上海Atezolizumab注射液III期临床试验-评价Atezolizumab联合化疗和培美曲塞治疗非小细胞肺癌的研究

登记号	CTR20170064	试验状态	进行中
申请人联系人	刘臻	首次公示信息日期	2017-04-06
申请人名称	F.Hoffmann-La Roche Ltd/ Roche Diagnostics GmbH/ 罗氏（中国）投资有限公司

登记号	CTR20170064
相关登记号	暂无
药物名称	Atezolizumab注射液
药物类型	生物制品
临床申请受理号	JXSL1600017
适应症	既往未接受过化疗的IV期非鳞状非小细胞肺癌
试验专业题目	未接受化疗的IV期非鳞状非小细胞肺癌患者评价Atezolizumab联合卡铂或顺铂+培美曲塞开放性、随机化、III期研究
试验通俗题目	评价Atezolizumab联合化疗和培美曲塞治疗非小细胞肺癌的研究
试验方案编号	GO29438	方案最新版本号	暂无
版本日期:	暂无	方案是否为联合用药	企业选择不公示

申请人名称	1 2 3
联系人姓名	刘臻	联系人座机	021-28922888	联系人手机号	暂无
联系人Email	china.public_cco@roche.com	联系人邮政地址	上海市浦东新区龙东大道1100号	联系人邮编	201203

评价Atezolizumab联合卡铂或顺铂+培美曲塞对比卡铂或顺铂+培美曲塞在治疗既往未接受过化疗的IV期非鳞状非小细胞肺癌患者的疗效，安全性，药理学和患者自报结果。

试验分类	安全性和有效性	试验分期	III期	设计类型	平行分组
随机化	随机化	盲法	开放	试验范围	国际多中心试验

年龄	18岁(最小年龄)至 无岁(最大年龄)
性别	男+女
健康受试者	无
入选标准	1 签署知情同意书 2 年龄18岁及18岁以上，性别不限 3 ECOG体力状况评分为0或1， 组织学或细胞学检查结果证实为IV期非鳞状NSCLC（根据国际抗癌联盟/美国癌症联合委员会癌症分期系统，第7版）。 患有混合型非鳞状细胞组织学（即，鳞状和非鳞状）肿瘤的患者，如果主要组织学类型显示为非鳞状，则符合入选资格。 4 既往未治疗过的 IV 期非鳞状 NSCLC 鉴于厄洛替尼、吉非替尼或其他 EGFR TKI 适用于初治 EGFR 突变型 NSCLC，排除 EGFR 敏化突变的患者。 鉴于克唑替尼或其他 ALK 抑制剂适用于初治携带 ALK 融合基因的 NSCLC 患者，排除携带 ALK 融合基因患者。 对 EGFR 和 ALK 状态不明的患者需在筛选期进行测定。ALK 和/或 EGFR 状态由当地或中心实验室进行评估。 5 已接受过以治愈为目的的新辅助治疗、辅助化疗、放疗或放化疗治疗非转移性疾病的患者必须自末次化疗和/或放疗后至随机分配至少间隔6个月。 6 已接受过治疗的无症状CNS转移癌病史患者，只要符合下列所有标准，即可参与本项研究： 仅发生幕上和小脑转移（即，未转移至中脑、脑桥、延髓或脊髓） 目前无需皮质类固醇治疗的CNS病情 在随机分配前7天内未进行立体定向放射治疗或前14天内未进行全脑放射治疗 在CNS定向治疗结束后至筛选期影像学检查，无中期进展的证据 如果在筛选期扫描时检测到患者出现新的无症状CNS转移，则必须接受放射治疗和/或CNS转移灶的手术。上述患者治疗结束后，如果满足全部其他标准，无需接受随机分配前额外的脑部扫描也可认定符合入选资格。 7 患者应当递交一份治疗前肿瘤组织样本（如存在）。没有存档样本肿瘤组织时（如诊断检查前已用尽），患者仍可进入研究。如果可以提供肿瘤组织样本，首选代表性的福尔马林固定石蜡包埋（FFPE）肿瘤样本，或FFPE肿瘤标本的未染色新制备的连续组织切片（至少10张）。如果不足10张切片，可以递交较少的切片。 如果无上述FFPE样本，其他类型的样本（包括细针抽吸样本、分离细胞样本 [如，来自胸腔积液] 和灌洗液样本）也可接受。 还必须提供上述标本的相关病理报告。应当在入选前或入选后4周内递交任何可用的肿瘤组织样本。 8 根据RECIST v1.1定义的可测量病灶 只有在既往照射病灶在放疗后出现明确疾病进展，并且该既往照射病灶不是唯一病灶的情况下，才可以考虑该病灶为可测量病灶。 9 满足下述实验室检查结果定义的足够的血液学和终末器官功能，这些检查结果需在随机分配前14天内完成： 未接受粒细胞集落刺激因子支持治疗的情况下，ANC ≥ 1500个细胞/μL 淋巴细胞计数≥500/μL 未输液的血小板计数≥ 100,000/μL 血红蛋白≥9.0 g/dL 患者可能因输血达到该项标准。 INR或aPTT≤1.5倍的正常值上限（ULN） 该标准仅适用于目前没有接受抗凝治疗的患者；对于目前正在接受抗凝治疗的患者，应已在接受稳定剂量的抗凝剂治疗。 AST、ALT和碱性磷酸酶≤2.5倍ULN，但下列情况除外： 确诊肝转移的患者：AST和/或ALT≤5 x ULN 确诊肝转移或骨转移患者：碱性磷酸酶≤5 x ULN 血清胆红素 ≤ 1.25倍ULN 患Gilbert病，血清胆红素水平≤3 x ULN的患者可入选。 计算的肌酐清除率（CRCL）≥45 mL/分钟，或如果使用顺铂治疗，计算的CRCL必须≥60 mL/分钟。 10 对于入选中国延长期队列的患者，必须为居住在中华人民共和国的居民。 11 对于具有生育能力的女性：同意在治疗期间以及研究治疗atezolizumab末次给药后至少5个月内或顺铂末次给药后至少6个月内保持禁欲（避免异性性交）或采取年失败率 12 对于男性患者：同意禁欲（避免异性性交）或采取避孕措施，并同意避免捐精，规定如下：对于其伴侣有生育能力的男性患者，必须在化疗治疗期间以及化疗末次给药后至少6个月内保持禁欲或采取避孕套+另一种避孕法，使年失败率
排除标准	1 EGFR敏感型基因或ALK融合致癌基因突变的患者 2 筛选期和既往影像学评估期间，经CT或磁共振成像（MRI）检测发现活动性或未治疗的CNS转移灶 3 未接受最终手术和/或放疗的脊髓压迫，或既往诊断和治疗的脊髓压迫，无证据显示在随机分配前该疾病在临床上已稳定达≥2周 4 软脑膜病灶 5 无法控制的肿瘤相关疼痛 需要止痛药治疗的患者必须在进入研究时已在接受稳定的止痛治疗方案。 若有适合姑息性放疗的症状性病灶（如骨转移或转移侵犯神经），应在随机分配前完成治疗。患者应从之前的放疗作用中得到恢复，未要求最短恢复期。 无症状的转移性病灶，如果其进一步生长可能会导致功能障碍或顽固性疼痛（如未表现出脊髓压迫的硬膜外转移），若适合，应在随机分配前考虑局部治疗。 6 无法控制的胸腔积液、心包积液，或需要反复引流的腹水（一月一次或更频繁） 留置导管（如PleurX？）的患者允许入选。 7 无法控制的或症状性高钙血症（> 1.5 mmol/L离子钙或钙> 12 mg/dL或校正后血清钙>ULN） 随机分配前接受地舒单抗治疗的患者，必须同意愿意在进入研究后终止地舒单抗治疗，并改用二磷酸盐治疗。 8 随机分配前5年内有除NSCLC外的恶性肿瘤病史，但转移或死亡风险可忽略不计（例如预期5年OS>90%），且经治疗后预期可痊愈的恶性肿瘤除外（如已适当治疗的宫颈原位癌，基底或鳞状细胞皮肤癌，接受根治性手术治疗的局限性前列腺癌，根治性手术治疗的导管原位癌） 9 采用IHC法确定的肿瘤PD-L1表达情况（如在进入抗PD-1或抗PD-L1抗体试验的筛选期间，测得PD-L1表达情况但不符合资格要求的患者从本研究中排除）。 10 妊娠、哺乳或计划在研究期间怀孕的女性 11 对嵌合或人源化抗体或融合蛋白有重度过敏、过敏性或其他超敏反应病史 12 已知对由中国仓鼠卵巢细胞生产的生物药品或atezolizumab制剂任何成分具有超敏反应或过敏反应 13 自身免疫性疾病病史，包括但不限于重症肌无力、肌炎、自身免疫性肝炎、系统性红斑狼疮、类风湿性关节炎、炎症性肠病、抗磷脂综合征相关的血管血栓形成、韦格纳肉芽肿病、干燥综合征、格林－巴利综合征、多发性硬化、血管炎、肾小球肾炎等自身免疫疾病，具有自身免疫相关甲状腺机能减退病史但已在接受稳定剂量的甲状腺激素替代疗法的患者有资格入选研究。 血糖得以控制的1型糖尿病患者，如果已在接受稳定剂量的胰岛素治疗方案，则有资格参与本项研究。 仅出现皮肤病症的湿疹、银屑病、慢性单纯性苔藓或白癜风神经性皮炎患者（如，排除银屑病关节炎患者）允许参与本研究，但需符合以下标准： 皮疹占据的体表面积应小于10% 基线时疾病得到充分控制，并且仅需使用低效局部甾体类药物。 过去12个月内基础疾病未出现急性加重（无需PUVA[补骨脂素+紫外线A照射]、甲氨蝶呤、维甲类化合物、生物制剂、口服钙神经素抑制剂或者高效或口服甾体类药物） 14 患有特发性肺纤维化病史、机化性肺炎（如闭塞性细支气管炎）、药物性肺炎、特发性肺炎或胸部CT扫描筛选时发现活动性肺炎证据 照射野出现放射性肺炎（纤维化）病史的患者可参与本研究。 15 HIV检测结果呈阳性 在入选研究前对所有患者实施HIV检测，HIV检测结果呈阳性的患者将从临床研究中排除。 16 活动性乙肝（慢性或急性；定义为筛选期乙肝病毒表面抗原[HBsAg]检测结果呈阳性）或丙肝患者 既往乙肝病毒（HBV）感染或HBV感染已治愈的患者（定义为乙肝核心抗体[HBcAb]阳性且HBsAg阴性），仅HBV DNA为阴性的患者可参与本项研究。 丙肝病毒（HCV）抗体呈阳性的患者中，仅PCR显示HCV RNA呈阴性的患者可参与本项研究。 17 活动性肺结核 18 随机分配前4周内发生严重感染，包括但不限于需住院治疗的感染并发症、菌血症、重症肺炎等 19 随机分配前2周内接受过口服或静脉输注抗生素治疗 接受预防性抗生素治疗（如为预防尿路感染或预防慢性阻塞性肺疾病）的患者可入选。 20 患有严重的心血管疾病，如纽约心脏病学会心脏疾病（Ⅱ级或更高）、或随机分配前3个月内发生的心肌梗死或脑血管意外、不稳定性心律失常或不稳定型心绞痛 已知患有冠状动脉疾病、不符合上述标准的充血性心力衰竭、或左心室射血分数 21 随机分配前28天内接受过除诊断外的重大手术，或预期将在研究期间接受重大手术 22 既往接受过同种异体骨髓移植或实体器官移植的患者 23 随机分配前4周内接种减毒活疫苗的患者，或估计研究期间需要接种减毒活疫苗 24 任何其他疾病、代谢障碍、体检结果或实验室检查异常结果，并有理由怀疑可能导致禁忌使用研究药物、或影响研究结果可靠性、或使患者处于高风险的治疗并发症的疾病或病症。 25 影响患者理解、遵循和/或依从研究流程的疾病或病症 26 之前已用EGFR抑制剂或ALK抑制剂治疗 27 开始研究治疗前21天内接受任何已批准的抗癌治疗（包括激素疗法）。 28 随机分配前28天内，接受过以治疗为目的的任何其他研究药物治疗 29 既往接受过CD137激动剂或免疫检查点阻断疗法、抗PD-1和抗PD-L1治疗性抗体治疗 既往接受过抗细胞毒性T淋巴细胞相关抗原4（CTLA-4）治疗的患者，如果满足下列标准，则可以入选至研究： 抗CTLA-4末次给药至少在随机分配前6周 抗CTLA-4（NCI CTCAE 3或4级）治疗中未出现重度免疫相关不良反应史 30 在随机分配前4周内接受过全身免疫刺激剂治疗（包括但不限于干扰素或白介素-2）或仍处于治疗药物的5个半衰期内（取二者中较长者） 允许既往接受过癌症疫苗治疗。 31 随机分配前2周内，接受过全身免疫抑制药物治疗（包括但不限于皮质类固醇、环磷酰胺、硫唑嘌呤、甲氨蝶呤、沙利度胺和抗肿瘤坏死因子[抗TNF]药物）。 接受过急性、低剂量（≤10 mg口服泼尼松或等效药物）全身免疫抑制药物治疗的患者可入选本研究。 使用皮质类固醇（≤10 mg口服泼尼松或同等药物）治疗慢性阻塞性肺疾病的患者、盐皮质激素类（如氟氢可的松）治疗直立性低血压的患者，和使用低剂量皮质类固醇补充剂治疗肾上腺皮质功能减退的患者可以入选。 32 对顺铂、卡铂或其他铂化合物有过敏史 33 听力损伤的患者（顺铂） 34 按照NCI CTCAE v4.0标准，患有≥2级的周围神经病变（顺铂） 35 CRCL

试验药	序号 名称 用法 1 中文通用名:Atezolizumab注射剂 用法用量:注射液；规格1200mg/20ml；静脉注射，每3周一次，每次1200mg，治疗将持续直到失去临床获益、不可耐受的毒性、患者或医生决定中止治疗、或接受试验治疗的患者死亡。
对照药	序号 名称 用法 1 中文通用名:培美曲塞注射液英文名：Pemetrexed商品名：力比泰 用法用量:注射液；规格500mg；静脉注射，每3周一次，剂量为500mg/m2体表面积（BSA）。治疗将持续直到失去临床获益、不可耐受的毒性、患者或医生决定中止治疗、或接受试验治疗的患者死亡。

主要终点指标及评价时间	序号 指标 评价时间 终点指标选择 1 研究者按照RECIST v1.1 评估的无进展生存期和总生存期。 45个月 有效性指标
次要终点指标及评价时间	序号 指标 评价时间 终点指标选择 1 客观缓解率，缓解持续时间，达到缓解的时间，缓解时间，由独立评审机构评估的无进展生存期，标志性时间点（1年和2年）的总体生存率，患者自评结果。 45个月 有效性指标

1	姓名	陆舜	学位	暂无	职称	教授，主任医师
	电话	+86 13601813062	Email	shun_lu@hotmail.com	邮政地址	上海市徐汇区淮海西路241号
	邮编	200030	单位名称	上海市胸科医院

序号	机构名称	主要研究者	国家	省（州）	城市
1	上海市胸科医院	陆舜	中国	上海	上海
2	上海市胸科医院	陆舜	中国	上海	上海
3	浙江大学医学院附属第一医院	周建英	中国	浙江	杭州
4	浙江大学医学院附属第一医院	周建英	中国	浙江	杭州
5	安徽省立医院	潘跃银	中国	安徽	合肥
6	安徽省肿瘤医院	潘跃银	中国	安徽	合肥
7	常州市第一人民医院	朱丽娜	中国	江苏	常州
8	常州市第一人民医院	朱丽娜	中国	江苏	常州
9	复旦大学附属中山医院	胡洁	中国	上海	上海
10	复旦大学附属中山医院	胡洁	中国	上海	上海
11	北京大学肿瘤医院	方健	中国	北京	北京
12	北京肿瘤医院	方健	中国	北京	北京
13	天津医科大学总医院	钟殿胜	中国	天津	天津
14	天津医科大学总医院	钟殿胜	中国	天津	天津
15	湖南省肿瘤医院	杨农	中国	湖南	长沙
16	湖南省肿瘤医院	杨农	中国	湖南	长沙
17	江苏省人民医院	束永前	中国	江苏	南京
18	江苏省人民医院	束永前	中国	江苏	南京
19	广州医科大学附属第一医院	何建行	中国	广州	广东
20	国立台湾大学医学院附属医院	施金元	中国	台湾	台北
21	台湾荣民总医院	邱昭华	中国	台湾	台北
22	安徽省肿瘤医院	操乐杰	中国	安徽	合肥
23	福建医科大学附属协和医院	陈椿	中国	福建	福州
24	台湾三军总医院	张峰义	中国	台湾	台北
25	Peninsula and South Eastern Haematology and Oncology Grou	VINOD GANJU	AUSTRALIA	Victoria	FRANKSTON
26	复旦大学附属肿瘤医院	陈海泉	中国	上海	上海
27	浙江省肿瘤医院	范云	中国	浙江	杭州
28	Redcliffe Hospital	Kieron Bigby	AUSTRALIA	Queensland	Redcliffe
29	首都医科大学附属北京友谊医院	曹邦伟	中国	北京	北京
30	Ballarat Health Services	Stephen Brown	AUSTRALIA	Victoria	Ballarat
31	中国医科大学附属第一医院	刘云鹏	中国	辽宁	沈阳
32	St Vincents Hospital Sydney	Rachel Dear	AUSTRALIA	New South Wales	Darlinghurst
33	Medizinische Universitt Wien; Univ.Klinik für Innere Medizin I - Abt. für Onkologie	SABINE ZOECHBAUER-MUELLER	AUSTRIA	WIEN	WIEN
34	浙江大学医学院附属邵逸夫医院	潘宏铭	中国	浙江	杭州
35	O. Gesundheits- und Spitals-AG/LKH Steyr	JOSEF BOLITSCHEK	AUSTRIA	STEYR	STEYR
36	华中科技大学同济医学院附属同济医院	陈元	中国	湖北	武汉
37	Klinikum Wels-Grieskirchen GmbH	JOSEF ECKMAYR	AUSTRIA	WELS	WELS
38	北京肿瘤医院	王子平	中国	北京	北京
39	天津市肿瘤医院	王长利	中国	天津	天津
40	AZ Maria Middelares	Paul Germonpré	BELGIUM	Gent	Gent
41	国立台湾大学医学院附属医院	施金元	中国	台湾	台北
42	AZ Delta (Campus Wilgenstraat), Apotheek	Ingel Demedts	BELGIUM	Roeselare	Roeselare
43	UZ Antwerpen	Jan Van Meerbeeck	BELGIUM	EDEGEM	EDEGEM
44	台湾荣民总医院	邱昭华	中国	台湾	台北
45	Clinique André Renard; Pneumologie	Léon Bosquee	BELGIUM	Herstal	Herstal
46	台湾三军总医院	张峰义	中国	台湾	台北
47	Multiprofile Hospital for Active Treatment Dji Med EOOD; Department of Medical Oncology	Mayya Mileva	BULGARIA	Village Branipole	Village Branipole
48	Multiprofile Hospital for Active Treatment Dji Med EOOD; Department of Medical Oncology	Mayya Mileva	BULGARIA	Village Branipole	Village Branipole
49	National Specialized Hospital for Active Treatment of Oncology; Clinic of Chemotherapy	GALINA KURTEVA	BULGARIA	Sofia	Sofia
50	National Specialized Hospital for Active Treatment of Oncology; Clinic of Chemotherapy	GALINA KURTEVA	BULGARIA	Sofia	Sofia
51	Multiprofile Hospital for Active Treatment Serdika EOOD	Krasimir Koynov	BULGARIA	SOFIA	SOFIA
52	Multiprofile Hospital for Active Treatment Serdika EOOD	Krasimir Koynov	BULGARIA	SOFIA	SOFIA
53	Cross Cancer Institute	Naveen Basappa	CANADA	Alberta	EDMONTON
54	Cross Cancer Institute	Naveen Basappa	CANADA	Alberta	EDMONTON
55	Royal Victoria Regional Health Centre	Robert El-Maraghi	CANADA	Ontario	BARRIE
56	Royal Victoria Regional Health Centre	Robert El-Maraghi	CANADA	Ontario	BARRIE
57	Southlake Regional Health Center	LABIB ZIBDAWI	CANADA	Ontario	NEWMARKET
58	Southlake Regional Health Center	LABIB ZIBDAWI	CANADA	Ontario	NEWMARKET
59	Lakeridge Health Center	Jeffrey Rothenstein	CANADA	Ontario	Oshawa
60	Lakeridge Health Center	Jeffrey Rothenstein	CANADA	Ontario	Oshawa
61	Fraser Valley Centre British Columbia Cancer Agency	Thuan Do	CANADA	British Columbia	SURREY
62	Fraser Valley Centre British Columbia Cancer Agency	Thuan Do	CANADA	British Columbia	SURREY
63	Clinica Santa Maria	Eric Orellana Ulunque	CHILE	Santiago	Santiago
64	Clinica Santa Maria	Eric Orellana Ulunque	CHILE	Santiago	Santiago
65	Instituto Clínico Oncologico del Sur	Eduardo Yanez	CHILE	Temuco	Temuco
66	Instituto Clínico Oncologico del Sur	Eduardo Yanez	CHILE	Temuco	Temuco
67	Hospital Clinico Vina del Mar	Alejandro Andres Acevedo Gaete	CHILE	Via del Mar	Via del Mar
68	Hospital Clinico Vina del Mar	Alejandro Andres Acevedo Gaete	CHILE	Via del Mar	Via del Mar
69	Health & Care SPA	FRANSCICO ORLANDI	CHILE	Santiago	Santiago
70	Health & Care SPA	FRANSCICO ORLANDI	CHILE	Santiago	Santiago
71	Centro de Investigacion; Clinica - Clinica Viedma S.A.	Rubén Kowalyszyn	ARGENTINA	Viedma	Viedma
72	Centro de Investigacion; Clinica - Clinica Viedma S.A.	Rubén Kowalyszyn	ARGENTINA	Viedma	Viedma
73	Fundacion Sanatorio Guemes	Manuel Vilanova	ARGENTINA	CABA	CABA
74	Fundacion Sanatorio Guemes	Manuel Vilanova	ARGENTINA	CABA	CABA
75	Fundacion Centro Oncologico de Integracion Regional (COIR)	Lino Arboit	ARGENTINA	Mendoza	Mendoza
76	Fundacion Centro Oncologico de Integracion Regional (COIR)	Lino Arboit	ARGENTINA	Mendoza	Mendoza
77	Fundacion Clinica Colombo	Norma Pilnik	ARGENTINA	Cordoba	Cordoba
78	Fundacion Clinica Colombo	Norma Pilnik	ARGENTINA	Cordoba	Cordoba
79	Hospital Militar Central Cirujano Mayor Dr. Cosme Argerich	Emilio Batagelj	ARGENTINA	BUENOS AIRES	BUENOS AIRES
80	Hospital Militar Central Cirujano Mayor Dr. Cosme Argerich	Emilio Batagelj	ARGENTINA	BUENOS AIRES	BUENOS AIRES
81	ISIS Clinica Especializada	CESAR RAUL BLAJMAN	ARGENTINA	SANTA FE	SANTA FE
82	ISIS Clinica Especializada	CESAR RAUL BLAJMAN	ARGENTINA	SANTA FE	SANTA FE
83	Royal Hobart Hospital	Louise Nott	Australia	Tasmania	Hobart
84	Royal Hobart Hospital	Louise Nott	Australia	Tasmania	Hobart
85	Sydney Adventist Hospital	Gavin Marx	Australia	NSW	Sydney
86	Sydney Adventist Hospital	Gavin Marx	Australia	NSW	Sydney
87	Barwon Health	Madhu Singh	Australia	Victoria	Geelong
88	Barwon Health	Madhu Singh	Australia	Victoria	Geelong
89	General Hospital Pula	Dragan Trivanovic	CROATIA	Pula	Pula
90	General Hospital Pula	Dragan Trivanovic	CROATIA	Pula	Pula
91	General Hospital Dubrovnik	Zarko Vrbica	CROATIA	Dubrovnik	Dubrovnik
92	General Hospital Dubrovnik	Zarko Vrbica	CROATIA	Dubrovnik	Dubrovnik
93	Clinical Hospital Sestre Milosrdnice	Ana Frobe	CROATIA	Zagreb	Zagreb
94	Clinical Hospital Sestre Milosrdnice	Ana Frobe	CROATIA	Zagreb	Zagreb
95	Clinical Hospital Osijek	Dejan Labudovic	CROATIA	Osijek	Osijek
96	Clinical Hospital Osijek	Dejan Labudovic	CROATIA	Osijek	Osijek
97	Klinichki Bolnicki Centar Zagreb	MIROSLAV SAMARZIJA	CROATIA	ZAGREB	ZAGREB
98	Klinichki Bolnicki Centar Zagreb	MIROSLAV SAMARZIJA	CROATIA	ZAGREB	ZAGREB
99	Institut Sainte Catherine	Werner Hilgers	FRANCE	Avignon	Avignon
100	Institut Sainte Catherine	Werner Hilgers	FRANCE	Avignon	Avignon
101	Centre Hospitalier Intercommunal; Service de Pneumologie	ISABELLE MONNET	FRANCE	Creteil Cedex	Creteil Cedex
102	Centre Hospitalier Intercommunal; Service de Pneumologie	ISABELLE MONNET	FRANCE	Creteil Cedex	Creteil Cedex
103	Hopital Louis Pradel; Pneumologie	Benedicte Mastroianni	FRANCE	Bron	Bron
104	Hopital Louis Pradel; Pneumologie	Benedicte Mastroianni	FRANCE	Bron	Bron
105	Hopital Nord AP-HM	Fabrice Barlesi	FRANCE	Marseille	Marseille
106	Hopital Nord AP-HM	Fabrice Barlesi	FRANCE	Marseille	Marseille
107	Hopital de La Source	Adrien Dixmier	FRANCE	La Source	La Source
108	Hopital de La Source	Adrien Dixmier	FRANCE	La Source	La Source
109	Hopital d'Instruction des Armees de Begin	Carole Helissey	FRANCE	Saint-Mande	Saint-Mande
110	Hopital d'Instruction des Armees de Begin	Carole Helissey	FRANCE	Saint-Mande	Saint-Mande
111	Hopital d Instruction des Armees de Sainte Anne	HENRI BERARD	FRANCE	Toulon	Toulon
112	Hopital d Instruction des Armees de Sainte Anne	HENRI BERARD	FRANCE	Toulon	Toulon
113	Centre Jean Perrin Centre Regional de Lutte Contre Le Cancer D auvergne	Pascale Dubray Longeras	FRANCE	Clermont-ferrand	Clermont-ferrand
114	Centre Jean Perrin Centre Regional de Lutte Contre Le Cancer D auvergne	Pascale Dubray Longeras	FRANCE	Clermont-ferrand	Clermont-ferrand
115	Polyclinique de Limoges - Site Chenieux; Oncologie Medicale	Dominique Genet	FRANCE	Limoges	Limoges
116	Polyclinique de Limoges - Site Chenieux; Oncologie Medicale	Dominique Genet	FRANCE	Limoges	Limoges
117	Centre Hospitalier Francois Quesnay	JEAN-BERNARD AULIAC	FRANCE	MANTES LA JOLIE	MANTES LA JOLIE
118	Centre Hospitalier Francois Quesnay	JEAN-BERNARD AULIAC	FRANCE	MANTES LA JOLIE	MANTES LA JOLIE
119	Centre Regional de Lutte contre le Cancer Val d Aurelle - Paul Lamarque; Service d oncologie	Xavier Quantin	FRANCE	Montpellier	Montpellier
120	Centre Regional de Lutte contre le Cancer Val d Aurelle - Paul Lamarque; Service d oncologie	Xavier Quantin	FRANCE	Montpellier	Montpellier
121	Centre Hospitalier de Mulhouse - Hopital Emile Muller	DIDIER DEBIEUVRE	FRANCE	Mulhouse	Mulhouse
122	Centre Hospitalier de Mulhouse - Hopital Emile Muller	DIDIER DEBIEUVRE	FRANCE	Mulhouse	Mulhouse
123	Centre D'oncologie de Gentilly	DOMINIQUE SPAETH	FRANCE	NANCY	NANCY
124	Centre D'oncologie de Gentilly	DOMINIQUE SPAETH	FRANCE	NANCY	NANCY
125	Queen Mary Hospital	Chung Man Ho	中国	Hong Kong	Hong Kong
126	Queen Mary Hospital	Chung Man Ho	中国	Hong Kong	Hong Kong
127	Pamela Youde Nethersole Eastern Hospital	Siu Hong Chan	中国	Chai Wan	Chai Wan
128	Pamela Youde Nethersole Eastern Hospital	Siu Hong Chan	中国	Chai Wan	Chai Wan
129	Queen Elizabeth Hospital	Jacky Li	中国	Hong Kong	Hong Kong
130	Queen Elizabeth Hospital	Jacky Li	中国	Hong Kong	Hong Kong
131	Petz Aladar Megyei Oktato Korhaz	ZSUZSANNA SZALAI	HUNGARY	Gyr	Gyr
132	Petz Aladar Megyei Oktato Korhaz	ZSUZSANNA SZALAI	HUNGARY	Gyr	Gyr
133	Fejer Megyei Szent Gyorgy Egyetemi Oktato Korhaz	ZSOLT PAPAI-SZEKELY	HUNGARY	SZEKESFEHERVAR	SZEKESFEHERVAR
134	Fejer Megyei Szent Gyorgy Egyetemi Oktato Korhaz	ZSOLT PAPAI-SZEKELY	HUNGARY	SZEKESFEHERVAR	SZEKESFEHERVAR
135	Vas Megyei Markusovszky Lajos Korhaz	ANDRAS CSEJTEI	HUNGARY	Szombathely	Szombathely
136	Vas Megyei Markusovszky Lajos Korhaz	ANDRAS CSEJTEI	HUNGARY	Szombathely	Szombathely
137	Veszprem Megyei Tudogyogyintezet	Zsolt Kiraly	HUNGARY	Farkasgyepu	Farkasgyepu
138	Veszprem Megyei Tudogyogyintezet	Zsolt Kiraly	HUNGARY	Farkasgyepu	Farkasgyepu
139	Tudogyogyintezet Torokbalint; II. Osztaly	ákos Lantos	HUNGARY	Torokbalint	Torokbalint
140	Tudogyogyintezet Torokbalint; II. Osztaly	ákos Lantos	HUNGARY	Torokbalint	Torokbalint
141	Adelaide & Meath Hospital, Dublin, Incorporating the National Children's Hospital	Fergal Kelleher	IRELAND	Dublin	Dublin
142	Adelaide & Meath Hospital, Dublin, Incorporating the National Children's Hospital	Fergal Kelleher	IRELAND	Dublin	Dublin
143	Cork University Hospital	Deirdre O Mahony	IRELAND	CORK	CORK
144	Cork University Hospital	Deirdre O Mahony	IRELAND	CORK	CORK
145	Mater Misecordiae University Hospital	Michaela Higgins	IRELAND	Dublin	Dublin
146	Mater Misecordiae University Hospital	Michaela Higgins	IRELAND	Dublin	Dublin
147	St James's Hospital	Sinead Cuffe	IRELAND	DUBLIN	DUBLIN
148	St James's Hospital	Sinead Cuffe	IRELAND	DUBLIN	DUBLIN
149	University Hospital Limerick - PIN	Linda Coate	IRELAND	LIMERICK	LIMERICK
150	University Hospital Limerick - PIN	Linda Coate	IRELAND	LIMERICK	LIMERICK
151	Barzilai Medical Center	TATIANA CHARKOVSKY	ISRAEL	ASHKELON	ASHKELON
152	Barzilai Medical Center	TATIANA CHARKOVSKY	ISRAEL	ASHKELON	ASHKELON
153	Edith Wolfson Medical Center	Ronen Brener	ISRAEL	Holon	Holon
154	Edith Wolfson Medical Center	Ronen Brener	ISRAEL	Holon	Holon
155	Assuta Medical Centers	Ella Tepper	ISRAEL	Tel Aviv	Tel Aviv
156	Assuta Medical Centers	Ella Tepper	ISRAEL	Tel Aviv	Tel Aviv
157	Rabin Medical Center	Nir Peled	ISRAEL	Petah Tikva	Petah Tikva
158	Rabin Medical Center	Nir Peled	ISRAEL	Petah Tikva	Petah Tikva
159	The Baruch Padeh MC, Poriya	SUHEIL NASRALLAH	ISRAEL	Nahariya	Nahariya
160	The Baruch Padeh MC, Poriya	SUHEIL NASRALLAH	ISRAEL	Nahariya	Nahariya
161	Lin Medical Center	Shoshana Keren- Rozenberg	ISRAEL	HAIFA	HAIFA
162	Lin Medical Center	Shoshana Keren- Rozenberg	ISRAEL	HAIFA	HAIFA
163	IRCCS Ospedale Casa Sollievo Della Sofferenza	EVARISTO MAIELLO	ITALY	Puglia	SAN GIOVANNI ROTONDO
164	IRCCS Ospedale Casa Sollievo Della Sofferenza	EVARISTO MAIELLO	ITALY	Puglia	SAN GIOVANNI ROTONDO
165	Azienda Ospedaliera Di Rilievo Nazionale E Di Alta Specializzazione Garibaldi	ROBERTO BORDONARO	ITALY	Sicilia	Catania
166	Azienda Ospedaliera Di Rilievo Nazionale E Di Alta Specializzazione Garibaldi	ROBERTO BORDONARO	ITALY	Sicilia	Catania
167	Istituto Nazionale per la Ricerca sul Cancro di Genova	FRANCESCO GROSSI	ITALY	Liguria	GENOVA
168	Istituto Nazionale per la Ricerca sul Cancro di Genova	FRANCESCO GROSSI	ITALY	Liguria	GENOVA
169	Azienda Ospedaliero Universitaria di Parma	Marcello Tiseo	ITALY	Emilia-Romagna	PARMA
170	Azienda Ospedaliero Universitaria di Parma	Marcello Tiseo	ITALY	Emilia-Romagna	PARMA
171	Ospedale San Vincenzo Taormina :Divisione di Oncologia Medica	FRANCESCO FERRAU	ITALY	Sicilia	Taormina
172	Ospedale San Vincenzo Taormina :Divisione di Oncologia Medica	FRANCESCO FERRAU	ITALY	Sicilia	Taormina
173	Ospedale San Luca - USL2 Lucca	Editta Baldini	ITALY	Toscana	Lucca
174	Ospedale San Luca - USL2 Lucca	Editta Baldini	ITALY	Toscana	Lucca
175	Istituto Nazionale Tumori Regina Elena	FRANCESCO COGNETTI	ITALY	Lazio	Roma
176	Istituto Nazionale Tumori Regina Elena	FRANCESCO COGNETTI	ITALY	Lazio	Roma
177	Presidio Ospedaliero Vito Fazzi; Unita Operativa Di Oncologia Medica	Gianpiero Romano	ITALY	Puglia	Lecce
178	Presidio Ospedaliero Vito Fazzi; Unita Operativa Di Oncologia Medica	Gianpiero Romano	ITALY	Puglia	Lecce
179	Azienda Policlinico Umberto I	ENRICO CORTESI	ITALY	Lazio	ROMA
180	Azienda Policlinico Umberto I	ENRICO CORTESI	ITALY	Lazio	ROMA
181	Azienda Sanitaria Ospedaliera S Luigi Gonzaga; S.C.D.U. di Oncologia Toracica	Silvia Novello	ITALY	Piemonte	Orbassano
182	Azienda Sanitaria Ospedaliera S Luigi Gonzaga; S.C.D.U. di Oncologia Toracica	Silvia Novello	ITALY	Piemonte	Orbassano
183	Ospedale Santa Maria Delle Croci	FEDERICO CAPPUZZO	ITALY	Emilia-Romagna	Ravenna
184	Ospedale Santa Maria Delle Croci	FEDERICO CAPPUZZO	ITALY	Emilia-Romagna	Ravenna
185	Kanazawa University Hospital	Kazuo Kasahara	JAPAN	Ishikawa	Ishikawa
186	Kanazawa University Hospital	Kazuo Kasahara	JAPAN	Ishikawa	Ishikawa
187	National Cancer Center Hospital East	Koichi Goto	JAPAN	CHIBA	CHIBA
188	National Cancer Center Hospital East	Koichi Goto	JAPAN	CHIBA	CHIBA
189	Kanagawa Cancer Center	Haruhiro Saito	JAPAN	Kanagawa	Kanagawa
190	Kanagawa Cancer Center	Haruhiro Saito	JAPAN	Kanagawa	Kanagawa
191	Kagoshima University Hospital	Keiko Mizuno	JAPAN	Kagoshima	Kagoshima
192	Kagoshima University Hospital	Keiko Mizuno	JAPAN	Kagoshima	Kagoshima
193	Hiroshima University Hospital	Morihito Okada	JAPAN	Hiroshima	Hiroshima
194	Hiroshima University Hospital	Morihito Okada	JAPAN	Hiroshima	Hiroshima
195	Juntendo University Hospital	Motoyasu Kato	JAPAN	Tokyo	Tokyo
196	Juntendo University Hospital	Motoyasu Kato	JAPAN	Tokyo	Tokyo
197	Tohoku University Hospital	Tatsuma Okazaki	JAPAN	Miyagi	Miyagi
198	Tohoku University Hospital	Tatsuma Okazaki	JAPAN	Miyagi	Miyagi
199	Tokyo Metropolitan Cancer and Infectious diseases Center Komagome Hospital	Yusuke Okuma	JAPAN	Tokyo	Tokyo
200	Tokyo Metropolitan Cancer and Infectious diseases Center Komagome Hospital	Yusuke Okuma	JAPAN	Tokyo	Tokyo
201	National Hospital Organization Asahikawa Medical Center	Yuka Fujita	JAPAN	Hokkaido	Hokkaido
202	National Hospital Organization Asahikawa Medical Center	Yuka Fujita	JAPAN	Hokkaido	Hokkaido
203	Tokushima University Hospital	Yasuhiko Nishioka	JAPAN	Tokushima	Tokushima
204	Tokushima University Hospital	Yasuhiko Nishioka	JAPAN	Tokushima	Tokushima
205	The Cancer Institute Hospital of JFCR	Makoto Nishio	JAPAN	Tokyo	Tokyo
206	The Cancer Institute Hospital of JFCR	Makoto Nishio	JAPAN	Tokyo	Tokyo
207	Osaka Medical College Hospital	Yasuhito Fujisaka	JAPAN	Osaka	Osaka
208	Osaka Medical College Hospital	Yasuhito Fujisaka	JAPAN	Osaka	Osaka
209	Osaka University Hospital	Takashi Kijima	JAPAN	Osaka	Osaka
210	Osaka University Hospital	Takashi Kijima	JAPAN	Osaka	Osaka
211	Nippon Medical School Hospital	Kaoru Kubota	JAPAN	Tokyo	Tokyo
212	Nippon Medical School Hospital	Kaoru Kubota	JAPAN	Tokyo	Tokyo
213	National Hospital Organization Yamaguchi - Ube Medical Center	Kenichi Chikamori	JAPAN	Yamaguchi	Yamaguchi
214	National Hospital Organization Yamaguchi - Ube Medical Center	Kenichi Chikamori	JAPAN	Yamaguchi	Yamaguchi
215	Niigata University Medical & Dental Hospital	Satoshi Watanabe	JAPAN	Niigata	Niigata
216	Niigata University Medical & Dental Hospital	Satoshi Watanabe	JAPAN	Niigata	Niigata
217	National Hospital Organization Nagoya Medical Center	Hideo Saka	JAPAN	Aichi	Aichi
218	National Hospital Organization Nagoya Medical Center	Hideo Saka	JAPAN	Aichi	Aichi
219	National Hospital Organization Himeji Medical Center	Yasuharu Nakahara	JAPAN	Hyogo	Hyogo
220	National Hospital Organization Himeji Medical Center	Yasuharu Nakahara	JAPAN	Hyogo	Hyogo
221	Saga University Hospital	Naoko Aragane	JAPAN	Saga	Saga
222	Saga University Hospital	Naoko Aragane	JAPAN	Saga	Saga
223	NTT Medical Center Tokyo	Kazuhiro Usui	JAPAN	Tokyo	Tokyo
224	NTT Medical Center Tokyo	Kazuhiro Usui	JAPAN	Tokyo	Tokyo
225	Samsung Medical Center	Se-Hoon Lee	KOREA, REPUBLIC OF	Seoul	Seoul
226	Samsung Medical Center	Se-Hoon Lee	KOREA, REPUBLIC OF	Seoul	Seoul
227	Asan Medical Center	Dae Ho Lee	KOREA, REPUBLIC OF	Seoul	Seoul
228	Asan Medical Center	Dae Ho Lee	KOREA, REPUBLIC OF	Seoul	Seoul
229	Seoul National University Hospital	Tae Min Kim	KOREA, REPUBLIC OF	Seoul	Seoul
230	Seoul National University Hospital	Tae Min Kim	KOREA, REPUBLIC OF	Seoul	Seoul
231	Riga East; Clinical University Hospital; Latvian Oncology Centre	ZANETE ZVIRBULE	LATVIA	RIGA	RIGA
232	Riga East; Clinical University Hospital; Latvian Oncology Centre	ZANETE ZVIRBULE	LATVIA	RIGA	RIGA
233	PANEVEZYS HOSPITAL	Donatas Vajauskas	LITHUANIA	Panevezys	Panevezys
234	PANEVEZYS HOSPITAL	Donatas Vajauskas	LITHUANIA	Panevezys	Panevezys
235	Hospital of Lithuanian University of Health. Sciences Kaunas Clinics	Marius Zemaitis	LITHUANIA	KAUNAS	KAUNAS
236	Hospital of Lithuanian University of Health. Sciences Kaunas Clinics	Marius Zemaitis	LITHUANIA	KAUNAS	KAUNAS
237	Hospital Tengku Ampuan Afzan	Soo Hin How	MALAYSIA	Pahang	Pahang
238	Hospital Tengku Ampuan Afzan	Soo Hin How	MALAYSIA	Pahang	Pahang
239	Hospital Kuala Lumpur	Muthukkumaran Thiagarajan	MALAYSIA	Kuala Lumpur	Kuala Lumpur
240	Hospital Kuala Lumpur	Muthukkumaran Thiagarajan	MALAYSIA	Kuala Lumpur	Kuala Lumpur
241	Advanced Medical and Dental Institute; Kompleks Klinikal	Gokula Kumar Appalanaido	MALAYSIA	PENANG	Kepala Batas
242	Advanced Medical and Dental Institute; Kompleks Klinikal	Gokula Kumar Appalanaido	MALAYSIA	PENANG	Kepala Batas
243	Haga Ziekenhuis	H.E. CODRINGTON	NETHERLANDS	DEN HAAG	DEN HAAG
244	Haga Ziekenhuis	H.E. CODRINGTON	NETHERLANDS	DEN HAAG	DEN HAAG
245	Leids Universitair Medisch Centrum	Christian Taube	NETHERLANDS	Mainz	Mainz
246	Leids Universitair Medisch Centrum	Christian Taube	NETHERLANDS	Mainz	Mainz
247	Amphia Ziekenhuis	Kornelis van der Leest	NETHERLANDS	BREDA	BREDA
248	Amphia Ziekenhuis	Kornelis van der Leest	NETHERLANDS	BREDA	BREDA
249	Martini Ziekenhuis	J.W.G. van PUTTEN	NETHERLANDS	Groningen	Groningen
250	Martini Ziekenhuis	J.W.G. van PUTTEN	NETHERLANDS	Groningen	Groningen
251	ISALA KLINIEKEN, LOKATIE WEEZENLANDEN; DEPT OF LUNG DISEASES	J.A. STIGT	NETHERLANDS	Zwolle	Zwolle
252	ISALA KLINIEKEN, LOKATIE WEEZENLANDEN; DEPT OF LUNG DISEASES	J.A. STIGT	NETHERLANDS	Zwolle	Zwolle
253	Ziekenhuis St. Jansdal	S.J.M. GANS	NETHERLANDS	HARDERWIJK	HARDERWIJK
254	Ziekenhuis St. Jansdal	S.J.M. GANS	NETHERLANDS	HARDERWIJK	HARDERWIJK
255	Meander MC	E. VAN VELZEN	NETHERLANDS	AMERSFOORT	AMERSFOORT
256	Meander MC	E. VAN VELZEN	NETHERLANDS	AMERSFOORT	AMERSFOORT
257	Spaarne ziekenhuis	Dominic Snijders	NETHERLANDS	HOOFDDORP	HOOFDDORP
258	Spaarne ziekenhuis	Dominic Snijders	NETHERLANDS	HOOFDDORP	HOOFDDORP
259	Zuyderland Medisch Centrum	FRANK L.J. CUSTERS	NETHERLANDS	Heerlen	Heerlen
260	Zuyderland Medisch Centrum	FRANK L.J. CUSTERS	NETHERLANDS	Heerlen	Heerlen
261	Ziekenhuis Gelderse Vallei	Wouter de Jong	NETHERLANDS	Ede	Ede
262	Ziekenhuis Gelderse Vallei	Wouter de Jong	NETHERLANDS	Ede	Ede
263	ETZ Elisabeth	Jeroen Kloover	NETHERLANDS	TILBURG	TILBURG
264	ETZ Elisabeth	Jeroen Kloover	NETHERLANDS	TILBURG	TILBURG
265	Elkerliek Ziekenhuis	W.R. PIETERS	NETHERLANDS	HELMOND	HELMOND
266	Elkerliek Ziekenhuis	W.R. PIETERS	NETHERLANDS	HELMOND	HELMOND
267	Hospital Nacional Cayetano Heredia	Carmen Laura Acevedo Zanabria	PERU	Lima	Lima
268	Hospital Nacional Cayetano Heredia	Carmen Laura Acevedo Zanabria	PERU	Lima	Lima
269	Hospital Central Fuerza; Aerea del Peru	Giovanna Abrill Mendoza	PERU	Lima	Lima
270	Hospital Central Fuerza; Aerea del Peru	Giovanna Abrill Mendoza	PERU	Lima	Lima
271	Instituto Oncologico Miraflores	Ruth Huaringa Leiva	PERU	Lima	Lima
272	Instituto Oncologico Miraflores	Ruth Huaringa Leiva	PERU	Lima	Lima
273	Centrum Onkologii im. Prof. F. Lukaszczyka w Bydgoszczy	EWA CHMIELOWSKA	POLAND	BYDGOSZCZ	BYDGOSZCZ
274	Centrum Onkologii im. Prof. F. Lukaszczyka w Bydgoszczy	EWA CHMIELOWSKA	POLAND	BYDGOSZCZ	BYDGOSZCZ
275	Samodzielny Publiczny Zespol Gruzlicy i Chorob Pluc w Olsztynie; Poradnia Onkologiczna	Andrzej Kazarnowicz	POLAND	Olsztyn	Olsztyn
276	Samodzielny Publiczny Zespol Gruzlicy i Chorob Pluc w Olsztynie; Poradnia Onkologiczna	Andrzej Kazarnowicz	POLAND	Olsztyn	Olsztyn
277	Gdanski Uniwersytet Medyczny	Rafal Dziadziuszko	POLAND	Gdansk	Gdansk
278	Gdanski Uniwersytet Medyczny	Rafal Dziadziuszko	POLAND	Gdansk	Gdansk
279	Hospital CUF Porto; Servico de Imunoalergologia	Barbara Parente	PORTUGAL	Porto	Porto
280	Hospital CUF Porto; Servico de Imunoalergologia	Barbara Parente	PORTUGAL	Porto	Porto
281	Hospital Beatriz ngelo	Margarida Felizardo	PORTUGAL	LISBOA	LISBOA
282	Hospital Beatriz ngelo	Margarida Felizardo	PORTUGAL	LISBOA	LISBOA
283	Centro Hospitalar Trás Os Montes E Alto Douro EPE	Ana Fernandes	PORTUGAL	Vila Real	Vila Real
284	Centro Hospitalar Trás Os Montes E Alto Douro EPE	Ana Fernandes	PORTUGAL	Vila Real	Vila Real
285	Unidade Local de Saude de Matosinhos SA	Fernanda Estevinho	PORTUGAL	Senhora da Hora	Senhora da Hora
286	Unidade Local de Saude de Matosinhos SA	Fernanda Estevinho	PORTUGAL	Senhora da Hora	Senhora da Hora
287	Instituto Portugues de Oncologia de Lisboa Francisco Gentil, E.P.E.; Pneumologia	Teresa Almodovar	PORTUGAL	Lisbon	Lisbon
288	Instituto Portugues de Oncologia de Lisboa Francisco Gentil, E.P.E.; Pneumologia	Teresa Almodovar	PORTUGAL	Lisbon	Lisbon
289	Euroclinic Center of Oncology SRL	Constantin Volovat	ROMANIA	Iasi	Iasi
290	Euroclinic Center of Oncology SRL	Constantin Volovat	ROMANIA	Iasi	Iasi
291	Ianuli Med Consult S.R.L.	Carmen Hariclea Ianuli	ROMANIA	Bucharest	Bucharest
292	Ianuli Med Consult S.R.L.	Carmen Hariclea Ianuli	ROMANIA	Bucharest	Bucharest
293	Medisprof SRL	Anghel Adrian Udrea	ROMANIA	Cluj-Napoca	Cluj-Napoca
294	Medisprof SRL	Anghel Adrian Udrea	ROMANIA	Cluj-Napoca	Cluj-Napoca
295	Prof. Dr. I. Chiricuta Institute of Oncology	CARMEN FLOARES	ROMANIA	Cluj-Napoca	Cluj-Napoca
296	Prof. Dr. I. Chiricuta Institute of Oncology	CARMEN FLOARES	ROMANIA	Cluj-Napoca	Cluj-Napoca
297	Spitalul Clinic Judetean de Urgenta Sf. Apostol Andrei Constanta	Laura Mazilu	ROMANIA	Constanta	Constanta
298	Spitalul Clinic Judetean de Urgenta Sf. Apostol Andrei Constanta	Laura Mazilu	ROMANIA	Constanta	Constanta
299	Coltea Clinical Hospital	CIPRIAN ALDEA	ROMANIA	BUCHAREST	BUCHAREST
300	Coltea Clinical Hospital	CIPRIAN ALDEA	ROMANIA	BUCHAREST	BUCHAREST
301	Cluj-Napoca Emergency Clinical County Hospital; Medical Oncology	Mihaela Trif	ROMANIA	Cluj-Napoca	Cluj-Napoca
302	Cluj-Napoca Emergency Clinical County Hospital; Medical Oncology	Mihaela Trif	ROMANIA	Cluj-Napoca	Cluj-Napoca
303	Emergency Clinical County Hospital; Oncology Department	Cosmin Boldeanu	ROMANIA	Braila	Braila
304	Emergency Clinical County Hospital; Oncology Department	Cosmin Boldeanu	ROMANIA	Braila	Braila
305	Moscow City Oncology Hospital #62	Daniil Stroyakovskii	RUSSIAN FEDERATION	MOSKOVSKAJA OBLAST	Moscow area, Krasnogorskii d-t
306	Moscow City Oncology Hospital #62	Daniil Stroyakovskii	RUSSIAN FEDERATION	MOSKOVSKAJA OBLAST	Moscow area, Krasnogorskii d-t
307	Regional Clinical Oncology Hospital	Nikolay Kislov	RUSSIAN FEDERATION	Yaroslavl	Yaroslavl
308	Regional Clinical Oncology Hospital	Nikolay Kislov	RUSSIAN FEDERATION	Yaroslavl	Yaroslavl
309	Republican Clinical Oncology Dispensary of Ministry of Healthcare of Tatarstan Republic	FOAT AKHMETZYANOV	RUSSIAN FEDERATION	Kazan	Kazan
310	Republican Clinical Oncology Dispensary of Ministry of Healthcare of Tatarstan Republic	FOAT AKHMETZYANOV	RUSSIAN FEDERATION	Kazan	Kazan
311	Chelyabinsk Regional Clinical Oncology Dispensary	Natalia Fadeeva	RUSSIAN FEDERATION	Chelyabinsk	Chelyabinsk
312	Chelyabinsk Regional Clinical Oncology Dispensary	Natalia Fadeeva	RUSSIAN FEDERATION	Chelyabinsk	Chelyabinsk
313	Nemocnica s poliklinikou S Kukuru Michalovce a s; Oddelenie onkologie a radioterapie	Gabriela Hermanova	SLOVAKIA	Michalovce	Michalovce
314	Nemocnica s poliklinikou S Kukuru Michalovce a s; Oddelenie onkologie a radioterapie	Gabriela Hermanova	SLOVAKIA	Michalovce	Michalovce
315	Mary Potter Oncology Centre	GRAHAM COHEN	SOUTH AFRICA	Groenkloof	Groenkloof
316	Mary Potter Oncology Centre	GRAHAM COHEN	SOUTH AFRICA	Groenkloof	Groenkloof
317	Steve Biko Academic Hospital; Oncology	LYDIA DREOSTI	SOUTH AFRICA	Pretoria	Pretoria
318	Steve Biko Academic Hospital; Oncology	LYDIA DREOSTI	SOUTH AFRICA	Pretoria	Pretoria
319	GVI Oncology Outeniqua Unit; GVI Oncology Outeniqua Unit	Michiel Botha	SOUTH AFRICA	Bloemfontein	Bloemfontein
320	GVI Oncology Outeniqua Unit; GVI Oncology Outeniqua Unit	Michiel Botha	SOUTH AFRICA	Bloemfontein	Bloemfontein
321	Langenhoven Drive Oncology Centre	Louis Dupper	SOUTH AFRICA	Port Elizabeth	Port Elizabeth
322	Langenhoven Drive Oncology Centre	Louis Dupper	SOUTH AFRICA	Port Elizabeth	Port Elizabeth
323	MERC Oncology; Lifestyle Building, UNITAS Hospital	Sheynaz Bassa	SOUTH AFRICA	Pretoria	Pretoria
324	MERC Oncology; Lifestyle Building, UNITAS Hospital	Sheynaz Bassa	SOUTH AFRICA	Pretoria	Pretoria
325	Hospital Universitario Virgen del Rocio	Reyes Bernabe Caro	SPAIN	SEVILLA	SEVILLA
326	Hospital Universitario Virgen del Rocio	Reyes Bernabe Caro	SPAIN	SEVILLA	SEVILLA
327	Centro Oncologico de Galicia	Margarita Amenedo Gancedo	SPAIN	LA CORUA	LA CORUA
328	Centro Oncologico de Galicia	Margarita Amenedo Gancedo	SPAIN	LA CORUA	LA CORUA
329	Hospital Lucus Augusti; Servicio de Oncologia	Sergio Vazquez Estevez	SPAIN	LUGO	LUGO
330	Hospital Lucus Augusti; Servicio de Oncologia	Sergio Vazquez Estevez	SPAIN	LUGO	LUGO
331	HOSPITAL GENERAL UNIV. DE ALICANTE	Bartomeu Massuti Sureda	SPAIN	ALICANTE	Alicante
332	HOSPITAL GENERAL UNIV. DE ALICANTE	Bartomeu Massuti Sureda	SPAIN	ALICANTE	Alicante
333	Instituto Valenciano Oncologia; Oncologia Medica	Miguel Angel Muoz Quintana	SPAIN	VALENCIA	Valencia
334	Instituto Valenciano Oncologia; Oncologia Medica	Miguel Angel Muoz Quintana	SPAIN	VALENCIA	Valencia
335	Corporacio Sanitaria Parc Tauli; Servicio de Oncologia	Yolanda Garcia Garcia	SPAIN	BARCELONA	SABADELL
336	Corporacio Sanitaria Parc Tauli; Servicio de Oncologia	Yolanda Garcia Garcia	SPAIN	BARCELONA	SABADELL
337	Clinica Universitaria de Navarra; Servicio de Oncologia	Alfonso Gurpide Ayarra	SPAIN	NAVARRA	PAMPLONA
338	Clinica Universitaria de Navarra; Servicio de Oncologia	Alfonso Gurpide Ayarra	SPAIN	NAVARRA	PAMPLONA
339	Hospital General Universitario de Elche; Servicio de Oncologia	Maria Guirado Risueo	SPAIN	ALICANTE	Elche
340	Hospital General Universitario de Elche; Servicio de Oncologia	Maria Guirado Risueo	SPAIN	ALICANTE	Elche
341	Hospital de la Santa Creu i Sant Pau	Margarita Majem Tarruella	SPAIN	BARCELONA	BARCELONA
342	Hospital de la Santa Creu i Sant Pau	Margarita Majem Tarruella	SPAIN	BARCELONA	BARCELONA
343	Hospital Univ Vall d'Hebron; Servicio de Oncologia	Nuria Pardo Aranda	SPAIN	BARCELONA	Barcelona
344	Hospital Univ Vall d'Hebron; Servicio de Oncologia	Nuria Pardo Aranda	SPAIN	BARCELONA	Barcelona
345	Hospital Clinic de Barcelona	Nuria Violas Segarra	SPAIN	BARCELONA	Barcelona
346	Hospital Clinic de Barcelona	Nuria Violas Segarra	SPAIN	BARCELONA	Barcelona
347	Complejo Hospitalario Universitario Insular-Materno Infantil, Servicio de Reumatologia	Delvys Rodriguez Abreu	SPAIN	LAS PALMAS	LAS PALMAS DE GRAN CANARIA
348	Complejo Hospitalario Universitario Insular-Materno Infantil, Servicio de Reumatologia	Delvys Rodriguez Abreu	SPAIN	LAS PALMAS	LAS PALMAS DE GRAN CANARIA
349	MD Anderson Cancer Center	Maria Pilar Lopez Criado	SPAIN	MADRID	Madrid
350	MD Anderson Cancer Center	Maria Pilar Lopez Criado	SPAIN	MADRID	Madrid
351	Hospital Universitario Doctor Peset	Inmaculada Maestu Maiquez	SPAIN	ALICANTE	ALCOY
352	Hospital Universitario Doctor Peset	Inmaculada Maestu Maiquez	SPAIN	ALICANTE	ALCOY
353	Hospital de Mataro	Pilar Lianes Barragan	SPAIN	BARCELONA	MATARO
354	Hospital de Mataro	Pilar Lianes Barragan	SPAIN	BARCELONA	MATARO
355	Hospital Universitario de Salamanca	Lorena Bellido Hernandez	SPAIN	SALAMANCA	SALAMANCA
356	Hospital Universitario de Salamanca	Lorena Bellido Hernandez	SPAIN	SALAMANCA	SALAMANCA
357	Hospital Universitario Ramon y Cajal	Pilar Garrido Lopez	SPAIN	MADRID	Madrid
358	Hospital Universitario Ramon y Cajal	Pilar Garrido Lopez	SPAIN	MADRID	Madrid
359	Hospital Universitari i Politecnic La Fe de Valencia	Oscar Juan Vidal	SPAIN	VALENCIA	VALENCIA
360	Hospital Universitari i Politecnic La Fe de Valencia	Oscar Juan Vidal	SPAIN	VALENCIA	VALENCIA
361	Hospital Universitario Germans Trias i Pujol	Teresa Moran Bueno	SPAIN	BARCELONA	Badalona
362	Hospital Universitario Germans Trias i Pujol	Teresa Moran Bueno	SPAIN	BARCELONA	Badalona
363	Hospital Universitario Virgen de La Arrixaca; Servicio De Oncologia	Jose Luis Alonso	SPAIN	BURGOS	Burgos
364	Hospital Universitario Virgen de La Arrixaca; Servicio De Oncologia	Jose Luis Alonso	SPAIN	BURGOS	Burgos
365	Complejo Hospitalario Nuestra Senora de Valme	Jose Fuentes Pradera	SPAIN	SEVILLA	Dos Hermanas
366	Complejo Hospitalario Nuestra Senora de Valme	Jose Fuentes Pradera	SPAIN	SEVILLA	Dos Hermanas
367	Hospital Universitari de Girona Dr Josep Trueta; Departamento de Oncologia Medica	Joaquim Bosch	SPAIN	GIRONA	GIRONA
368	Hospital Universitari de Girona Dr Josep Trueta; Departamento de Oncologia Medica	Joaquim Bosch	SPAIN	GIRONA	GIRONA
369	HM Sanchinarro – CIOCC	Cristobal Belda Iniesta	SPAIN	MADRID	Madrid
370	HM Sanchinarro – CIOCC	Cristobal Belda Iniesta	SPAIN	MADRID	Madrid
371	C.A.U de Burgos- Hospital Universitario de Burgos; Servicio de Oncologia	Carlos Garcia Giron	SPAIN	BURGOS	BURGOS
372	C.A.U de Burgos- Hospital Universitario de Burgos; Servicio de Oncologia	Carlos Garcia Giron	SPAIN	BURGOS	BURGOS
373	Onkologikoa; Ensayos Clinicos	Ainhara Lahuerta Martinez	SPAIN	GUIPUZCOA	Donostia
374	Onkologikoa; Ensayos Clinicos	Ainhara Lahuerta Martinez	SPAIN	GUIPUZCOA	Donostia
375	Hospital Regional Universitario de Malaga – Hospital General; Servicio de Neurologia	Manuel Cobo Dols	SPAIN	MALAGA	Malaga
376	Hospital Regional Universitario de Malaga – Hospital General; Servicio de Neurologia	Manuel Cobo Dols	SPAIN	MALAGA	Malaga
377	Complejo Hospitalario de Navarra; Servicio de Oncologia	Berta Hernandez	SPAIN	NAVARRA	Pamplona
378	Complejo Hospitalario de Navarra; Servicio de Oncologia	Berta Hernandez	SPAIN	NAVARRA	Pamplona
379	Hospital Universitari Dexeus - Grupo Quironsalud; Servicio de Oncologia Medica	Maria Gonzalez Cao	SPAIN	BARCELONA	Barcelona
380	Hospital Universitari Dexeus - Grupo Quironsalud; Servicio de Oncologia Medica	Maria Gonzalez Cao	SPAIN	BARCELONA	Barcelona
381	ICO L'Hospitalet; Servicio de oncologia medica	Ernest Nadal	SPAIN	BARCELONA	L'Hospitalet de Llobregat
382	ICO L'Hospitalet; Servicio de oncologia medica	Ernest Nadal	SPAIN	BARCELONA	L'Hospitalet de Llobregat
383	ST GEORGE HOSPITAL; MEDICAL ONCOLOGY	Chee Lee	Australia	New South Wales	Kogarah
384	ST GEORGE HOSPITAL; MEDICAL ONCOLOGY	Chee Lee	Australia	New South Wales	Kogarah
385	Mater Adult Hospital	Vikram Jain	Australia	Queensland	South Brisbane
386	Mater Adult Hospital	Vikram Jain	Australia	Queensland	South Brisbane
387	Cairns Base Hospital	Ritwik Pandey	Australia	Queensland	Cairns
388	Cairns Base Hospital	Ritwik Pandey	Australia	Queensland	Cairns
389	E-DA Hospital; Chest	Yu-Feng Wei	中国	Kaohsiung	Kaohsiung
390	E-DA Hospital; Chest	Yu-Feng Wei	中国	Kaohsiung	Kaohsiung
391	Chi Mei Medical Center Liou Ying Campus	Chao-Hsun Chen	中国	Tainan	Tainan
392	Chi Mei Medical Center Liou Ying Campus	Chao-Hsun Chen	中国	Tainan	Tainan
393	Chang Gung Medical Foundation Linkou Branch	HAN PIN KUO	中国	TAOYUAN	TAOYUAN
394	Chang Gung Medical Foundation Linkou Branch	HAN PIN KUO	中国	TAOYUAN	TAOYUAN
395	Kaohsiung Medical University Hospital; Chung-Ho Memorial Hospital	Inn-Wen Chong	中国	Kaohsiung	Kaohsiung
396	Kaohsiung Medical University Hospital; Chung-Ho Memorial Hospital	Inn-Wen Chong	中国	Kaohsiung	Kaohsiung
397	Chang Gung Medical Foundation-Kaoshiung Branch	Mao-Chang Su	中国	Kaohsiung	Kaohsiung
398	Chang Gung Medical Foundation-Kaoshiung Branch	Mao-Chang Su	中国	Kaohsiung	Kaohsiung
399	Buddhist Dalin Tzuchi General Hospital	Chun-Liang Lai	中国	Chiayi	Chiayi
400	Buddhist Dalin Tzuchi General Hospital	Chun-Liang Lai	中国	Chiayi	Chiayi
401	Municipal Institution Kirovograd Regional Oncology Dispensary	Andrij Gardashnikov	UKRAINE	Kirovograd	Kirovograd
402	Municipal Institution Kirovograd Regional Oncology Dispensary	Andrij Gardashnikov	UKRAINE	Kirovograd	Kirovograd
403	MI Zaporizhzhia Regional Clinical Oncological Dispensary Zaporizhzhia SMU Ch of Oncology	Oleksii Kolesnik	UKRAINE	Zaporizhzhya	Zaporizhzhya
404	MI Zaporizhzhia Regional Clinical Oncological Dispensary Zaporizhzhia SMU Ch of Oncology	Oleksii Kolesnik	UKRAINE	Zaporizhzhya	Zaporizhzhya
405	Regional Municipal Institution Sumy Regional Clinical Oncology Dispensary; Oncothoracic department	Ihor Vynnychenko	UKRAINE	Sumy	Sumy
406	Regional Municipal Institution Sumy Regional Clinical Oncology Dispensary; Oncothoracic department	Ihor Vynnychenko	UKRAINE	Sumy	Sumy
407	Private Enterprise Private Manufactire Company	Grygoriy Ursol	UKRAINE	Kirovograd	Kirovograd
408	Private Enterprise Private Manufactire Company	Grygoriy Ursol	UKRAINE	Kirovograd	Kirovograd
409	Khmelnytskyi Regional Oncology Dispensary; Surgery department #1	Igor Drobner	UKRAINE	Khmelnytskyi	Khmelnytskyi
410	Khmelnytskyi Regional Oncology Dispensary; Surgery department #1	Igor Drobner	UKRAINE	Khmelnytskyi	Khmelnytskyi
411	MICR Oncology Dispensary of Cherkasy Regional Council; Regional Center of Clinical Oncology	VICTOR PARAMONOV	UKRAINE	Cherkassy	Cherkassy
412	MICR Oncology Dispensary of Cherkasy Regional Council; Regional Center of Clinical Oncology	VICTOR PARAMONOV	UKRAINE	Cherkassy	Cherkassy
413	MI Dnipropetrovsk City Multifield Clinical Hospital 4 of Dnipropetrovsk Regional Council	IGOR BONDARENKO	UKRAINE	Dnipropetrovsk	Dnipropetrovsk
414	MI Dnipropetrovsk City Multifield Clinical Hospital 4 of Dnipropetrovsk Regional Council	IGOR BONDARENKO	UKRAINE	Dnipropetrovsk	Dnipropetrovsk
415	Transcarpathian Regional Clinical Oncology Dispensary	Andriy Rusyn	UKRAINE	Uzhhorod	Uzhhorod
416	Transcarpathian Regional Clinical Oncology Dispensary	Andriy Rusyn	UKRAINE	Uzhhorod	Uzhhorod
417	Kyiv Railway Clinical Hospital #3 of Branch Health Center of PJSC Ukrainian Railway; Surgery Dept	Roman Vereshchako	UKRAINE	KIEV GOVERNORATE	Kyiv
418	Kyiv Railway Clinical Hospital #3 of Branch Health Center of PJSC Ukrainian Railway; Surgery Dept	Roman Vereshchako	UKRAINE	KIEV GOVERNORATE	Kyiv
419	Charing Cross Hospital	Conrad Lewanski	UNITED KINGDOM	LONDON	LONDON
420	Charing Cross Hospital	Conrad Lewanski	UNITED KINGDOM	LONDON	LONDON
421	Churchill Hospital	Meenali Chitnis	UNITED KINGDOM	OXFORD	OXFORD
422	Churchill Hospital	Meenali Chitnis	UNITED KINGDOM	OXFORD	OXFORD
423	Royal Cornwall Hospital	Toby Talbot	UNITED KINGDOM	Truro	Truro
424	Royal Cornwall Hospital	Toby Talbot	UNITED KINGDOM	Truro	Truro
425	Velindre Hospital	Alison Brewster	UNITED KINGDOM	Whitchurch	Whitchurch
426	Velindre Hospital	Alison Brewster	UNITED KINGDOM	Whitchurch	Whitchurch
427	Bristol Haematology and Oncology Centre	Alfredo Addeo	UNITED KINGDOM	Bristol	Bristol
428	Bristol Haematology and Oncology Centre	Alfredo Addeo	UNITED KINGDOM	Bristol	Bristol
429	Royal Preston Hospital	Geraldine Skailes	UNITED KINGDOM	Preston	Preston
430	Royal Preston Hospital	Geraldine Skailes	UNITED KINGDOM	Preston	Preston
431	Queen's Hospital	Simon Ball	UNITED KINGDOM	Romford	Romford
432	Queen's Hospital	Simon Ball	UNITED KINGDOM	Romford	Romford
433	DERRIFORD HOSPITAL; PLYMOUTH ONCOLOGY CENTRE	Amy Roy	UNITED KINGDOM	Plymouth	Plymouth
434	DERRIFORD HOSPITAL; PLYMOUTH ONCOLOGY CENTRE	Amy Roy	UNITED KINGDOM	Plymouth	Plymouth
435	Raigmore Hospital	Carol MacGregor	UNITED KINGDOM	Inverness	Inverness
436	Raigmore Hospital	Carol MacGregor	UNITED KINGDOM	Inverness	Inverness
437	Gartnavel General Hospital; Beatson West of Scotland Cancer Centre	Nicola Steele	UNITED KINGDOM	Glasgow	Glasgow
438	Gartnavel General Hospital; Beatson West of Scotland Cancer Centre	Nicola Steele	UNITED KINGDOM	Glasgow	Glasgow
439	St George’s Hospital	TIM BENEPAL	UNITED KINGDOM	LONDON	LONDON
440	St George’s Hospital	TIM BENEPAL	UNITED KINGDOM	LONDON	LONDON
441	Royal United Hospital	Ashley Cox	UNITED KINGDOM	BATH	BATH
442	Royal United Hospital	Ashley Cox	UNITED KINGDOM	BATH	BATH
443	Peninsula Cancer Institute	WILLIAM W. MACLAUGHLIN	UNITED STATES	VA	CHESAPEAKE
444	Peninsula Cancer Institute	WILLIAM W. MACLAUGHLIN	UNITED STATES	VA	CHESAPEAKE
445	Carle Cancer Center	Vamsi Vasireddy	UNITED STATES	IL	URBANA
446	Carle Cancer Center	Vamsi Vasireddy	UNITED STATES	IL	URBANA
447	Fort Wayne Med Oncology & Hematology Inc	Ahad Sadiq	UNITED STATES	IN	Fort Wayne
448	Fort Wayne Med Oncology & Hematology Inc	Ahad Sadiq	UNITED STATES	IN	Fort Wayne
449	New England Cancer Specialists	CHRISTIAN THOMAS	UNITED STATES	ME	Scarborough
450	New England Cancer Specialists	CHRISTIAN THOMAS	UNITED STATES	ME	Scarborough
451	Swedish Cancer Institute	Howard West	UNITED STATES	WA	Seattle
452	Swedish Cancer Institute	Howard West	UNITED STATES	WA	Seattle
453	University of Michigan	Bryan Schneider	UNITED STATES	MI	Ann Arbor
454	University of Michigan	Bryan Schneider	UNITED STATES	MI	Ann Arbor
455	PROVIDENCE PORTLAND MEDICAL CENTER	Rachel Sanborn	UNITED STATES	OR	Portland
456	PROVIDENCE PORTLAND MEDICAL CENTER	Rachel Sanborn	UNITED STATES	OR	Portland
457	Northside Hospital	Rodolfo Bordoni	UNITED STATES	GA	Atlanta
458	Northside Hospital	Rodolfo Bordoni	UNITED STATES	GA	Atlanta
459	Blue Ridge Cancer Care	Jerome Goldschmidt-Jr	UNITED STATES	VA	Blacksburg
460	Blue Ridge Cancer Care	Jerome Goldschmidt-Jr	UNITED STATES	VA	Blacksburg
461	St. Vincent Hospital	Anthony Jaslowski	UNITED STATES	WI	Green Bay
462	St. Vincent Hospital	Anthony Jaslowski	UNITED STATES	WI	Green Bay
463	Gettysburg Cancer Center	Tina Khair	UNITED STATES	PA	Gettysburg
464	Gettysburg Cancer Center	Tina Khair	UNITED STATES	PA	Gettysburg
465	Stamford Hospital; BCC, MOHR	SALVATORE DEL PRETE	UNITED STATES	CT	STAMFORD
466	Stamford Hospital; BCC, MOHR	SALVATORE DEL PRETE	UNITED STATES	CT	STAMFORD
467	Montefiore Medical Center	Haiying Cheng	UNITED STATES	NY	Bronx
468	Montefiore Medical Center	Haiying Cheng	UNITED STATES	NY	Bronx
469	University of Washington	Rafael Santana-Davila	UNITED STATES	WA	Seattle
470	University of Washington	Rafael Santana-Davila	UNITED STATES	WA	Seattle
471	HEMATOLOGY & ONCOLOGY ASSOC; NORTH EASTERN PENNSYLVANIA	Kristin Liptock	UNITED STATES	PA	Dunmore
472	HEMATOLOGY & ONCOLOGY ASSOC; NORTH EASTERN PENNSYLVANIA	Kristin Liptock	UNITED STATES	PA	Dunmore
473	Illinois Cancer Care	Gregory J. Gerstner	UNITED STATES	IL	Peoria
474	Illinois Cancer Care	Gregory J. Gerstner	UNITED STATES	IL	Peoria
475	Orlando Health Inc.	Tirrell Tremayne Johnson	UNITED STATES	FL	Orlando
476	Orlando Health Inc.	Tirrell Tremayne Johnson	UNITED STATES	FL	Orlando
477	Los Angeles Hematology Oncology Medical Group	Lasika Seneviratne	UNITED STATES	CA	Los Angeles
478	Los Angeles Hematology Oncology Medical Group	Lasika Seneviratne	UNITED STATES	CA	Los Angeles
479	Allegheny Cancer Center	Gene Finley	UNITED STATES	PA	Pittsburg
480	Allegheny Cancer Center	Gene Finley	UNITED STATES	PA	Pittsburg
481	St. Joseph Heritage Healthcare	Wes Lee	UNITED STATES	CA	SANTA ROSA
482	St. Joseph Heritage Healthcare	Wes Lee	UNITED STATES	CA	SANTA ROSA
483	University of Minnesota.	Manish Patel	UNITED STATES	MN	Minneapolis
484	University of Minnesota.	Manish Patel	UNITED STATES	MN	Minneapolis
485	Tallahassee Memorial Hospital	Karen Russell	UNITED STATES	FL	Tallahassee
486	Tallahassee Memorial Hospital	Karen Russell	UNITED STATES	FL	Tallahassee
487	Oncology Consultants PA	Julio Peguero	UNITED STATES	TX	Houston
488	Oncology Consultants PA	Julio Peguero	UNITED STATES	TX	Houston
489	University of Kentucky; Markey Cancer Center	Susanne Arnold	UNITED STATES	KY	Lexington
490	University of Kentucky; Markey Cancer Center	Susanne Arnold	UNITED STATES	KY	Lexington
491	Oncology Hematology West PC	ROBERT LANGDON	UNITED STATES	NE	Omaha
492	Oncology Hematology West PC	ROBERT LANGDON	UNITED STATES	NE	Omaha
493	Cooper Health System; MD Anderson Cancer Center	Polina Khrizman	UNITED STATES	NJ	Camden
494	Cooper Health System; MD Anderson Cancer Center	Polina Khrizman	UNITED STATES	NJ	Camden
495	CHI Health St. Francis	Mehmet Copur	UNITED STATES	NE	Grand Island
496	CHI Health St. Francis	Mehmet Copur	UNITED STATES	NE	Grand Island
497	Goshen Health System	Ebenezer Kio	UNITED STATES	IN	Goshen
498	Goshen Health System	Ebenezer Kio	UNITED STATES	IN	Goshen
499	Coast Hematology Oncology Associates	Eknath Deo	UNITEDUNITED STATES STATES	CA	Long Beach
500	Coast Hematology Oncology Associates	Eknath Deo	UNITEDUNITED STATES STATES	CA	Long Beach
501	Ingalls Memorial Hospital	James Wallace	UNITED STATES	IL	Harvey
502	Ingalls Memorial Hospital	James Wallace	UNITED STATES	IL	Harvey
503	Trinitas Comprehensive Cancer Center	Barry Levinson	UNITED STATES	NJ	Elizabeth
504	Trinitas Comprehensive Cancer Center	Barry Levinson	UNITED STATES	NJ	Elizabeth
505	HealthCare Research Network II, LLC - PPDS	Subramanya Rao	UNITED STATES	IL	Tinley Park
506	HealthCare Research Network II, LLC - PPDS	Subramanya Rao	UNITED STATES	IL	Tinley Park
507	Maryland Oncology Hematology Columbia - USOR	Mohit Narang	UNITED STATES	MD	Columbia
508	Maryland Oncology Hematology Columbia - USOR	Mohit Narang	UNITED STATES	MD	Columbia
509	Virginia Cancer Specialists (Fairfax) - USOR	Alexander I. Spira	UNITED STATES	VA	Fairfax
510	Virginia Cancer Specialists (Fairfax) - USOR	Alexander I. Spira	UNITED STATES	VA	Fairfax
511	Peninsula and South Eastern Haematology and Oncology Group	VINOD GANJU	AUSTRALIA	Victoria	FRANKSTON
512	Redcliffe Hospital	Kieron Bigby	AUSTRALIA	Queensland	Redcliffe
513	Ballarat Health Services	Stephen Brown	AUSTRALIA	Victoria	Ballarat
514	St Vincents Hospital Sydney	Rachel Dear	AUSTRALIA	New South Wales	Darlinghurst
515	Medizinische Universitt Wien; Univ.Klinik für Innere Medizin I - Abt. für Onkologie	SABINE ZOECHBAUER-MUELLER	AUSTRIA	WIEN	WIEN
516	O. Gesundheits- und Spitals-AG/LKH Steyr	JOSEF BOLITSCHEK	AUSTRIA	STEYR	STEYR
517	Klinikum Wels-Grieskirchen GmbH	JOSEF ECKMAYR	AUSTRIA	WELS	WELS
518	AZ Maria Middelares	Paul Germonpré	BELGIUM	Gent	Gent
519	AZ Delta (Campus Wilgenstraat), Apotheek	Ingel Demedts	BELGIUM	Roeselare	Roeselare
520	UZ Antwerpen	Jan Van Meerbeeck	BELGIUM	EDEGEM	EDEGEM
521	Clinique André Renard; Pneumologie	Léon Bosquee	BELGIUM	Herstal	Herstal

序号	名称	审查结论	批准日期/备案日期
1	浙江大学医学院附属第一医院医学伦理委员会	修改后同意	2017-02-09

进行中（招募完成）

目标入组人数	国内: 170 ； 国际: 568 ；
已入组人数	国内: 登记人暂未填写该信息； 国际: 登记人暂未填写该信息；
实际入组总人数	国内: 164  ； 国际: 578 ；

第一例受试者签署知情同意书日期	国内：2017-08-16；     国际：登记人暂未填写该信息；
第一例受试者入组日期	国内：登记人暂未填写该信息；     国际：登记人暂未填写该信息；
试验完成日期	国内：登记人暂未填写该信息；     国际：登记人暂未填写该信息；