沈阳BMS-986165片其他临床试验-在银屑病参与者中比较氘可来昔替尼与乌司奴单抗的长期安全性研究（PRAGMATYK）

登记号	CTR20260285	试验状态	进行中
申请人联系人	高祥	首次公示信息日期	2026-01-29
申请人名称	Bristol-Myers Squibb Company/ 百时美施贵宝（中国）投资有限公司/ PATHEON INC. ; Bristol-Myers Squibb Co.

登记号	CTR20260285
相关登记号	暂无
药物名称	BMS-986165片
药物类型	化学药物
临床申请受理号	企业选择不公示
适应症	中重度斑块状银屑病
试验专业题目	一项在中重度斑块状银屑病参与者中比较氘可来昔替尼与乌司奴单抗的IIIb/IV期、多中心、随机、开放标签、长期安全性研究（PRAGMATYK）
试验通俗题目	在银屑病参与者中比较氘可来昔替尼与乌司奴单抗的长期安全性研究（PRAGMATYK）
试验方案编号	IM0111130	方案最新版本号	原始版方案
版本日期:	2025-07-21	方案是否为联合用药	否

申请人名称	[["Bristol-Myers Squibb Company"],["百时美施贵宝（中国）投资有限公司"],["PATHEON INC. ; Bristol-Myers Squibb Co."]]
联系人姓名	高祥	联系人座机	021-22238100	联系人手机号	18221197585
联系人Email	xiang.gao2@bms.com	联系人邮政地址	上海市-上海市-静安区南京西路1717号会德丰广场12楼	联系人邮编	200040

主要目的：在中重度斑块状银屑病成人参与者中评估长期使用氘可来昔替尼与乌司奴单抗相比的心血管安全性 次要目的：在中重度斑块状银屑病成人参与者中评估长期使用氘可来昔替尼与乌司奴单抗相比的安全性

试验分类	安全性	试验分期	其他	设计类型	平行分组
随机化	随机化	盲法	开放	试验范围	国际多中心试验

年龄	40岁(最小年龄)至 无上限 (最大年龄)
性别	男+女
健康受试者	无
入选标准	[["签署ICF时参与者年龄须至少≥40岁（含）"],["在筛选访视和第 1 天时，适合接受光疗或系统治疗的中重度斑块状银屑病参与者（定义为银屑病面积与严重性指数（PASI）≥ 12、体表面积（BSA）≥10%且静态医师总体评估（sPGA）≥ 3）。"],["筛选访视时至少存在以下 1 个心血管危险因素：1.目前吸烟者，注：电子烟不视为吸烟；2.诊断为高血压（定义为血压 ≥ 130/90 mmHg）或使用降压药；3.诊断为血脂异常（定义为总胆固醇 ≥ 240 mg/dL，或低密度脂蛋白胆固醇 ≥ 160 mg/dL，或高密度脂蛋白胆固醇 < 40 mg/dL[男性，以出生时的性别为准]或 < 50 mg/dL[女性，以出生时的性别为准]，或使用降脂药物 [例如，他汀类药物]）"],["4.1型或2型糖尿病；5.以下 1 种或多种 CVD 事件病史：冠状动脉血运重建术，包括经皮冠状动脉介入治疗（PCI）或冠状动脉搭桥术（CABG）、MI、心脏骤停、因不稳定型心绞痛、急性冠脉综合征、卒中或短暂性脑缺血发作而住院；6.肥胖，定义为体重指数 ≥ 30 kg/m2"],["7.早发冠心病家族史（定义为年龄小于 55 岁的一级男性（以出生时的性别为准）亲属或年龄小于 65 岁的一级女性（以出生时的性别为准）亲属发生临床冠心病或猝死）；8.有生育能力的个体同意在研究期间需要采取有效避孕措施"]]
排除标准	[["目标疾病相关排除标准：在筛选访视或第1天时有活动性非斑块状银屑病（即点滴状、脓疱型、红皮病型或药物诱导的银屑病）"],["医疗状况相关排除标准：1.近期发生以下心血管事件之一：第 1 天前 90 天内发生 MI、卒中或冠状动脉血运重建或 VTE；2.不稳定型CVD，定义为第1天前90天内发生临床心血管事件（例如，不稳定型心绞痛、快速房颤）或心脏病住院（例如，起搏器植入、HF）；3.c)t有过去 5 年内的活动性癌症证据或癌症史（实质器官或血液系统恶性肿瘤，包括骨髓异常增生综合征）或患有淋巴细胞增生性疾病（切除的皮肤基底细胞癌或鳞状细胞癌或接受过治疗且无复发证据的宫颈原位癌除外）；4.第1天前30天内发生任何重大创伤或接受重大手术操作"],["感染/免疫相关排除标准：1.筛选访视时有乙型肝炎病毒（HBV）证据或检测结果为阳性；2.筛选访视时有丙型肝炎病毒（HCV）证据或检测结果为阳性"],["既往治疗相关排除标准：1.既往接受过氘可来昔替尼治疗的参与者; 2.既往接受过JAK抑制剂（口服或外用）治疗的参与者；3.对研究药物（即氘可来昔替尼和乌司奴单抗）的任何成分有超敏反应"]]

试验药

[["中文通用名:BMS-986165片 英文通用名:BMS-986165Tablet 商品名称:NA","剂型:片剂 规格:6mg 用法用量:口服，每日一次，每次一片 用药时程:维持260周"],["中文通用名:BMS-986165片 英文通用名:BMS-986165Tablets 商品名称:NA","剂型:片剂 规格:6mg 用法用量:口服，每日一次，每次一片 用药时程:维持260周"],["中文通用名:BMS-986165片 英文通用名:BMS-986165Tablets 商品名称:NA","剂型:片剂 规格:6mg 用法用量:口服，每日一次，每次一片 用药时程:维持260周"],["中文通用名:BMS-986165片 英文通用名:BMS-986165Tablets 商品名称:NA","剂型:片剂 规格:6mg 用法用量:口服，每日一次，每次一片 用药时程:维持260周"]] 序号 名称 用法

对照药

[["中文通用名:乌司奴单抗注射液 英文通用名:UstekinumabInjection 商品名称:NA","剂型:注射液，单剂量预充式注射器 规格:45mg/0.5ml/支 用法用量:体重≤100kg；第1天和第4周皮下注射45mg；之后每12周皮下注射45mg 用药时程:维持260周"],["中文通用名:乌司奴单抗注射液 英文通用名:UstekinumabInjection 商品名称:NA","剂型:注射液，单剂量预充式注射器 规格:90mg/1.0ml/支 用法用量:体重>100kg；第1天和第4周皮下注射90mg；之后每12周皮下注射90mg 用药时程:维持260周"]] 序号 名称 用法

主要终点指标及评价时间

[["复合心血管终点定义为：裁定的3点","主要目的的主要估计目标n治疗：氘可来昔替尼对比 乌司奴单抗","安全性指标"],["主要不良心血管事件（MACE）","人群：参与者年龄≥40岁，患有中重度斑块状银屑病，至少有1个心血管危险因素","安全性指标"],["非致死性心肌梗死[MI]","变量：复合心血管终点，定义为：裁定的3点MACE（非致死性MI、非致死性卒中和心血管死亡）加冠状动脉血运重建","安全性指标"],["非致死性卒中","伴发事件：终止研究治疗将使用假想策略处理（参与者将在终止治疗后60天被删失）","安全性指标"],["和心血管死亡加冠状动脉血运重建","群体层面汇总：氘可来昔替尼与乌司奴单抗相比的风险比","安全性指标"]] 序号 指标 评价时间 终点指标选择

次要终点指标及评价时间

[["裁定事件：n非致死性 MI；非致死性卒中；心血管死亡；冠状动脉血运重建","治疗：氘可来昔替尼 相比 乌司奴单抗；人群：参与者年龄≥40岁，患有中重度斑块状银屑病，至少有1个心血管危险因素","安全性指标"],["3点MACE（非致死性MI、非致死性卒中和心血管死亡）","变量：裁定事件（不包括恶性肿瘤）","安全性指标"],["肺栓塞（PE）n深静脉血栓形成（DVT）","伴发事件：n终止研究治疗将使用假想策略处理（参与者将在终止治疗后 60 天被删失）","安全性指标"],["复合静脉血栓栓塞（VTE）（即，PE、DVT和视网膜静脉闭塞）","群体层面汇总：氘可来昔替尼与乌司奴单抗相比的风险比","安全性指标"],["动脉血栓事件（包括视网膜动脉闭塞）","次要目的的主要估计目标：裁定的恶性肿瘤事件n治疗：氘可来昔替尼 相比 乌司奴单抗","安全性指标"],["需要住院或急诊就诊的心力衰竭（HF）n恶性肿瘤（不包括非黑色素瘤皮肤癌[NMSC]）","人群：参与者年龄≥40岁，患有中重度斑块状银屑病，至少有1个心血管危险因素","安全性指标"],["NMSC机会性感染，包括结核病和复杂性带状疱疹（例如，播散性带状疱疹、累及2个以上皮节、眼部或脑膜脑病受累，以及其他非典型表现）","变量：裁定的恶性肿瘤事件","安全性指标"],["严重不良事件（SAE）、全因性死亡和导致永久终止治疗的AE","伴发事件：n终止研究治疗将使用疗法策略处理（将不对参与者进行删失，终止治疗后发生的任何事件均将归因于随机分配治疗组。）","安全性指标"],["实验室检查：基线时和每 26 周进行代谢全套检查，包括肝功能检查、空腹血脂全项检查","群体层面汇总：氘可来昔替尼与乌司奴单抗相比的风险比","安全性指标"]] 序号 指标 评价时间 终点指标选择

1	姓名	高兴华	学位	医学博士	职称	主任医师，二级教授，博士生导师
	电话	13940152467	Email	gaobarry@hotmail.com	邮政地址	辽宁省-沈阳市-和平区南京北街155号
	邮编	110001	单位名称	中国医科大学附属第一医院

[["中国医科大学附属第一医院","高兴华","中国","辽宁省","沈阳市"],["浙江大学医学院附属第一医院","方红","中国","浙江省","杭州市"],["华中科技大学附属同济医院","陈辉","中国","湖北省","武汉市"],["华中科技大学同济医学院附属协和医院","陶娟","中国","湖北省","武汉市"],["福建医科大学附属第一医院","邹颖","中国","福建省","福州市"],["首都医科大学附属北京友谊医院","禚风麟","中国","北京市","北京市"],["浙江大学医学院附属第二医院","满孝勇","中国","浙江省","杭州市"],["宁波大学医学院附属医院","林秉奖","中国","浙江省","宁波市"],["山西医科大学附属第一医院","郭书萍","中国","山西省","太原市"],["香港大学深圳医院","张振颖","中国","广东省","深圳市"],["北京大学第三医院","张春雷","中国","北京市","北京市"],["山东大学齐鲁医院","孙青","中国","山东省","济南市"],["浙江省人民医院","陶小华","中国","浙江省","杭州市"],["重庆医科大学附属第一医院","黄琨","中国","重庆市","重庆市"],["杭州市第三人民医院","徐田红","中国","浙江省","杭州市"],["南方医科大学皮肤病医院","杨斌","中国","广东省","广州市"],["哈尔滨医科大学附属第二医院","栗玉珍","中国","黑龙江省","哈尔滨市"],["首都医科大学附属北京同仁医院","魏爱华","中国","北京市","北京市"],["温州医科大学附属第一医院","李智铭","中国","浙江省","温州市"],["蚌埠医科大学附属第一医院","江从军","中国","安徽省","蚌埠市"],["广州市第一人民医院","方锐华","中国","广东省","广州市"],["西安交通大学第二附属医院","耿松梅","中国","陕西省","西安市"],["嘉兴第一医院","殷文浩","中国","浙江省","嘉兴市"],["江苏大学附属医院","李遇梅","中国","江苏省","镇江市"],["深圳市南山区人民医院","刘晓明","中国","广东省","深圳市"],["武汉市第一医院","陈柳青","中国","湖北省","武汉市"],["河南省人民医院","刘鸿伟","中国","河南省","郑州市"],["河北医科大学第一医院","张国强","中国","河北省","石家庄市"],["Chang Gung Memorial Hospital (CGMH) - Linkou Branch","Yu-Huei Huang","中国台湾","台湾省","桃园市"],["Taipei Veterans General Hospital","Yun-Ting Chang","中国台湾","台湾省","台北市"],["Chang Gung Medical Foundation - Kaohsiung Branch","Ji-Chen Ho","中国台湾","台湾省","高雄市"],["National Taiwan University Hospital","Tsen-Fang Tsai","中国台湾","台湾省","台北市"],["Kaohsiung Veterans General Hospital","Chien-Hui Hong","中国台湾","台湾省","高雄市"],["Mackay Memorial Hospital-Taipei Branch","Nan-Lin Wu","中国台湾","台湾省","台北市"],["Far Eastern Memorial Hospital","Ya-Chu Tsai","中国台湾","台湾省","台北市"],["Centro Internacional de Estudios Clinicos","Fernando Valenzuela","智利","Region Metropolitana","Comuna de Recoleta"],["Clinica Dermacross","Claudia de la Cruz","智利","Santiago de","Santiago de"],["Centro Medico Skin Med","Carola Zapata","智利","Region Metropolitana","Las Condes"],["Medical Skin Center","Antonio Guglielmetti","智利","Valparaiso","Valparaiso"],["Barts Health NHS Trust - Whipps Cross University Hospital","Anthony Bewley","英国","London","Leytonstone"],["Guy's and St Thomas' NHS Foundation Trust - Guy's Hospital","Richard Woolf","英国","London","London"],["University Hospital Southampton NHS Foundation Trust - Southampton General Hospital","Michelle Oakford","英国","Southampton","Southampton"],["NHS Fife - Queen Margaret Hospital","Ann Sergeant","英国","Scotland","Dunfermline"],["Salford Care Organisation","Richard Warren","英国","Greater Manchester","Salford"],["Velocity Clinical Research - North London","Kamran Hussain","英国","North Finchley","London"],["Velocity Clinical Research, High Wycombe","Judith Mackay","英国","Desborough Road","High Wycombe"],["Velocity Clinical Research - Bristol","Kirsten Peacey","英国","Bristol","Bristol"],["Universita' degli Studi di Cagliari","Laura Atzori","意大利","Sardegna","Cagliari"],["Istituto Clinico Humanitas","Antonio Costanzo","意大利","Milano","Rozzano"],["Seconda Universita degli Studi di Napoli","Anna Balato","意大利","Caserta","Caserta"],["Ospedale Regionale San Salvatore","Maria Esposito","意大利","L Aquila AQ","Coppito"],["Azienda Ospedaliero-Universitaria di Modena (AOU Modena) - Ospedale Civile di Baggiovara","Marco Manfredini","意大利","Emilia-Romagna","Modena"],["Fondazione Policlinico Universitario Agostino Gemelli","Ketty Peris","意大利","Rome","Rome"],["Universita G. D'Annunzio","Paolo Amerio","意大利","Pescara","Pescara"],["Szegedi Tudomanyegyetem Szent-Gyorgyi Albert Klinikai Kozpont","Robert Kui","匈牙利","Csongrad-Csanad","Szeged"],["Clinexpert Gyogycentrum","Dorottya Asboth","匈牙利","Budapest","Budapest"],["Dermamed Research Kft","Piroska Dosa","匈牙利","Bekes","Oroshaza"],["Orvostudomanyi Kutato es Fejleszto Kft","Tamas Almadi","匈牙利","Hajdu-Bihar","Debrecen"],["Debreceni Egyetem Klinikai Kozpont","Andrea Szegedi","匈牙利","Hajdu-Bihar","Debrecen"],["Allergo-Derm Kft","Noemi Bakos","匈牙利","Jasz-Nagykun-Szolnok","Szolnok"],["DERMA-B Kft.","Emese Heredi","匈牙利","Hajdu-Bihar","Debrecen"],["UNO Medical Trials Kft.","Eva Apostol","匈牙利","Budapest","Budapest"],["Medmare Bt.","Levente Kovago Pal","匈牙利","Veszprem","Veszprem"],["Grupo Pedro Jaen - Serrano","Alvaro GonzAlez-Cantero","西班牙","Madrid","Madrid"],["Hospital Universitari Germans Trias i Pujol","Jose Manuel Carrascosa","西班牙","Barcelona","Barcelona"],["Hospital Universitario Virgen Macarena","David Moreno Ramirez","西班牙","Andalucia","Sevilla"],["Hospital Clinic de Barcelona","Josep Riera-Monroig","西班牙","Barcelona","Barcelona"],["Instituto de Investigacion Biomedica de Salamanca (IBSAL)","Monica Roncero Riesco","西班牙","Provincia de Salamanca","Salamanca"],["Hospital Universitario 12 de Octubre","Raquel Rivera-Diaz","西班牙","Madrid","Madrid"],["Hospital Universitario de Gran Canaria Doctor Negrin","ALICIA GONZALEZ QUESADA","西班牙","Las Palmas","Las Palmas"],["Hospital Vithas Malaga","Enrique Herrera Acosta","西班牙","Andalucia","MAlaga"],["Hospital Viamed Santa Angela de la Cruz","Jose Bernabeu-Wittel","西班牙","Andalucia","Sevilla"],["FutureMeds - Madrid - Santa Elena","Jose Domingo Dominguez Aunon","西班牙","Madrid","Madrid"],["ProbarE i Lund AB","Anders Luts","瑞典","Skane","Lund"],["Ladulaas Kliniska Studier","Katarina Berndtsson Blom","瑞典","Vastra Gotalands lan","Boraas"],["Uppsala University Hospital","Eniko Sonkoly","瑞典","Uppsala","Uppsala"],["St. Luke's International Hospital","Satoru Arai","日本","Tokyo-to","Chuo-Ku"],["Fukuoka University Hospital","Shinichi Imafuku","日本","Fukuoka","Fukuoka"],["Nagoya City University Hospital","Akimichi Morita","日本","Aichi","Nagoya-shi"],["Teikyo University Hospital","Yayoi Tada","日本","Tokyo-to","Itabashi-Ku"],["University of Tsukuba - Mito Kyodo General Hospital","Shijima Taguchi","日本","Kanto region","Mito"],["Asahikawa Medical University Hospital","Hiroyoshi Nozaki","日本","Hokkaido","Asahikawa"],["Kanazawa University Hospital","Takashi Matsushita","日本","Ishikawa","Kanazawa"],["Kurume University Hospital","Eri Katayama","日本","Fukuoka","Kurume"],["Dermatology and Ophthalmology Kume Clinic","Kume Akihiro","日本","Osaka","Osaka"],["Fujita Health University Hospital","Kazumitsu Sugiura","日本","Aich","Toyoake"],["Shiga University of Medical Science","Toshifumi Takahashi","日本","Shiga-ken","Otsu"],["Hospital de Jesus","Luis Hernandez","墨西哥","Ciudad de Mexico","Cuauhtemoc"],["Kohler & Milstein Research S.A. de C.V.","Jesus Abraham Simon Campos","墨西哥","YucatAn","Merida"],["Instituto Nacional de Ciencias Medicasy Nutricion Salvador Zubiran","Virgnia Pascual-Ramos","墨西哥","Political divisions of Mexico","Ciudad de Mexico"],["IMACEN S.A de C.V.","Ricardo Alberto Venegas Yanez","墨西哥","Chihuahua","Chihuahua"],["Centro Medico del Angel","Beatriz Zazueta Montiel","墨西哥","Morelos","Cuautla"],["Hospital Universitario Dr. Jose Eleuterio GonzAlez","Alejandra Martinez","墨西哥","N.L.","Monterrey"],["Instituto Dermatologico de Jalisco","Maria Moreno","墨西哥","Jalisco","Zapopan"],["Skin Search of Rochester - Dermatology Associates of Rochester","John Tu","美国","New York","Rochester"],["Oregon Dermatology and Research Center","Phoebe Rich MD","美国","Oregon","Portland"],["Palmetto Clinical Trial Services","Theresa Knoepp","美国","South Carolina","Anderson"],["Forest Hills Dermatology Group","Jeffrey Weinberg","美国","New York","Kew Gardens"],["Minnesota Clinical Study Center (MCSC)","Steven Kempers","美国","Minnesota","New Brighton"],["UC Davis Dermatology Clinic","Emanual Maverakis","美国","California","Sacramento"],["Arlington Center for Dermatology","Angela Moore","美国","Texas","Arlington"],["GCM Medical Group, PSC - Hato Rey Site","Gregorio Cortes-Maisonet","美国","Puerto Rico","San Juan"],["Tulane University School of Medicine - Tulane Dermatology & Multispecialty Clinic","Erin Boh","美国","Louisiana","New Orleans"],["Driven Research LLC","Javier Alonso-Llamazares","美国","Florida","Coral Gables"],["Cary Dermatology Center","Catherine Hren","美国","North Carolina","Cary"],["Dawes Fretzin Clinical Research Group, LLC (DFCRG)","Scott Fretzin","美国","Indiana","Indianapolis"],["Renstar Medical Research","Ashley Cauthen","美国","Florida","Ocala"],["Texas Dermatology and Laser Specialists - Alamo Heights","John Browning","美国","Texas","San Antonio"],["Modern Research Associates, PLLC","Jennifer Cather","美国","Texas","Dallas"],["Center For Dermatology Cosmetic and Laser Surgery - Fremont Office","Sunil Dhawan","美国","California","Fremont"],["The University of Alabama at Birmingham (UAB)","Boni Elewski","美国","Alabama","Birmingham"],["Olympian Clinical Research, LLC","Matthew Zook","美国","Florida","Tampa"],["Oakland Hills Dermatology","Christofer Buatti","美国","Michigan","Auburn Hills"],["UPMC Department of Dermatology","Joe Tung","美国","Pennsylvania","Pittsburgh"],["Physician Skin Care, PLLC","Leon Kircik","美国","Kentucky","Louisville"],["MetroBoston Clinical Partners LLC","Mark Amster","美国","Massachusetts","Brighton"],["Southern Indiana Clinical Trials","Megan Landis","美国","Indiana","New Albany"],["Florida Academic Dermatology Center","Francisco Kerdel","美国","Florida","Coral Gables"],["Unity Clinical Research (UCR)","Robert Westcott","美国","Oklahoma","Oklahoma"],["LENUS Research","John Niven","美国","Florida","Sweetwater"],["Unison Clinical Trials","Shahram Jacobs","美国","California","Sherman Oaks"],["First OC Dermatology - Fountain Valley","Vivian Laquer","美国","California","Fountain Valley"],["Northwest Arkansas Clinical Trials Center (NWACTC), PLLC","Cheryl Hull","美国","Arkansas","Rogers"],["Endeavor Health Medical Group - Dermatology – Skokie","Stephanie Mehlis","美国","Illinois","Skokie"],["Dundee Dermatology","Paul Getz","美国","Illinois","West Dundee"],["Somerset Skin Centre - Derm Center","George Murakawa","美国","Michigan","Troy"],["International GCC Research","Gilberto Jimenez","美国","Florida","Miami"],["T. Joseph Raoof Md, In/Encino Research Center","TOORAJ RAOOF","美国","California","Encino"],["Shondra L. Smith, MD - Dermatology and Advanced Aesthetics","Shondra Smith","美国","Louisiana","Lake Charles"],["Skin Care Research LLC (SCR)","Ann Reed","美国","Florida","Boca Raton"],["Clinical Trials Management","Robert Koppel","美国","Louisiana","Metairie"],["Central Sooner Research (CSR)","Yaohan Lam","美国","Oklahoma","Oklahoma"],["Deaconess Clinic Downtown","Jamie Mull","美国","Indiana","Evansville"],["Alliance Dermatology & MOHS Center","Sasha Jazayeri","美国","Arizona","Phoenix"],["Elyse S. Rafal, MD PC - Rafal Center for Dermatology & Cosmetic Surgery","Elyse Rafal","美国","New York","Stony Brook"],["Advanced Dermatology and Skin Cancer Institute - Beverly Hills","Michael Lin","美国","California","Sherman Oaks"],["Premier Clinical Research","William Werschler","美国","Washington","Spokane"],["Marvel Clinical Research, LLC","David Rayhan","美国","California","Huntington Beach"],["Studies in Dermatology, LLC","Lauren Campbell","美国","Texas","Cypress"],["Dermatology Research Associates","Howard Sofen","美国","California","Los Angeles"],["Oregon Medical Research Center","Benjamin Ehst","美国","Oregon","Portland"],["Golden State Dermatology - Ygnacio Valley Road","Michael Wang","美国","California","Walnut Creek"],["Wright State Physicians","Craig Rohan","美国","Ohio","Fairborn"],["Dermatologists of Southwest Ohio","Rocco Serrao","美国","Ohio","Mason"],["Frontier Dermatology","Ein Gun Song","美国","Washington","Mill Creek"],["California Dermatology & Clinical Research Institute","Stacy Smith","美国","California","Encinitas"],["Wilmington Dermatology Center (WDC)","Rosalyn George","美国","North Carolina","Wilmington"],["Palmetto Clinical Trial Services - Administrative Office","Matthew Miller","美国","South Carolina","Greenville"],["Wallace Skin & Body Institute","Paul Wallace","美国","California","Los Angeles"],["Apex Dermatology - Mayfield Heights","Jorge Garcia-Zuazaga","美国","Ohio","Mayfield Heights"],["Saint Louis University","Maria Hurley","美国","Missouri","St. Louis"],["Best Skin Research","Stephen Schleicher","美国","Pennsylvania","Camp Hill"],["Hamilton Dermatology (Atlanta Dermatology, Vein & Research Center, LLC)","Tiffani Hamilton","美国","Georgia","Alpharetta"],["Institute of Clinical Research and Consulting, Inc., d/b/a Clinical Science Institute","Paul Yamauchi","美国","California","Santa Monica"],["Miami Dermatology & Laser Research","Jill Waibel","美国","Florida","Miami"],["Aesthetic and Dermatology Center","Lawrence Green","美国","Maryland","Rockville"],["Integrative Skin Science and Research","Raja Sivamani","美国","California","Sacramento"],["Michigan Dermatology Institute - Waterford","Cory Rubin","美国","Michigan","Waterford"],["Michigan Center for Skin Care Research","Mary Veremis-Ley","美国","Michigan","Clinton Twp"],["U.S. Dermatology Partners Rockville","Benjamin Lockshin","美国","Maryland","Rockville"],["Clinical Trials Institute of Northwest Arkansas","Mildred Clifton","美国","Arkansas","Fayetteville"],["International Clinical Research (IC Research) - Murfreesboro","Christina Feser","美国","Tennessee","Murfreesboro"],["Cumberland Skin Center for Clinical Research","Judy Hu","美国","Tennessee","Hermitage"],["Schweiger Dermatology, P.C.","Avnee Shah","美国","New Jersey","Verona"],["Center for Clinical Studies","Stephen Tyring","美国","Texas","Webster"],["Empire Clinical Research - Pomona","Radhika Shah","美国","California","Pomona"],["The Skin Center Dermatology Group","Peter Friedman","美国","New York","New City"],["Velocity Clinical Research, Medford","Sarah Smiley","美国","Oregon","Medford"],["Las Vegas Clinical Trials, LLC","Alton Walters","美国","Nevada","North Las Vegas"],["Hickory Dermatology Research Center","Jake Turrentine","美国","North Carolina","Hickory"],["Discover Dermatology, LLC d/b/a Goodlettsville Dermatology Research","Keith Loven","美国","Tennessee","Goodlettsville"],["Pinnacle Dermatology - Nashville","Ashley Matthews","美国","Tennessee","Nashville"],["Kuchnir Dermatology & Dermatologic Surgery","Shiu-chung Au","美国","Massachusetts","Milford"],["Northridge Clinical Trials - Elite Clinical Network","Navid Ezra","美国","California","Northridge"],["Pasadena Clinical Trials","Tzu-Jen Tzao","美国","California","Pasadena"],["Cura Clinical Research - Palmdale","Aram Kechichian","美国","California","Palmdale"],["Cura Clinical Research - Santa Clarita","Bernard Raskin","美国","California","Santa Clarita"],["Dermatology Affiliates - Buckhead","Anita Shetty","美国","Georgia","Atlanta"],["Equity Medical - Bowling Green","David Johnson","美国","Kentucky","Bowling Green"],["Dermatology Partners Inc. - Medina Clinical Research","Justin Hastings","美国","Ohio","Medina"],["Clinical Trials Management, LLC - Northshore Office","Martha Stewart","美国","Louisiana","Mandeville"],["JDR Dermatology Research, LLC","James Del Rosso","美国","Nevada","Las Vegas"],["CRC Research","Amarilis Perez de Jesus","美国","Puerto Rico","Caguas"],["ARS-Maitland-Alcanza","Eva-Maria Heurich","美国","Florida","Maitland"],["Apex Clinical Research Center","Jorge Garcia-Zuazaga","美国","Ohio","Canton"],["StracSkin","Abel Jarell","美国","New Hampshire","Portsmouth"],["Bioresearch Partner","Oscar Hevia","美国","Florida","Miami"],["Equity Medical","Maira Fonseca","美国","New York","New York"],["Medical Dermatology Specialists","Lindsay Ackerman","美国","Arizona","Phoenix"],["MetroMed Clinical Trials","Ana Gavrilovici","美国","Illinois","Chicago"],["Velocity Clinical Research","Paul Bradley","美国","Georgia","Savannah"],["Scottsdale Clinical Trials","Todd Dreitzler","美国","Arizona","Scottsdale"],["UT Southwestern Medical Center","Alice Gottlieb","美国","Tax","Dallas"],["Clarity Dermatology PLLC","James Jensen","美国","Colorado","Castle Rock"],["Saguaro Dermatology","Dathan Hamann","美国","Arizona","Phoenix"],["Omni Dermatology","Andrew Racette","美国","Arizona","Peoria"],["Omni Dermatology","Jeffrey Dickman","美国","Arizona","Peoria"],["C.M.D.T.A. Neomed SRL","Anca-Ioana Purcaru","罗马尼亚","Brasov","Brasov"],["Sana Medical Center","Horia Beti","罗马尼亚","Bucuresti","Bucuresti"],["Derma Luxury Style","Diana Ramona Serban-Pescar","罗马尼亚","Mures","Reghin"],["Spitalul Clinic Judetean De Urgenta Sfantul Apostol Andrei","Laurentiu Tony Hangan","罗马尼亚","Constanta","Constanta"],["Spitalul Clinic Colentina","Rodica Olteanu","罗马尼亚","Bucuresti","Bucuresti"],["Cabinet Dermatologie Lauderma","Laura Gheuca Solovastru","罗马尼亚","Iasi","Iasi"],["Centrul Medical Dr. Ianosi","Simona Ianosi","罗马尼亚","Dolj","Craiova"],["Bio Terra Med","Maria Magdalena Constantin","罗马尼亚","Bucuresti","Bucuresti"],["New Derm Clinic","Stefania Avram","罗马尼亚","Timis","Timisoara"],["Fundatia Medicala Providenta","Elena Crihan","罗马尼亚","Iasi","Iasi"],["DERMAMEDICA, s.r.o.","Romana Machackova","捷克","KrAlovehradecky kraj","Nachod"],["Praglandia s.r.o.","Andrea Vocilkova","捷克","Prague","Praha 5"],["CCR Ostrava s.r.o.","Sylva ZajicovA","捷克","Moravskoslezsky kraj","Ostrava"],["Pratia Prague s.r.o.","Peter Kicko","捷克","Prague","Praha 3"],["KrajskA zdravotni, a. s. - Masarykova nemocnice v usti nad Labem, o.z.","Olga Filipovska","捷克","ustecky kraj","usti nad Labem"],["Fakultni Nemocnice Kralovske Vinohrady (FNKV) - Dermatovenerologicka Klinika","Spyridon Gkalpakiotis","捷克","Prague","Praha 10"],["Nemocnice AGEL Novy Jicin a.s.","Marie Selerova","捷克","Moravskoslezsky kra","Novy Jicin"],["Clintrial s.r.o.","Otakar Komarek","捷克","Prague","Praha 10"],["Dermatologicka ambulance - Svitavy","Petr Trestik","捷克","KrAlovehradecky kraj","Svitavy"],["Sanatorium Profesora Arenbergera","Petr Arenberger","捷克","Prague","Praha 1"],["JRB Research Inc","Jennifer Beecker","加拿大","Ontario","Ottawa"],["Centricity Research","Jeffery Cowger","加拿大","Ontario","London"],["Enverus Medical Research","Lorne Albrecht","加拿大","British Columbia","Surrey"],["SimcoDerm Medical and Surgical Dermatology Center","Maryam Alam","加拿大","Ontario","Barrie"],["Dermatology Research Institute Inc.","Vimal Prajapati","加拿大","Alberta","Calgary"],["Alberta Dermasurgery Centre","Jaggi Rao","加拿大","Alberta","Edmonton"],["Laser Rejuvenation Clinics Edmonton D.T. Inc.","Parbeer Grewal","加拿大","Alberta","Edmonton"],["Centre de Recherche Saint-Louis","Virginie Kelly","加拿大","Quebec","Quebec"],["Wiseman Dermatology Research Inc.","Marni Wiseman","加拿大","Manitoba","Winnipeg"],["SKiN Centre for Dermatology","Melinda Gooderham","加拿大","Ontario","Peterborough"],["North York Research Inc.","Firouzeh Niakosari","加拿大","Ontario","Toronto"],["CCA Medical Research","David Adam","加拿大","Ontario","Ajax"],["Ryan Clinical Research Inc.","Sanjay Siddha","加拿大","Ontario","Newmarket"],["Skincare Studio Inc.","Tracey Brown-Maher","加拿大","Newfoundland and Labrador","St. John's"],["Kirk Barber Research Inc.","Kirk Barber","加拿大","Alberta","Calgary"],["DermEffects","Wei Jing Loo","加拿大","Ontario","London"],["DermEdge Research","Mark Lomaga","加拿大","Ontario","Mississauga"],["Sima Recherche","Simon Nigen","加拿大","Quebec","Verdun"],["Toronto Research Centre","Maxwell Sauder","加拿大","Ontario","Toronto"],["Stratica Dermatology","Andrew Ferrier","加拿大","Alberta","Edmonton"],["Beacon Dermatology","Andrei Metelitsa","加拿大","Alberta","Calgary"],["Lynderm Research Inc.","Charles Walter Lynde","加拿大","Ontario","Markham"],["Lovegrove Dermatology","Fiona Lovegrove","加拿大","Ontario","London"],["Skin Care West","Gabriele Weichert","加拿大","British Columbia","Nanaimo"],["Centre de Recherche Saint-Louis","Annie Genois","加拿大","Quebec","Montreal"],["North Bay Dermatology Center","Leslie Rosoph","加拿大","Ontario","North Bay"],["Vida Clinical Research","Anil Kurian","加拿大","Alberta","Edmonton"],["The Centre for Dermatology","Mani Raman","加拿大","Ontario","Richmond Hill"],["Centre de Recherche Saint Louis","Evelyn Alarcon Chinchilla","加拿大","Quebec","Sherbrooke"],["Interior Dermatology Center","Diane Emilie Burrows","加拿大","British Columbia","Kelowna"],["The Centre for Clinical Trials","Sheetal Sapra","加拿大","Ontario","Oakville"],["Chosun University Hospital","Bong Seok Shin","韩国","Gwangju","Gwangju"],["The Catholic University of Korea, Seoul St. Mary's Hospital","Chul Hwan Bang","韩国","Seoul","Seoul"],["Pusan National University Hospital","Byung-Soo Kim","韩国","Busan","Busan"],["Yonsei University Health System, Severance Hospital","Shinwon Hwang","韩国","Seoul","Seoul"],["Kyunghee University Hospital","Ki-Heon Jeong","韩国","Seoul","Seoul"],["CHA Bundang Medical Center, CHA University","Dong Hyun Kim","韩国","Gyeonggi-do","Seongnam-si"],["Seoul National University Hospital","Seong Jin Jo","韩国","Seoul","Seoul"],["Seoul National University Bundang Hospital - Comprehensive Cancer Center","Sangwoong Youn","韩国","Seoul","Seoul"],["Korea University Guro Hospital","Yoo Sang Baek","韩国","Seoul","Seoul"],["Konkuk University Medical Center","Yong-Beom Choe","韩国","Seoul","Seoul"],["Centre Hospitalier Universitaire de Nantes (CHU de Nantes) - Hotel-Dieu","Helene Aubert-Wastiaux","法国","Loire Atlantique","Nantes Cedex 01"],["Cideazur - Dermatologie","Abdallah Khemis","法国","Loire Atlantique","Nice"],["CHU Site Sud","Antoine Bertolotti","法国","Reunion","St Pierre"],["Studienzentrum an der Hase GbR","Ansgar Weyergraf","德国","Lower Saxony","Bramsche"],["Fachklinik Bad Bentheim - Klinisches Stuidenzentrum","Athanasios Tsianakas","德国","Lower Saxony","Bad Bentheim"],["Universitaetsklinikum Wuerzburg Klinik und Poliklinik fur Dermatologie, Venerologie und Allergologie","Andreas Kerstan","德国","Bavaria","Wuerzburg"],["Universitaetsklinikum Freiburg - Klinik fur Dermatologie und Venerologie","Franziska Schauer","德国","Baden-Wuerttemberg","Freiburg"],["Universitaetsklinikum Heidelberg (UKHD) - Hautklinik","Knut Schaekel","德国","Baden-Wuerttemberg","Heidelberg"],["Praxis fur Dermatologie und Venerologie","Beatrice Gerlach","德国","Saxony","Dresden"],["Beldio Research GmbH","Nicolai Treiber","德国","Bavaria","Memmingen"],["BAG Dres. Quist PartG","Sven Quist","德国","Rhineland-Palatinate","Mainz"],["Universitaetsklinikum Muenster (UKM) Klinik fur Hautkrankheiten; ZID","Nina Magnolo","德国","North Rhine-Westphalia","Muenster"],["Hautarztpraxis Dr. Hoffmann","Matthias Hoffmann","德国","North Rhine-Westphalia","Witten"],["Studienzentrum Dr. med. Beate Schwarz Dermatologie und Allergologie","Beate Schwarz","德国","Baden-Wuerttemberg","Langenau"],["Johann Wolfgang Goethe-Universitaet Frankfurt - Klinik fuer Dermatologie, Venerologie & Allergologie","Andreas Pinter","德国","Hesse","Frankfurt"],["Universitaetsklinikum Erlangen Hautklinik - Studienambulanz","Lukas Sollfrank","德国","Bavaria","Erlangen"],["Dermatologikum Hamburg GmbH","Peter Weisenseel","德国","Hamburg","Hamburg"],["Universitatsklinikum Schleswig-Holstein - Klinik fur Dermatologie, Venerologie und Allergologie Zentrum fur entzuendliche Hauterkrankungen","Sascha Gerdes","德国","Schleswig-Holstein","Kiel"],["Universitaetsmedizin der Johannes Gutenberg-Universitaet Mainz Hautklinik und Poliklinik - Clinical Research Center (CRC)","Joanna Wegner","德国","Rhineland-Palatinate","Mainz"],["Harzklinikum Dorothea Christiane Erxleben GmbH- Klinikum Quedlinburg Klinik fuer Dermatologie und Allergologie","Christiane Schreck","德国","Saxony-Anhalt","Quedlinburg"],["Universitaetsklinikum Carl Gustav Carus - Klinik und Poliklinik fuer Dermatologie","Stefan Beissert","德国","Saxony","Dresden"],["Universitaetsklinikum Tuebingen, Universitaets-Hautklinik Sektion Dermatologische Onkologie","Matthias Hahn","德国","Baden-Wuerttemberg","Tuebingen"],["ISA - Interdisciplinary Study Organisation GmbH","Margrit Simon","德国","Berlin","Berlin"],["Charite-Universitaetsmedizin Berlin Klinik fuer Dermatologie, Venerologie und Allergologie Inflammations- und Immundermatologie Charite (IIDC)","Sonja Molin","德国","Berlin","Berlin"],["Hautmedizin Saar Science – HMS GmbH","Sebastian Zimmer","德国","Saarland","Merzig"],["Dermatologische Gemeinschaftspraxis Mahlow","Michael Sebastian","德国","Brandenburg","Mahlow"],["MVZ DermaKiel GmbH","Harald Bruening","德国","Schleswig-Holstein","Kiel"],["Eurofins bioskin GmbH","Swarna Ekanayake-Bohlig","德国","Hamburg","Hamburg"],["Praxis Dr. Zarzou","Abdou Zarzour","德国","Saxony-Anhalt","Halle"],["Derma-Study-Center-FN GmbH","Peter Radny","德国","Baden-Wuerttemberg","Friedrichshafen"],["Studienzentrum KorSearch","Christian Kors","德国","Berlin","Berlin"],["Bispebjerg Hospital","Simon Thomsen","丹麦","Hovedstaden","Copenhagen NV"],["Gentofte Hospital","Claus Zachariae","丹麦","NA","Hellerup"],["Aarhus University Hospital","Christian Vestergaard","丹麦","NA","Aarhus N"],["Aalborg University Hospital","Kasper Fjellhaugen Hjuler","丹麦","NA","Aalborg"],["Sanos Clinic","Hans Christian Ring","丹麦","NA","Herlev"],["Centrum Badan Klinicznych PI House Sp. Z O.O.","Aleksandra Okuniewska","波兰","pomorskie","Gdansk"],["dermMedica Sp. z o.o","Jolanta Weglowska","波兰","dolnoslaskie","WrocIaw"],["Ai Centrum Medyczne","Anna Rychlewska-Hanczewska","波兰","wielkopolskie","Poznan"],["Clinical Research Group Sp. z o.o.","Kamila Padlewska","波兰","mazowieckie","Warszawa"],["Centrum Medyczne Angelius Provita (Angelius Provita Medical Centre)","Anita Lewartowska-Bialek","波兰","Slaskie","Katowice"],["MICS Centrum Medyczne Warszawa","Joanna Kolinek","波兰","mazowieckie","Warszawa"],["Lidia Rajzer - Specjalistyczny Gabinet Dermatologiczno-Kosmetyczny","Lidia Rajzer","波兰","maIopolskie","Krakow"],["Clinical Best Solutions","Magdalena Raszewska-Famielec","波兰","lubelskie","Lublin"],["Synexus Katowice","Marcin Zakrzewski","波兰","Slaskie","Katowice"],["Centrum Medyczne Pratia - Katowice","Kamila Placzek","波兰","Slaskie","Katowice"],["Clinic Med Bialystok","Marta Wilkowska-Trojniel","波兰","podlaskie","BiaIystok"],["WroMedica","Wojciech Baran","波兰","dolnoslaskie","WrocIaw"],["LUXDERM","Dorota Krasowska","波兰","lubelskie","Lublin"],["Prywatny Gabinet Dermatologiczny Elzbieta Klujszo","Elzbieta Klujszo","波兰","Swietokrzyskie","Kielce"],["Centrum Wsparcia Badan Klinicznych","Mariusz Sikora","波兰","mazowieckie","Warszawa"],["Uniwersytecki Szpital Kliniczny im. Fryderyka Chopina w Rzeszowie","Adam Reich","波兰","podkarpackie","Rzeszow"],["Klinika Zdybski - Dermedic","Piotr Parcheta","波兰","maIopolskie","Ostrowiec Swietokrzyski"],["MICS Centrum Medyczne Torun","Aleksandra Badzian","波兰","kujawsko-pomorskie","Torun"],["Royalderm","Witold Owczarek","波兰","mazowieckie","Warszawa"],["DERMED Centrum Medyczne Sp. z o.o.","Andrzej Kaszuba","波兰","Iodzkie","Iodz"],["Niepubliczny Zaklad Opieki Zdrowotnej SPECDERM","Maria Poznanska","波兰","podlaskie","BiaIystok"],["Niepubliczny Zaklad Opieki Zdrowotnej Osteo-Medic s.c. A. Racewicz, J. Supronik","Malgorzata Janczylo-Jankowska","波兰","podlaskie","BiaIystok"],["Klinika Ambroziak Dermatologia Kliniczna","Monika Kalowska","波兰","mazowieckie","Warszawa"],["Centrum Kliniczno-Badawcze J. Brzezicki, B. Gornikiewicz-Brzezicka Lekarze Spolka Partnerska","Jan Brzezicki","波兰","warminsko-mazurskie","Elblag"],["ST-Inspire sp. z.o.o (Twoja Med)","Santa Vanaga-Besser","波兰","Slaskie","MikoIow"],["Velocity Clinical Research, Skierniewice","Witold Urban","波兰","Iodzkie","Skierniewice"],["Etyka Osrodek Badan Klinicznych","Maria Welenc","波兰","warminsko-mazurskie","Olsztyn"],["FutureMeds Targowek","Patrycja Wislinska","波兰","mazowieckie","Warszawa"],["Certus - Szpital i Ambulatorium","Agnieszka Mankowska","波兰","wielkopolskie","Poznan"],["CM Pratia Gdynia","Dominika Bielinska-Warezak","波兰","pomorskie","Gdynia"],["Cliniques Universitaires Saint-Luc","Pierre-Dominique Ghislain","比利时","NA","Bruxelles"],["Dermatolgie Maldegem","Sven Lanssens","比利时","NA","Maldegem"],["University Hospital Gent","Reinhart Speeckaert","比利时","NA","Gent"],["Medical Center MedConsult - Pleven","Kameliya Vekovska","保加利亚","Pleven","Pleven"],["Medical Center MedConsult - Lovech","Krasimira Vasileva","保加利亚","Lovech","Lovech"],["Medical Center MedConsult - Burgas","Karen Manuelyan","保加利亚","Burgas","Burgas"],["Diagnostic Consultative Center I -Ruse","Nadezhda Yordanova","保加利亚","Ruse","Ruse"],["University Multiprofile Hosp. For Active Treatment Sv Georgi","Krasimir Kraev","保加利亚","Pleven","Pleven"],["University Multiprofile Hospital for Active Treatment","Petranka Troyanova","保加利亚","Sofia","Sofia"],["DCC V - Plovdiv - St. Archbishop Luka","Melita Encheva","保加利亚","Plovdiv","Plovdiv"],["Medical Center “Markovs","Yana Zdravkova","保加利亚","Sofia","Sofia"],["Hospital Federal dos？Servidores do Estado (H.F.S.E.)","Luna Azulay Abulafia","巴西","Rio de Janeiro","Rio de Janeiro"],["Clinica Ibis","Gleison Vieira Duarte","巴西","Estado de bahia","Salvador"],["Hospital Moinhos de Vento","Andre Vicente Esteves De Carvalho","巴西","Rio de Janeiro","Porto Alegre"],["Centro Mineiro de Pesquisa (CMiP)","Silviane Vassalo","巴西","Minas Gerais","Minas Gerais"],["Hospital Alemao Oswaldo Cruz","Maria Victoria Suarez Restrepo","巴西","Sao Paulo","Bela Vista"],["Hospital das Clinicas da Faculdade de Medicina da Universidade de Sao Paulo","Ricardo Romiti","巴西","Sao Paulo","Cerqueira Cesar"],["Universidade Estadual de Campinas - Cidade UniversitAria Zeferino Vaz","Renata Ferreira Magalhaes","巴西","Sao Paulo","Campinas"],["Hospital Universitario Evangelico de Curitiba","Anber Tanaka","巴西","ParanA","Curitiba"],["CEPEC - Centro Paraibano de Pesquisa e Estudos Clinicos","Esther Bastos Palitot","巴西","P.B.","Joao Pessoa"],["Hospital de Clinicas de Porto Alegre","Tania Cestari","巴西","Rio de Janeiro","Porto Alegre"],["Universidade Estadual Paulista - Hospital das Clinicas da Faculdade de Medicina de Botucatu (HCFMB)","Luciane Donida Bartoli Miot","巴西","Sao Paulo","Botucatu"],["Faculdade de Medicina de Sao Jose do Rio Preto","Joao Roberto Antonio","巴西","Sao Paulo","Sao Jose do Rio Preto"],["Pontificia Universidade Catolica do Parana","Caio Cesar Silva De Castro","巴西","ParanA","Curitiba"],["Office of Luiza Keiko Matsuka Oyafuso","Luiza Keiko Matsuka Oyafuso","巴西","Sao Paulo","Sao Paulo"],["Hospital das Clinicas da Faculdade de Medicina de Ribeirao Preto da Universidade de Sao Paulo (USP) - HCFMRP","Cacilda da Silva Souza","巴西","Sao Paulo","Botucatu"],["Dr Rodney Sinclair Pty Ltd","Samantha Eisman","澳大利亚","Victoria","East Melbourne"],["St George Dermatology & Skin Cancer Centre","Esther Hong","澳大利亚","New South Wale","Kogarah"],["Westmead Hospital","Pablo Fernandez Penas","澳大利亚","New South Wale","Westmead"],["The Skin Hospital","John Frew","澳大利亚","New South Wale","Darlinghurst"],["Skin Health Institute Inc.","Peter Foley","澳大利亚","Victoria","Carlton"],["Veracity Clinical Research Pty Ltd","Lynda Spelman","澳大利亚","Queensland","Woolloongabba"],["Monash Medical Centre","Francis Lai","澳大利亚","Clayton","246 Clayton Road"],["Buenos Aires Skin S.A","Matias Turienzo","阿根廷","Ciudad Autonoma de Buenos Aires","Ciudad Autonoma de Buenos Aires"],["STAT Research S.A.","Claudio Greco","阿根廷","Ciudad Autonoma de Buenos Aires","Ciudad Autonoma de Buenos Aires"],["CEMEDIAB - Centro Medico Diabetologico","Debora Kaplan","阿根廷","Ciudad Autonoma de Buenos Aires","Ciudad Autonoma de Buenos Aires"],["Psoriahue","Gabriel Magarinos","阿根廷","Ciudad Autonoma de Buenos Aires","Ciudad Autonoma de Buenos Aires"],["Conexia Investigacion Clinica SA","Pablo Javier Gonzalez","阿根廷","Ciudad Autonoma de Buenos Aires","Ciudad Autonoma de Buenos Aires"],["Hospital Italiano de Buenos Aires","Luis Daniel Mazzuoccolo","阿根廷","Ciudad Autonoma de Buenos Aires","Ciudad Autonoma de Buenos Aires"],["Consultorios Reumatologicos Pampa","Cristina Echeverria","阿根廷","Ciudad Autonoma de Buenos Aires","Ciudad Autonoma de Buenos Aires"],["Instituto de Neumonologia y Dermatologia","Paula Carolina Luna","阿根廷","Ciudad Autonoma de Buenos Aires","Ciudad Autonoma de Buenos Aires"],["Viviana Parra Instituto Parra Dermatologia","Viviana Parra","阿根廷","Mendoza","Ciudad de Mendoza"],["Derma Internacional S.A.","Maria Laura Galimberti","阿根廷","Ciudad Autonoma de Buenos Aires","Ciudad Autonoma de Buenos Aires"],["Instituto Privado de Investigaciones Clinicas de Cordoba","Leandro Perrotat","阿根廷","Ciudad de Cordoba","Ciudad de Cordoba"],["Hospital de Clinicas Jose de San Martin","Graciela Manzur","阿根廷","Ciudad Autonoma de Buenos Aires","Ciudad Autonoma de Buenos Aires"]]

序号	机构名称	主要研究者	国家	省（州）	城市

[["中国医科大学附属第一医院医学伦理委员会","同意","2025-11-04"]]

序号	名称	审查结论	批准日期/备案日期

进行中（尚未招募）

目标入组人数	国内: 225 ； 国际: 3040 ；
已入组人数	国内: 登记人暂未填写该信息； 国际: 149 ；
实际入组总人数	国内: 登记人暂未填写该信息； 国际: 登记人暂未填写该信息；

第一例受试者签署知情同意书日期	国内：登记人暂未填写该信息；     国际：2025-09-22；
第一例受试者入组日期	国内：登记人暂未填写该信息；     国际：2025-10-06；
试验完成日期	国内：登记人暂未填写该信息；     国际：登记人暂未填写该信息；