北京Nipocalimab注射液III期临床试验-Nipocalimab用于中重度系统性红斑狼疮成人患者的研究（GARDENIA）

登记号	CTR20261056	试验状态	进行中
申请人联系人	王璐	首次公示信息日期	2026-03-20
申请人名称	Janssen Research & Development, LLC/ 强生（中国）投资有限公司/ Vetter Pharma-Fertigung GmbH & Co.KG/ Janssen Pharmaceutica NV, Division of Janssen Research and Development; Fisher Clinical Services Inc.; Fisher Clinical Services UK Limited; Fisher Clinical Services AG; Catalent Pharma Solutions, LLC; Catalent Germany Schorndorf GmbH

登记号	CTR20261056
相关登记号	暂无
药物名称	Nipocalimab注射液
药物类型	生物制品
临床申请受理号	企业选择不公示
适应症	系统性红斑狼疮
试验专业题目	Nipocalimab用于中重度系统性红斑狼疮成人患者的III期、随机、双盲、安慰剂对照、多中心研究
试验通俗题目	Nipocalimab用于中重度系统性红斑狼疮成人患者的研究（GARDENIA）
试验方案编号	80202135SLE3001	方案最新版本号	原始版本
版本日期:	2025-11-13	方案是否为联合用药	否

申请人名称	[["Janssen Research & Development, LLC"],["强生（中国）投资有限公司"],["Vetter Pharma-Fertigung GmbH & Co.KG"],["Janssen Pharmaceutica NV, Division of Janssen Research and Development; Fisher Clinical Services Inc.; Fisher Clinical Services UK Limited; Fisher Clinical Services AG; Catalent Pharma Solutions, LLC; Catalent Germany Schorndorf GmbH"]]
联系人姓名	王璐	联系人座机	010-59523011	联系人手机号
联系人Email	lwang194@its.jnj.com	联系人邮政地址	北京市-北京市-朝阳区建国路77号19层	联系人邮编	100025

本试验的目的是评估nipocalimab在中重度系统性红斑狼疮受试者中的疗效，并与安慰剂进行比较（系统性红斑狼疮是一种长期疾病，其特征为免疫系统错误地攻击自身健康组织，导致多个器官出现肿胀和炎症）

试验分类	安全性和有效性	试验分期	III期	设计类型	平行分组
随机化	随机化	盲法	双盲	试验范围	国际多中心试验

年龄	18岁(最小年龄)至 75岁(最大年龄)
性别	男+女
健康受试者	无
入选标准	[["签署知情同意书时，年龄≥18至≤75岁或符合当地法规规定的法定同意年龄"],["筛选时的体格检查、病史、生命体征和12导联心电图（ECG）检查结果显示病情稳定"],["根据欧洲抗风湿病联盟/美国风湿病学会（EULAR/ACR） 2019分类标准，在筛选前临床确诊系统性红斑狼疮≥24周"],["筛选时SLEDAI-2K评分必须≥6分且临床SLEDAI-2K评分≥4分，并且第0周时临床SLEDAI-2K评分≥4分（剔除“狼疮性头痛”、“脱发”和“器质性脑综合征”对应的分数）"],["筛选时至少1项英岛狼疮评定组（BILAG）-2004 A级评分或2项BILAG-2004 B级评分，其中黏膜皮肤和/或肌肉骨骼维度至少有1项A级和/或1项B级评分"],["具有生育能力的受试者必须在筛选时提供血清 β 人绒毛膜促性腺激素（β hCG）阴性结果，并在第 0 周随机分组前提供尿 β hCG 阴性结果"],["必须按照研究方案所述提供知情同意"],["如果受试者同意提供可选的DNA样本供研究使用（如果当地法规允许），则受试者（或其法定代理人）必须签署单独的知情同意书（ICF）。拒绝提供关于可选DNA研究样本的知情同意书不会导致受试者被排除在研究之外"],["必须愿意并能够遵守本研究方案规定的所有特定要求，包括但不限于研究药物给药、完成所需评估（患者报告结局[PRO]、给药日记等）、遵守访视时间表以及遵循生活方式限制的要求"],["目前正在接受至少一种方案允许的用于治疗SLE的药物"],["可规律或根据需要接受研究方案允许的药物治疗，不得改变剂量或给药频率：非甾体类抗炎药（NSAID）或其他镇痛药：研究药物首次给药前≥2周；允许用于皮肤病的外用药物：研究药物首次给药前≥4周"],["对于女性受试者，在研究药物治疗期间和研究药物末次给药后30天内，受试者必须：a. 不得哺乳或妊娠; b. 不得捐献配子（即卵子）或冷冻配子以备将来用于辅助生殖; c. 若为具有生育能力的女性，还须符合以下规定：n- 筛选时的高灵敏度（如β-hCG）妊娠检查结果和第0周（随机化前）尿妊娠试验结果均呈阴性，且同意接受后续妊娠检查。n- 采用至少1种高效避孕方法；如果使用口服避孕药，还必须使用屏障避孕方法。n对于男性受试者，在研究药物治疗期间和研究药物末次给药后90天内，受试者必须：a. 不得捐献配子（即精子）或冷冻配子以备将来用于辅助生殖; b. 使用外用避孕套; c. 如果受试者的伴侣为具有生育能力的女性，除非受试者接受过输精管切除术，否则其伴侣必须采用高效避孕方法"]]
排除标准	[["既往患有重度、进展性和/或未受控制的肝脏、胃肠道、肾脏、肺、心血管、精神、神经或肌肉骨骼疾病、高血压，和/或任何其他可能干扰完全参与研究或者可能危及受试者安全或研究结果有效性的医学状况或未受控制的自身免疫性疾病或筛选时有临床意义的实验室检查结果异常"],["任何SLE不稳定或进展性表现，可能需要接受允许的背景治疗药物以外的升级疗法"],["当前或既往患有重度、进展性或未受控制的肾病（在入组资格裁定期间确定的活动性狼疮性肾炎[LN]除外）。必须在筛选前24周内通过至少2次蛋白尿或尿蛋白-肌酐比率（UPCR）检测结果证明肾病控制情况"],["预计在研究药物首次给药前52周内需接受透析治疗"],["有药物性狼疮病史或疑似发生药物性狼疮"],["已确诊或疑似存在可能干扰疗效评价的炎症性疾病，包括但不限于类风湿关节炎、银屑病关节炎、类风湿关节炎/狼疮重叠综合征、银屑病、克罗恩病、系统性硬化症、多发性肌炎、皮肌炎或活动性莱姆病"],["导致严重症状或体征的未受控制的重度纤维肌痛，这些症状或体征包括疲劳、疼痛、全身压痛和/或认知功能障碍，可能影响研究者评估SLE活动度和/或治疗应答的能力"],["有合并症（SLE除外，例如哮喘、慢性阻塞性肺疾病），在筛选前52周内需要接受≥3个疗程的全身性GC治疗，并且在52周双盲治疗期内可能需要多个疗程的全身性GC治疗"],["筛选前1年内有灾难性抗磷脂综合征（APS）病史。必须根据当地指南通过抗凝和/或抗血小板治疗充分控制APS。在受试者随机化前，申办方（或其指定人员）将通过裁定程序确定候选受试者参与研究的适宜性"],["确诊或疑似患有与SLE治疗无关的临床免疫缺陷综合征，或有先天性或遗传性免疫缺陷家族史（除非经确认受试者没有免疫缺陷综合征）"],["在筛选前12周内发生过心肌梗死、不稳定型缺血性心脏病或卒中"],["有复发性深静脉血栓形成（DVT）病史或随机化前1年内具有无诱因肺栓塞（PE）病史"],["解剖性或功能性无脾畸形"],["曾接受器官移植"],["在筛选前12周内接受过重大手术，或尚未完全从手术中恢复，或计划在受试者参加本研究期间进行手术"],["在筛选前8周内发生重度感染，包括需要接受胃肠外抗感染药和/或住院治疗的机会性感染，和/或经研究者评估为严重/有临床意义的感染。受试者可在8周排除期结束后重新进行筛选"],["筛选前有证据表明存在慢性感染，或需长期使用抗感染药物治疗的感染，预防性使用抗生素除外"],["符合以下任何一项结核病（TB）筛查标准：a. 有活动性TB病史，或在筛选时发现有活动性TB的体征或症状； b. 筛选前有未经治疗的潜伏性TB史"],["筛选时存在恶性肿瘤或筛选前3年内有恶性肿瘤病史"],["既往对治疗性蛋白药物发生过重度速发型超敏反应，例如速发过敏反应"],["疑似或已知对Nipocalimab或其辅料或安慰剂制剂中使用的辅料过敏、有超敏反应或不耐受"],["如方案定义的肝功能、肾功能和血液学检查结果"],["筛选时确认乙型肝炎病毒（HBV）、丙型肝炎病毒（HCV）或人类免疫缺陷病毒（HIV）抗体检测呈阳性"],["曾接受Nipocalimab或其他新生儿Fc受体（FcRn）抑制剂治疗"],["研究药物首次给药前12周内接受过方案特定的治疗"],["研究药物首次给药前24周内接受过方案特定的治疗"],["在研究药物首次给药前52周内接受过anti-BAFF-R治疗"],["在研究药物首次给药前90天内或5个半衰期内（以较长者为准）接受过方案特定的治疗"],["在研究药物首次给药前8周内接受过Janus激酶[JAK]抑制剂（或酪氨酸激酶[TYK]-2抑制剂治疗"],["在研究药物首次给药前6周内接受过以下任一治疗：硬膜外、静脉注射（IV）、肌肉注射（IM）、关节内、囊内或病灶内GC给药；具有以下潜在影响的补充疗法：激活（如紫雏菊）或抑制免疫系统，与抗血栓药物产生相互作用"],["研究药物首次给药前4周内接受过以下任一治疗，且覆盖体表面积（BSA）＞20%（环孢霉素A眼科用药除外）：环孢霉素A外用乳膏/软膏制剂；高效外用GC；其他外用免疫调节剂"],["在研究药物首次给药前4周内（卡介苗[BCG]为1年内）接种过活疫苗，或已知在研究期间或研究药物末次给药后至少8周内需要接种活疫苗（包括BCG）"],["在研究药物首次给药前90天/12周或5个半衰期（以较长者为准）内接受过试验用药物（包括试验用疫苗），或在研究药物首次给药前90天/12周内使用过侵入性的试验用医疗器械，或当前正在参加一项临床研究"]]

试验药	[["中文通用名:尼卡利单抗 英文通用名:nipocalimab 商品名称:NA","剂型:注射液 规格:230mg/mL 用法用量:受试者将在双盲期（第0周至第52周）以及开放标签延长期（LTE，第52周至第156周）接受nipocalimab治疗 用药时程:双盲期：受试者将自第0周至第52周接受nipocalimab治疗。开放标签LTE：受试者将自第52周至第156周接受nipocalimab治疗"]] 序号 名称 用法
对照药	[["中文通用名:安慰剂（20%（w/w）PEG4K，10mM组氨酸，Ph6.0） 英文通用名:placebo 商品名称:NA","剂型:注射液 规格:NA 用法用量:受试者将在双盲期（第0周至第52周）接受安慰剂治疗 用药时程:受试者将自第0周至第52周接受安慰剂治疗"]] 序号 名称 用法

主要终点指标及评价时间

[["第 52 周达到系统性红斑狼疮（SLE）应答指数（SRI） 4 复合应答的受试者比例","第52周","有效性指标"]] 序号 指标 评价时间 终点指标选择

次要终点指标及评价时间

[["基线时具有高水平干扰素（IFN）基因特征（IFN高水平）的受试者中，第52周SRI-4复合应答","第52周","有效性指标"],["第52周实现SRI-4复合应答且口服糖皮质激素（GC）剂量持续降低的受试者比例","第52周","有效性指标"],["第52周时实现狼疮低疾病活动状态（LLDAS）的受试者比例","第52周","有效性指标"],["基线时有≥2个活动性关节的受试者中，第52周时活动性关节＜2个的受试者比例","第52周","有效性指标"],["第52周时狼疮症状关节痛评分较基线的变化","基线，第52周","有效性指标"],["基线时接受＞5 mg/天泼尼松（或等效药物）口服GC治疗的受试者中，第52周时实现口服GC剂量持续降低的受试者比例","第52周","有效性指标"],["第52周时慢性病治疗功能评估（FACIT ）-疲劳评分较基线的变化","基线，第52周","有效性指标"],["截至第52周无BILAG复发的受试者比例","至第52周","有效性指标"],["基线自身抗体高水平的受试者中，第52周实现SRI-4复合应答的受试者比例","第52周","有效性指标"]] 序号 指标 评价时间 终点指标选择

1	姓名	栗占国	学位	医学博士	职称	主任医师
	电话	010-88324172	Email	li99@bjmu.edu.cn	邮政地址	北京市-北京市-北京大学人民医院风湿免疫科
	邮编	100044	单位名称	北京大学人民医院

[["北京大学人民医院","栗占国","中国","北京市","北京市"],["浙江大学医学院附属第二医院","张婷","中国","浙江省","杭州市"],["南昌大学第二附属医院","段新旺","中国","江西省","南昌市"],["吉林大学第一医院","赵令","中国","吉林省","长春市"],["南京大学医学院附属鼓楼医院","孙凌云","中国","江苏省","南京市"],["四川大学华西医院（四川省国际医院）","赵毅","中国","四川省","成都市"],["中山大学附属第一医院","杨念生","中国","广东省","广州市"],["中国科学技术大学附属第一医院（安徽省立医院）","陈竹","中国","安徽省","合肥市"],["上海交通大学医学院附属仁济医院","丁慧华","中国","上海市","上海市"],["山西白求恩医院（山西医学科学院）","张莉芸","中国","山西省","太原市"],["中南大学湘雅医院","李通","中国","湖南省","长沙市"],["河南科技大学第一附属医院","史晓飞","中国","河南省","洛阳市"],["新乡市中心医院","范文强","中国","河南省","新乡市"],["宁波市医疗中心李惠利医院","张瑾","中国","浙江省","宁波市"],["中山大学孙逸仙纪念医院深汕中心医院","莫颖倩","中国","广东省","汕尾市"],["金华市中心医院","华丽","中国","浙江省","金华市"],["济宁市第一人民医院","李树杰","中国","山东省","济宁市"],["广西医科大学第一附属医院","莫汉有","中国","广西壮族自治区","南宁市"],["东莞市人民医院","韩光明","中国","广东省","东莞市"],["核工业总医院（苏州大学附属第二医院）","刘志纯","中国","江苏省","苏州市"],["临汾市中心医院","强树华","中国","山西省","临汾市"],["台北医学大学附设医院","张棋桢","中国台湾","台湾","台北市"],["奇美医院永康院区","陈弘安","中国台湾","台湾","台南市"],["台北荣民总医院","陈铭翰","中国台湾","台湾","台北市"],["林口长庚纪念医院","方耀凡","中国台湾","台湾","桃园市"],["高雄长庚纪念医院","许钟元","中国台湾","台湾","高雄市"],["国立台湾大学医学院附设医院","蓝鼎渊","中国台湾","台湾","台北市"],["中国医药大学附设医院","蓝忠亮","中国台湾","台湾","台中市"],["新竹台大分院","李泰如","中国台湾","台湾","新竹市"],["高雄荣民总医院","王丽风","中国台湾","台湾","高雄市"],["Bioclinic Research","Damaris Alvarez","阿根廷","Ciudad Autonoma de Buenos Aire","Buenos Aires"],["Arsema","Federico Ariel","阿根廷","NA","Ciudad de Buenos Aires"],["Consultorios Medicos Alto Dorrego","Matias Benavente","阿根廷","Mendoza","Mendoza"],["Centro de Investigaciones Medicas Tucuman","Horacio Berman","阿根廷","Tucuman","San Miguel De Tucuman"],["Cer Instituto Medico","Graciela Betancur","阿根廷","Provincia de Buenos Aires","Quilmes"],["Sanatorio de la Mujer","Marina Carcamo","阿根廷","Santa Fe","Rosario"],["Hospital Central Militar Cirujano Mayor Dr Cosme Argerich","Gustavo Casado","阿根廷","Buenos Aires","CABA"],["MR Medicina Reumatologica","Alejandra Cusa","阿根廷","Provincia de Buenos","San Fernando"],["Global Psy Asociacion Civil","Rodrigo Garcia Salinas","阿根廷","NA","La Plata"],["Mautalen Salud e Investigacion","Julio Hofman","阿根廷","Buenos Aires","CABA"],["Centro de Investigacion en Enfermedades Reumaticas CIER","Pablo Maid","阿根廷","NA","Ciudad de Buenos Aires"],["ARCIS Salud SRL Aprillus asistencia e investigacion","Pablo Mannucci","阿根廷","CABA","Buenos Aires"],["Centro Privado de Medicina Familiar","Leonardo Naftal","阿根廷","Buenos Aires","Buenos Aires"],["Instituto de Investigaciones Clinicas Quilmes","Jose Luis Velasco Zamora","阿根廷","Buenos Aires","Quilmes"],["BOX HILL","Christopher Fong","澳大利亚","VIC","Box Hill"],["Liverpool Hospital","Geraldine Hassett","澳大利亚","NSW","Liverpool"],["Austin Hospital","Jessica Leung","澳大利亚","VIC","Heidelberg"],["Epping Specialist Group","Mueed Mian","澳大利亚","VIC","Epping"],["Footscray Hospital, Western Health","Maninder Mundae","澳大利亚","VIC","Footscray"],["Princess Alexandra Hospital","Amee Sonigra","澳大利亚","QLD","Woolloongabba"],["Westmead Hospital","Peter Wong","澳大利亚","NSW","Westmead"],["Fundacao Faculdade Regional De Medicina S Jose Rio Preto Hospital De Base","Mariana Alves Ferreira Martins","巴西","SP","Sao Jose do Rio Preto"],["Empresa Brasileira De Servicos Hospitalares EBSERH Hospital De Clinicas De Uberlandia","Mariana Cecconi","巴西","MG","Uberlandia"],["CEPIC Centro Paulista de Investigacao Clinica e Servicos Medicos","Flora Maria D'Andrea Marcolino","巴西","SP","Sao Paulo"],["L2IP Instituto de Pesquisas Clinicas","Lucas de Oliveira Santana","巴西","DF","Brasília"],["Hospital Alianca (HA) - Rede D'Or","Gustavo Pinto","巴西","BA","Salvador"],["Instituto D Or de Pesquisa e Ensino","Gustavo De Paiva Costa","巴西","DF","Brasilia"],["CEMEC - Centro Multidisciplinar de Estudos Clínicos","Anna Ferreira","巴西","Sao Paulo","Sao Bernardo do Campo"],["CEDOES Centro de Pesquisa Clinica e Diagnostico do Espirito Santo Ltda","Valquiria Garcia Dinis","巴西","ES","Vitoria"],["Sociedade Beneficente Israelita Brasileira Hospital Albert Einstein","Ari Halpern","巴西","SP","Sao Paulo"],["ESHO Empresa De Servicos Hospitalares S A","Henrique Helson Herter Dalmolin","巴西","SP","Sao Paulo"],["Chronos Clinica Medica Ltda","Alexandre Hidaka","巴西","DF","Brasilia"],["LMK Servicos Medicos S S","Mauro Keiserman","巴西","RS","Porto Alegre"],["UNESP - Faculdade de Medicina da Universidade Estadual Paulista - Campus Botucatu","Sean Lancas","巴西","SP","Botucatu"],["Fundacao do ABC Centro Universitario FMABC","Sonia Maria Loduca","巴西","SP","Santo Andre"],["Hospital das Clinicas - UFG","Ana Carolina Montandon","巴西","Goias","Goiania"],["Associacao Hospitalar Moinhos de Vento","Tamara Mucenic","巴西","RS","Porto Alegre"],["Uniao Brasileira de Educacao e Assistencia Hospital Sao Lucas da PUCRS","Tatiana Muller","巴西","RS","Porto Alegre"],["Santa Casa de Misericordia de Belo Horizonte","Claudia Lopes Santoro Neiva","巴西","MG","Belo Horizonte"],["Hospital das Clinicas da Faculdade de Medicina de Ribeirao Preto","Rodrigo Oliveira","巴西","SP","Ribeirao Preto"],["BR TRIALS Ensaios Clinicos e Consultoria Ltda","Mariana Ortega Perez","巴西","SP","Sao Paulo"],["Hospital Das Clinicas Da Faculdade De Medicina Da USP","Luciana Parente Costa Seguro","巴西","SP","Sao Paulo"],["Hospital Alianca (HA) - Rede D'Or","Gustavo Pinto","巴西","BA","Salvador"],["Instituto D Or de Pesquisa e Ensino","Gustavo De Paiva Costa","巴西","DF","Brasilia"],["A2Z Clinical","Alisson Pugliesi","巴西","SP","Valinhos"],["Universidade Federal do Ceara Hospital Universitario Walter Cantidio","Raquel Quixada","巴西","CE","Fortaleza"],["Hospital De Clinicas De Porto Alegre","Xavier Ricardo","巴西","RS","Porto Alegre"],["SER - Servicos Especializados em Reumatologia da Bahia","Mittermayer Santiago","巴西","BA","Salvador"],["CMIP - Centro Mineiro de Pesquisa Ltda","Antonio Scotton","巴西","MG","Juiz de Fora"],["Irmandade Santa Casa de Misericordia de Porto Alegre","Thiago Willers","巴西","RS","Porto Alegre"],["UMHAT 'Sveti Ivan Rilsky'","Vladimira Boyadzhieva","保加利亚","NA","Sofia"],["University Multi Profile Hospital for Active Treatment UMHAT St. Marina","Tsvetoslav Georgiev","保加利亚","NA","Varna"],["Diagnostic-Consultative Center (DCC) Aleksandrovska","Delina Ivanova","保加利亚","Sofia Grad","Sofia"],["Medical Center Hera EOOD","Sarita Kostova","保加利亚","NA","Sofia"],["MC Medtech Services Ltd","Krasimir Kraev","保加利亚","NA","Haskovo"],["Military Medical Academy Multiprofile Hospital for Active Treatment Sofia","Boycho Oparanov","保加利亚","NA","Sofia"],["Multiprofile Hosptal for Active Treatment Eurohospital Plovdiv","Dimitar Penev","保加利亚","NA","Plovdiv"],["MC Ekselsior","Tzvetanka Petranova","保加利亚","NA","Sofia"],["Diagnostic consulting center 1 Ruse EOOD","Nadezhda Yordanova","保加利亚","NA","Ruse"],["CIRCARIBE SAS","Mauricio Abello","哥伦比亚","Atlantico","Barranquilla"],["Clinica de la Costa SAS","Andres Cadena Bonfanti","哥伦比亚","Atlantico","Barranquilla"],["Medplus Medicina Prepagada S.A.","Philippe Chalem","哥伦比亚","NA","Bogota"],["Centro de Investigacion Medico Asistencial SAS - CIMEDICAL SAS","Juan Jose Jaller Raad","哥伦比亚","Atlantico","Barranquilla"],["PREVENTIVE CARE LTDA","John Londono Patino","哥伦比亚","CUNDINAMARCA","CHIA"],["Centro de Investigación en Reumatología y especialidades médicas S.A.S. - CIREEM S.A.S.","Diego Javier Martinez Lozano","哥伦比亚","Distrito Capital de Bogotá","Bogotá"],["Servimed S A S","William Otero","哥伦比亚","NA","Bucaramanga"],["HOSPITAL PABLO TOBON URIBE","Luis Fernando Pinto","哥伦比亚","Antioquia","Medellin"],["Centro de Medicina Interna Julian Coronel","Victor Santos","哥伦比亚","Valle del Cauca","Cali"],["Universidad Pontificia Bolivariana Campus Robledo","Carlos Velasquez Franco","哥伦比亚","Antioquia","Medellin"],["MUDr Angelika Lapcikova iMedica s r o","Angelika Lapcikova","捷克","Brno","Jihomoravsky kraj"],["INREA s r o","Martina Malcova","捷克","Ostrava","NA"],["Revmatologicky ustav","Marta Olejarova","捷克","Praha 2","NA"],["Fakultní nemocnice u sv. Anny v Brn","Radoslav Roman","捷克","Brno","Jihomoravsky kraj"],["Revimex Pro s r o","Gabriela Stolarz","捷克","Karvina Frystat","Moravskoslezsky kraj"],["Zealand University Hospital","Ada Colic","捷克","NA","Koge"],["Rigshospitalet","Soren Jacobsen","捷克","NA","Copenhagen"],["Aalborg University Hospital","Salome Kristensen","捷克","NA","Aalborg"],["Zealand University Hospital","Ada Colic","丹麦","NA","Koge"],["Rigshospitalet","Soren Jacobsen","丹麦","NA","Copenhagen"],["Aalborg University Hospital","Salome Kristensen","丹麦","NA","Aalborg"],["Helsinki University Hospital","Ritva Peltomaa","芬兰","NA","Helsinki"],["Turku University Hospital","Laura Pirila","芬兰","Varsinais Suomi","Turku"],["Paijat Hame Central Hospital","Joonas Rautavaara","芬兰","NA","Lahti"],["Northern Clinical Trial Coordinators","Antti Satomaa","芬兰","Pohjois Pohjanmaa","Oulu"],["Hopital Michallon CHU Grenoble Alpes","Laurence Bouillet","法国","Auvergne Rhone Alpes","La Tronche"],["Hopital Cochin","Véronique Le Guern","法国","NA","Paris"],["Centre Hospitalier Le Mans","Paul Legendre","法国","Pays de la Loire","Le Mans"],["CHU de Caen","Remi Philip","法国","Normandie","Caen"],["CHU Toulouse - Hopital de Rangueil","Gregory Pugnet","法国","Occitanie","Toulouse"],["Hospices Civils de Lyon - HOPITAL DE LA CROIX ROUSSE","Gaelle Richard Colmant","法国","Auvergne Rhone Alpes","Lyon"],["CHRU de Strasbourg - Hopital de Hautepierre","Marc Scherlinger","法国","Grand Est","Strasbourg"],["LTD Clinic Deaderma","Nona Chopikashvili","格鲁吉亚","NA","Tbilisi"],["LTD Healthycore LTD Israeli Georgian Medical Research Clinic Healthycore","Nodar Emukhvari","格鲁吉亚","NA","Tbilisi"],["LTD NEW HOSPITALS","Maka Ioseliani","格鲁吉亚","NA","Tbilisi"],["Tbilisi Heart and Vascular Clinic Ltd","Lali Kilasonia","格鲁吉亚","NA","Tbilisi"],["LTD INNOVA","Nino Kiparoidze","格鲁吉亚","NA","Tbilisi"],["LTD The First Medical Center","Tamta Kobakhidze","格鲁吉亚","NA","Tbilisi"],["TSMU The First University Clinic","Khatuna Letsveridze","格鲁吉亚","NA","Tbilisi"],["LTD MediClub Georgia","Mamuka Lortkipanidze","格鲁吉亚","NA","Tbilisi"],["LTD TIM Tbilisi Institution of Medicine","Irine Malazonia","格鲁吉亚","NA","Tbilisi"],["JSC K Eristavi National Center of experimental and Clinical surgery","Tamar Partsvania","格鲁吉亚","NA","Tbilisi"],["Clinic on Mtskheta Street","Levan Shalamberidze","格鲁吉亚","NA","Tbilisi"],["Caucasus Medical Centre","Marine Toidze","格鲁吉亚","NA","Tbilisi"],["Caucasus Medical Centre","Nino Tsiskarishvili","格鲁吉亚","NA","Tbilisi"],["Universitatsklinikum Carl-Gustav-Carus Dresden","Susanne Abraham","德国","NA","Dresden"],["Fraunhofer Institut fur Transnationale Medizin und Pharmakologie ITMP","Frank Behrens","德国","NA","Frankfurt"],["CAIR Heidelberg","Bernhard Heilig","德国","NA","Heidelberg"],["Medicover Muenchen Ost MVZ","David Kofler","德国","BY","Munchen"],["St Elisabeth Hospital Meerbusch Lank","Tuerker Kurt","德国","NRW","Meerbusch"],["Klinikum der Universitaet Muenchen","Hendrik Schulze-Koops","德国","BY","Munchen"],["Universitaetsklinikum Leipzig","Ulf Wagner","德国","SN","Leipzig"],["University General Hospital of Heraklion","Georgios Bertsias","希腊","NA","Iraklio"],["University General Hospital Attikon General Hospital Of West Attica H Agia Varvara","Dimitrios Boumpas","希腊","NA","Athens"],["General University Hospital Of Larissa","Christina Katsiari","希腊","Thessalia","Larissa"],["LAIKO GENERAL HOSPITAL OF ATHENS","Menelaos Manoussakis","希腊","NA","Athens"],["Vital Medical Center Orvosi es Fogaszati Kozpont","Edit Drescher","匈牙利","NA","Veszprem"],["Semmelweis University","Zsofia Kiss","匈牙利","NA","Budapest"],["Obudai Egeszsegugyi Centrum Kft","Monika Kovacs","匈牙利","NA","Zalaegerszeg"],["Szegedi Tudományegyetem áok Szent-Gyorgyi Albert Klinikai Kozpont","Laszlo Kovacs","匈牙利","NA","Szeged"],["Bekes Varmegyei Kozponti Korhaz Pandy Kalman Tagkorhaz","Tibor Martyin","匈牙利","NA","Gyula"],["Betegapolo Irgalmas Rend Budai Irgalmasrendi Korhaz","Bernadette Rojkovich","匈牙利","NA","Budapest"],["Qualiclinic Kft","Istvan Szombati","匈牙利","NA","Budapest"],["Debreceni Egyetem Klinikai Kozpont","Tunde Tarr","匈牙利","Hajdu-Bihar","Debrecen"],["Vita Verum Medical Egeszsegugyi Szolgaltato Bt","Tunde Varga","匈牙利","NA","Szekesfehervar"],["Pecsi Tudomanyegyetem Klinikai Kozpont","Cecilia Varju","匈牙利","NA","Pecs"],["Barzilai Medical Center","Jennifer Ben Shimol","以色列","South District","Ashkelon"],["Rambam Health Care Campus","Yolanda Braun","以色列","NA","Haifa"],["Tel Aviv Sourasky Medical Center","Tali Eviatar","以色列","Tel Aviv District","Tel Aviv Yafo"],["Meir Medical Center","Shay Kivity","以色列","Center District","Kfar-Sava"],["Sheba Medical Center","Merav Lidar","以色列","Tel Aviv District","Ramat Gan"],["Hadassah Ein-Qarem Medical Center","Bracha Mazal Markovich","以色列","Jerusalem District","Jerusalem"],["Galilee Medical Center","Mohammad Naffaa","以色列","North District","Nahariyya"],["Rabin Medical Center","Ari Polachek","以色列","Center District","Petah Tikva"],["Tzafon Medical Center Poria","Firas Sabbah","以色列","NA","Ramat Poriya"],["Bnai Zion Medical Center","Gleb Slobodin","以色列","Haifa District","Haifa"],["Carmel Medical Center","Devy Zisman","以色列","Haifa District","Haifa"],["Azienda Ospedaliera Universitaria Integrata Verona","Giovanni Adami","意大利","Verona","Verona"],["Ospedale La Colletta","Dario Camellino","意大利","Liguria","Arenzano"],["ASST Spedali Civili Brescia","Ilaria Cavazzana","意大利","Lombardia","Brescia"],["Fondazione Policlinico Universitario A Gemelli IRCCS","Maria Antonietta D Agostino","意大利","Lazio","Roma"],["Ospedale San Raffaele di Milano","Lorenzo Dagna","意大利","Lombardia","Milano"],["Ospedale S. Maria Della Misericordia","Ginevra De Marchi","意大利","NA","Udine"],["Azienda Ospedaliero-Universitaria Policlinico di Catania","Rosario Foti","意大利","Sicilia","Catania"],["A.O. Ordine Mauriziano Di Torino - Ospedale Mauriziano Umberto","Mariele Gatto","意大利","Piemonte","Torino"],["Centro Specialistico Ortopedico Traumatologico Gaetano Pini CTO","Maria Gerosa","意大利","Lombardia","Milano"],["Bio-Medico Campus University Hospital","Roberto Giacomelli","意大利","Lazio","Roma"],["Istituto Clinico Humanitas","Elisa Gremese","意大利","Lombardia","Rozzano"],["Azienda Ospedaliero Universitaria Policlinico Paolo Giaccone","Giuliana Guggino","意大利","Sicilia","Palermo"],["Azienda Ospedaliero Universitaria Delle Marche","Gianluca Moroncini","意大利","Marche","Ancona"],["A.O.U. Citta della Salute e della Scienza di Torino - Presidio Molinette","Simone Parisi","意大利","Piemonte","Torino"],["Azienda Ospedaliera di Perugia Ospedale S.Maria della Misericordia","Carlo Perricone","意大利","Umbria","Perugia"],["Azienda Ospedaliera San Camillo-Forlanini","Giandomenico Sebastiani","意大利","Lazio","Roma"],["National Hospital Organization Asahikawa Medical Center","Fuminori Hirano","日本","NA","Asahikawa"],["Institute of Science Tokyo Hospital","Tadashi Hosoya","日本","Tokyo","Bunkyo ku"],["Shimane University Hospital","Kunihiro Ichinose","日本","NA","Shimane"],["Kitano Hospital","Yoshitaka Imura","日本","NA","Osaka"],["National Hospital Organization Kyushu Medical Center","Motoko Ishida","日本","Fukuoka","Fukuoka"],["Tohoku Medical And Pharmaceutical University Hospital","Tomonori Ishii","日本","Miyagi","Sendai"],["Hyogo Prefectural Amagasaki General Medical Center","Goichi Kageyama","日本","NA","Hyogo"],["National Center for Global Health and Medicine","Hiroshi Kaneko","日本","Tokyo","Shinjuku- Ku"],["Toyama University Hospital","Masaru Kato","日本","Toyama","Toyama-shi"],["Tokyo Women's Medical University Hospital","Yasuhiro Katsumata","日本","Tokyo","Shinjuku-ku"],["Chukyo Hospital","Masanari Kodera","日本","NA","Aichi"],["Hokkaido University Hospital","Michihito Kono","日本","Hokkaido","Sapporo-shi"],["Juntendo University Hospital Urayasu","Shinji Morimoto","日本","NA","Chiba"],["Ome Medical Center","Kenji Nagasaka","日本","NA","Tokyo"],["University of Yamanashi Hospital","Daiki Nakagomi","日本","NA","Chuo"],["Hitachinaka General Hospital","Hidetomo Oguni","日本","NA","Ibaraki"],["St. Luke's International Hospital","Masato Okada","日本","NA","Tokyo"],["Tokai University Hospital","Kenji Oku","日本","Kanagawa","Isehara"],["Shinkenko Clinic","Masato Oroku","日本","Okinawa","Naha"],["Tokyo Metropolitan Cancer and Infectious Diseases Center Komagome Hospital","Keigo Setoguchi","日本","NA","Tokyo"],["Fukushima Medical University Hospital","Yasuhiro Shimojima","日本","Fukushima","Fukushima"],["Toho University Medical Center Omori Hospital","Takahiko Sugihara","日本","NA","Ota"],["Hiroshima Prefectural Hospital","Satoshi Yamasaki","日本","Hiroshima","Hiroshima-shi"],["Tokyo Metropolitan Tama Medical Center","Naoto Yokogawa","日本","Tokyo","Fuchu"],["Gachon University Gil Medical Center","Hyo Jin Choi","韩国","Incheon","Incheon"],["Seoul National University Bundang Hospital","You-Jung Ha","韩国","NA","Gyeonggi-do"],["Chonnam National University Hospital","Shin Seok Lee","韩国","Gwangju","Gwangju"],["Asan Medical Center","ChangKeun Lee","韩国","Seoul","Seoul"],["Dong-A University Hospital","Sung Won Lee","韩国","Busan","Busan"],["Seoul National University Hospital","Jin Kyun Park","韩国","Seoul Teugbyeolsi","Seoul"],["The Catholic university of Korea, St. Vincent's Hospital","Yune-Jung Park","韩国","NA","Gyeonggi-do"],["Ajou University Hospital","Chang-Hee Suh","韩国","Gyeonggi-do","Suwon-si"],["Hanyang University Medical Center","Yoon Kyoung Sung","韩国","Seoul","Seoul"],["Hospital Sultanah Nur Zahirah","Siti Mariam Ab Rahim","马来西亚","Terengganu","Kuala"],["Prince Court Medical Centre","Ramani Arumugam","马来西亚","NA","Kuala Lumpur"],["Sunway Medical Centre","Chee Ken Cheah","马来西亚","Selangor","Petaling Jaya, Selangor"],["Hospital Taiping","Ee Ling Lai","马来西亚","Perak","Taiping"],["Hospital Pulau Pinang","Ai Lee Lim","马来西亚","Pulau Pinang","George Town"],["Hospital Tuanku Jaafar","Nadiah Mohd Noor","马来西亚","Negeri Sembilan","Seremban"],["Hospital Kuala Lumpur","Choon Seong Ng","马来西亚","Wilayah Persekutuan Kuala Lumpur","Kuala Lumpur"],["Hospital Sultan Ismail","Surendran Ramasamy","马来西亚","Johor Darul Ta zim","Johor Bahru"],["Hospital Putrajaya","Azwarina Hanim Ramlan","马来西亚","Wilayah Persekutuan Putrajaya","Putrajaya"],["University Kebangsaan Malaysia Medical Centre","Syahrul Sazliyana Shaharir","马来西亚","Kuala Lumpur","Kuala Lumpur"],["Hospital Umum Sarawak","Cheng Lay Teh","马来西亚","Sarawak","Kuching"],["University Malaya Medical Centre","Fariz Yahya","马来西亚","Kuala Lumpur","Kuala Lumpur"],["CICMEX Centro de Investigacion Clinica de Mexico","Maria Dolores Alonso Martinez","墨西哥","Mic","Morelia"],["Instituto Nacional de Rehabilitacion","Deshire Alpizar Rodriguez","墨西哥","Ciudad de Mexico","Ciudad de Mexico"],["Medical Care & Research SA de CV","Aaron Alejandro Barrera Rodriguez","墨西哥","Yucatan","Merida"],["Clinica de Investigacion en Reumatologia y Obesidad","Sergio Duran Barragan","墨西哥","Jalisco","Guadalajara"],["Hospital Universitario Dr Jose Eleuterio Gonzalez","Diana Elsa Flores Alvarado","墨西哥","Nuevo Leon","Monterrey"],["Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran","Diana Gomez-Martin","墨西哥","CDMX","Mexico D F"],["Centro Medico Nacional Siglo XXI IMSS","Jose Ramiro Hernandez Vasquez","墨西哥","CDMX","Ciudad de Mexico"],["Arke SMO SA de CV","Claudia Liliana Larrondo Hernandez","墨西哥","Veracruz","Veracruz"],["Centro de Investigacion de Tratamientos Innovadores de Sinaloa","Marco Antonio Maradiaga Cecena","墨西哥","Sinaloa","Culiacan"],["Investigación y Biomedicina de Chihuahua","Cesar Pacheco","墨西哥","Chihuahua","Chihuahua"],["Hospital SMIQ","Angelica Pena Ayala","墨西哥","Queretaro","Queretaro"],["Instituto Jalisciense de Metabolismo, SC","Maria Esther Perez Bastidas","墨西哥","Jalisco","Guadalajara"],["RM Pharma Specialists","Jaime Reyes Gonzaga","墨西哥","CDMX","Ciudad de Mexico"],["Centro de Alta Especialidad en Reumatologia e Investigacion del Potosi","Juan Cruz Rizo Rodriguez","墨西哥","S L P","San Luis Potosi"],["Hospital Angeles Lomas","Luis Francisco Valdes Corona","墨西哥","NA","Huixquilucan"],["Centro Medico del Angel","Beatriz Zazueta","墨西哥","NA","Mexicali"],["Haukeland University Hospital","Bjorg Tilde Fevang","挪威","NA","Bergen"],["Sykehuset Ostfold","Anne Julsrud Haugen","挪威","Ostfold","Gralum"],["Oslo universitetssykehus HF, Rikshospitalet","Oyvind Molberg","挪威","NA","Oslo"],["Universitetssykehuset Nord-Norge HF","Aksel Thuv Nilsen","挪威","NA","Tromso"],["Stavanger University Hospital","Jens Vikse","挪威","Rogaland","Stavanger"],["Malopolskie Badania Kliniczne Sp z o o","Bogdan Batko","波兰","NA","Krakow"],["MICS Centrum Medyczne Warszawa","Malgorzata Gryka Marton","波兰","NA","Warszawa"],["MICS Centrum Medyczne Bydgoszcz","Katarzyna Kolossa","波兰","NA","Bydgoszcz"],["NZOZ Lecznica MAK MED S C","Marek Krogulec","波兰","Wojewodztwo mazowieckie","Nadarzyn"],["NZOZ BIF MED","Hanna Mastalerz","波兰","Wojewodztwo slaskie","Bytom"],["Twoja Przychodnia - Centrum Medyczne Nowa Sol","Malgorzata Miakisz","波兰","NA","Nowa Sol"],["Rheuma Medicus Sp z o o","Robert Rupinski","波兰","Mazowieckie","Warszawa"],["Provita Sp z o o","Magdalena Wloch-Targonska","波兰","NA","Katowice"],["Jan Biziel's University Hospital","Rafal Wojciechowski","波兰","Wojewodztwo kujawsko pomorskie","Bydgoszcz"],["Innova Clinic sp z o o","Tomasz Wysocki","波兰","NA","Plonsk"],["Twoja Przychodnia Poznanskie Centrum Medyczne","Agata Wytyk-Nowak","波兰","NA","Poznan"],["ULSAM - HOSP. CONDE DE BERTIANDOS","Jose Antonio Costa","葡萄牙","NA","Ponte de Lima"],["ULS COIMBRA - HOSP. UNIV. COIMBRA","Luis Inês","葡萄牙","NA","Coimbra"],["ULS SANTA MARIA - HOSP. SANTA MARIA","Nikita Khmelinskii","葡萄牙","NA","Lisboa"],["ULS SANTO ANTONIO - HOSP. SANTO ANTONIO","Antonio Marinho","葡萄牙","Porto","Porto"],["ULS SAO JOSE - HOSP. CURRY CABRAL","Eunice Patarata","葡萄牙","Lisboa","Lisboa"],["ULS GAIA ESPINHO","Patricia Pinto","葡萄牙","Porto","Vila Nova de Gaia"],["ULS ALGARVE - HOSP. FARO","Celia Ribeiro","葡萄牙","Faro","Faro"],["ULS ALMADA SEIXAL - HOSP. GARCIA DE ORTA","Sandra Sousa","葡萄牙","Setubal","Almada"],["Hiperdia Piata Sudului","Georgeta Camelia Badea","罗马尼亚","Bucuresti","Bucuresti"],["Spitalul Clinic Sfanta Maria","Andra Balanescu","罗马尼亚","Bucuresti","Bucharest"],["Spitalul Clinic Judetean de Urgenta","Iuliana-Mirela Biagini","罗马尼亚","Bacau","Bacau"],["OEC Perseide Research SRL","Anca Maria Dima","罗马尼亚","Ilfov","Afumati"],["Centrul Medical de Diagnostic si Tratament Ambulator NEOMED","Liliana Duca","罗马尼亚","NA","Brasov"],["Quantum Medical Center Srl","Catalina Irina Florea","罗马尼亚","Sector 2","Bucharest"],["Spitalul Clinic Colentina","Razvan Ionescu","罗马尼亚","Bucuresti","Bucuresti"],["Medisof Diagnostic S R L","Anca Emanuela Musetescu","罗马尼亚","DJ","Craiova"],["CCBR Clinical Research","Sorica Mustatea","罗马尼亚","Bucuresti","Bucuresti"],["Spitalul Clinic Judetean de Urgenta Cluj","Simona Rednic","罗马尼亚","CJ","Cluj Napoca"],["Spitalul Clinic Judetean de Urgenta Oradea","Cristian Gavril Toma","罗马尼亚","BH","Oradea"],["Private Practice Dr Carina Anna Triff","Carina Anna Triff","罗马尼亚","Timis","Timisoara"],["Clinical Center of Vojvodina","Sonja Golubovic","塞尔维亚","Vojvodina","Novi Sad"],["Institute of Rheumatology","Predrag Ostojic","塞尔维亚","NA","Belgrade"],["Institute of Rheumatology","Slavica Pavlov Dolijanovic","塞尔维亚","NA","Belgrade"],["Military Medical Academy","Gorica Ristic","塞尔维亚","Beograd","Belgrade"],["Institute of Rheumatology","Mirjana Sefik Bukilica","塞尔维亚","NA","Belgrade"],["University Clinical Center Kragujevac","Aleksandra Tomic Lucic","塞尔维亚","sumadijski okrug","Kragujevac"],["University Clinical Center Kragujevac","Mirjana Veselinovic","塞尔维亚","sumadijski okrug","Kragujevac"],["MEDMAN s.r.o.","Viliam Manka","斯洛伐克","Zilinsky kraj","Martin"],["Zazabie s.r.o.","Juraj Semancik","斯洛伐克","NA","Kosice"],["Narodny Ustav Reumatickych Chorob","Alena Tuchynova","斯洛伐克","Trnavsky kraj","Piestany"],["Reumatologicka ambulancia MUDr Michaele Zarikova","Michaele Zarikova","斯洛伐克","NA","Kosice"],["Panorama Medical Centre","Ingrid Louw","南非","NA","Cape Town"],["TASK Central","Reinard McPherson","南非","Western Cape","Cape Town"],["Netcare Umhlanga Medical Centre","Asokan Naidoo","南非","KZN","Umhlanga Rocks"],["Excellentis Clinical trial Consultants","Marinda Smit","南非","Western Cape","George"],["Arthritis Clinical Research Centre","Catherine Elizabeth Spargo","南非","Western Cape","Cape Town"],["Winelands Medical Research Centre","Gareth Tarr","南非","WC","Stellenbosch"],["HOSP. UNIV. RIO HORTEGA","Maria Julia Barbado Ajo","西班牙","NA","Valladolid"],["HOSP. UNIV. MARQUES DE VALDECILLA","Ricardo Blanco Alonso","西班牙","CB","Santander"],["Hospital Vall d'Hebron","Josefina Cortes Hernandez","西班牙","BARCELONA","Barcelona"],["COMPLEJO HOSP DE NAVARRA - HOSP DE NAVARRA","Patricia Fanlo","西班牙","NC","Pamplona"],["HOSP. INFANTA LUISA","Lola Fernandez De La Fuente Burson","西班牙","NA","Sevilla"],["HOSP.UNIV.PARC TAULI","Silvia Garcia Cirera","西班牙","CT","Sabadell"],["HOSP. CLINICO UNIV. LOZANO BLESA","Borja Gracia","西班牙","NA","Zaragoza"],["HOSP. GRAL. JUAN RAMON JIMENEZ","Marta Llanes","西班牙","NA","Huelva"],["HOSP. DE LA SANTA CREU I SANT PAU","Berta Paula Magallares Lopez","西班牙","CT","Barcelona"],["HOSP. CLINICO UNIV. DE SANTIAGO","Eva Perez Pampin","西班牙","GA","Santiago de Compostela"],["HOSP. CLINIC DE BARCELONA","Ignasi Rodriguez Pinto","西班牙","CT","Barcelona"],["HOSP. UNIV. INFANTA LEONOR","Ana Salome","西班牙","MD","Madrid"],["HOSP. DE MERIDA","Raul Veroz","西班牙","Badajoz","Merida"],["Universitatsspital Basel","Diego Kyburz","瑞士","BS","Basel"],["Kantonsspital St Gallen","Andrea Rubbert-Roth","瑞士","SG","St Gallen"],["Hopitaux Universitaires de Geneve - HUG","Geoffrey Urbanski","瑞士","GE","Geneve"],["Saraburi Hospital","Nittayawadee Aeamsaard","泰国","NA","Saraburi"],["Phramongkutklao Hospital","Sumapa Chaiamnuay","泰国","NA","Bangkok"],["Maharaj Nakorn Chiang Mai Hospital","Nuntana Kasitanon","泰国","NA","Chiang Mai"],["Siriraj Hospital","Ajchara Koolvisoot","泰国","Krung Thep Maha Nakhon","Bangkok"],["Ramathibodi Hospital Mahidol University","Pintip Ngamjanyaporn","泰国","NA","Bangkok"],["Chakri Naruebodindra Medical Institute","Pipat Ngammisri","泰国","NA","Samut Prakan"],["Phrapokklao Hospital","Veerapong Phumethum","泰国","NA","Chanthaburi"],["Ankara Bilkent Sehir Hastanesi","Berkan Armagan","土耳其","NA","Ankara"],["Ankara University Medical Faculty","Askin Ates","土耳其","Ankara","Ankara"],["Antalya Training And Research Hospital","Sibel Bakirci","土耳其","NA","Antalya"],["Kocaeli University Medical Faculty","Ayse Cefle","土耳其","Kocaeli","Kocaeli"],["Uludag Universitesi Tip Fakultesi Hastanesi","Ediz Dalkilic","土耳其","Nilufer","Bursa"],["Marmara University Istanbul Pendik Education and Research Hospital","Guzide Nevsun Inanc","土耳其","Istanbul","Istanbul"],["Hacettepe University Medical Faculty","Levent Kilic","土耳其","Sihhiye","Ankara"],["Sanko Universitesi Hastanesi","Bunyamin Kisacik","土耳其","Gaziantep","Gaziantep"],["Firat University Hospital","Suleyman Serdar Koca","土耳其","NA","Elazig"],["Necmettin Erbakan University Meram Medical Faculty","Adem Kucuk","土耳其","NA","Konya"],["Izmir Katip Celebi University Ataturk Training and Research Hospital","Dilek Solmaz","土耳其","NA","Izmir"],["Newcastle Freeman Hospital","Lucy Marie Carter","英国","NA","Newcastle Upon Tyne"],["University Hospitals of Derby and Burton NHS Trust","Sudipto Das","英国","NA","Derby"],["Southampton University Hospital","Christopher Edwards","英国","England","Southampton"],["Guy's and St Thomas' NHS Foundation Trust","Michelle Fernando","英国","England","Greater London"],["Royal Berkshire Hospital","Jeremy McNally","英国","NA","Reading"],["Royal Free London NHS Foundation Trust","Rapti Mediwake","英国","NA","Barnet"],["Great Western Hospital","Elizabeth Price","英国","NA","Swindon"],["Peterborough City Hospital","Poonam Sharma","英国","England","Peterborough"],["Addenbrookes Hospital","Nicholas Shenker","英国","England","Cambridge"],["Royal National Hospital for Rheumatic Diseases","Sarah Skeoch","英国","England","Bath"],["Haywood Hospital","Bilal Tarar","英国","England","Stoke on Trent"],["Morehouse School of Medicine","Ganiat Adeogun","美国","GA","Atlanta"],["West Tennessee Research Institute","Jacob Aelion","美国","TN","Jackson"],["CTR Sanford LLC","Ajay Ajmani","美国","NC","Sanford"],["LeJenue Research Associates PLLC","Jose Aldrich","美国","FL","Miami"],["Midtown Allergy and Arthritis Care PC","Frederick Ast","美国","NY","New York"],["Omega Research Consultants","Kwabena Ayesu","美国","FL","Debary"],["Carilion Clinic Virginia Tech Carilion School of Medicine","Adegbenga Bankole","美国","VA","Roanoke"],["Epic Medical Research","Rajat Bhatt","美国","TX","Richmond"],["DJL Clinical Research, PLLC","Emily Jane Box","美国","NC","Charlotte"],["Advanced Rheumatology of Houston","Tamar Brionez","美国","TX","The Woodlands"],["Trio Clinical Trials LLC","Hina Budhwani","美国","TX","Houston"],["Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center","Viet Bui","美国","CA","Torrance"],["Rutgers New Jersey Medical School","Eugenio Capitle","美国","NJ","Newark"],["Clinical Research of West Florida","John Carter","美国","FL","Tampa"],["Hometown Urgent Care and Research","Steve Choi","美国","OH","Huber Heights"],["Clindove Research LLC","Nelly Cohen","美国","NY","Brooklyn"],["Profound Research LLC at Associated Rheumatology Consultants","Bryan Coniglio","美国","MI","Farmington Hills"],["Willow Rheumatology and Wellness PLLC","Angela Crowley","美国","IL","Willowbrook"],["Overlake Arthritis and Osteoporosis Center","Arinola Dada","美国","WA","Bellevue"],["Epic Medical Research","Maria De Jesus Salinas","美国","Texas","San Marcos"],["Pro-Care Research Center, Corp.","Daniel De Lamadrid","美国","FL","Miami Gardens"],["Cross Creek Medical Clinic","Nitin Desai","美国","NC","Fayetteville"],["Paramount Medical Research & Consulting","Isam Diab","美国","OH","Middleburg Heights"],["Icahn School of Medicine at Mt. Sinai","Chrisanna Dobrowolski","美国","NY","New York"],["Soha Dolatabadi MD","Soha Dolatabadi","美国","CA","Los Angeles"],["Paradigm Clinical Research Centers, Inc.","Zachary Fellows","美国","CA","San Diego"],["Avanti Clinical Research Corp","Lazaro Garrido","美国","FL","Hialeah"],["Arthritis & Rheumatic Disease Specialties","Norman Gaylis","美国","FL","Aventura"],["East Bay Rheumatology Medical Group","Suneet Grewal","美国","CA","San Leandro"],["David S Hallegua MD A Professional Corporation","David Hallegua","美国","CA","Beverly Hills"],["Fort Bend Rheumatology Associates PLLC","Jesus Edward Hernandez","美国","TX","Sugar Land"],["Advanced Medical Research","Gerald Ho","美国","CA","La Palma"],["Alpine Research TC LLC","Ryan Hoggan","美国","UT","Clinton"],["Revive Research Institute","Syed Ali Husain","美国","MI","Sterling Heights"],["Vantage Clinical Trials Tampa","Edgard Janer","美国","FL","Tampa"],["St. Lawrence Health System","Eyal Kedar","美国","NY","Potsdam"],["Albuquerque Clinical Trials, Inc.","Satkirin Khalsa","美国","NM","Albuquerque"],["R and H Clinical Research","Maryam Khawari","美国","TX","Katy"],["Solace Clinical Research California","Roger Kornu","美国","CA","Tustin"],["Purushotham, Akther & Roshan Kotha, MD Inc.","Roshan Kotha","美国","Ca","La Mesa"],["Novak Clinical Research","Thili Kulatilake","美国","AZ","Tucson"],["Medvin Clinical Research","Dan La","美国","CA","Tujunga"],["Boeson Research","Richard Lai","美国","MT","Great Falls"],["Stryde Research - Allen Medical Pavilion","John Lavery","美国","TX","Allen"],["Inland Rheumatology Clinical Trials Inc.","Eric Lee","美国","CA","Upland"],["Clinical Research Philadelphia","Lawrence Leventhal","美国","PA","Philadelphia"],["Clinical Research of West Florida","Robert Levin","美国","FL","Clearwater"],["Latin Clinical Trial Center","Reynaldo Lopez","美国","FL","Tamarac"],["TriWest Research Associates, LLC","Arthur Mabaquiao","美国","CA","Chula Vista"],["CTR Oakwater LLC","Arvind Madan","美国","FL","Orlando"],["Millennium Clinical Trials LLC","Tony Makhlouf","美国","CA","Westlake Village"],["Southland Arthritis and Osteoporosis Medical Center Inc dba Southland Arthritis","Amal Mehta","美国","CA","Hemet"],["Hawthorne Health Bienestar Lindenwold","Suzanne Mela","美国","NJ","Lindenwold"],["Accurate Clinical Research, Inc.","Enrique Mendez","美国","LA","Lake Charles"],["Dolphin Medical Research","Otto Mendoza","美国","FL","Doral"],["Floridian Clinical Research LLC","Christopher Mesa","美国","FL","Miami Lakes"],["Low Country Rheumatology PA","Jennifer Murphy","美国","SC","Summerville"],["Joint and Muscle Research Institute","Alireza Nami","美国","NC","Charlotte"],["Valerius Medical Group & Research Center","Nathaniel Neal","美国","CA","Los Alamitos"],["Imax Clinical Trials, LLC","Minh Nguyen","美国","CA","La Palma"],["Providence Medical Foundation","Shirley Pang","美国","CA","Fullerton"],["Epic Medical Research","Sunny Patel","美国","TX","Red Oak"],["Arthritis and Rheumatology Research Institute","Megha Patel-Banker","美国","TX","Allen"],["University of Tennessee Health Science Center","Debendra Pattanaik","美国","TN","Memphis"],["CTR Clermont LLC","Priya Prakash","美国","FL","Clermont"],["Atlanta Research Center for Rheumatology","Roel Querubin","美国","GA","Marietta"],["Sun Research Institute","Leonel Reyes","美国","TX","San Antonio"],["St. Paul Rheumatology P A","David Ridley","美国","MN","Eagan"],["Rheumatology Center of San Diego","Tania Rivera","美国","CA","San Diego"],["Wright State Physicians Health Center","Craig Rohan","美国","OH","Fairborn"],["Amarillo Center for Clinical Research","Constantine Saadeh","美国","TX","Amarillo"],["ERA Research Solutions","Sergey Shealy Sorin","美国","MO","Springfield"],["Unity Health-White County Medical Center","Shailendra Singh","美国","AR","Searcy"],["Southwest Rheumatology Research LLC","Atul Singhal","美国","TX","Mesquite"],["Adtremed Inc","Raidel Valdes Crespo","美国","FL","Tampa"],["Integral Rheumatology And Immunology Specialists","Guillermo Valenzuela","美国","FL","Plantation"],["West Texas Clinical Research","Jitendra Vasandani","美国","TX","Lubbock"],["Texas Rheumatology Research Institute LLC","Fehmida Zahabi Unwala","美国","TX","Plano"]]

序号	机构名称	主要研究者	国家	省（州）	城市

[["北京大学人民医院伦理审查委员会","同意","2026-02-06"]]

序号	名称	审查结论	批准日期/备案日期

进行中（尚未招募）

目标入组人数	国内: 60 ； 国际: 600 ；
已入组人数	国内: 登记人暂未填写该信息； 国际: 登记人暂未填写该信息；
实际入组总人数	国内: 登记人暂未填写该信息； 国际: 登记人暂未填写该信息；

第一例受试者签署知情同意书日期	国内：登记人暂未填写该信息；     国际：登记人暂未填写该信息；
第一例受试者入组日期	国内：登记人暂未填写该信息；     国际：登记人暂未填写该信息；
试验完成日期	国内：登记人暂未填写该信息；     国际：登记人暂未填写该信息；