute, LLC	Bullock, Jeff	United States of America	Texas	San Antonio
144	Gastroenterology Research of A	Randall, Charles	United States of America	New York	New York
145	Hospital Italiano de Buenos Aires	De Paula, Juan	Argentina	Buenos Aires	Ciudad Autonoma Buenos Aires
146	Volyn regional clinical hospital	Shulga, Dmytro	Ukraine	Volynska oblast	Lutsk
147	Advanced Research for Health Improvement	Bustamante, Manuel	United States of America	Florida	Naples
148	Complejo Asistencial Dr. Sotero del Rio	Walsen, Gustavo	Chile	Region Metropolitana de Santiago	SANTIAGO
149	Akershus universitetssykehus	Jahnsen, Jorgen	Norway	Akershus	Nordbyhagen
150	Kyiv Municipal Clinical Hospital #18	Dorofeyev, Andriy	Ukraine	Kyiv	Kiev
151	Kyiv Municipal Clinical Hospital #18	Dubovyi, Vladyslav	Ukraine	Kyiv	Kiev
152	Hamamatsu Minami Hospital	Hanai, Hiroyuki	Japan	Shizuoka	HAMAMATSU-SHI
153	Okayama University Hospital	Hiraoka, Sakiko	Japan	Okayama	Okayama-shi
154	Mount Sinai Hosp.-Toronto	Steinhart, Hillary	Canada	Ontario	TORONTO
155	Allen Whey Khye Lim Professional Corporation	Lim, Allen	Canada	Alberta	EDMONTON
156	Riverside Clinical Research	DeCarli, Antonio	United States of America	Florida	EDGEWATER
157	Medical Center	Barna, Olha	Ukraine	Kyiv	????
158	CHI Nebraska d/b/a CHI Health	Kizer, Robert	United States of America	Nebraska	OMAHA
159	Borland-Groover Clinic	Fleisher, Mark	United States of America	Florida	JACKSONVILLE
160	Clinresco Centres	Coetzer, Thomas	South Africa	Gauteng	JOHANNESBURG
161	Univ Oklahoma HSC	Harty, Richard	United States of America	Oklahoma	OKLAHOMA CITY
162	Kyiv City Clinical Hospital #1	Markevych, Inna	Ukraine	Kyiv	????
163	Digestive Disease Specialists - South	Chang, Maria	United States of America	Oklahoma	Oklahoma City
164	Texas Digestive Disease Consultants	Siddiqui, Junaid	United States of America	Texas	Cedar Park
165	Vista Health Research LLC - Miami	Otero, Anisia	United States of America	Florida	MIAMI
166	Stanford University	Park, KT	United States of America	California	PALO ALTO
167	Concorde Medical Group PLLC	Brettholz, Edward	United States of America	New York	New York
168	Florida Hospital Tampa	Seminerio, Jennifer	United States of America	Florida	Tampa
169	Hometown Urgent Care and Resea	Choi, Steven	United States of America	Ohio	DAYTON
170	Theageneio Anticancer Hospital	Soufleris, Konstantinos	Greece	Thessaloniki	Thessaloniki
171	Yokohama City Univ Medical Ctr	Kunisaki, Reiko	Japan	Kanagawa	YOKOHAMA
172	Medical Center of Edelweiss Medics LLC	Bilotkach, Oleksandra	Ukraine	Kyiv	Kyiv
173	Clinical Res of West FL, Inc.	Dunn, Leonard	United States of America	Florida	CLEARWATER
174	Instytut Pomnik - Centrum Zdrowia Dziecka	Kierkus, Jaroslaw	Poland	Mazowieckie	Warsaw
175	Skanes Universitetssjukhus	Hertervig, Erik	Sweden	Skane lan	Malm？
176	The Royal London Hospital	Parkes, Gareth	United Kingdom	London, City of	LONDON
177	TLC Clinical Research Inc	Enayati, Pedram	United States of America	California	Beverly Hills
178	Vinnytsia Regional Clinical Hospital n.a. M.I.Pyrogov	Kizlova, Nataliia	Ukraine	Vinnytska oblast	Vinnytsia
179	CHU Amiens Picardie	Fumery, Mathurin	France	Somme	Amiens CEDEX 1
180	GHP Stockholm Gastro Center	Hoog, Charlotte	Sweden	Stockholms lan	Stockholms lan
181	The Ohio State University - Columbus	Afzali, Anita	United States of America	Ohio	COLUMBUS
182	Connecticut GI	Wysocki, John D.	United States of America	Connecticut	FARMINGTON
183	Daido Clinic	Kikuchi, Masakazu	Japan	Aichi	Nagoya-shi
184	Rapid City Medical Center	Jones, Blake	United States of America	South Dakota	RAPID CITY
185	Alliance Medical Research	Gupta, Vipin	United States of America	Florida	Lighthouse Point
186	Cedars-Sinai Medical Center ? West Hollywood	Melmed, Gil	United States of America	California	West Hollywood
187	University Clinical Centre of the Republic of Srpska	Jovicic, Gordana	Bosnia and Herzegovina	Republika Srpska	BANJA LUKA
188	Wakayama Medical University	Tsuda, Saya	Japan	Wakayama	WAKAYAMA
189	Hopital Centenario	Tanno, Hugo	Argentina	Santa Fe	Rosario
190	Plains Clinical Research Center, LLC	Schock, Joel	United States of America	North Dakota	Fargo
191	Carl R. Meisner Medical Clinic	Meisner, Carl	United States of America	Texas	SUGAR LAND
192	Lenus Research & Medical Group	Elosegui, Ana	United States of America	Florida	SWEETWATER
193	Alabama Medical Group, PC	Siegel, Jonathan	United States of America	Alabama	Mobile
194	Weill Cornell Medicine	Lawlor, Garrett	United States of America	New York	New York
195	Wasatch Clinical Research	Killpack, Michael	United States of America	Utah	SALT LAKE CITY
196	Saint Louis University School of Medicine	Schroeder, Katie	United States of America	Missouri	Saint Louis
197	Top Medical Research, Inc.	Ruiz, Jose	United States of America	Florida	MIAMI
198	Advanced Research Institute	Freedland, Curtis	United States of America	Florida	NEW PORT RICHEY
199	Upland Clinical Research	Cornejo, Brenda	United States of America	California	Upland
200	Alliance Clinical Research	Connor, Gordon	United States of America	Alabama	BIRMINGHAM
201	Gastroenterology Assoc. LA	Chapman, Jonathan	United States of America	Louisiana	BATON ROUGE
202	Charm City Research Group	Novick, James	United States of America	Maryland	TOWSON
203	University of Vermont Medical Center	Ganguly, Eric	United States of America	Vermont	Burlington
204	Carl R. Darnall Army Medi Ctr	Gancayco, John	United States of America	Texas	FT. HOOD
205	E Squared Research	Garber, Jeffrey	United States of America	Alabama	HUNTSVILLE
206	Bee Caves Family Pract.	Freeland, Daniel	United States of America	Vermont	AUSTIN
207	Comprehensive Digestive Instit	Stone, Christian	United States of America	Nevada	LAS VEGAS
208	NYU Langone Medical Center	Hudesman, David	United States of America	New York	New York
209	Nirvana Research Center	Sanchez, Jose	United States of America	Florida	Miami
210	Pharmacorp Clinical Trials	Durrence, Hugh	United States of America	South Carolina	CHARLESTON
211	Digestive and Liver Disease Sp	Thiwan, Syed	United States of America	Virginia	NORFOLK
212	Care Access Research	Pedersen, Peder	United States of America	Utah	Salt Lake City
213	Gabrail Cancer Center Research	Gabrail, Nashat	United States of America	Ohio	CANTON
214	Nova Clinical Research Center,	Abreu, Rafael	United States of America	Florida	HIALEAH
215	The Vancouver Clinic, INC. PS	Etzel, Jason	United States of America	Washington	VANCOUVER
216	Univ Kansas Med Ctr	Esfandyari, Tuba	United States of America	Kansas	KANSAS CITY
217	Clinical Applications Lab, CA	Pratha, Vijayalakshmi	United States of America	California	SAN DIEGO
218	Community Research Foundation	Binker, Josefa	United States of America	Florida	MIAMI
219	Geriatrics & Family Medicine C	Adegbile, Joy	United States of America	Ohio	COLOMBUS
220	Ashford and St Peter's Hospitals NHS Foundation Trust	Gunasekera, Anton Viran	United Kingdom	Surrey	Chertsey
221	Precision Clinical Research	Schneider, Jeffrey	United States of America	Florida	Sunrise
222	Universiti Sains Malaysia	Mustaffa, Nazri	Malaysia	Kelantan	Kelantan
223	Crystal Pharmacology Research	Vega, Ramses	United States of America	Florida	MIAMI
224	Revival Research Institute, LLC	Pasha, Tousif	United States of America	Nevada	Las Vegas
225	Pediatric Specialty of VA	Leibowitz, Ian	United States of America	Virginia	FAIRFAX
226	Tyler Research Institute, LLC	DuVall, George Aaron	United States of America	Texas	TYLER
227	Newport Coast Center	DeGuzman, Lino	United States of America	California	NEWPORT BEACH
228	Universit？tsklinikum St.P？lten	Maieron, Andreas	Austria	Niederoesterreich	St. P？lten
229	Princess Alexandra Hospital	Martin, Neal	Australia	Queensland	WOOLLOONGABBA
230	Optimed Research, Ltd.	Tzagournis, Michael	United States of America	Ohio	COLUMBUS
231	Baylor College of Medicine	Karam, Lina	United States of America	Texas	Houston
232	Hospital Universitario de Bellvitge	Guardiola Capon, Jordi	Spain	Barcelona	L'Hospitalet de Llobregat
233	Hospital das Clínicas da Faculdade de Medicina da Universidade de S？o Paulo - HC	Sobrado, Carlos	Brazil	Sao Paulo	S？o Paulo
234	Intermountain Medical Center	Gilroy, Richard	United States of America	Utah	Murray
235	CHUS - Universite de Sherbrook	Plamondon, Sophie	Canada	Quebec	SHERBROOKE
236	Ospedale Policlinico San Martino/ Università Degli Studi Di Genova	Giannini, Edoardo Giovanni	Italy	Liguria	Genoa
237	GI Associates	Hogan II, Reed	United States of America	Mississippi	FLOWOOD
238	Gastroenterology Group Naples	Phillips, Raymond	United States of America	Florida	NAPLES
239	VA Pittsburgh	Francis, Fadi	United States of America	Pennsylvania	PITTSBURGH
240	Advanced Clinical Research	Sariol, Juan	United States of America	Florida	MIAMI
241	Policlinico Universitario Campus Bio-Medico	Cicala, Michele	Italy	Lazio	Rome
242	National Taiwan University Hospital	Wei, Shu Chen	Taiwan	Taipei	Taipei City
243	Diverse Research Solutions	Simon, Karen	United States of America	California	OXNARD
244	Louisiana Research Ctr. LLC	Aguilar, Humberto	United States of America	Louisiana	Shreveport
245	Baylor Scott & White Health ? Temple	Johnson, Christopher	United States of America	Texas	TEMPLE
246	Brandon Premier Health Care, PA	Bowman, Steven	United States of America	Florida	Brandon
247	Evangelisches Krankenhaus Kalk	Streetz, Konrad	Germany	Nordrhein-Westfalen	Cologne
248	Advantage Clinical Trials	Guido, Giancarlo	United States of America	New York	BRONX
249	Southern Therapy and Advanced Research (STAR) LLC	Borg, Brian	United States of America	Mississippi	JACKSON
250	The Polyclinic	Headstrom, Peggy	United States of America	Washington	SEATTLE
251	Resurgence Clinical Research	Hodge, Rasean	United States of America	Georgia	ATLANTA
252	CB Flock	Johnson, Charles	United States of America	Alabama	MOBILE
253	Phoenix VA Healthcare	Alishahi, Yasmin	United States of America	Arizona	PHOENIX
254	Spotlight Research Center, LLC	Jimenez, Gilberto	United States of America	Florida	MIAMI
255	University of Washington	Afzali, Anita	United States of America	Washington	SEATTLE
256	MTM Clinical Trials	Michael, Mahfouz	United States of America	California	LOS ANGELES
257	KH Martha-Maria Halle Dolau	Krummenerl, Annette	Germany	Sachsen-Anhalt	Halle (Saale)
258	Charité Universit？tsmedizin Campus Mitte	Siegmund, Martina	Germany	Berlin	Berlin
259	Elion & Volhard, PR, Inc.	Daniel, Gelrud	United States of America	Florida	MIAMI
260	Rochester Regional Hospital	Casey, Kevin	United States of America	New York	NEW YORK
261	University of Pennsylvania	Klapproth, Jan-Michael	United States of America	Pennsylvania	Philadelphia
262	PhysicianHealth Care Network	Colombo, John	United States of America	Washington	MARYSVILE
263	The Digestive Group	Muhumuza, Robert	United States of America	Louisiana	BATON ROUGE
264	Instituto D'or de Pesquisa e Ensino	Moraes, Ant？nio Carlos	Brazil	Rio de Janeiro	Rio de Janeiro
265	Hopital Beaujon	Treton, Xavier	France	Ile-de-France	Clichy
266	University of Campinas	Coy, Claudio	Brazil	Sao Paulo	CAMPINAS
267	Medical University of South Carolina	Hoffman, Brenda	United States of America	South Carolina	CHARLESTON
268	SIH Research, LLC	Mumtaz, Syed	United States of America	Florida	KISSIMMEE
269	Healthcare Research Consultant	Morris, David	United States of America	Oklahoma	TULSA
270	Mayo Clinic - Rochester	Loftus, Edward	United States of America	Minnesota	Rochester
271	Quality Clinical Research Inc.	Jasper, David	United States of America	Nebraska	OMAHA
272	Hamamatsu University Hospital	Sugimoto, Ken	Japan	Shizuoka	Hamamatsu-shi
273	Krankenhaus der Barmherzigen Brüder Wien	Eser, Alexander	Austria	Wien	Vienna
274	Omega Research Consultants, LLC	Ayesu, Kwabena	United States of America	Florida	Debary
275	ACCEL Research Sites	Gupta, Vishal	United States of America	Florida	DELAND
276	AZ Arthritis and Rheum Assoc	Salomon, Nehad	United States of America	Arizona	PHOENIX
277	MHAT Trakia	Sirakov, Ivan	Bulgaria	Stara Zagora	Stara Zagora
278	University of Minnesota Health Clinical Research Unit	Shmidt, Eugenia	United States of America	Minnesota	Minneapolis
279	Gokeikai Ofuna Chuo Hospital	Endo, Yutaka	Japan	Kanagawa	Kamakura-shi
280	Clinical Res of West FL, Inc.	Lynn, Lon	United States of America	Florida	CLEARWATER
281	Univerzitna nemocnica Martin	Lietava, Peter	Slovakia	Zilinsky kraj	Martin
282	Clinical Trials of Texas,Inc.	Denham, Douglas	United States of America	Texas	SAN ANTONIO
283	CHUM - Notre-Dame Hospital	Weber, Audrey	Canada	Quebec	Montréal
284	Hadassah Ein Kerem Medical Ctr	Katz, Lior	Israel	Yerushalayim	Jerusalem
285	IWK Health Center	Otley, Anthony	Canada	Nova Scotia	HALIFAX
286	Scott Shulman Medicine Professional Corporation	Shulman, Scott	Canada	Ontario	NORTH BAY
287	Gcp Research	Mazza, Giuseppe	Canada	Quebec	MONTREAL
288	Hospital Privado Univesitario	Balderramo, Domingo	Argentina	Cordoba	CORDOBA
289	Tzaneio general hospital of Piraeus	Xourgias, Vasileios	Greece	Attiki	PIRAEUS
290	General Hospital of Athens Laiko	Papatheodoridis, George	Greece	Attiki	Athens
291	Dong-A University Hospital	Lee, Jonghun	South Korea	Busan Gwang yeogsi	BUSAN
292	CHA Bundang Medical center, CHA University	Hahm, KiBaik	South Korea	Gyeonggido	Seongnam-si
293	Carolinas Medical Center	Hanson, John	United States of America	North Carolina	CHARLOTTE
294	Pusan National University Hosp	Song, Geun Am	South Korea	Busan Gwang yeogsi	BUSAN
295	Research Protocol Mgmt Special	David, Glorioso	United States of America	Pennsylvania	PITTSBURGH
296	Kangbuk Samsung Hospital	Park, Dong Il	South Korea	Seoul Teugbyeolsi	Jongno-Gu
297	Ormond Beach Clinical Research	Daas, Adel	United States of America	Florida	ORMOND BEACH
298	Seoul National Univ Bundang ho	Yoon, Hyuk	South Korea	Gyeonggido	Seongnam
299	Penn State University and Milton S. Hershey Medical Center	Haight, Joel	United States of America	Pennsylvania	Hershey
300	Asan Medical Center	Ye, ByongDuk	South Korea	N/A	Seoul
301	Guthrie Medical Group, PC	Georgetson, Michael	United States of America	Pennsylvania	SAYRE
302	Yeungnam University Med Ctr	Jang, Byung Ik	South Korea	Daegu Gwang yeogsi	Daegu
303	WI Center for Advanced Res	Geenen, Daniel	United States of America	Wisconsin	Milwaukee
304	University of Washington	Cleland, Todd	United States of America	Washington	SEATTLE
305	Medical College of Wisconsin	Stein, Daniel	United States of America	Wisconsin	Milwaukee
306	Samsung Medical Center	Kim, Young-Ho	South Korea	Seoul Teugbyeolsi	SEOUL
307	Froedtert & the Medical College of Wisconsin	Perera, Lilani	United States of America	Wisconsin	Milwaukee
308	Universitatsklinikum Munster	Bettenworth, Dominik	Germany	Niedersachsen	MUNSTER
309	Universitaetsklinikum Erlangen	Atreya, Raja	Germany	Bayern	ERLANGEN
310	Hospital Universitario La Paz	Martin Arranz, Maria	Spain	Madrid	Madrid
311	Krankenanstalt Rudolfstiftung	Fuchs, Eva-Maria	Austria	Wien	Vienna
312	Hospital Maisonneuve-Rosemont	Lachance, Jean-Rene	Canada	Quebec	MONTREAL
313	Fraser Clinical Trials Inc	Atkinson, Kenneth	Canada	British Columbia	NEW WESTMINSTER
314	Corporacion Hospitalaria Juan Ciudad sede Denominada Hospital Universitario Mayo	Figueroa, Carlos	Colombia	Cundinamarca	BOGOTA DC
315	Duplicate_S Paul Sharma Medical Corp	Arora, Sartaj	United States of America	California	Covina
316	TX Clinical Research Institute	Al-Assi, M. Tarek	United States of America	Texas	ARLINGTON
317	Univ Hosp Schleswig-Holstein	Schreiber, Stefan	Germany	Schleswig-Holstein	KIEL
318	Wits Clinical Research Site	Barrow, Peter	South Africa	Gauteng	Johannesburg
319	UZ Gent	Hindryckx, Pieter	Belgium	Oost-Vlaanderen	Gent
320	Klinicki bolnicki centar Zagreb	Krznaric, Zeljko	Croatia	Grad Zagreb	Zagreb
321	Cliniques Universitaires Saint Luc	Dewit, Olivier	Belgium	Bruxelles-Capitale	Woluwe-Saint-Lambert
322	Klinicka bolnica Dubrava Zagreb	Banic, Marko	Croatia	Grad Zagreb	Zagreb
323	Klinicki bolnicki centar Osijek	Borzan, Vladimir	Croatia	Osjecko-baranjska zupanija	Osijek
324	Complejo Hospitalario Universitario de Ferrol	Echarri Piudo, Ana	Spain	Galicia	Ferrol
325	Universitair Medisch Centrum Utrecht	Fidder, Henrica	Netherlands	Utrecht	Utrecht
326	Hospital Universitario y Politecnico La Fe	Aguas Peris, Mariam	Spain	Valenciana	Valencia
327	Clinical Center University of Sarajevo	Puhalovic, Amra	Bosnia and Herzegovina	Sarajevo	Sarajevo
328	DHAT Research Institute	Sarles Jr., Harry	United States of America	Texas	Garland
329	Gastro United of Tulsa	James, David	United States of America	Oklahoma	TULSA
330	Hospital Universitario Profess	Silva, Genoile	Brazil	Bahia	SALVADOR
331	Spring Gastroenterol and Asso	Moparty, Ravi	United States of America	Texas	HUMBLE
332	University Clinical Center Tuzla	Basic Denjagic, Mirela	Bosnia and Herzegovina	Tuzlanski	TUZLA
333	University of Kansas Health Sy	Batista, Daisy	United States of America	Kansas	Kansas City
334	Clinical Trials America	Pfitzner, Glenn	United States of America	North Carolina	HICKORY
335	University Clinical Center Tuzla	Salkic, Nermin	Bosnia and Herzegovina	Tuzlanski	TUZLA
336	Gastro Clinic of Acadiana, LA	Arterburn, James	United States of America	Louisiana	LAFAYETTE
337	NYU Langone Long Island CRA	Katz, Seymour	United States of America	New York	GREAT NECK
338	Instituto do Cancer Arnaldo Vi	Pereira, Maria	Brazil	Sao Paulo	SAO PAULO
339	Professional Quality Research	Kumar, Pradeep	United States of America	Texas	AUSTIN
340	Kaiser Clinica e Hospital Dia	Kaiser Junior, Roberto	Brazil	Sao Paulo	SAO JOSE DO RIO PRETO
341	Baylor College of Medicine	Hou, Jason	United States of America	Texas	Houston
342	UPECLIN FMB - UNESP	Sassaki, Ligia	Brazil	Sao Paulo	BOTUCATU
343	TX Digestive Disease Consultan	Marek, Shannon	United States of America	Texas	DALLAS
344	Instituto Goiano de Gastroenterologia e Endoscopia Digestiva Ltda	Bafutto, Mauro	Brazil	Goias	GOIANIA
345	Hospital das Clinicas da Faculdade de Medicina de Ribeir？o Preto - USP	Parra, Rogerio	Brazil	Sao Paulo	Ribeir？o Preto
346	CliniCore International, LLC	Anandu, Darshan	United States of America	Texas	Houston
347	Hospital Nossa Senhora das Gra？as	Amarante, Heda Maria	Brazil	Parana	CURITIBA
348	Millennium Medical Centre	Ghila, Nitinkumar	South Africa	Kwazulu-Natal	DURBAN
349	Hospital de Clinicas de Porto Alegre	Francesconi, Carlos	Brazil	Rio Grande do Sul	PORTO ALEGRE
350	Dallas VA Medical Center	Feagins, Linda	United States of America	Texas	DALLAS
351	Hosp U Clementino Fraga Filho	Zaltman, Cyrla	Brazil	Rio de Janeiro	RIO DE JANEIRO
352	Diagnostic Clinic Of Houston	Colman, Ronald	United States of America	Texas	HOUSTON
353	Dr Eduan Deetlefs	Deetlefs, Eduan	South Africa	Western Cape	Cape Town,Milnerton
354	Medical University of Vienna	Vogelsang, Harald	Austria	Wien	Vienna
355	Hospital Israelita Albert Einstein/Farmacia da Oncologia	Steinwurz, Flavio	Brazil	Sao Paulo	S？o Paulo
356	LKH-Univ. Klinikum Graz	Hoegenauer, Christoph	Austria	Steiermark	Graz
357	Hospital das Clinicas da Faculdade de Medicina de Ribeir？o Preto - USP	Leite, Andre	Brazil	Sao Paulo	Ribeir？o Preto
358	Tufts Medical Center	Allison, Harmony	United States of America	Massachusetts	BOSTON
359	South Denver Gastroenterology	Nichols, Matthew	United States of America	Colorado	LONE TREE
360	New Horizon Research Center	Miranda, Francisco	United States of America	Florida	MIAMI
361	Johns Hopkins	Chowdhury, Reezwana	United States of America	Maryland	BALTIMORE
362	Tel Aviv Sourasky Medical Ctr	Fishman, Sigal	Israel	Tel-Aviv	Tel Aviv-Yafo
363	Houma Digestive Health Special	Winstead, Nathaniel	United States of America	Louisiana	HOUMA
364	Palmetto Research, LLC	Gonzalez, Jeff	United States of America	Florida	HIALEAH
365	Northwest Health Care Associat	Shapiro, Bradley	United States of America	Illinois	HOFFMAN ESTATES
366	Coral Research Clinic	Paoli-Bruno, Jorge	United States of America	Florida	Miami
367	Soroka Medical Center	Segal, Arik	Israel	HaDarom	Be'er Sheva
368	Northwest Gastroenterology Cli	Jazrawi, Saad	United States of America	Oregon	PORTLAND
369	NorthShore University HealthSystem - Evanston	Yen, Eugene	United States of America	Illinois	EVANSTON
370	Moonshine Research Center, Inc	Grillo, Rafael	United States of America	Florida	DORAL
371	University Clinical Centre of the Republic of Srpska	Dobrovoljski, Aleksandar	Bosnia and Herzegovina	Republika Srpska	BANJA LUKA
372	MediSphere Medical Research Center	Dela Llana, Alexander	United States of America	Indiana	EVANSVILLE
373	Digestive Health Center of Ind	Shirish, Amin	United States of America	Pennsylvania	INDIANA
374	University Clinical Centre of the Republic of Srpska	Barac, Tatjana	Bosnia and Herzegovina	Republika Srpska	BANJA LUKA
375	Cotton-O'Neil Clinical Res Ctr	Baum, Curtis	United States of America	Kansas	TOPEKA
376	Mid-State Gastroenterology	Sarvaria, Sunil	United States of America	Tennessee	MURFREESBORO
377	Klinicki bolnicki centar Sestre milosrdnice	Hrabar, Davor	Croatia	Grad Zagreb	Zagreb
378	Rush University	Mutlu, Ece	United States of America	Illinois	CHICAGO
379	Univ CA, Irvine Med Ctr	Parekh, Nimisha	United States of America	California	ORANGE
380	University Clinical Centre of the Republic of Srpska	Rajic, Romana	Bosnia and Herzegovina	Republika Srpska	BANJA LUKA
381	Northwestern University	Bellaguarda, Emanuelle	United States of America	Illinois	Chicago
382	Houston Methodist Hospital	Abraham, Bincy	United States of America	Texas	HOUSTON
383	Intermountain Medical Center	Charlton, Michael	United States of America	Utah	Murray
384	Arapahoe Gastroenterology,PC	Hansen, Richard	United States of America	Colorado	LITTLETON
385	University of Louisville	Dryden, Gerald	United States of America	Kentucky	LOUISVILLE
386	Professional Quality Research	Ziebert, John	United States of America	Texas	AUSTIN
387	Univ of Colorado Cancer Center	Fennimore, Blair	United States of America	Colorado	AURORA
388	Baylor Scott & White Research	Dassopoulos, Themistocles	United States of America	Texas	DALLAS
389	Severance Hospital	Cheon, Jae Hee	South Korea	Seoul Teugbyeolsi	SEOUL
390	University of Utah	Valentine, John	United States of America	Utah	Salt Lake City
391	University of Michigan Hospitals	Higgins, Peter	United States of America	Michigan	Ann Harbor
392	Utah Clinical Trials LLC	Desautels, Steven	United States of America	Utah	SALT LAKE CITY
393	Univ of Colorado Cancer Center	Levine, Joel	United States of America	Colorado	AURORA
394	Nature Coast Clinical Research	Hellstern Jr., Paul	United States of America	Florida	INVERNESS
395	United Gastroenterologists - Murrieta	Hong, John	United States of America	California	MURRIETA
396	Adobe Clinical Research LLC	Moussa, Sam	United States of America	Arizona	TUCSON
397	Orlin & Cohen	Good, Larry	United States of America	New York	LYNBROOK
398	Desert Sun Clinical Res, LLC	Gross, Craig	United States of America	Arizona	TUCSON
399	Houston Methodist Neurological	Woods, Karen	United States of America	Texas	HOUSTON
400	Arizona Digestive Health	Trivedi, Chirag	United States of America	Arizona	SUN CITY
401	Scott and White Medical Center	Thomas, Harry	United States of America	Texas	TEMPLE
402	University of Arizona	Taleban, Sasha	United States of America	Arizona	TUCSON
403	University of Michigan Hospitals	Higgins, Peter	United States of America	Michigan	Ann Harbor
404	Univ California, San Francisco	Terdiman, Jonathan	United States of America	California	San Francisco
405	Huron Gastroenterology Assoc	Gunaratnam, Naresh	United States of America	Michigan	ANN ARBOR
406	Carle Cancer Center	Greenberg, Eugene	United States of America	Illinois	URBANA
407	Premier Medical Group	Khurana, Sunil	United States of America	New York	POUGHKEEPSIE
408	University of Alabama at Birmingham - Main	Malik, Talha	United States of America	Alabama	BIRMINGHAM
409	University of Massachusetts Wo	Houghton, JeanMarie	United States of America	Massachusetts	WORCESTER
410	Birmingham Gastroenterology	Bluhm, Charles	United States of America	Alabama	BIRMINGHAM
411	Clin Res Inst of Michigan, LLC	Fogel, Ronald	United States of America	Michigan	CHESTERFIELD
412	Cordova Research Institute	Somodevilla, Guillermo	United States of America	Florida	MIAMI
413	Beyer Research	Beyer, Roger	United States of America	Michigan	KALAMAZOO
414	Delta Waves, Inc.	Lewey, Scot Michael	United States of America	Colorado	COLORADO SPRINGS
415	NY Scientific	Grosman, Igor	United States of America	New York	BROOKLYN
416	Lynn Institute of Pueblo	Vahil, Atul	United States of America	Colorado	PUEBLO
417	Gastro Group of Rochester	Goldstein, Jonathan	United States of America	New York	Rochester
418	Arapahoe Gastroenterology,PC	Triebling, Andrzej	United States of America	Colorado	LITTLETON
419	Johns Hopkins University	Olivia-Hemker, Maria	United States of America	Maryland	BALTIMORE
420	Hepato-Gastroenterologie HK s.r.o.	Vanasek, Tomas	Czechia	Hradec Kralove	HRADEC KRALOVE
421	UMHAT Sv. Ivan Rilski	Spassova, Zoya	Bulgaria	Sofia	Sofia
422	Tohoku Rosai Hospital	Kojima, Yasuhiro	Japan	Miyagi	SENDAI-SHI
423	Axon Clinical, s.r.o.	Matous, Jan	Czechia	Praha 5	Praha
424	CTCenter MaVe, s.r.o.	Macecek, Jaroslav	Czechia	Olomoucky kraj	OLOMOUC
425	Duplicate_Stanford University	Park, KT	United States of America	California	Palo Alto
426	Indiana University	Pfefferkorn, Marian	United States of America	Indiana	INDIANAPOLIS
427	Quality Medical Research, PLLC	Herring Jr, Robert	United States of America	Tennessee	NASHVILLE
428	Centro Hospitalar do Algarve - Hospital de Portim？o	Tavares, Helena	Portugal	Faro	PORTIMAO
429	Univ California, San Francisco	Mahadevan, Uma	United States of America	California	San Francisco
430	Centro Hospitalar Lisboa Ocidental, EPE	Bana e Costa, Tiago	Portugal	Lisboa	Lisbon
431	Kingsbury Hospital	Wright, John	South Africa	Western Cape	CAPE TOWN
432	Digestive Disease Associates, LTD	Altomare, John	United States of America	Pennsylvania	Wyomissing
433	Wits Clinical Research Site	Mahomed, Adam	South Africa	Gauteng	Johannesburg
434	Mediclinic Constantiaberg	Rajabally, Muhammad	South Africa	Western Cape	CAPE TOWN
435	IKEM	Drastich, Pavel	Czechia	Praha 4	Prague 4
436	Allegiance Research Specialist	Idarraga, Samuel	United States of America	Wisconsin	MILWAUKEE
437	Southern Therapy and Advanced Research (STAR) LLC	Borg, Brian	United States of America	Mississippi	JACKSON
438	Carle Cancer Center	Gordon, Glenn	United States of America	Illinois	URBANA
439	Carilion Medical Center	Sorrentino, Dario	United States of America	Virginia	ROANOKE
440	Western States Clinical Research, Inc.	Goff, John	United States of America	Colorado	Wheat Ridge
441	Plano Primary Care Clinic	Farooqi, Muhammed	United States of America	Texas	PLANO
442	Digestive Disease Associates	Sninsky, Charles	United States of America	Florida	TAMARAC
443	Univ NC Chapel Hill	Herfarth, Hans	United States of America	North Carolina	Chapel Hill
444	Medic Management Group LLC	Vladic, Franjo	United States of America	Ohio	AKRON
445	MGG Group, Inc.Chevy Chase Clinical Research	Korman, Louis	United States of America	Maryland	Chevy Chase
446	Brandon Premier Health Care, PA	Weiss, Michael	United States of America	Florida	Brandon
447	Charlotte Gastro Hepatology	Mohanty, Sanjib	United States of America	North Carolina	CHARLOTTE
448	Infinite Clinical Trials	O'Heron, Sara	United States of America	Georgia	PEACHTREE CITY
449	Iowa Digestive Disease Center	Leman, Bernard	United States of America	Iowa	CLIVE
450	Aarhus University Hospital	Dahlerup, Jens-Frederik	Denmark	Midtjylland	Aarhus N
451	Gastro & Hepato Consul of N. V	Mirkin, Kenneth	United States of America	Virginia	FAIRFAX
452	University of Miami	Kerman, David	United States of America	Florida	MIAMI
453	Long Island Clinical Research	Ginzburg, Lev	United States of America	New York	GREAT NECK
454	Arizona Digestive Health	Patel, Sumir	United States of America	Arizona	SUN CITY
455	Texas Digestive Disease Consul	Ritter, Timothy	United States of America	Texas	SOUTHLAKE
456	Medical Research Ctr CT	Ginsburg, Philip	United States of America	Connecticut	HAMDEN
457	Henry Ford Health System	Kaur, Nirmal	United States of America	Michigan	DETROIT
458	Univ Hosp Cleveland	Yacyshyn, Bruce	United States of America	Ohio	CLEVELAND
459	Azienda Ospedaliera San Camillo Forlanini	Cosintino, Rocco	Italy	Lazio	Rome
460	Icahn School of Med Mt. Sinai	Marion, James	United States of America	New York	NEW YORK
461	PMA Medical Specialist, LLC	Rock, Elizabeth	United States of America	Pennsylvania	LIMERICK
462	AOU Policlinico S. Orsola Malpighi	Gionchetti, Paolo	Italy	Emilia-Romagna	Bologna
463	Clinical Research West FL	Lunseth, Paul	United States of America	Florida	TAMPA
464	New River Valley Research Inst	Ringold, Mark	United States of America	Virginia	CHRISTIANSBURG
465	Birmingham Gastroenterology	Miller, Peter	United States of America	Alabama	BIRMINGHAM
466	ClinSearch, LLC, US	Krause, Richard	United States of America	Tennessee	CHATTANOOGA
467	A.O. Ospedali Riuniti Villa Sofia - Cervello	Orlando, Ambrogio	Italy	Sicilia	Palermo
468	Medvin Clinical Research	McGuire, Jr., Richard	United States of America	California	LA MIRADA
469	IMIC Inc.	Rodriguez, Miguel	United States of America	Florida	PALMETTO BAY
470	Sjaellands Universitets Hospit	Munck, Lars	Denmark	Sj？lland	Roskilde
471	Clinical Hosp Center Zvezdara	Svorcan, Petar	Serbia	Beograd	Belgrade
472	Clinical Center of Nis	Petrovic, Bratislav	Serbia	Nisavski okrug	NIS
473	Virginia Mason Medical Center	Chiorean, Michael	United States of America	Washington	SEATTLE
474	Military Medical Academy	Doder, Radoje	Serbia	Beograd	Belgrade
475	UC San Diego Health Systems	Sandborn, William	United States of America	California	La Jolla
476	ProLive Medical Research	Romero, Sandor	United States of America	Florida	MIAMI
477	Clinical Center Serbia	Popovic, Dragan	Serbia	Beograd	Belgrade
478	Eminence Medical & Clinical Re	Hernandez, Tatiana	United States of America	Florida	TAMPA
479	Clin Hosp Ctr Bezanijska Kosa	Jovanovic, Igor	Serbia	Beograd	Belgrade
480	Herlev Hospital	Haaber, Anne	Denmark	Hovedstaden	Herlev
481	Clinical Center Kragujevac	Knezevic, Slavko	Serbia	Sumadijski okrug	Kragujevac
482	IMC- Diagnostic & Medical Clin	Alnoah, Zaid	United States of America	Alabama	MOBILE
483	Digestive Health Center	Fein, Steven	United States of America	Texas	PASADENA
484	Univ of Colorado Cancer Center	Hoffenberg, Edward	United States of America	Colorado	AURORA
485	The Jackson Clinic, PA	Wilding, Kellie	United States of America	Tennessee	JACKSON
486	Clinical Center Vojvodina	Damjanov, Dragomir	Serbia	Vojvodina	Novi Sad
487	Family Clinical Trials	Cedeno, Jeanne-Elyse	United States of America	Florida	PEMBROKE PINES
488	Univ Virginia Primary Care Ctr	Behm, Brian	United States of America	Virginia	CHARLOTTESVILLE
489	Carle Cancer Center	Gordon, Glenn	United States of America	Illinois	URBANA
490	Sun Research Institute	Grant, David	United States of America	Texas	SAN ANTONIO
491	Ehrhardt Clinical Research	Connor, Michael	United States of America	Missouri	BELTON
492	Presidio Columbus, Fondazione Policlinico Gemelli Universita Cattolica S. Cuore	Armuzzi, Alessandro	Italy	Roma	Rome
493	Ctr for Gastrointestinal Healt	Rashid, Zahid	United States of America	Virginia	FRANKLIN
494	Continental Clinical Solutions	Stevens, Saleh	United States of America	Maryland	Towson
495	Istituto Clinico Humanitas	Danese, Silvio	Italy	Milano	Rozzano
496	Fondazione IRCCS Ca? Granda Ospedale Maggiore Policlinico	Caprioli, Flavio	Italy	Lombardia	MILAN
497	University of Chicago	Rubin, David	United States of America	Illinois	Chicago
498	Oregon Ctr for Clin Inv	Tran, Drissana	United States of America	Oregon	Salem
499	Chicago Clinical Trials	Fatima, Shaheen	United States of America	Illinois	Chicago
500	Gastrointestinal Biosciences	Karyotakis, Nicholas	United States of America	California	Los Angeles
501	Zeidler Ledcor Centre	Dieleman, Levinus	Canada	Alberta	Edmonton
502	Gastroenterology Clinic of San	Stump, David	United States of America	Texas	SAN ANTONIO
503	University of Washington	Zisman, Timothy	United States of America	Washington	SEATTLE
504	Vanderbilt Univ Med Ctr	Horst, Sara	United States of America	Tennessee	Nashville
505	University of Washington	Lee, Scott	United States of America	Washington	SEATTLE
506	CHU de Liege	Louis, Edouard	Belgium	Liege	Liège
507	McGill Univ HC	Bessissow, Talat	Canada	Quebec	MONTREAL
508	Breakthrough Clinical Trials	Frei, Karen	United States of America	California	SAN BERNARDINO
509	Physicians Clinical Research	Do, Khai	United States of America	California	GARDEN GROVE
510	NYU Langone Winthrop Hospital	Vrabie, Raluca	United States of America	New York	MINEOLA
511	GIRI Gastrointestinal Research Institute	Rosenfeld, Gregory	Canada	British Columbia	VANCOUVER
512	Minnesota Gastroenterology, P. A.	McCabe, Robert	United States of America	Minnesota	PLYMOUTH
513	Clinical Trials of SC	Tavel, Edward	United States of America	South Carolina	CHARLESTON
514	UZ Brussel	Fazia, Mana	Belgium	Bruxelles-Capitale	Jette
515	QEII - Victoria Building	Jones, Jennifer	Canada	Nova Scotia	HALIFAX
516	Physicians Choice Clinical Res	Hsieh, John	United States of America	California	LONG BEACH
517	Inquest Clinical Research	Afzal, Haider	United States of America	Texas	Baytown
518	Hospital Clinico y Provincial Barcelona	Panes, Julian	Spain	Barcelona	Barcelona
519	Academisch Medisch Centrum	D'Haens, Geert	Netherlands	Noord-Holland	AMSTERDAM
520	London Health Sciences Centre	Beaton, Melanie	Canada	Ontario	LONDON
521	Univ Hospitals Birmingham NHS Foundation trust	Iacucci, Marietta	United Kingdom	Birmingham	Birmingham
522	Toronto Digestive Disease Asso	Axler, Jeffrey	Canada	Ontario	VAUGHAN
523	RD&E Hospital	Ahmad, Tariq	United Kingdom	Devon	Exeter
524	McMaster University Med Cent	Marshall, John	Canada	Ontario	HAMILTON
525	Guy's and St Thomas' NHS Found	Irving, Peter	United Kingdom	London, City of	London
526	University Hospital Galway	Egan, Laurence	Ireland	Ireland	Galway
527	Global Clinical Trials	Kellogg, Jason	United States of America	California	IRVINE
528	Care Access Research	Kogan, Mark	United States of America	Utah	Salt Lake City
529	University of Calgary	Panaccione, Remo	Canada	Alberta	Calgary
530	Medicor Research Inc.	Tilbe, Kimberley	Canada	Ontario	Sudbury
531	Carl R. Darnall Army Medi Ctr	Patel, Anish	United States of America	Texas	FT. HOOD
532	University of California, San	Heyman, Melvin	United States of America	California	SAN FRANCISCO
533	University of Michigan Hospitals	Higgins, Peter	United States of America	Michigan	Ann Harbor
534	Wellington Hospital (Capital and Coast District Health Board)	Griffiths, Ben	New Zealand	Wellington	WELLINGTON
535	Middlemore Clinical Trials	Raj, Ashok	New Zealand	Auckland	Auckland
536	Flinders Medical Centre	Mountifield, Reme	Australia	South Australia	BEDFORD PARK
537	Adult Gastroenterology Associates - Main	McNamara, Kevin	United States of America	Oklahoma	Tulsa
538	Eastern Health	Niewiadomski, Olga	Australia	Victoria	BOX HILL
539	The Canberra Hospital	Subramaniam, Kavitha	Australia	Australian Capital Territory	GARRAN
540	Christchurch Hospital	Gearry, Richard	New Zealand	Canterbury	CHRISTCHURCH
541	Mater Hospital	Begun, Jakob	Australia	Queensland	Brisbane
542	Community Clinical Trials, CA	Ennis, Craig	United States of America	California	ORANGE
543	ClinAde	Agim, Onyinye	United States of America	Texas	HOUSTON
544	Internal Medicine Specialists	Aggarwal, Avanish	United States of America	Louisiana	NEW ORLEANS
545	Center for Digestive Health	Weber, John	United States of America	Michigan	Troy
546	Emory University Hospital	Iskandar, Heba	United States of America	Georgia	ATLANTA
547	Wake Research Associates, LLC	Barish, Charles	United States of America	North Carolina	RALEIGH
548	Gastrointestinal Specialists	Sheikh, Aasim	United States of America	Georgia	MARIETTA
549	Shafran Gastroenterology Ctr	Shafran, Ira	United States of America	Florida	WINTER PARK
550	West Bay Clinical Research	Verma, Sunil	United States of America	Rhode Island	WARWICK
551	Options Health Research, LLC	Tatum, Harvey	United States of America	Oklahoma	TULSA
552	Consultants for Clinical Res	Safdi, Alan	United States of America	Ohio	CINCINNATI
553	Medical University of South Carolina	Seminerio, Jennifer	United States of America	South Carolina	CHARLESTON
554	Gastro Assoc of Central GA	Sedghi, Shahriar	United States of America	Georgia	MACON
555	Medic Management Group LLC	Martin, Odessa	United States of America	Ohio	AKRON
556	Florida Hospital	Navaneethan, Udayakumar	United States of America	Florida	ORLANDO
557	Gastro One	Younes, Ziad	United States of America	Tennessee	GERMANTOWN
558	Digestive Disease Associates	Narayen, Vijay	United States of America	Maryland	CATONSVILLE
559	Atlantic Gastroenterology, PA	Fountain, Raetta	United States of America	North Carolina	GREENVILLE
560	Tri-State Endoscopy	O'Toole, Terrance	United States of America	Ohio	CINCINNATI
561	STAT Research, Inc.	Nwokoro, Ugo	United States of America	Ohio	Vandalia
562	Charm City Research Group	Novick, James	United States of America	Maryland	TOWSON
563	Tri County Research, Inc.	Williams, Jeffrey	United States of America	Georgia	ATHENS
564	The Ctr for Gastro Disorders	Lamet, Mark	United States of America	Florida	HOLLYWOOD
565	Cotton-O'Neil Clinical Res Ctr	Baum, Curtis	United States of America	Kansas	TOPEKA
566	UT Erlanger womens Health Spec	Lambiase, Louis	United States of America	Tennessee	CHATTANOOGA
567	Gastro One	Wruble, Lawrence	United States of America	Tennessee	GERMANTOWN
568	Dayton Gastroenterology, Inc.	Lutter, Donald	United States of America	Ohio	ENGLEWOOD
569	Atlanta Gastro Assoc	Wolf, Douglas	United States of America	Georgia	ATLANTA
570	Advanced Research Institute	Lowe, John	United States of America	Utah	Ogden
571	Dallas Clinical Research	Farooq, Hassan	United States of America	Texas	GREENVILLE
572	Piedmont Medical Research	Liu, Debra	United States of America	North Carolina	WINSTON-SALEM
573	Memorial Hermann Hospital	Ertan, Atilla	United States of America	Texas	HOUSTON
574	PennState Milton S.Hershey Med	Clarke, Kofi	United States of America	Pennsylvania	HERSHEY
575	Aspen Clinical Research	Frantz, David	United States of America	Utah	OREM
576	Gastroenterology Associates, P.A.	Kim, Suzy	United States of America	South Carolina	Greenville
577	Commonwealth Clinical Studies	Finklestein, Mark	United States of America	Massachusetts	BROCKTON
578	Digestive Health Specialists of the Southeast	Jackson, Daniel	United States of America	Alabama	DOTHAN
579	Investigative Clinical Research	Epstein, Michael	United States of America	Maryland	ANNAPOLIS
580	Charlottesville Medical Resear	Clark, James	United States of America	Virginia	CHARLOTTESVILLE
581	Medical Assoc Research Grp	Bennett, Michael	United States of America	California	SAN DIEGO
582	Digestive Disease Specialists	Stokesberry, David	United States of America	Oklahoma	OKLAHOMA CITY
583	Fukuoka University Chikushi Hospital	Hirai, Fumihito	Japan	Fukuoka	CHIKUSHINO
584	Clinical Research Trials of Florida, Inc.	Alpizar, Sady	United States of America	Florida	TAMPA
585	Zentrum für Gastroenterologie Saar MVZ GmbH	Mohl, Wolfgang	Germany	Saarland	Saarbrücken
586	Universita di Catanzaro Magna Graecia	Luzza, Francesco	Italy	Calabria	CATANZARO
587	San Jorge Children Hospital	Del Valle-Segarra, Antonio	Puerto Rico	Puerto Rico	San Juan
588	Stanford University	Streett, Sarah	United States of America	California	STANFORD
589	University of Louisville	Galandiuk, Susan	United States of America	Kentucky	LOUISVILLE
590	Intercity Advanced Gastroentertology Center	Shahzad, Ghulamullah	United States of America	New York	Fresh Meadows
591	Kemerovo Regional Clinical Hospital n.a. S.V. Belyaev	Gerasimova, Evgenia	Russian Federation	Kemerovskaya oblast	Kemerovo
592	Kazan State Medical University	Abdulhakov, Sayar	Russian Federation	Tatarstan, Respublika	KAZAN
593	Planetmed Sp. z o.o.	Wozniak-Stolarska, Barbara	Poland	Dolnoslaskie	Wroc?aw
594	Tokyo Women?s Medical University Hospital	Tokushige, Katsutoshi	Japan	Tokyo	Shinjuku-ku
595	Precision Research Institute - San Diego	Desta, Taddese	United States of America	California	San Diego
596	Kepler Universit？tsklinikum	Sedlak, Markus	Austria	Oberoesterreich	LINZ
597	CHU NANCY - H？pital Brabois Adultes	Peyrin-Biroulet, Laurent	France	Meurthe-et-Moselle	Vandoeuvre les Nancy CEDEX
598	Regional Center of Diagnostic, Treatment and Prevention of GI diseases	Svystun, Sergiy	Ukraine	Zaporizka oblast	Zaporizhzhia
599	Thomayerova nemocnice	Kohout, Pavel	Czechia	Praha 4	PRAGUE
600	Atria Clinical Research	Budhraja, Meenakshi	United States of America	Arkansas	Little Rock
601	Queen Mary Hospital	Leung, Wai Keung	Hong Kong	Hong Kong	Hong Kong
602	Cleveland Clinic Main Campus	Lashner, Bret	United States of America	Ohio	CLEVELAND
603	Infinite Clinical Trials	Amoo-Bonsu, Felix	United States of America	Georgia	RIVERDALE
604	Sapporo Medical Univ Hosp	Ishigami, Keisuke	Japan	Hokkaido	Little Rock
605	Ishida Clinic of IBD and Gastroenterology	Ishida, Tetsuya	Japan	Oita	Oita-shi
606	Saratoga Schenectady Gastroenterology Associates ? Burnt Hills	Feinberg, Zachary (Zach)	United States of America	New York	Burnt Hills
607	Texas Digestive Disease Consultants	Inamdar, Nikhil	United States of America	Texas	Cedar Park
608	Nishinomiya Munic Central Hosp	Ogawa, Hiroyuki	Japan	Hyogo	Nishinomiya-shi
609	DRK Kliniken Berlin	Sturm, Andreas	Germany	Berlin	BERLIN
610	North Shore University Hospital	Sultan, Keith	United States of America	New York	NEW HYDE PARK
611	East Tennessee Research Instit	Reddy, Chakradhar	United States of America	Tennessee	JOHNSON CITY
612	Azienda Ospedaliero-Universitaria Policlinico di Modena	Villa, Erica	Italy	Emilia-Romagna	Modena
613	Inquest Clinical Research	Malhotra, Advitya	United States of America	Texas	Baytown
614	Ospedale Maggiore Carlo Alberto Pizzardi	Alvisi, Patrizia	Italy	Bologna	BOLOGNA
615	Azienda Ospedaliera Univ. Meyer	Lionetti, Paolo	Italy	Toscana	Florence
616	Pediatric Gastro & Nutr Assoc	Baron, Howard	United States of America	Nevada	LAS VEGAS
617	Advanced Biomedical Research of America	Hoon, Vrijendra	United States of America	Nevada	LAS VEGAS
618	Sahlgrenska US Gbg	Mavroudis, Georgios	Sweden	Vastra Gotalands lan	G？teborg
619	Weill Cornell Medicine	Solomon, Aliza	United States of America	New York	NEW YORK
620	Western Connecticut Medical Group	Gorelick, Adam	United States of America	Connecticut	Danbury
621	Northwest Health Care Associat	Shapiro, Bradley	United States of America	Illinois	HOFFMAN ESTATES
622	Hunter Holmes McGuire VA Medical Center	Gaidos, Jill	United States of America	Virginia	RICHMOND
623	Univ Maryland School Medicine	Cross Jr., Raymond	United States of America	Maryland	BALTIMORE
624	Houston Digestive Dis Clinic	Glombicki, Alan	United States of America	Texas	HOUSTON
625	Connecticut Clinical Res Found	Zakko, Salam	United States of America	Tennessee	BRISTOL
626	MGH, Boston	Yajnik, Vijay	United States of America	Massachusetts	BOSTON
627	Hospital Universitario Virgen Macarena	Castro Laria, Luisa	Spain	Sevilla	Sevilla
628	Gastroenterology Clinic of San	Havranek, Russell	United States of America	Texas	SAN ANTONIO
629	Goryeb Chidlren's Hospital	Arsenescu, Razvan	United States of America	New Jersey	MORRISTOWN
630	Abdullah Mubarak MD	Pervaiz, Rahman	United States of America	Texas	DALLAS
631	Rutgers Robert Wood Johnson	Seril, Darren	United States of America	New Jersey	NEW BRUNSWICK
632	Penn State University and Milton S. Hershey Medical Center	Pfeiffer, Laurie	United States of America	Pennsylvania	Hershey
633	Nagoya City University Hospital	Tanida, Satoshi	Japan	Aichi	Nagoya-shi
634	Toho University Sakura Medical Center	Matsuoka, Katsuyoshi	Japan	Chiba	Sakura-shi
635	Hokkaido P.W.F.A.C. Sapporo-Kosei General Hospital	Motoya, Satoshi	Japan	Hokkaido	Sapporo-shi
636	Medical Hospital of Tokyo Medical and Dental University	Fujii, Toshimitsu	Japan	Tokyo	Bunkyo-ku
637	Tokai University Hachioji Hospital	Ichikawa, Hitoshi	Japan	Tokyo	Hachioji
638	Aichi Medical University Hosp	Sasaki, Makoto	Japan	Aichi	NAGAKUTE
639	National Hospital Organization Mito Medical Center	Ishida, Hiroyasu	Japan	Ibaraki	Higashi Ibaraki-gun
640	Charles L. Krone, MD	Krone, Charles	United States of America	Arizona	TUCSON
641	Yamanashi Prefectural Ctr Hosp	Kojima, Yuichiro	Japan	Yamanashi	Kofu-shi
642	Saitama Medical Center, Saitama Medical University	Kato, Shingo	Japan	Saitama	Kawagoe-shi
643	Kyorin University Hospital	Sakuraba, Akihito	Japan	Tokyo	Mitaka-shi
644	Osaka City University Hospital	Hosomi, Shuhei	Japan	Osaka	Osaka-shi
645	Nagoya University Hospital	Nakamura, Masanao	Japan	Aichi	Nagoya-shi
646	Tokito Clinic	Tokito, Satoki	Japan	Saitama	Saitama-shi
647	Hirosaki National Hospital	Ishiguro, Yoh	Japan	Aomori	Hirosaki-shi
648	The Hospital of Hyogo College of Medicine	Hida, Nobuyuki	Japan	Hyogo	Nishinomiya-shi
649	Kurume University Hospital	Mitsuyama, Keiichi	Japan	Fukuoka	Kurume-shi
650	Hiroshima University Hospital	Tanaka, Shinji	Japan	Hiroshima	Hiroshima
651	JP Red Cross Kyoto Daiichi Hos	Okuyama, Yusuke	Japan	Kyoto	Kyoto-shi
652	Aoyama Clinic	Aoyama, Nobuo	Japan	Hyogo	KOBE
653	Kitasato Univ Kitasato Inst Ho	Kobayashi, Taku	Japan	Tokyo	Minato-ku
654	Kyushu University Hospital	Esaki, Motohiro	Japan	Fukuoka	Fukuoka-shi
655	China Medical University Hosp	Chou, Jen-Wei	Taiwan	Taichung	Taichung City
656	National Taiwan University Hospital	Tu, Chia-Hung	Taiwan	Taipei	Taipei City
657	National Cheng Kung University Hospital	Chuang, Chiao-Hsiung	Taiwan	Tainan	Tainan City
658	PennState Milton S.Hershey Med	Clarke, Kofi	United States of America	Pennsylvania	HERSHEY
659	Hospital Universitario La Paz	Martin, Maria	Spain	Madrid	Madrid
660	Trihealth Digestive Institute	Peck, Allan	United States of America	Ohio	CINCINNATI
661	Peak Gastroenterology Associat	Patel, Bhaktasharan	United States of America	Colorado	COLORADO SPRINGS
662	Emeritus Research	Hall, Stephen	Australia	Victoria	Camberwell
663	Regional Clinical Hospital #1	Sharapova, Ksenia	Russian Federation	Tyumenskaya oblast	TYUMEN
664	Alliance Biomedical Ural Group	Pimenov, Leonid	Russian Federation	Udmurtskaya Respublika	IZHEVSK
665	Private institution Center of educational and clinical gastroenterology, hepatol	Pasechnikov, Viktor	Russian Federation	Stavropol skiy kray	Stavropol
666	Perm Clinical Center of FMBA	Osokina, Natalia	Russian Federation	Permskiy kray	PERM
667	Icahn School of Med Mt. Sinai	Cohen, Benjamin	United States of America	New York	NEW YORK
668	Minneapolis VA Medical Center	Reinink, Andrew	United States of America	Minnesota	Minneapolis
669	Advanced Research Center, Inc.	Victoria, Rafaelito	United States of America	California	ANAHEIM
670	Affinity Clinical Research	Mehta, Bhupatkumar	United States of America	Illinois	OAK BROOK
671	Rocky Mountain Pediatric Gastroenterology	Stathos, Theodore	United States of America	Colorado	Lone Tree
672	Clinical Neuroscience	Usdan, Lisa	United States of America	Tennessee	MEMPHIS
673	Main Line Gastro Assoc	Kaufman, Adam	United States of America	Pennsylvania	MALVERN
674	Hightower Clinical	Ali, Tauseef	United States of America	Oklahoma	Oklahoma City
675	Endoscopic Research, Inc.	Levine, Henry	United States of America	Florida	ORLANDO
676	Gastrointestinal Medicine Asso	Elevado, Morris	United States of America	Rhode Island	CRANSTON
677	Miami Pediatric Gastroenterolo	Loret de Mola, Oscar	United States of America	Florida	MIAMI
678	Clin Res Inst of Michigan, LLC	Fogel, Ronald	United States of America	Michigan	CHESTERFIELD
679	Saleem Desai, M.D. Inc.	Desai, Saleem	United States of America	California	NORTHRIDGE

序号	名称	审查结论	批准日期/备案日期
1	上海交通大学医学院仁济医院伦理委员会	同意	2019-04-10

进行中（尚未招募）

目标入组人数	国内: 24 ； 国际: 959 ；
已入组人数	国内: 登记人暂未填写该信息； 国际: 登记人暂未填写该信息；
实际入组总人数	国内: 登记人暂未填写该信息； 国际: 登记人暂未填写该信息；

第一例受试者签署知情同意书日期	国内：登记人暂未填写该信息；     国际：登记人暂未填写该信息；
第一例受试者入组日期	国内：登记人暂未填写该信息；     国际：登记人暂未填写该信息；
试验完成日期	国内：登记人暂未填写该信息；     国际：登记人暂未填写该信息；