上海PF-07248144片III期临床试验-在既往接受上一线治疗后进展的 HR 阳性、HER2 阴性晚期或转移性乳腺癌患者中评估研究药物 PF-07248144 与氟维司群联合治疗的研究

登记号	CTR20253640	试验状态	进行中
申请人联系人	汪婷婷	首次公示信息日期	2025-09-10
申请人名称	Pfizer Inc./ 辉瑞投资有限公司

登记号	CTR20253640
相关登记号	暂无
药物名称	PF-07248144片
药物类型	化学药物
临床申请受理号	JXHL2500148/JXHL2500149
适应症	晚期/转移性乳腺癌
试验专业题目	一项在既往接受 CDK4/6 抑制剂治疗后疾病进展的HR阳性、HER2 阴性晚期/转移性乳腺癌成人研究参与者中比较 PF-07248144 + 氟维司群与研究者所选治疗的干预性、开放性、随机、多中心、III 期研究
试验通俗题目	在既往接受上一线治疗后进展的 HR 阳性、HER2 阴性晚期或转移性乳腺癌患者中评估研究药物 PF-07248144 与氟维司群联合治疗的研究
试验方案编号	C4551002	方案最新版本号	最终方案
版本日期:	2025-04-07	方案是否为联合用药	否

申请人名称	[["Pfizer Inc."],["辉瑞投资有限公司"]]
联系人姓名	汪婷婷	联系人座机	021-60432500	联系人手机号
联系人Email	tingting.wang2@pfizer.com	联系人邮政地址	上海市-上海市-静安区南京西路1168号中信泰富广场36楼	联系人邮编	200041

本研究的目的是在既往接受细胞周期蛋白依赖性激酶 (CDK) 4/6 抑制剂治疗后出现进展的激素受体 (HR) 阳性、人表皮生长因子受体 2 (HER2) 阴性晚期或转移性乳腺癌 (A/mBC) 研究参与者中，评估 PF-07248144 联合氟维司群相较于研究者所选治疗（ICT；依维莫司联合内分泌治疗 [ET；依西美坦或氟维司群]）是否可以改善临床结局。

试验分类	安全性和有效性	试验分期	III期	设计类型	平行分组
随机化	随机化	盲法	开放	试验范围	国际多中心试验

年龄	18岁(最小年龄)至 无上限 (最大年龄)
性别	男+女
健康受试者	无
入选标准	[["筛选时 ≥ 18 岁（或按照当地法规确定的最低同意年龄）。n- 男性（第 10.4.1 节）和女性（第 10.4.2 节）研究参与者的生殖标准参见附录 4。n- 根据 SoA 和第 6.9.1 节，绝经前/围绝经期女性研究参与者和男性研究参与者必须在研究治疗干预首次给药前至少 2 周开始接受 LHRH 激动剂。"],["经组织学检查确认乳腺癌，并有证据表明为局部晚期/转移性乳腺癌，且通过根治性切除术或放射治疗无法治愈。n- 有记录在案的 ER 和/或 PR 阳性肿瘤（根据当地评估），定义为在最近一次肿瘤活检中通过符合当地标准的检测明确 ER 和/或 PR 阳性染色细胞 ≥ 1%。n- 根据 ASCO/CAP 指导原则，有 IHC 检查或原位杂交 (ISH) 检查记录证实的 HER2 阴性肿瘤。n注：HER2 阴性定义为 IHC 染色强度为 0 或 1+，或者 IHC 染色强度为 2+ 且 ISH 检查未发现扩增证据。"],["必须提供足够数量的具有代表性的 FFPE 肿瘤组织样本。n注：肿瘤组织样本最好是在既往 CDK4/6i 治疗后通过活检重新采集的样本。如果由于监管限制和/或医学考量而无法进行活检，则需要提供在诊断为复发性或转移性疾病时采集的存档样本。如果没有复发性或转移性疾病诊断时的组织样本，例如仅骨病灶，则需要提供在初始诊断或手术时采集的存档样本。参见第 8.7.1 节。"],["既往必须接受过属于以下情况之一的 CDK4/6 抑制剂治疗：ni) 在 A/mBC 治疗中接受过 CDK4/6i + ET 治疗，或nii) 接受过 CDK4/6i + ET 辅助治疗，并在 CDK4/6i 给药期间或末次给药后 12 个月内记录到 PD/复发。n 此外，符合以下条件的研究参与者也有资格参与研究：n 既往在 A/mBC 治疗中接受过 CDK4/6i 或 ET 单药治疗，或联合治疗的再挑战治疗。n注：允许使用过氟维司群或依西美坦，但并非强制要求。n 既往接受过靶向 ESR1 或 BRCA1/2 的治疗。"],["必须有可测量病灶，或不可测量病灶（仅骨病灶），定义见 RECIST v1.1。n注：对于既往接受过放疗或其他局部治疗的肿瘤病灶，仅在治疗完成后明确记录到治疗部位发生进展时，才被视为可测量病灶。不可测量的仅骨病灶可能包括以下任何一种：成骨性病灶、无可测量软组织成分的溶骨性病灶、无可测量软组织成分的溶骨-成骨混合性病灶。"],["ECOG PS 0 或 1。n注：如果研究参与者具有适当的器官功能、预期寿命且符合其他方案资格标准，据研究者判断且经申办方同意，可将 ECOG 为 2 的研究参与者视为符合标准。"]]
排除标准	[["可能增加研究参与的风险或根据研究者判断可能使研究参与者不适合参加研究的任何医学或精神状况，包括过去一年内任何活跃的自杀想法/行为或过去 5 年内的自杀行为，或实验室检查异常。"],["短期内有需要即刻接受化疗方案（包括抗体偶联药物 [ADC]）或有即时危及生命并发症风险的内脏危象或器官衰竭的研究参与者，或有大量未受控制的积液、肺淋巴管炎或肝脏受累 > 50% 的研究参与者。"],["已知存在活动性未控制的或症状性 CNS 转移、癌性脑膜炎，有临床症状的软脑膜疾病、脑水肿和/或肿瘤进行性生长。n注：对于有 CNS 转移病史或脊髓受压的研究参与者，如果已接受根治性治疗（如放射治疗、立体定向手术），在筛选期间无新发或扩大转移灶的影像学证据，且随机化前至少 4 周内在不使用抗痉挛药和类固醇的情况下保持临床状态稳定，则有资格入组研究。"],["入组前 3 年内患有任何其他活动性恶性肿瘤或有任何证据表明先前诊断的恶性肿瘤有残留病灶的研究参与者，但经充分治疗的基底细胞或鳞状细胞皮肤癌或宫颈原位癌、鲍温病除外。患有其他不干扰研究中主要癌症评估的惰性癌的研究参与者，在获得申办方事先批准后可参加研究。"],["入组前 3 年内患有任何其他活动性恶性肿瘤或有任何证据表明先前诊断的恶性肿瘤有残留病灶的研究参与者，但经充分治疗的基底细胞或鳞状细胞皮肤癌或宫颈原位癌、鲍温病除外。患有其他不干扰研究中主要癌症评估的惰性癌的研究参与者，在获得申办方事先批准后可参加研究。"],["心血管功能受损或有临床意义的心血管疾病，定义为：na. 过去 6 个月内发生过以下任一情况：心肌梗死、长 QT 综合征、尖端扭转性室性心动过速、有临床意义的房性或室性心律失常（包括持续性室性快速性心律失常和室颤）、严重传导系统异常（比如双分支传导阻滞 [即左前后半支传导阻滞]、三度房室传导阻滞）、不稳定型心绞痛、冠状动脉/外周动脉搭桥术、症状性 CHF、纽约心脏病协会心功能分级 III 级或 IV 级、脑血管意外、短暂性脑缺血发作、症状性肺栓塞和/或其他有临床意义的血栓栓塞疾病发作。nb. NCI CTCAE ≥ 2 级的持续性心律不齐、任何级别的房颤（如果为孤立性无症状性房颤，则须 ≥ 2 级）。nc. 筛选 ECG 显示 QTcF 间期 > 470 msec。n注：如果基线 QTcF > 500 msec，只要通过了心脏科医生的评估及申办方医学监查员的协商，则研究参与者仍可能符合参与标准。nd. 对于携带心脏节律装置/起搏器或者携带心脏节律装置/起搏器且 QTcF > 470 ms 的研究参与者，仍可能将其视为符合资格标准，但须与申办方的医学监查员一起评估和讨论。n注：携带心脏节律装置/起搏器的研究参与者将被视为不符合参与 QTc 子研究的资格。"],["患有活动性结核病的受试者。"],["已知活动性感染，包括 SARS-CoV-2 感染、HBV、HCV 以及 HIV 或 AIDS 相关疾病（不需要进行慢性疾病筛查）。除非国家/地区卫生主管部门强制要求，否则不需要进行检测。a. 活动性 HBV 定义为 HBsAg 反应性，活动性 HCV 定义为检测到 HCV RNA [定性]。如果有 12 周的持续病毒学应答记录，则允许接受丙型肝炎感染治愈性治疗的参与者参加研究。nb. 健康且 AIDS 相关结局风险低的 HIV 血清阳性受试者可能被视为符合资格：nc. 应根据当前和过去的 CD4 和 T 细胞计数、艾滋病标志性病变（如机会性感染）的病史（如有）和 HIV 治疗状态，与申办方的医学监查员一起评估和讨论 HIV 阳性受试者的资格标准。此外，还将考虑 DDI 的潜在可能性。在血清学检查呈阳性的不明确病例中，病毒载量呈阴性的研究参与者可能有资格参加研究，前提是符合其他入选标准。"],["既往接受禁用的抗癌治疗和相关毒性：na. 针对 A/mBC 的既往系统性治疗线数超过 2 线。nb. 既往接受过 PIK3CA/AKT1/PTEN 变异靶向治疗。nc. 既往针对不可手术的局部晚期或转移性疾病接受过化疗，包括 ADC。本研究不排除既往在（新）辅助治疗中接受过化疗的患者。nd. 随机化前 2 周内接受过系统性抗癌治疗或放射治疗。"],["受试者在既往治疗（包括放射治疗或手术）后出现有临床意义的持续毒性，且尚未缓解至 ≤ 1 级 (NCI-CTCAE v5.0) 或恢复至基线水平。"],["随机化前 4 周内接受过大手术，研究参与者在开始研究治疗前必须已从治疗干预并发症中充分恢复。n注：在入组研究前，小手术必须已过去至少 1 周，且研究参与者必须已从手术并发症中充分恢复。"],["研究参与者既往接受过异体干细胞或实体器官移植。"],["当前使用任何禁用伴随用药，或不愿意或不能使用要求的伴随用药。参见第 6.9 节。"],["受试者在随机化前 30 天内接种过减毒活疫苗。活疫苗的示例包括但不限于：麻疹、流行性腮腺炎、风疹、水痘/带状疱疹（水痘）、黄热病、狂犬病、卡介苗和伤寒疫苗。注射用季节性流感疫苗通常是灭活病毒疫苗，可允许使用；但鼻内流感疫苗（例如 FluMist&reg;）是减毒活疫苗，不允许使用。"],["随机化时正在接受全身性抗菌治疗活动性感染（病毒、细菌或真菌感染）。允许进行常规抗微生物预防治疗。"],["在本研究所用的研究治疗干预药物首次给药前 30 天或 5 个半衰期（以较长者为准）内接受过其他研究用药品（抗癌治疗药物或疫苗）。n注：在入组研究前 4 周内参加过涉及研究治疗干预的其他研究。如果研究参与者处于某研究的随访期，只要其已持续 1 个月没有接受该研究中的治疗，则仍有资格参加本研究。"],["有记录显示 肿瘤通过F1CDx 检测法检出存在 PIK3CA/AKT1/PTEN 变异。n - 没有当地 F1CDx 检测结果的所有研究参与者都将在入组前接受检测。n注：可使用当地 F1CDx 组织检测结果确定入组资格。"],["如下所述的肾功能损害、肝功能障碍或血液学异常：na. 肾功能损害定义为成人中 BSA 校正 eGFR < 45 mL/min。n注：根据筛选时的研究参与者年龄，使用推荐的公式（CDK-EPI 公式；第 10.7.1 和 10.7.2 节）计算 eGFR。通过将患者的 eGFR 乘以患者的 BSA 再除以 1.73，计算出 BSA 校正 eGFR 用于确定资格。nb. 肝功能障碍，定义为：n 总胆红素 ≥ [1.5 × ULN]（患有 Gilbert's 综合征的研究参与者 ≥ 3× ULN ，直接胆红素 > ULN 需排除）n AST > 2.5 × ULN（如果发生肝转移，则为 > 5 × ULN）n ALT> 2.5 × ULN（如果发生肝转移，则为 > 5 × ULN）n 碱性磷酸酶 > [2.5 × ULN]（如果发生肝转移或骨转移，则为 > [5 × ULN]）nc. 血液学异常，定义为：n ANC < 1500/mm3n 血小板 < 100,000/mm3n 血红蛋白 < 9 g/dL"],["直接参与研究实施的研究中心工作人员及其家庭成员、受研究者监管的其他研究中心工作人员、直接参与研究实施的申办方和申办方代表员工及其家庭成员。"]]

试验药

[["中文通用名:PF-07248144 英文通用名:PF-07248144 商品名称:NA","剂型:片剂 规格:1mg 用法用量:口服，每日一次，每次1mg/2mg/3mg（根据不良反应引起的剂量降低用药） 用药时程:连续给药，28天为一个周期，直至疾病进展及不可接受的毒性等原因会导致永久终止研究治疗干预"],["中文通用名:PF-07248144 英文通用名:PF-07248144 商品名称:NA","剂型:片剂 规格:5mg 用法用量:口服，每日一次，每次5mg 用药时程:连续给药，28天为一个周期，直至疾病进展及不可接受的毒性等原因会导致永久终止研究治疗干预"],["中文通用名:氟维司群 英文通用名:Fulvestrant 商品名称:普来和","剂型:注射液 规格:250mg/5mL 用法用量:肌内给药，50mg/mL（2×250mg/5mL注射液），每次500mg 用药时程:500mg，在第1周期第1天和第15天给药，然后从第2周期第1天开始在每个周期第1天给药（28天为一个周期），直至疾病进展及不可接受的毒性等原因会导致永久终止研究治疗干预"]] 序号 名称 用法

对照药

[["中文通用名:依维莫司 英文通用名:Everolimus 商品名称:飞尼妥","剂型:片剂 规格:2.5mg 用法用量:口服，每日一次，2.5mg（根据不良反应引起的剂量降低用药） 用药时程:每日一次(QD)，直至疾病进展及不可接受的毒性等原因会导致永久终止研究治疗干预"],["中文通用名:依维莫司 英文通用名:Everolimus 商品名称:飞尼妥","剂型:片剂 规格:5mg 用法用量:口服，每日一次，每次2片，每片5mg；或者如因不良反应引起剂量降低，每日一次，每次5mg 用药时程:每日一次(QD)，直至疾病进展及不可接受的毒性等原因会导致永久终止研究治疗干预"],["中文通用名:依西美坦 英文通用名:Exemestane 商品名称:阿诺新","剂型:片剂 规格:25mg 用法用量:口服，每日一次，25mg 用药时程:每日一次(QD)，直至疾病进展及不可接受的毒性等原因会导致永久终止研究治疗干预"]] 序号 名称 用法

主要终点指标及评价时间	[["PFS，定义为从随机化日期到首次记录疾病进展（由盲态独立中心审查委员会[BICR]根据RECIST v1.1确定）或未出现疾病进展 (PD) 的情况下任何原因导致死亡日期（以先发生者为准）的时间","整个试验过程","有效性指标"]] 序号 指标 评价时间 终点指标选择
次要终点指标及评价时间	[["OS，定义为从随机化日期到任何原因导致死亡日期的时间","整个试验过程","有效性指标"],["BICR根据RECIST v1.1评估的客观缓解 (OR)nBICR根据RECIST v1.1评估的DoRnBICR根据RECIST v1.1评估的临床获益率","整个试验过程","有效性指标+安全性指标"],["不良事件的类型、发生率、严重程度（根据美国国家癌症研究所不良事件通用术语标准分级）和严重性、任何实验室检查或心电图异常，以及PF-07248144对校正QT间期 (QTc)较基线变化的影响分析。","整个试验过程","有效性指标+安全性指标"],["PF-07248144 的 Ctrough（计划给药前的最低血药浓度）","整个试验过程","有效性指标+安全性指标"]] 序号 指标 评价时间 终点指标选择

1	姓名	邵志敏	学位	医学博士	职称	科室主任
	电话	021-64175590-88808	Email	szmgcp2016@163.com	邮政地址	上海市-上海市-东安路270号
	邮编	200032	单位名称	复旦大学附属肿瘤医院

[["复旦大学附属肿瘤医院","邵志敏","中国","上海市","上海市"],["中山大学肿瘤防治中心","王树森","中国","广东省","广州市"],["广东省人民医院","王坤","中国","广东省","广州市"],["南京大学医学院附属鼓楼医院","谢丽","中国","江苏省","南京市"],["哈尔滨医科大学附属肿瘤医院","蔡莉","中国","黑龙江省","哈尔滨市"],["大连医科大学附属第二医院","李曼","中国","辽宁省","大连市"],["山东第一医科大学附属肿瘤医院（山东省肿瘤防治研究院、山东省肿瘤医院）","王永胜","中国","山东省","济南市"],["西安交通大学第二附属医院","张淑群","中国","陕西省","西安市"],["温州医科大学附属第一医院","王瓯晨","中国","浙江省","温州市"],["湖北省肿瘤医院","吴新红","中国","湖北省","武汉市"],["福建医科大学附属协和医院","侯培锋","中国","福建省","福州市"],["郑州大学第一附属医院","李靖若","中国","河南省","郑州市"],["湖南省肿瘤医院","欧阳取长","中国","湖南省","长沙市"],["北京肿瘤医院","李惠平","中国","北京市","北京市"],["华中科技大学同济医学院附属同济医院","熊慧华","中国","湖北省","武汉市"],["西安交通大学第一附属医院","杨谨","中国","陕西省","西安市"],["南方医科大学南方医院","姚广裕","中国","广东省","广州市"],["安徽省肿瘤医院","潘跃银","中国","安徽省","合肥市"],["北京大学人民医院（北京大学第二临床医学院）","王殊","中国","北京市","北京市"],["临沂市肿瘤医院","王京芬","中国","山东省","临沂市"],["中国医科大学附属第一医院","滕月娥","中国","辽宁省","沈阳市"],["浙江大学医学院附属邵逸夫医院","王娴","中国","浙江省","杭州市"],["浙江大学医学院附属第二医院","陈益定","中国","浙江省","杭州市"],["南昌市人民医院","陈文艳","中国","江西省","南昌市"],["广西医科大学附属肿瘤医院","陆永奎","中国","广西壮族自治区","南宁市"],["浙江省肿瘤医院","胡海","中国","浙江省","杭州市"],["吉林大学第一医院","吕铮","中国","吉林省","长春市"],["河北大学附属医院","杨华","中国","河北省","保定市"],["National Cancer Center Hospital","Dr.Kan Yonemori","日本","TOKYO","Tokyo"],["National Cancer Center Hospital East","Dr.Toru Mukohara","日本","CHIBA","Kashiwa"],["University of Texas MD Anderson Cancer Center","Dr.Rachel M Layman","美国","TEXAS","Houston"],["Kanagawa cancer center","Dr.Toshinari Yamashita","日本","KENTUCKY","Yokohama"],["Yale-New Haven Hospital","Dr.Adriana Kahn","美国","CONNECTICUT","New Haven"],["The University of Louisville, James Graham Brown Cancer Center","Brian Dong","美国","KENTUCKY","Louisville"],["St John of God Hospital Subiaco","Dr.Timothy Dudley Clay","澳大利亚","WA","SUBIACO"],["Cancer Research SA","Dr.Rohit Joshi","澳大利亚","SOUTH AUSTRALIA","Adelaide"],["Hadassah Medical Center","Prof.Shani Paluch-Shimon","以色列","YERUSHALAYIM","Jerusalem"],["Hospital Universitario Virgen de la Victoria","Dr.Javier Pascual López","西班牙","ANDALUCíA","Malaga"],["Showa University Hospital","Prof.Junji Tsurutani","日本","TOKYO","Shinagawa-ku"],["Hospital Moinhos de Vento","Mr.Rafael Dal Ponte Ferreira","巴西","RIO GRANDE DO SUL","Porto Alegre"],["Okayama University Hospital","Dr.Tadahiko Shien","日本","OKAYAMA","Okayama"],["Centro de Investigacion Clinica de Oaxaca","Dr.Roberto Ivan Romero","墨西哥","OAXACA","Oaxaca"],["The University of Osaka Hospital","Dr.Tetsuhiro Yoshinami","日本","OSAKA","Suita"],["Rambam Health Care Campus","Dr.Ayelet Shai","以色列","HEIFā","Haifa"],["Institut de Cancérologie de l`Ouest","Mrs.Anne Patsouris","法国","MAINE-ET-LOIRE","Angers"],["Adana Sehir Egitim ve Arastirma Hastanesi","Prof.Timucin Cil","土耳其","ADANA","Adana"],["Fundación Respirar","Dr.Christian Sebastian Fuentes","阿根廷","CIUDAD AUTóNOMA DE BUENOS AIRES","Ciudad Autónoma de Buenos Aires"],["Hospital de Cancer de Londrina","Dr.Vitor Teixeira Liutti","巴西","PARANá","Londrina"],["I.A.ü VM Medical Park Florya Hastanesi","Prof.Irfan Cicin","土耳其","ISTANBUL","Istanbul"],["Gunma Prefectural Cancer Center","Dr.Tomomi Fujisawa","日本","GUNMA","Ohta"],["Hacettepe Universite Hastaneleri","Prof.Sercan Aksoy","土耳其","ANKARA","Ankara"],["Ospedale San Raffaele","Dr.Giampaolo Bianchini","意大利","MILANO","Milano"],["Shaare Zedek Medical Center","Albert Grinshpun","以色列","YERUSHALAYIM","Jerusalem"],["Juntendo University Hospital","Prof.Junichiro Watanabe","日本","TOKYO","Tokyo"],["Hospital Santa Rita de Cassia","GLAUCIO ANTONIO BERTOLLO","巴西","ESPíRITO SANTO","VITóRIA"],["Bon Secours St. Francis Medical Center","Dr.William J. Irvin","美国","VIRGINIA","Midlothian"],["Gulhane Egitim Arastirma Hastanesi","Dr.Nuri Karadurmus","土耳其","ANKARA","Ankara"],["Onkologicky Ustav sv. Alzbety","Bela Mrinakova","斯洛伐克","BRATISLAVSKY KRAJ","Bratislava"],["Centre Hospitalier Régional Universitaire de Tours - Hopital Bretonneau","Ms.Helene Vegas","法国","INDRE-ET-LOIRE","Tours"],["Dana-Farber Cancer Institute","Dr.Antonio Giordano","美国","MASSACHUSETTS","Boston"],["National Hospital Organization Shikoku Cancer Center","Dr.Mariko KOCHI","日本","EHIME","Matsuyama"],["Nirmal Hospital Pvt Ltd.","Anshul Agarwal","印度","GUJARAT","Surat"],["CHUAC-Complejo Hospitalario Universitario A Coruna","Dr.Silvia Antolin Novoa","西班牙","A CORUNA [LA CORUNA]","A Coruna"],["Multiprofile Hospital for Active Treatment Serdika EOOD","Dr.Nadezhda Pencheva Miteva-Yovcheva NPM","保加利亚","SOFIA (STOLITSA)","Sofia"],["Princess Alexandra Hospital","Dr.Katharine Ellen Cuff","澳大利亚","QUEENSLAND","Woolloongabba"],["Tergooiziekenhuizen, locatie Hilversum","Annelieke E.C.A.B. Willemsen","荷兰","NOORD-HOLLAND","Hilversum"],["COI Centro Oncológico Internacional S.A.P.I de C.V","Dr.Georgina Garnica Jaliffe","墨西哥","DISTRITO FEDERAL","Mexico City"],["Fakultni nemocnice v Motole","Dr.Tomas Buchler","捷克共和国","PRAHA 5","Prague"],["Complex Oncology Center - Burgas","Krasimir Nikolov","保加利亚","BURGAS","Burgas"],["MHAT for Women`s Health Nadezhda","Radostina Bozhidarova Gencheva","保加利亚","SOFIA","Sofia"],["Istituto Nazionale Tumori Regina Elena","Dr.Patrizia Vici","意大利","LAZIO","Roma"],["Vseobecna fakultni nemocnice v Praze","Dr.Martina Zimovjanova Ph.D","捷克共和国","PRAHA 2","Praha 2"],["IDIM – Instituto de Investigaciones Metabólicas","Dr.Juan Esteban Cundom","阿根廷","BUENOS AIRES","Buenos Aires"],["Organizacion Medica de Investigacion","Dr.Margarita Sonia Alfie","阿根廷","CIUDAD AUTóNOMA DE BUENOS AIRES","Buenos Aires"],["Ankara Bilkent Sehir Hastanesi","Prof.Mehmet Ali Nahit Sendur","土耳其","ANKARA","Ankara"],["Vychodoslovensky Onkologicky ustav a.s.","Dr.Andrea Cipkova","斯洛伐克","KOSICKY KRAJ","Kosice"],["MVZ für Hamatologie und Onkologie Ravensburg GmbH - Studienzentrum","Thomas Decker","德国","BADEN-WüRTTEMBERG","Ravensburg"],["Specialized Hospital for Active Treatment of Oncology - Haskovo","Dr.Stoil Boychev","保加利亚","HASKOVO","Haskovo"],["Memorial Ankara Hastanesi","Prof.Umut Demirci","土耳其","ANKARA","Ankara"],["Instituto D’Or de Pesquisa e Ensino (IDOR) – Filial Salvador","Dr.Livia Andrade","巴西","BAHIA","Salvador"],["INSTITUTO NACIONAL DE CANCEROLOGIA","Dr.Claudia Haydeé Arce Salinas","墨西哥","DISTRITO FEDERAL","Mexico City"],["The Cancer Institute Hospital of JFCR","Jun Masuda","日本","TOKYO","Tokyo"],["National Center for Global Health and Medicine","Dr.Akihiko Shimomura","日本","TOKYO","Shinjuku-ku"],["Institut de Cancérologie de l`Ouest","Prof.Mario Campone","法国","LOIRE-ATLANTIQUE","Saint Herblain"],["Narodny onkologicky ustav","Dr.Eva Oravcova","斯洛伐克","BRATISLAVSKY KRAJ","Bratislava"],["Nemocnice AGEL Novy Jicin a.s.","Dr.David Vrana","捷克共和国","NOVY JICíN","Novy Jicin"],["Azienda USL Toscana Nord Ovest_Ospedale Civile di Livorno","Dr.GIACOMO ALLEGRINI","意大利","TOSCANA","Livorno"],["Sint Antonius Ziekenhuis, locatie Nieuwegein","Mariette Agterof","荷兰","UTRECHT","Utrecht"],["The Catholic Univ. of Korea Seoul St. Mary`s Hospital","Jieun Lee","韩国","SEOUL-TEUKBYEOLSI [SEOUL]","Seoul"],["CHU de Québec-Université Laval, Hopital du Saint-Sacrement","Dr.Catherine Doyle","加拿大","QUEBEC","Québec"],["Centre Georges Francois Leclerc","Dr.Sylvain Ladoire","法国","COTE-D`OR","Dijon"],["Highlands Oncology Group, PA","Dr.Joseph Thaddeus Beck","美国","ARKANSAS","Springdale"],["Fundación Instituto Valenciano de Oncología","Dr.Angel Luis Luis Guerrero Zotano","西班牙","VALENCIANA, COMUNITAT","València"],["Hospital Universitario San Cecilio","Dr.Maria Isabel Blancas López-Barajas","西班牙","GRANADA","Granada"],["Gustave Roussy","Cyril Roussel-simonin","法国","VAL-DE-MARNE","Villejuif"],["ANIMI - Unidade de Tratamento Oncologico","Dr.MAITE DE LIZ VASSEN SCHURMANN","巴西","SANTA CATARINA","Lages"],["Oncosite – Centro de Pesquisa Clínica em Oncologia","Dr.Fabio Andre Franke","巴西","RIO GRANDE DO SUL","Ijui"],["Mercy Medical Center - Baltimore","Dr.David A. Riseberg","美国","MARYLAND","Baltimore"],["Fakultna nemocnica s poliklinikou Nove Zamky","Dr.Pavol Demo","斯洛伐克","NITRIANSKY KRAJ","Nové Zámky"],["Fakultna nemocnica Trencin","Dr.Branislav Bystricky PhD","斯洛伐克","TRENCIANSKY KRAJ","Trencín"],["FUNDACIóN CENIT PARA LA INVESTIGACIóN EN NEUROCIENCIAS","Dr.Guillermo Luis Lerzo","阿根廷","CIUDAD AUTóNOMA DE BUENOS AIRES","Buenos Aires"],["Gangnam Severance Hospital, Yonsei University Health System","Dr.Jee Hung Kim","韩国","SEOUL-TEUKBYEOLSI [SEOUL]","Seoul"],["Centrum Badań Klinicznych Jagiellońskie Centrum Innowacji sp. z o.o.","Dr.Wojciech Piskorski","波兰","MALOPOLSKIE","Krakow"],["Nemocnica AGEL Komarno","Olga Rosinska","斯洛伐克","NITRIANSKY KRAJ","Komarno"],["Complex Oncology Center - Plovdiv EOOD","Dr.Antoaneta Dimitrova Tomova","保加利亚","PLOVDIV","Plovdiv"],["Istituto Europeo di Oncologia IRCCS","Dr.Marco Angelo Oscar Colleoni","意大利","MILANO","Milano"],["Korea University Anam Hospital","Dr.Kyong Hwa Park MD","韩国","SEOUL-TEUKBYEOLSI [SEOUL]","Seoul"],["Sheba Medical Center","Dr.Amit Itay","以色列","HAMERKAZ","Ramat Gan"],["Atrium-Orbis - Zuyderland Medisch Centrum Heerlen","Dr.Franchette van den Berkmortel","荷兰","LIMBURG","Geleen"],["Fakultni nemocnice Kralovske Vinohrady","Dr.Renata Soumarova","捷克共和国","PRAHA 10","Praha 10"],["I.E.U. Medical Point Hastanesi","Dr.Cagatay Arslan","土耳其","IZMIR","izmir"],["Sunnybrook Research Institute","Katarzyna J. Jerzak","加拿大","ONTARIO","Toronto"],["Kuopion Yliopistollinen Sairaala","Dr.Paivi Kaarina Auvinen","芬兰","POHJOIS-SAVO","Kuopio"],["Institut Català d`Oncologia - L`Hospitalet","Andrea Carolina Vethencourt Casado","西班牙","BARCELONA [BARCELONA]","Hospitalet de Llobregat"],["Institut Régional du Cancer Montpellier","Dr.Angelique BOBRIE","法国","HéRAULT","Montpellier"],["Fondazione IRCCS San Gerardo dei Tintori","Dr.Marina Elena Cazzaniga","意大利","LOMBARDIA","Monza"],["Krajská nemocnice Liberec","Dr.Marek Sochor","捷克共和国","LIBEREC","Liberec"],["Unidad de Investigación en Salud de Chihuahua, S.C.","Dr.Raul Gerardo Ramírez Medina","墨西哥","CHIHUAHUA","Chihuahua"],["Universitaetsklinikum Erlangen","Prof.Peter A Fasching","德国","BAYERN","Erlangen"],["Jewish General Hospital","Dr.Cristiano Ferrario","加拿大","QUEBEC","Montreal"],["Oaxaca Site Management Organization S.C.","Sandy Ruiz Cruz","墨西哥","OAXACA","Oaxaca de Juárez"],["Renati Innovation, S.A.P.I. de C.V.","Dr.Carlos Jose Zuloaga Fernandez del Valle","墨西哥","JALISCO","Guadalajara"],["Ad-Vance Medical Research","Dr.Hector A. Velez-Cortes","波多黎各","PUERTO RICO","Ponce"],["Institut de Cancérologie de Lorraine Alexis Vautrin","Dr.Vincent Massard","法国","LORRAINE","Vandoeuvre les Nancy"],["Centre Francois Baclesse","Dr.George Emile","法国","LORRAINE","Caen"],["CHRU de Brest","Dr.Laura Deiana","法国","BASSE-NORMANDIE","Brest"],["Centre Eugène Marquis Rennes - Centre de Lutte Contre le Cancer","Dr.Veronique DIERAS","法国","BRETAGNE","Rennes"],["Fakultna nemocnica Trnava","Dr.Marian Stresko","斯洛伐克","TRNAVSKY KRAJ","Trnava"],["Nemocnica s poliklinikou Stefana Kukuru Michalovce, a.s.","Dr.Lenka Rusinova","斯洛伐克","KOSICKY KRAJ","Michalovce"],["ICESP - INSTITUTO DO CANCER DO ESTADO DE SAO PAULO","Andrea Clemente Baptista Silva","巴西","SAO PAULO","Sao Paulo"],["Országos Onkológiai Intézet","Dr.Gabor Rubovszky","匈牙利","BUDAPEST","Budapest"],["Institut Jules Bordet","Dr.Andrea Gombos","比利时","BRUXELLES-CAPITALE, RéGION DE","Anderlecht"],["COE (Centro Oncológico de Excelencia)","Juan Manuel Puig","阿根廷","SAN JUAN","San Juan"],["Centro Medico Fleischer","Dr.Rosselli Gerónimo","阿根廷","CIUDAD AUTóNOMA DE BUENOS AIRES","Buenos Aires"],["IBCC – Núcleo de Pesquisa e Ensino","Dr.Felipe José Silva Melo Cruz","巴西","SAO PAULO","Sao Paulo"],["CHU Besancon","Dr.Laura Mansi","法国","DOUBS","Besancon"],["The Ottawa Hospital - General Campus","Dr.Sharon McGee","加拿大","ONTARIO","Ottawa"],["Centre Hospitalier de l`Université de Montréal","Dr.Jean-Pierre Ayoub","加拿大","QUEBEC","Montréal"],["Ventura County Hematology Oncology Specialists","Dr.Lynn R Kong","美国","CALIFORNIA","Oxnard"],["Medipol Mega Universite Hastanesi","Ahmet Bilici","土耳其","ISTANBUL","istanbul"],["The Royal Cornwall Hospital","Dr.Alastair Harrop Thomson","英国","ENGLAND","Truro"],["Fakultni Thomayerova nemocnice","Dr.Eugen Kubala","捷克共和国","PRAHA 4","Prague"],["Fundación CORI para la Investigación y Prevención del Cáncer","Dr.Diego Lucas Kaen","阿根廷","LA RIOJA","La Rioja"],["Debreceni Egyetem Klinikai Kozpont","Dr.Peter Arkosy","匈牙利","DEBRECEN","Debrecen"],["Ironwood Cancer & Research Centers","Dr.Sumeet K. Mendonca","美国","ARIZONA","Gilbert"],["Maastricht UMC+","Dr.Maaike De Boer","荷兰","LIMBURG","Maastricht"],["Institut Paoli-Calmettes","Dr.Alexandre Tassin de Nonneville","法国","BOUCHES-DU-RHONE","Marseille"],["Western Health-Sunshine & Footscray Hospitals","Dr.Catherine Angela Oakman","澳大利亚","VICTORIA","St Albans"],["Erciyes Universitesi Tip Fakultesi Hastaneleri","Mevlude Inanc","土耳其","KAYSERI","Kayseri"],["Samsun Medical Park Hastanesi","Dr.Yasemin Kemal","土耳其","SAMSUN","Samsun"],["Dicle üniversitesi","Prof.Muhammet Ali kaplan","土耳其","DIYARBAKIR","sur"],["TC Saglik Bakanligi Goztepe Prof. Dr. Suleyman Yalcin Sehir Hastanesi","Prof.Mahmut Gumus","土耳其","ISTANBUL","Istanbul"],["Wits Clinical Research","Prof.Georgia Savva Demetriou","南非","GAUTENG","Johannesburg"],["Complex Oncology Center - Shumen","Dr.Nikolay Nachkov Nikolov","保加利亚","SHUMEN","Shumen"],["The Royal Surrey County Hospital","Dr.Panagiotis Koliou","英国","SURREY","Guildford"],["Chiba cancer center","Dr.Rikiya Nakamura","日本","CHIBA","Chiba"],["HOSPITAL UNIVERSITARIO DE JAEN","Dr.ROCIO URBANO CUBERO","西班牙","JAéN","JAEN"],["Tampereen yliopistollinen sairaala","Mrs.Minna Tanner","芬兰","PIRKANMAA","Tampere"],["Hospital Universitario Ramón y Cajal","Dr.Maria Fernandez Abad","西班牙","MADRID, COMUNIDAD DE","Madrid"],["THEAGENIO Cancer Hospital of Thessaloniki","Dr.Anastasios Boutis","希腊","THESSALONíKI","Thessaloniki"],["Sahlgrenska Universitetssjukhuset","Ms.Karolina Frida Larsson","瑞典","VASTRA GOTALANDS LAN [SE-14]","Goteborg"],["The Cancer & Hematology Centers","Dr.Amy C. VanderWoude","美国","MICHIGAN","city"],["Admiraal de Ruyter Ziekenhuis, locatie Goes","Dr.Ellen Van Vliet","荷兰","ZEELAND","Goes"],["Institut Bergonié - Centre Régional de Lutte Contre Le Cancer de Bordeaux et Sud Ouest","Maxime Brunet Dr.","法国","GIRONDE","Bordeaux"],["University General Hospital of Larissa","Prof.Athanasios Kotsakis","希腊","THESSALíA","Larissa"],["Euromedical General Clinic/Europeran Interbalkan Medical Center (Athens Medical Center S.A)","Dr.Konstantinos Papazisis","希腊","THESSALONíKI","Thessaloniki"],["Musgrove Park Hospital","Dr.Saiqa Spensley","英国","SOMERSET","Taunton"],["Cliniques universitaires Saint-Luc","Prof.Francois P Duhoux","比利时","BRUXELLES-CAPITALE, RéGION DE","Brussels"],["National Hospital Organization Kyushu Cancer Center","Dr.Eriko Tokunaga","日本","FUKUOKA","Fukuoka"],["Uniwersytecki Szpital Kliniczny w Poznaniu","Prof.Rodryg Ramlau Mr","波兰","WIELKOPOLSKIE","Poznan"],["Centro de Oncología e Investigación de Buenos Aires","Dr.Mirta Susana Varela","阿根廷","BUENOS AIRES","Berazategui"],["Sourasky Medical Center","Prof.Amir Sonnenblick","以色列","HAMERKAZ","Tel Aviv-Yafo"],["Antwerp University Hospital","Dr.Konstantinos Papadimitriou","比利时","ANTWERPEN","Edegem"],["IRCCS - Istituto Romagnolo per lo Studio dei Tumori (IRST)","Prof.Antonino Musolino","意大利","EMILIA-ROMAGNA","Meldola"],["Institut Curie","Prof.Francois-Clement Bidard","法国","HAUTS-DE-SEINE","Saint-Cloud"],["Universitaetsklinikum Ulm","Prof.Brigitte Rack","德国","BADEN-WüRTTEMBERG","Ulm"],["Mammazentrum HH - Krankenhaus Jerusalem","Prof.Christian Schem","德国","HAMBURG","Hamburg"],["AZ Groeninge Campus Kennedylaan","Dr.Laure Nuytemans","比利时","WEST-VLAANDEREN","Kortrijk"],["Praxisklinik Krebsheilkunde fur Frauen","Dr. med.Gülten Oskay-Ozcelik","德国","BERLIN","Berlin"],["Grand Hopital de Charleroi","Alix Devaux","比利时","HAINAUT","Charleroi"],["Hospital Universitario HM Sanchinarro","ESTELA VEGA ALONSO","西班牙","MADRID","Madrid"],["Washington University School of Medicine","Dr.Andrew Davis","美国","MISSOURI","St. Louis"],["Kliniken Essen-Mitte, Evangelische Huyssens-Stiftung","Prof.Sherko Kümmel","德国","NORDRHEIN-WESTFALEN","Essen"],["Dolnoslaskie Centrum Onkologii, Pulmonologii i Hematologii","Katarzyna Soter","波兰","DOLNOSLASKIE","Wroclaw"],["National Cheng Kung University Hospital","Dr.Wei-Pang Chung","中国台湾","TAINAN","Tainan"],["Taipei Veterans General Hospital","Dr.Ling-Ming Tseng","中国台湾","TAIPEI","Taipei"],["ICON Cancer Centre - Kurralta Park","Dr.Kerry Alison Cheong","澳大利亚","SOUTH AUSTRALIA","Kurralta Park"],["Peter MacCallum Cancer Centre","Prof.Geoffrey J Lindeman","澳大利亚","VICTORIA","Melbourne"],["Seoul National University Bundang Hospital","Prof.Jee Hyun Kim","韩国","KYǒNGGI-DO","Seongnam-si"],["Chang Gung Medical Foundation-Linkou Branch","Dr.Shin-Cheh Chen","中国台湾","TAIPEI","Taipei"],["Mackay Memorial Hospital","Dr.Yuan-Ching Chang","中国台湾","TAIPEI","Taipei"],["Fundacion Estudios Clinicos","Dr.Betiana Romitelli","阿根廷","SANTA FE","Rosario"],["Hygeia Hospital","Dr.Flora Stavridi","希腊","ATTIKí","Marousi"],["Rabin Medical Center","Prof.Rinat Yerushalmi","以色列","HAMERKAZ","Petah Tikva"],["OSI BILBAO-BASURTO","ELENA GALVE CALVO","西班牙","BIZKAIA","Bilbao"],["Henry Ford Hospital","Hiba Jabbour-Aida","美国","MICHIGAN","Detroit"],["Wilmot Cancer Institute","Ajay Dhakal","美国","NEW YORK","Rochester"],["Complejo Asistencial Universitario de León - Hospital de León","Dr.Ana Lopez","西班牙","CASTILLA Y LEóN","Leon"],["Narodowy Instytut Onkologii im. Marii Sklodowskiej-Curie - Panstwowy Instytut Badawczy w Warszawie","Prof.Zbigniew Ireneusz Nowecki","波兰","MAZOWIECKIE","Warsaw"],["Fakultní nemocnice Brno Bohunice","Dr.Zdenek - Kral Csc","捷克共和国","BRNO-MěSTO","Brno"],["John Theurer Cancer Center at Hackensack University Medical Center","Dr.Deena M. Graham","美国","NEW JERSEY","Hackensack"],["National Taiwan University Hospital","Prof.Chiun-Sheng Huang","中国台湾","TAINAN","Taipei"],["Advocate Medical Group - Park Ridge, Luther Lane - Oncology","Dr.Sigrun Hallmeyer","美国","ILLINOIS","Park Ridge"],["Chi Mei Medical Center","Dr.Nai-Wen Kang","中国台湾","TAINAN","Yongkang Dist"],["Aurora Cancer Care-Grafton","Dr.Peter Polewski","美国","WISCONSIN","Grafton"],["UZ Leuven","Sileny Naeyu Han","比利时","VLAAMS-BRABANT","Leuven"],["University Specialized Hospital for Active Treatment of Oncology EAD","Dr.Assia Andrianova Konsoulova","保加利亚","SOFIA","Sofia"],["IASO General Clinic, Oncology Clinic","Sophia Karageorgopoulou","希腊","NA","Marousi"],["University General Hospital of Alexandroupoli","Dimitrios Matthaios","希腊","NA","Alexandroupolis"],["SP ZOZ Opolskie Centrum Onkologii im. prof. Tadeusza Koszarowskiego w Opolu","Dr.Barbara Radecka","波兰","OPOLSKIE","Opole"],["University General Hospital of Heraklion","Prof.Dimitrios Mavroudis","希腊","IRAKLEíO","Heraklion Crete"],["Nemocnica Bory - Penta Hospitals","Prof.Richard Hruby","斯洛伐克","BRATISLAVSKY KRAJ","Bratislava"],["Capital, Coast and Hutt Valley District - Wellington Regional Hospital","Dr.Sarah Barton","新西兰","WELLINGTON","Wellington"],["Fakultná nemocnica s poliklinikou Zilina","Dr.Dagmar Sudekova","斯洛伐克","ZILINSKY KRAJ","Zilina"],["Christchurch Hospital","Dr.David D Gibbs","新西兰","CANTERBURY","Christchurch"],["Sirio-Libanes Brasilia - Centro de Oncologia - Asa Sul","Tatiana Strava Correa","巴西","DISTRITO FEDERAL","Brasilia"],["Centro de Oncologia - CEON+ - Unidade Sao Caetano do Sul","Dr.Patricia Xavier Santi","巴西","SAO PAULO","Sao Caetano do Sul"],["centre hospitalier lyon sud","Dr.Julien Peron","法国","RHONE-ALPES","Pierrre Benite"],["Charité Universitaetsmedizin Berlin - Campus Mitte","Dr.Verena Kiver","德国","BERLIN","Berlin"],["Artemis hospital","Priya Tiwari","印度","HARYANA","Gurugram"],["Spandana Oncology Centre (SOC)","Dr.Satheesh Chiradoni Thungappa","印度","KARNATAKA","Bangaluru"],["Algemeen Ziekenhuis klina","Boudewijn Dullens","比利时","VLAAMS GEWEST","Brasschaat"],["Apex Wellness Hospital","Prof. Dr.SHAILESH ARJUN BONDARDE DR.","印度","MAHARASHTRA","NASHIK"],["Semmelweis Egyetem","Dr.Gyongyver Szentmartoni","匈牙利","BUDAPEST","Budapest"],["Istituto Nazionale Tumori IRCCS Fondazione Pascale","Dr.Michelino De Laurentiis","意大利","NAPOLI","Napoli"],["Sahyadri Super Speciality Hospital","Dr.Tushar Vishvasrao Patil","印度","MAHARASHTRA","Pune"],["The Oncology Centre","Dr.Gregory Ashley Landers","南非","KWAZULU-NATAL","Overport"],["Fakultni nemocnice Bulovka","Dr.Petra Beran Holeckova","捷克共和国","PRAHA 8","Praha 8"],["Korea University Guro Hospital","Prof.JaeHong Seo","韩国","SEOUL-TEUKBYEOLSI [SEOUL]","Seoul"],["Hiroshima City Hospital","Dr.Mitsuya Itoh","日本","HIROSHIMA","Hiroshima"],["St. Luke`s International Hospital","Dr.Shin Ogita","日本","TOKYO","Tokyo"],["City Hospital, Nottingham University Hospitals NHS Trust","Ms.Sarah Khan Dr","英国","NOTTINGHAM","Nottingham"],["Franciscus Gasthuis & Vlietland, Locatie Gasthuis","Quirine Van Rossum","荷兰","ZUID-HOLLAND","Schiedam"],["Medical Oncology Centre of Rosebank","Prof.Bernardo Leon Rapoport","南非","GAUTENG","Johannesburg"],["Aretaieio Hospital","Prof.FLORA ZAGOURI","希腊","ATTIKí","Athens"],["Centro Medico Zambrano Hellion","Dr.Cynthia Villarreal-Garza","墨西哥","NUEVO LEóN","Monterrey"],["Huntsman Cancer Institute","Roma Bhatia","美国","UTAH","Salt Lake City"],["Bhakti Vedanta Hospital and Research Institute","Nirmal Vivek Raut","印度","MAHARASHTRA","Mira Bhayandar"],["Samsung Medical Center","Prof. Dr.Yeon Hee Park","韩国","SEOUL-TEUKBYEOLSI [SEOUL]","Seoul"],["Koo Foundation Sun Yat-Sen Cancer Center","Chi-Feng Chung","中国台湾","TAIPEI","Taipei"],["Severance Hospital, Yonsei University Health System","Dr.Joo Hyuk Sohn","韩国","SEOUL-TEUKBYEOLSI [SEOUL]","Seoul"],["Fred Hutchinson Cancer Center","Dr.Vidhya Nair","美国","ILLINOIS","Chicago"],["Asan Medical Center","Dr.Sung-Bae Kim","韩国","SEOUL-TEUKBYEOLSI [SEOUL]","Seoul"],["Institute of Medical Sciences and Sum Hospital","Soumya Surath Panda Professor","印度","NA","Bhubaneswar, Odisha"],["SCRI Oncology Partners","Dr.Denise Aysel Yardley","美国","TENNESSEE","Nashville"],["Virginia Cancer Specialists, PC","Isabelle Le","美国","VIRGINIA","Arlington"],["Virginia Oncology Associates","Cristina Sampaio Do Vale Alencar","美国","VIRGINIA","Norfolk"],["Louisiana State University Health Sciences Center New Orleans","Dr.Michelle Loch","美国","LOUISIANA","New Orleans"],["Hospital Universitario Miguel Servet","Dr.Antonio Anton Torres","西班牙","ZARAGOZA","Zaragoza"],["Hospital Civil Fray Antonio Alcalde","Mr.Francisco Ramirez Godinez","墨西哥","JALISCO","Guadalajara"],["Seoul National University Hospital","Prof. Dr.Seock-Ah Im","韩国","SEOUL-TEUKBYEOLSI [SEOUL]","Seoul"],["Saint Luke`s Cancer Institute","Dr.Timothy J. Pluard","美国","MISSOURI","Kansas City"],["University of Arkansas for Medical Sciences","Sri Obulareddy","美国","ARKANSAS","Little Rock"],["Centre Hospitalier Universitaire de Liège - Domaine Universitaire du Sart Tilman","Dr.Andree Rorive","比利时","LIèGE","Liège"],["Texas Oncology - Central/South Texas","Jasmine Gowarty","美国","TEXAS","Austin"],["Sansum Clinic","Dr.Maira Campos","美国","CALIFORNIA","Santa Barbara"],["All India Institute of Medical Sciences","Ajay Gogia","印度","DELHI","South Delhi"],["Cross Cancer Institute","Bohdarianna Zorniak","加拿大","ALBERTA","Edmonton"],["Vaasan Keskussairaala","Dr.Natalja Eigeliene","芬兰","POHJANMAA","Vaasa"],["St Bartholomew`s Hospital","Dr.Vasileios Angelis","英国","ENGLAND","London"],["Hospital Universitari Vall d`Hebron","Prof.Ana Mafalda Antunes de Melo e Oliveira","西班牙","BARCELONA [BARCELONA]","Barcelona"],["Nucleo de Oncologia da Bahia","Ms.luciana landeiro","巴西","BAHIA","Salvador"],["CENEIT Oncológicos","Dr.Alberto Suarez Zaizar","墨西哥","MéXICO","CIUDAD DE MEXICO"],["Vardhman Mahavir Medical College and Safdarjung Hospital","Dr.Kaushal Kalra","印度","DELHI","New Delhi"],["Maidstone Hospital","Dr.Catherine Linda Harper-wynne","英国","KENT","Maidstone"],["MFSMC-HJWCI","Dr.Shweta Kurian","美国","MARYLAND","Baltimore"],["National Cancer Center","Dr.Keun Seok Lee","韩国","KYǒNGGI-DO","Goyang-si"],["Kyungpook National University Chilgok Hospital","Prof.Yee Soo Chae","韩国","TAEGU-KWANGYǒKSHI","DAEGU"],["Reinier de Graaf Ziekenhuis, locatie Delft","Dr.Lemonitsa Mammatas","荷兰","ZUID-HOLLAND","Sao Paulo"],["Instituto D`Or de Pesquisa e Ensino (IDOR)","Dr.Laura Testa","巴西","SAO PAULO","Bologna"],["IRCCS AOU di Bologna","Dr.Claudio Zamagni","意大利","EMILIA-ROMAGNA","Bologna"],["HCG Manavata Cancer Centre","Dr.Rajnish Vasant Nagarkar","印度","MAHARASHTRA","Nashik"],["Abraham Oncology","Dr.Smitha Abraham","南非","KWAZULU-NATAL","Richards Bay"],["Sodersjukhuset","Dr.Sara Margolin","瑞典","STOCKHOLMS LAN [SE-01]","Stockholm"],["Azienda Ospedaliero Universitaria","Dr.FEDERICO PIACENTINI","意大利","EMILIA-ROMAGNA","Modena"],["Mount Vernon Hospital","Stephanie Sutherland","英国","ENGLAND","Northwood"],["Békés Vármegyei Kozponti Kórház Pándy Kálmán Tagkórház","Dr.Laszlo Torday","匈牙利","BéKéS","Gyula"],["Mercy Research – David C. Pratt Cancer Center","Dr.Bethany Graham Sleckman","美国","MISSOURI","Creve Coeur"],["Hospital Sao Lucas da PUCRS","Dr.Fernanda Bronzon Damian","巴西","RIO GRANDE DO SUL","Porto Alegre"],["COI Centro Oncológico Internacional S.A.P.I. de C.V.","Dr.Rosario Marisol Quintero Solís","墨西哥","JALISCO","Tlajomulco de Zúniga"],["Banner MD Anderson Cancer Center","Dr.Hung Thieu Khong","美国","ARIZONA","Gilbert"],["Petz Aladar Egyetemi Oktato Korhaz","Dr.András Szigeti","匈牙利","GYOR-MOSON-SOPRON","Gyor"],["McGill University Health Centre","Dr.Jamil Asselah","加拿大","QUEBEC","Montréal"],["ROYAL MARSDEN HOSPITAL (CHELSEA)","Dr.Marina M. Parton","英国","NA","London"],["CENTRE LEON BERARD","Dr.Olivier Tredan","法国","RHONE","Lyon Cedex 08"],["Tata Memorial Hospital","Dr.Sudeep Gupta","印度","MAHARASHTRA","Mumbai"],["Docrates Cancer Center","Dr.Tuomo Valdemar Alanko","芬兰","UUSIMAA","Helsinki"],["CancerCare Manitoba","Dr.Danielle Desautels","加拿大","MANITOBA","Winnipeg"],["University Hospital Coventry & Warwickshire","Dr.Lucy McAvan","英国","WARWICKSHIRE","Coventry"],["Los Angeles Hematology Oncology Medical Group","Dr.Lasika Chandradatta Seneviratne","美国","CALIFORNIA","Los Angeles"],["University of Oklahoma Health Sciences Center, Stephenson Cancer Center","Supriya Koya","美国","OKLAHOMA","Oklahoma City"],["Summit Cancer Care","Dr.Michael Chahin","美国","GEORGIA","Savannah"],["Peterborough City Hospital","Dr.Antony Thottian","英国","CAMBRIDGESHIRE","Peterborough"],["Auckland City Hospital","Sheridan Wilson","新西兰","AUCKLAND","Auckland"],["Vanderbilt University Medical Center","Dr.Vandana Abramson","美国","TENNESSEE","Nashville"],["Centrum Onkologii im. Prof. Franciszka Lukaszczyka","Dr.Adrianna Makarewicz","波兰","KUJAWSKO-POMORSKIE","Bydgoszcz"],["Emory University School of Medicine","Dr.Kevin Michael Kalinsky","美国","GEORGIA","Atlanta"],["Clinique Saint Pierre","Dr.Lionel Raphael Duck","比利时","BRABANT WALLON","Ottignies"],["Chittaranjan National Cancer Institute","KALYAN KUSUM MUKHERJEE Dr.","印度","WEST BENGAL","Kolkata"],["Sawai Man Singh Medical College Hospital (SMS Hospital)","Prof. Dr.Sandeep Jasuja","印度","RAJASTHAN","Jaipur"],["Stanford Cancer Center","Jennifer Lee Caswell-Jin","美国","CALIFORNIA","Palo Alto"],["Rocky Mountain Cancer Centers, LLP","Dr.Mabel A. Mardones Dr","美国","COLORADO","Lone Tree"],["Wake Forest Baptist Health","Dr.Katherine Ansley","美国","NORTH CAROLINA","Winston-Salem"],["Maryland Oncology Hematology – Brandywine","Dr.Jose L. Mendoza","美国","MARYLAND","Rockville"],["Minnesota Oncology Hematology, P.A.","Dr.Yang Liu","美国","MINNESOTA","Minneapolis"],["Texas Oncology San Antonio","Emmalind Aponte-Garcia","美国","TEXAS","San Antonio"],["Texas Oncology - Flower Mound","Dr.Vibha Thomas","美国","COLORADO","Lakewood"],["Comprehensive Cancer Centers of Nevada","Stephani Christensen","美国","NEVADA","Henderson"],["Texas Oncology - El Paso Cancer Center","Dr.Ines Joan Sanchez Rivera","美国","TEXAS","El Paso"],["HOSPITAL CLíNIC DE BARCELONA","Ms.Barbara Adamo","西班牙","BARCELONA [BARCELONA]","Barcelona"],["Georgetown University Medical Center","Dr.Ami A. Chitalia MD","美国","DISTRICT OF COLUMBIA","Washington, DC"],["Hospital Universitario de Salamanca - Complejo Asistencial Universitario de Salamanca","Dr.Rebeca Lozano Mejorada","西班牙","CASTILLA Y LEóN","Salamanca"],["Jessa Ziekenhuis","Dr.Annelies Requile","比利时","LIMBURG","Hasselt"],["Universitaetsklinikum Duesseldorf","Prof.Eugen Ruckhaeberle","德国","NORDRHEIN-WESTFALEN","Duesseldorf"],["Universitaetsklinikum Freiburg","Dr.Beate Rautenberg","德国","BADEN-WüRTTEMBERG","Freiburg"],["Skanes Universitetssjukhus Malmo","Dr.Ulrik Christoffer Narbe","瑞典","SKANE LAN [SE-12]","Malmo"],["Orchard Healthcare Research Inc.","Dr.Ira A. Oliff","美国","ILLINOIS","Skokie"],["HOSPITAL GENERAL UNIVERSITARIO GREGORIO MARANON","Dr.Yolanda Jerez Gilarranz","西班牙","MADRID","Madrid"],["Hamatologie- Onkologie im Zentrum MVZ GmbH","Dr.Bernhard Heinrich","德国","BAYERN","Augsburg"],["Onkologie Ebersberg MVZ GmbH","Dr. med.Isolde Groell","德国","NA","Ebersberg"],["Endeavor Health","Dr.Mansoina Baweja","美国","ILLINOIS","Naperville"],["Roper St. Francis Healthcare","Dr.David Michael Ellison","美国","SOUTH CAROLINA","Charleston"],["Royal Marsden Hospital (Sutton)","Dr.Marina M. Parton","英国","SURREY","Sutton"],["Guy`s & St Thomas` NHS Foundation Trust","DrRosa Giuliani","英国","NA","London"],["Tokai University Hospital","Dr.Naoki Niikura","日本","KANAGAWA","Isehara"]]

序号	机构名称	主要研究者	国家	省（州）	城市

[["复旦大学附属肿瘤医院医学伦理委员会","同意","2025-06-09"],["中山大学肿瘤防治中心伦理委员会","同意","2025-07-28"]]

序号	名称	审查结论	批准日期/备案日期

进行中（尚未招募）

目标入组人数	国内: 60 ； 国际: 400 ；
已入组人数	国内: 登记人暂未填写该信息； 国际: 登记人暂未填写该信息；
实际入组总人数	国内: 登记人暂未填写该信息； 国际: 登记人暂未填写该信息；

第一例受试者签署知情同意书日期	国内：登记人暂未填写该信息；     国际：2025-08-05；
第一例受试者入组日期	国内：登记人暂未填写该信息；     国际：登记人暂未填写该信息；
试验完成日期	国内：登记人暂未填写该信息；     国际：登记人暂未填写该信息；